PRLD · Prelude Therapeutics Inc · Holdings

$4.59 -0.08 (-1.71%) At close · Sep 11

Russell 2000 member Rebalance outlook locked

Market Cap

$366.30M

79.80M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Use institutional holdings through the 13F API or MCP →

Quarter:

Holders: 77

Total Value: $265,997,370

Total Shares: 49,905,707

Institutional Ownership Trend

24 quarters

Holder Concentration

Across 77 13F filers · Δ vs Mar 31, 2026

Top Holder

27.5%

−7.9 pts

Top 5

72.4%

−8.2 pts

Top 10

85.8%

−3.6 pts

HHI

1,459

Broadly held−954

Quarterly Activity

vs Mar 31, 2026

New

Increased

Decreased

Sold Out

Unchanged

Holder count: +22

Institutional value: +152.6%

Shares held: +62.1%

Top Buyers

vs Mar 31, 2026

Institution	Added	Now Holds
Mid ORBIMED ADVISORS LLC	+2,815,315	13,724,571
Mega BlackRock, Inc.	+1,475,615	1,797,501
Mid Kynam Capital Management, LP	+822,536	2,415,087
Mega VANGUARD CAPITAL MANAGEMENT LLC	+779,039	2,009,445
Mid ADAR1 Capital Management, LLC	+748,075	900,900

Top Sellers

vs Mar 31, 2026

Institution	Sold	Now Holds
Large MARSHALL WACE, LLP	−168,214	190,692
Mega GOLDMAN SACHS GROUP INC	−115,635	120,834
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP	−114,088	174,700
Mega JANE STREET GROUP, LLC	−108,763	84,200
Mega CITADEL ADVISORS LLC	−54,424	69,954

Top New Positions

vs Mar 31, 2026

Institution	Acquired	Value (USD)
Large RA CAPITAL MANAGEMENT, L.P.	6,475,882	$34,516,451
Mid Soleus Capital Management, L.P.	3,378,378	$18,006,754
Large ADAGE CAPITAL PARTNERS GP, L.L.C.	766,095	$4,083,286
Mega VANGUARD PORTFOLIO MANAGEMENT LLC	193,920	$1,033,593
Mid Hillsdale Investment Management Inc.	81,400	$433,862

Top Sold-Out Positions

vs Mar 31, 2026

Institution	Previously Held	Last Value (USD)
Mid EcoR1 Capital, LLC	947,049	$3,238,907
Large HRT FINANCIAL LP	58,699	$200,750
Mid XTX Topco Ltd	57,190	$195,589
Large Focus Partners Wealth	50,007	$171,023
Large OMERS ADMINISTRATION Corp	32,700	$111,834

Filter: New 34 Increased 25 Reduced 10 Sold out 12 Unchanged 8

Showing 81 of 81

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

ORBIMED ADVISORS LLC

$73,151,963

27.50%

13,724,571

BAKER BROS. ADVISORS LP

$53,959,981

20.29%

10,123,824

RA CAPITAL MANAGEMENT, L.P.

$34,516,451

12.98%

6,475,882

Soleus Capital Management, L.P.

$18,006,754

6.77%

3,378,378

Kynam Capital Management, LP

$12,872,413

4.84%

2,415,087

VANGUARD CAPITAL MANAGEMENT LLC

$10,710,341

4.03%

2,009,445

BlackRock, Inc.

$9,580,676

3.60%

1,797,501

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	50,939	$271,504	2.8%	Sole
BlackRock Investment Management, LLC	83,112	$442,986	4.6%	Sole
BLACKROCK ADVISORS LLC	64,812	$345,447	3.6%	Sole
BlackRock Fund Advisors	1,014,729	$5,408,505	56.5%	Sole
BlackRock Institutional Trust Company, N.A.	583,909	$3,112,234	32.5%	Sole

SPHERA FUNDS MANAGEMENT LTD.

$5,435,704

2.04%

1,019,832

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Sphera Global Healthcare Management LP joint	1,019,832	$5,435,704	100.0%	Defined

TWO SIGMA INVESTMENTS, LP

$5,294,656

1.99%

993,369

ADAR1 Capital Management, LLC

$4,801,797

1.81%

900,900

MILLENNIUM MANAGEMENT LLC

$4,503,812

1.69%

844,993

GEODE CAPITAL MANAGEMENT, LLC

$4,487,124

1.69%

841,862

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	138,094	$736,041	16.4%	Defined
Held directly	703,768	$3,751,083	83.6%	Defined

ADAGE CAPITAL PARTNERS GP, L.L.C.

$4,083,286

1.54%

766,095

ACADIAN ASSET MANAGEMENT LLC

$3,258,543

1.23%

611,359

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Acadian Inc	611,359	$3,258,543	100.0%	Defined

MORGAN STANLEY

$2,685,571

1.01%

503,860

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	29	$154	0.0%	Defined
MORGAN STANLEY & CO. LLC	18,604	$99,159	3.7%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	24,893	$132,679	4.9%	Defined
MORGAN STANLEY SMITH BARNEY LLC	278,215	$1,482,885	55.2%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	182,119	$970,694	36.1%	Defined

STATE STREET CORP

$2,285,434

0.86%

428,787

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SSGA FUNDS MANAGEMENT, INC. joint	428,787	$2,285,434	100.0%	Defined

UBS Group AG

$1,699,187

0.64%

318,797

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Financial Services Inc	23	$122	0.0%	Defined
UBS AG	318,774	$1,699,065	100.0%	Defined

VANGUARD FIDUCIARY TRUST CO

$1,518,442

0.57%

284,886

RENAISSANCE TECHNOLOGIES LLC

$1,498,796

0.56%

281,200

NORTHERN TRUST CORP

$1,282,392

0.48%

240,599

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	236,255	$1,259,239	98.2%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC joint	4,344	$23,153	1.8%	Other

VANGUARD PORTFOLIO MANAGEMENT LLC

$1,033,593

0.39%

193,920

MARSHALL WACE, LLP

$1,016,388

0.38%

190,692

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Marshall Wace North America L.P. joint	190,692	$1,016,388	100.0%	Other

Connor, Clark & Lunn Investment Management Ltd.

$669,479

0.25%

125,606

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Manager 1	124,685	$664,571	99.3%	Sole
Held directly	921	$4,908	0.7%	Sole

GOLDMAN SACHS GROUP INC

$644,044

0.24%

120,834

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	49,756	$265,199	41.2%	Defined
GOLDMAN SACHS ASSET MANAGEMENT, L.P.	71,078	$378,845	58.8%	Defined

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$591,630

0.22%

111,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	111,000	$591,630	100.0%	Other

Hillsdale Investment Management Inc.

$433,862

0.16%

81,400

Bank of New York Mellon Corp

$363,436

0.14%

68,187

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Investments Corporation	19,253	$102,618	28.2%	Defined
The Bank of New York Mellon	48,934	$260,818	71.8%	Defined

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$360,425

0.14%

67,622

BRIDGEWAY CAPITAL MANAGEMENT, LLC

$343,785

0.13%

64,500

JANE STREET GROUP, LLC

$341,653

0.13%

64,100

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	64,100	$341,653	100.0%	Defined

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$339,521

0.13%

63,700

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	63,700	$339,521	100.0%	Other

Squarepoint Ops LLC

$317,348

0.12%

59,540

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Squarepoint Capital LLP	59,540	$317,348	100.0%	Defined

PANAGORA ASSET MANAGEMENT INC

$253,569

0.10%

47,574

Mariner, LLC

$241,241

0.09%

45,261

Nuveen, LLC

$197,332

0.07%

37,023

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
TEACHERS ADVISORS, LLC joint	37,023	$197,332	100.0%	Defined

DIMENSIONAL FUND ADVISORS LP

$187,668

0.07%

35,210

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Dimensional Fund Advisors Ltd.	2,078	$11,075	5.9%	Defined
Held directly	33,132	$176,593	94.1%	Sole

Invesco Ltd.

$185,173

0.07%

34,742

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invesco Advisers, Inc. joint	4,014	$21,394	11.6%	Defined
Invesco Trust Co joint	11,071	$59,008	31.9%	Defined
Invesco Capital Management LLC	19,657	$104,771	56.6%	Defined

Cerity Partners LLC

$175,223

0.07%

32,875

State of Wyoming

$175,154

0.07%

32,862

CITADEL ADVISORS LLC

$166,829

0.06%

31,300

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	31,300	$166,829	100.0%	Defined

Graham Capital Management, L.P.

$158,674

0.06%

29,770

DEUTSCHE BANK AG\

$148,301

0.06%

27,824

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DWS INVESTMENT MANAGEMENT AMERICAS, INC	741	$3,949	2.7%	Defined
DWS Investments UK Ltd	27,083	$144,352	97.3%	Defined

WELLS FARGO & COMPANY/MN

$134,982

0.05%

25,325

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO BANK N A	25,325	$134,982	100.0%	Defined

BANK OF AMERICA CORP /DE/

$127,253

0.05%

23,875

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	23,875	$127,253	100.0%	Defined

PRICE T ROWE ASSOCIATES INC /MD/

$121,300

0.05%

22,758

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T. Rowe Price International Ltd	22,758	$121,300	100.0%	Defined

CITADEL ADVISORS LLC

$120,212

0.05%

22,554

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	12,323	$65,681	54.6%	Defined
Held directly	10,231	$54,531	45.4%	Defined

RHUMBLINE ADVISERS

$117,654

0.04%

22,074

JANE STREET GROUP, LLC

$107,133

0.04%

20,100

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	20,100	$107,133	100.0%	Defined

Vanguard Global Advisers, LLC

$86,399

0.03%

16,210

CITADEL ADVISORS LLC

$85,813

0.03%

16,100

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	16,100	$85,813	100.0%	Defined

ExodusPoint Capital Management, LP

$82,481

0.03%

15,475

BARCLAYS PLC

$77,439

0.03%

14,529

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BARCLAYS BANK PLC	12,535	$66,811	86.3%	Defined
BARCLAYS CAPITAL INC.	1,994	$10,628	13.7%	Defined

NEW YORK STATE COMMON RETIREMENT FUND

$75,686

0.03%

14,200

HSBC HOLDINGS PLC

$72,765

0.03%

13,652

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
HSBC BANK PLC	13,652	$72,765	100.0%	Defined

JPMORGAN CHASE & CO

$72,156

0.03%

13,538

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JPMorgan Chase Bank, N.A.	11,648	$62,083	86.0%	Defined
J.P. Morgan Securities plc	1,890	$10,073	14.0%	Defined

MANGROVE PARTNERS IM, LLC

$71,166

0.03%

13,352

Qube Research & Technologies Ltd

$69,876

0.03%

13,110

CITIGROUP INC

$69,465

0.03%

13,033

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citigroup Financial Products Inc. joint	13,033	$69,465	100.0%	Defined

MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.

$68,138

0.03%

12,784

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Global X Management CO LLC joint	12,784	$68,138	100.0%	Defined

GSA CAPITAL PARTNERS LLP

$67,541

0.03%

12,672

Spark Investment Management LLC

$56,498

0.02%

10,600

ALLIANCEBERNSTEIN L.P.

$56,124

0.02%

10,530

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Equitable Holdings, Inc.	10,530	$56,124	100.0%	Defined

Police & Firemen's Retirement System of New Jersey

$55,922

0.02%

10,492

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Capital	10,492	$55,922	100.0%	Defined

LOS ANGELES CAPITAL MANAGEMENT LLC

$34,271

0.01%

6,430

FMR LLC

$30,002

0.01%

5,629

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	5,629	$30,002	100.0%	Defined

STRS OHIO

$29,315

0.01%

5,500

BNP PARIBAS ARBITRAGE, SA

$21,874

0.01%

4,104

GROUP ONE TRADING LLC

$20,824

0.01%

3,907

Legal & General Group Plc

$14,385

0.01%

2,699

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Legal & General Investment Management America Inc	2,699	$14,385	100.0%	Defined

ROYAL BANK OF CANADA

$14,166

0.01%

2,658

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RBC CMA LTD.	958	$5,106	36.0%	Defined
BREWIN DOLPHIN WEALTH MANAGEMENT LTD	1,699	$9,055	63.9%	Defined
Held directly	1	$5	0.0%	Sole

Ameritas Investment Partners, Inc.

$13,431

0.01%

2,520

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
EATON VANCE MANAGEMENT	2,520	$13,431	100.0%	Other

Tower Research Capital LLC (TRC)

$12,669

0.00%

2,377

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Latour Trading LLC (Latour)	2,377	$12,669	100.0%	Defined

Russell Investments Group, Ltd.

$11,832

0.00%

2,220

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Russell Investment Management, LLC	2,220	$11,832	100.0%	Defined

NISA INVESTMENT ADVISORS, LLC

$8,709

0.00%

1,634

PNC FINANCIAL SERVICES GROUP, INC.

$6,239

0.00%

1,171

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
PNC Bank, National Association	1,171	$6,239	100.0%	Other

Quarry LP

$4,024

0.00%

755

Fortitude Family Office, LLC

$1,225

0.00%

230

Sterling Capital Management LLC

$517

0.00%

SBI Securities Co., Ltd.

$117

0.00%

Caitong International Asset Management Co., Ltd

$95

0.00%

Optiver Holding B.V.

$21

0.00%

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Optiver VOF	4	$21	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
XTX EXECUTION SERVICES LLC joint	57,190	$195,589	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
PGIM Quantitative Solutions LLC	17,420	$59,576	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Thakore Nainoor	11,980	$40,971	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
AMERICAN CENTURY INVESTMENT MANAGEMENT INC	10,294	$35,205	100.0%	Defined

Key facts CIK 1678660 CUSIP 74065P101 13F (30d) 49 filings 49 filers Visit website Investor relations