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PRLD

Prelude Therapeutics Inc

Company with tickers: PRLD

CIK
1678660
CUSIP
74065P101
Shares Outstanding
64,917,172
13F Activity (30d)
53 filings 52 filers
Holders: 55
Total Value: $105,313,450
Total Shares: 30,793,416

Institutional Ownership Trend

23 quarters

Holder Concentration

Across 55 13F filers · Δ vs Dec 31, 2025
Top Holder
35.4%
Jun 2023 → Mar 2026 · range 28.3% – 40.2%
−2.8 pts
Top 5
80.5%
Jun 2023 → Mar 2026 · range 77.2% – 88.6%
−3.7 pts
Top 10
89.4%
Jun 2023 → Mar 2026 · range 87.4% – 95.4%
−2.5 pts
HHI
2,413
Jun 2023 → Mar 2026 · range 1,836 – 3,058
Moderately concentrated −371

Quarterly Activity

vs Dec 31, 2025
New
13
Increased
20
Decreased
11
Sold Out
6
Unchanged
11
Holder count: +7
Institutional value: +27.4%
Shares held: +8.0%

Top Buyers

vs Dec 31, 2025
Institution Added Now Holds Open
Mid Kynam Capital Management, LP +803,684 1,592,551
Small SPHERA FUNDS MANAGEMENT LTD. +435,587 558,339
Mega MILLENNIUM MANAGEMENT LLC +231,740 382,737
Mega TWO SIGMA INVESTMENTS, LP +134,931 923,626
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP +120,379 288,788

Top Sellers

vs Dec 31, 2025
Institution Sold Now Holds Open
Large Point72 Asset Management, L.P. −42,839 16,329
Large OMERS ADMINISTRATION Corp −40,300 32,700
Large ACADIAN ASSET MANAGEMENT LLC −24,184 511,519
Mega MORGAN STANLEY −12,755 322,161
Large Qube Research & Technologies Ltd −5,134 16,417

Top New Positions

vs Dec 31, 2025
Institution Acquired Value (USD) Open
Mega VANGUARD CAPITAL MANAGEMENT LLC 1,230,406 $4,207,988
Mid EcoR1 Capital, LLC 947,049 $3,238,907
Mega VANGUARD FIDUCIARY TRUST CO 157,380 $538,239
Mid ADAR1 Capital Management, LLC 152,825 $522,661
Mega CITADEL ADVISORS LLC 124,378 $425,372

Top Sold-Out Positions

vs Dec 31, 2025
Institution Previously Held Last Value (USD) Open
Mega VANGUARD GROUP INC 1,413,986 $4,100,559
Mega PRICE T ROWE ASSOCIATES INC /MD/ 755,956 $2,192,272
Large TWO SIGMA ADVISERS, LP 237,300 $688,170
Mega TD Asset Management Inc 160,652 $465,890
Mega MANUFACTURERS LIFE INSURANCE COMPANY, THE 70,546 $204,583
Filter: New 13 Increased 20 Reduced 11 Sold out 6 Unchanged 11
Showing 56 of 56
All Common Calls Puts
Export CSV
Holder Value (USD) % of 13F Shares Open
Mid ORBIMED ADVISORS LLC $37,309,655 35.43% 10,909,256
Large BAKER BROS. ADVISORS LP $34,623,478 32.88% 10,123,824
Mid Kynam Capital Management, LP $5,446,524 5.17% 1,592,551
Mega VANGUARD CAPITAL MANAGEMENT LLC $4,207,988 4.00% 1,230,406
Mid EcoR1 Capital, LLC $3,238,907 3.08% 947,049
Mega TWO SIGMA INVESTMENTS, LP $3,158,800 3.00% 923,626
Small SPHERA FUNDS MANAGEMENT LTD. $1,909,519 1.81% 558,339
Large ACADIAN ASSET MANAGEMENT LLC $1,749,394 1.66% 511,519
Mega MILLENNIUM MANAGEMENT LLC $1,308,960 1.24% 382,737
Large MARSHALL WACE, LLP $1,227,458 1.17% 358,906
Mega MORGAN STANLEY $1,101,789 1.05% 322,161
Mega BlackRock, Inc. $1,100,848 1.05% 321,886
Mega GEODE CAPITAL MANAGEMENT, LLC $1,034,406 0.98% 302,458
Large RENAISSANCE TECHNOLOGIES LLC $941,184 0.89% 275,200
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP $915,834 0.87% 267,788
Mega GOLDMAN SACHS GROUP INC $808,723 0.77% 236,469
Mega JANE STREET GROUP, LLC $659,933 0.63% 192,963
Mega VANGUARD FIDUCIARY TRUST CO Bank $538,239 0.51% 157,380
Mid ADAR1 Capital Management, LLC $522,661 0.50% 152,825
Mega STATE STREET CORP $472,750 0.45% 138,231
Mega CITADEL ADVISORS LLC $425,372 0.40% 124,378
Large Connor, Clark & Lunn Investment Management Ltd. $373,070 0.35% 109,085
Mega UBS Group AG $220,606 0.21% 64,505
Large HRT FINANCIAL LP $200,750 0.19% 58,699
Mid XTX Topco Ltd $195,589 0.19% 57,190
Mega BANK OF AMERICA CORP /DE/ Bank $193,315 0.18% 56,525
Mid BRIDGEWAY CAPITAL MANAGEMENT, LLC $182,970 0.17% 53,500
Mega NORTHERN TRUST CORP Bank $171,410 0.16% 50,120
Large Focus Partners Wealth $171,023 0.16% 50,007
Mega DIMENSIONAL FUND ADVISORS LP $120,417 0.11% 35,210
Large Cerity Partners LLC $112,432 0.11% 32,875
Large OMERS ADMINISTRATION Corp $111,834 0.11% 32,700
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP $71,820 0.07% 21,000
Large PRUDENTIAL FINANCIAL INC $59,576 0.06% 17,420
Large Qube Research & Technologies Ltd $56,146 0.05% 16,417
Large Point72 Asset Management, L.P. $55,845 0.05% 16,329
Mega HSBC HOLDINGS PLC $46,689 0.04% 13,652
Small Diametric Capital, LP $40,971 0.04% 11,980
Mid NINE MASTS CAPITAL Ltd $40,010 0.04% 11,699
Mid Graham Capital Management, L.P. $38,793 0.04% 11,343
Mega AMERICAN CENTURY COMPANIES INC $35,205 0.03% 10,294
Mega BARCLAYS PLC $29,412 0.03% 8,600
Mega FMR LLC $20,550 0.02% 6,009
Mega Vanguard Global Advisers, LLC $15,855 0.02% 4,636
Mid GROUP ONE TRADING LLC $13,361 0.01% 3,907
Mid SBI Securities Co., Ltd. Broker-Dealer $9,032 0.01% 2,641
Mega ROYAL BANK OF CANADA Bank $7,971 0.01% 2,331
Large NISA INVESTMENT ADVISORS, LLC $5,588 0.01% 1,634
Mega PNC FINANCIAL SERVICES GROUP, INC. $4,002 0.00% 1,171
Small CALDWELL SUTTER CAPITAL, INC. $3,420 0.00% 1,000
Large CWM, LLC $1,959 0.00% 573
Micro Fortitude Family Office, LLC Family Office $786 0.00% 230
Mega BNP PARIBAS ARBITRAGE, SA $324 0.00% 95
Mega JPMORGAN CHASE & CO $212 0.00% 62
Mid Optiver Holding B.V. $68 0.00% 20
Mega CITIGROUP INC $17 0.00% 5

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