TSHA · Taysha Gene Therapies, Inc. · Holdings

$5.02 -0.14 (-2.71%) At close · Sep 11

Russell 2000 member Rebalance outlook locked

Market Cap

$1.65B

325.83M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Use institutional holdings through the 13F API or MCP →

Quarter:

Holders: 208

Total Value: $2,046,049,828

Total Shares: 300,447,960

Showing 1–100 of 213 holdings by value · page 1 of 3

Institutional Ownership Trend

24 quarters

Holder Concentration

Across 208 13F filers · Δ vs Mar 31, 2026

Top Holder

8.0%

−0.9 pts

Top 5

36.7%

−2.4 pts

Top 10

59.1%

−5.3 pts

HHI

424

Broadly held−68

Quarterly Activity

vs Mar 31, 2026

New

Increased

100

Decreased

Sold Out

Unchanged

Holder count: +15

Institutional value: +72.1%

Shares held: +13.0%

Top Buyers

vs Mar 31, 2026

Institution	Added	Now Holds
Mega WELLINGTON MANAGEMENT GROUP LLP	+3,349,244	3,975,605
Mega Pictet Asset Management Holding SA	+2,751,383	2,770,701
Mega BlackRock, Inc.	+2,326,319	20,691,927
Mega VANGUARD CAPITAL MANAGEMENT LLC	+2,247,093	12,478,595
Large Avoro Capital Advisors LLC	+2,188,888	23,888,888

Top Sellers

vs Mar 31, 2026

Institution	Sold	Now Holds
Mega SG Americas Securities, LLC	−1,974,482	202,260
Mega MORGAN STANLEY	−1,477,892	16,487,479
Mega BARCLAYS PLC	−1,181,351	1,630,659
Mega MILLENNIUM MANAGEMENT LLC	−1,154,982	2,126,838
Mega FMR LLC	−984,842	13,336,413

Top New Positions

vs Mar 31, 2026

Institution	Acquired	Value (USD)
Mid MPM BIOIMPACT LLC	4,500,000	$30,645,000
Large FARALLON CAPITAL MANAGEMENT LLC	2,250,000	$15,322,500
Mega NORGES BANK	2,233,600	$15,210,816
Mid ORBIMED ADVISORS LLC	2,000,000	$13,620,000
Small HEIGHTS CAPITAL MANAGEMENT, INC	1,500,000	$10,215,000

Top Sold-Out Positions

vs Mar 31, 2026

Institution	Previously Held	Last Value (USD)
Mid DEERFIELD MANAGEMENT COMPANY, L.P.	2,722,165	$12,168,077
Large Point72 Asset Management, L.P.	461,856	$2,064,496
Large RENAISSANCE TECHNOLOGIES LLC	413,203	$1,847,017
Small SUPERSTRING CAPITAL MANAGEMENT LP	258,269	$1,154,462
Large TUDOR INVESTMENT CORP ET AL	143,575	$641,780

Filter: New 40 Increased 100 Reduced 40 Sold out 25 Unchanged 28

Showing 100 of 213

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

Avoro Capital Advisors LLC

$162,683,327

7.95%

23,888,888

RA CAPITAL MANAGEMENT, L.P.

$160,413,962

7.84%

23,555,648

GOLDMAN SACHS GROUP INC

$154,676,332

7.56%

22,713,118

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	13,581,628	$92,490,886	59.8%	Defined
GOLDMAN SACHS ASSET MANAGEMENT, L.P.	9,120,086	$62,107,785	40.2%	Defined
Goldman Sachs Trust Company, N.A.	11,404	$77,661	0.1%	Defined

BlackRock, Inc.

$140,912,017

6.89%

20,691,927

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	207,264	$1,411,467	1.0%	Sole
BlackRock Asset Management Canada Ltd	1,678	$11,427	0.0%	Sole
BlackRock Investment Management, LLC	654,410	$4,456,532	3.2%	Sole
BLACKROCK ADVISORS LLC	575,257	$3,917,500	2.8%	Sole
BlackRock Fund Advisors	10,784,595	$73,443,091	52.1%	Sole
BlackRock Institutional Trust Company, N.A.	7,417,390	$50,512,425	35.8%	Sole
BlackRock Fund Managers Ltd.	39,379	$268,170	0.2%	Sole
BlackRock Asset Management Ireland Ltd	833,839	$5,678,443	4.0%	Sole
BlackRock Asset Management Schweiz AG	23,782	$161,955	0.1%	Sole
Aperio Group, LLC	154,333	$1,051,007	0.7%	Sole

Vestal Point Capital, LP

$132,216,150

6.46%

19,415,000

MORGAN STANLEY

$112,279,729

5.49%

16,487,479

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	166	$1,130	0.0%	Defined
MORGAN STANLEY & CO. LLC	66,212	$450,903	0.4%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	16,001,130	$108,967,695	97.1%	Defined
MORGAN STANLEY SMITH BARNEY LLC	176,830	$1,204,212	1.1%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	243,141	$1,655,789	1.5%	Defined

RTW INVESTMENTS, LP

$92,345,356

4.51%

13,560,258

FMR LLC

$90,820,972

4.44%

13,336,413

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	7,877,773	$53,647,634	59.1%	Defined
FIDELITY MANAGEMENT TRUST CO	5,457,998	$37,168,966	40.9%	Defined
STRATEGIC ADVISERS LLC	642	$4,372	0.0%	Defined

VANGUARD CAPITAL MANAGEMENT LLC

$84,979,231

4.15%

12,478,595

STATE STREET CORP

$77,783,275

3.80%

11,421,920

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STATE STREET GLOBAL ADVISORS EUROPE LIMITED joint	11,421,920	$77,783,275	100.0%	Defined

Siren, L.L.C.

$67,055,202

3.28%

9,846,579

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invus Group, LLC	9,846,579	$67,055,202	100.0%	Defined

Octagon Capital Advisors LP

$66,010,991

3.23%

9,693,244

GEODE CAPITAL MANAGEMENT, LLC

$44,676,282

2.18%

6,560,394

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	940,693	$6,406,119	14.3%	Defined
Held directly	5,619,701	$38,270,163	85.7%	Defined

Polar Capital Holdings Plc

$34,847,675

1.70%

5,117,133

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Polar Capital LLP	5,117,133	$34,847,675	100.0%	Defined

MPM BIOIMPACT LLC

$30,645,000

1.50%

4,500,000

D. E. Shaw & Co., Inc.

$29,954,819

1.46%

4,398,652

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
D. E. SHAW & CO, L.P.	3,683,234	$25,082,823	83.7%	Defined
D. E. Shaw Investment Management, L.L.C. joint	715,418	$4,871,996	16.3%	Defined

BAKER BROS. ADVISORS LP

$27,272,388

1.33%

4,004,756

WELLINGTON MANAGEMENT GROUP LLP

$27,073,867

1.32%

3,975,605

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Wellington Management Company LLP	2,314,501	$15,761,751	58.2%	Defined
Wellington Managment Canada LLC	76,661	$522,061	1.9%	Defined
Wellington Management Singapore Pte. Ltd.	157,017	$1,069,285	3.9%	Defined
Wellington Management International Ltd	125,576	$855,172	3.2%	Defined
Wellington Trust Company, NA joint	1,258,930	$8,573,313	31.7%	Defined
Wellington Management Australia Pty Ltd	42,920	$292,285	1.1%	Defined

HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND

$26,460,261

1.29%

3,885,501

Casdin Capital, LLC

$22,132,500

1.08%

3,250,000

VANGUARD PORTFOLIO MANAGEMENT LLC

$21,383,461

1.05%

3,140,009

ADAR1 Capital Management, LLC

$20,705,573

1.01%

3,040,466

Pictet Asset Management Holding SA

$18,868,473

0.92%

2,770,701

Aberdeen Group plc

$15,847,905

0.77%

2,327,152

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
abrdn Inc.	2,327,152	$15,847,905	100.0%	Defined

FARALLON CAPITAL MANAGEMENT LLC

$15,322,500

0.75%

2,250,000

NORGES BANK

$15,210,816

0.74%

2,233,600

NORTHERN TRUST CORP

$15,160,487

0.74%

2,226,210

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	2,071,580	$14,107,459	93.1%	Defined
NORTHERN TRUST GLOBAL INVESTMENTS LTD	117,754	$801,903	5.3%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC joint	36,876	$251,125	1.7%	Other

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$14,986,732

0.73%

2,200,695

MILLENNIUM MANAGEMENT LLC

$14,483,766

0.71%

2,126,838

ORBIMED ADVISORS LLC

$13,620,000

0.67%

2,000,000

RICE HALL JAMES & ASSOCIATES, LLC

$13,567,079

0.66%

1,992,229

VANGUARD FIDUCIARY TRUST CO

$12,914,987

0.63%

1,896,474

B Group, Inc.

$12,261,786

0.60%

1,800,556

Affinity Asset Advisors, LLC

$11,917,500

0.58%

1,750,000

BARCLAYS PLC

$11,104,787

0.54%

1,630,659

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BARCLAYS BANK PLC	1,618,307	$11,020,670	99.2%	Defined
BARCLAYS CAPITAL INC.	12,352	$84,117	0.8%	Defined

CITADEL ADVISORS LLC

$10,455,303

0.51%

1,535,287

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	438,181	$2,984,012	28.5%	Defined
Held directly	1,097,106	$7,471,291	71.5%	Defined

Seven Fleet Capital Management LP

$10,244,964

0.50%

1,504,400

HEIGHTS CAPITAL MANAGEMENT, INC

$10,215,000

0.50%

1,500,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
CVI Investments, Inc.	1,500,000	$10,215,000	100.0%	Other

Palo Alto Investors LP

$9,475,311

0.46%

1,391,382

BANK OF AMERICA CORP /DE/

$9,349,073

0.46%

1,372,845

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	1,189,894	$8,103,178	86.7%	Defined
MERRILL LYNCH, PIERCE, FENNER & SMITH INC.	67,866	$462,167	4.9%	Defined
BOFA SECURITIES, INC.	115,085	$783,728	8.4%	Defined

Granahan Investment Management, LLC

$8,888,255

0.43%

1,305,177

Quantum Private Wealth, LLC

$5,529,903

0.27%

812,027

FIRST TRUST ADVISORS LP

$5,387,860

0.26%

791,169

JPMORGAN CHASE & CO

$5,218,378

0.26%

766,282

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JPMorgan Chase Bank, N.A.	99,405	$676,948	13.0%	Defined
J.P. Morgan Investment Management Inc.	203,565	$1,386,277	26.6%	Defined
J.P. Morgan Securities LLC	929	$6,326	0.1%	Defined
J.P. Morgan Securities plc	23,004	$156,657	3.0%	Defined
JPMorgan Asset Management (UK) Ltd	439,379	$2,992,170	57.3%	Defined

Sands Capital Alternatives, LLC

$4,936,385

0.24%

724,873

GordonMD Global Investments LP

$4,924,889

0.24%

723,185

Bank of New York Mellon Corp

$4,753,180

0.23%

697,971

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Investments Corporation	243,797	$1,660,257	34.9%	Defined
The Bank of New York Mellon	452,449	$3,081,177	64.8%	Defined
BNY Mellon, NA joint	360	$2,451	0.1%	Defined
BNY Mellon Advisors, Inc.	1,363	$9,282	0.2%	Defined
Held directly	2	$13	0.0%	Defined

BNP PARIBAS ARBITRAGE, SA

$4,358,638

0.21%

640,035

PANAGORA ASSET MANAGEMENT INC

$4,020,535

0.20%

590,387

UBS Group AG

$4,007,186

0.20%

588,427

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Financial Services Inc	15,600	$106,236	2.7%	Defined
UBS AG	560,035	$3,813,838	95.2%	Defined
UBS Switzerland AG	11,479	$78,171	2.0%	Defined
UBS Securities LLC	1,313	$8,941	0.2%	Defined

AFFINITY WEALTH MANAGEMENT LLC

$3,928,062

0.19%

576,808

Squarepoint Ops LLC

$3,876,721

0.19%

569,269

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Squarepoint Capital LLP	569,269	$3,876,721	100.0%	Defined

ACUTA CAPITAL PARTNERS, LLC

$3,825,912

0.19%

561,808

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$3,799,980

0.19%

558,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	558,000	$3,799,980	100.0%	Other

Nuveen, LLC

$3,784,268

0.18%

555,693

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Nuveen Asset Management, LLC joint	4,165	$28,363	0.7%	Defined
TEACHERS ADVISORS, LLC joint	551,528	$3,755,905	99.3%	Defined

ADAGE CAPITAL PARTNERS GP, L.L.C.

$3,765,930

0.18%

553,000

DIADEMA PARTNERS LP

$3,559,035

0.17%

522,619

Hennion & Walsh Asset Management, Inc.

$3,535,207

0.17%

519,120

Woodline Partners LP

$3,499,168

0.17%

513,828

Holocene Advisors, LP

$3,473,100

0.17%

510,000

Ghisallo Capital Management LLC

$3,439,050

0.17%

505,000

Burkehill Global Management, LP

$3,405,000

0.17%

500,000

POLEN CAPITAL MANAGEMENT LLC

$3,331,581

0.16%

489,219

DIMENSIONAL FUND ADVISORS LP

$3,165,088

0.15%

464,771

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Dimensional Fund Advisors Ltd.	27,856	$189,699	6.0%	Defined
Dimensional Fund Advisors Pte. Ltd.	4,139	$28,186	0.9%	Defined
Dimensional Ireland Ltd	84,523	$575,601	18.2%	Defined
Held directly	348,253	$2,371,602	74.9%	Sole

VOYA INVESTMENT MANAGEMENT LLC

$2,896,720

0.14%

425,363

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Voya Investment Management Co. LLC joint	425,363	$2,896,720	100.0%	Defined

Trexquant Investment LP

$2,584,919

0.13%

379,577

Swiss National Bank

$2,512,890

0.12%

369,000

MOORE CAPITAL MANAGEMENT, LP

$2,440,526

0.12%

358,374

WELLS FARGO & COMPANY/MN

$2,269,866

0.11%

333,314

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO BANK N A	218,732	$1,489,564	65.6%	Defined
WELLS FARGO ADVISORS FINANCIAL NETWORK, LLC	103,949	$707,892	31.2%	Defined
WELLS FARGO CLEARING SERVICES, LLC	10,633	$72,410	3.2%	Defined

Jefferies Financial Group Inc.

$2,239,128

0.11%

328,800

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jefferies Financial Services, Inc.	328,800	$2,239,128	100.0%	Defined

CITIGROUP INC

$2,090,035

0.10%

306,907

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citigroup Financial Products Inc. joint	306,907	$2,090,035	100.0%	Defined

RHUMBLINE ADVISERS

$2,042,829

0.10%

299,975

ALPS ADVISORS INC

$1,978,597

0.10%

290,543

UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC

$1,856,404

0.09%

272,600

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Group AG	1,695	$11,542	0.6%	Defined
UBS Asset Management Switzerland AG	223,940	$1,525,031	82.1%	Sole
Held directly	46,965	$319,831	17.2%	Other

Invesco Ltd.

$1,800,420

0.09%

264,379

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invesco Advisers, Inc. joint	36,631	$249,457	13.9%	Defined
Invesco Trust Co joint	95,456	$650,055	36.1%	Defined
Invesco Capital Management LLC	132,292	$900,908	50.0%	Defined

Ensign Peak Advisors, Inc

$1,790,321

0.09%

262,896

Qube Research & Technologies Ltd

$1,767,910

0.09%

259,605

SPHERA FUNDS MANAGEMENT LTD.

$1,702,500

0.08%

250,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Sphera Global Healthcare Management LP joint	250,000	$1,702,500	100.0%	Defined

ALLIANCEBERNSTEIN L.P.

$1,686,700

0.08%

247,680

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Equitable Holdings, Inc.	247,680	$1,686,700	100.0%	Defined

DEUTSCHE BANK AG\

$1,657,410

0.08%

243,379

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DWS INVESTMENT MANAGEMENT AMERICAS, INC	4,522	$30,794	1.9%	Defined
DWS Investments UK Ltd	238,857	$1,626,616	98.1%	Defined

TWO SIGMA INVESTMENTS, LP

$1,598,415

0.08%

234,716

JANE STREET GROUP, LLC

$1,555,096

0.08%

228,355

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	154,779	$1,054,044	67.8%	Defined
Jane Street Global Trading, LLC	73,576	$501,052	32.2%	Defined

Chicago Partners Investment Group LLC

$1,514,183

0.07%

222,347

SG Americas Securities, LLC

$1,377,390

0.07%

202,260

Monashee Investment Management LLC

$1,362,000

0.07%

200,000

PRICE T ROWE ASSOCIATES INC /MD/

$1,358,554

0.07%

199,494

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T. Rowe Price International Ltd	199,494	$1,358,554	100.0%	Defined

Privium Fund Management B.V.

$1,354,509

0.07%

198,900

VICTORY CAPITAL MANAGEMENT INC

$1,345,506

0.07%

197,578

Balyasny Asset Management L.P.

$1,289,350

0.06%

189,332

STATE OF WISCONSIN INVESTMENT BOARD

$1,205,976

0.06%

177,089

CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM

$1,153,436

0.06%

169,374

RAYMOND JAMES FINANCIAL INC

$1,130,745

0.06%

166,042

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RAYMOND JAMES & ASSOCIATES	51,909	$353,500	31.3%	Defined
Raymond James Financial Services Advisors, Inc.	114,133	$777,245	68.7%	Defined

WEXFORD CAPITAL LP

$1,094,053

0.05%

160,654

Rafferty Asset Management, LLC

$1,053,547

0.05%

154,706

Palumbo Wealth Management LLC

$1,015,868

0.05%

149,173

MetLife Investment Management, LLC

$959,161

0.05%

140,846

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
METLIFE INC	140,846	$959,161	100.0%	Defined

Vanguard Global Advisers, LLC

$911,321

0.04%

133,821

Persistent Asset Partners Ltd

$908,528

0.04%

133,411

VANGUARD ASSET MANAGEMENT, Ltd

$903,101

0.04%

132,614

AQR CAPITAL MANAGEMENT LLC

$876,881

0.04%

128,764

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Compound Planning, Inc.	20	$136	0.0%	Other
Arax Advisory Partners	310	$2,111	0.2%	Other
HALBERT HARGROVE GLOBAL ADVISORS, LLC	1,569	$10,684	1.2%	Other
Stokes Family Office, LLC	942	$6,415	0.7%	Other
Held directly	125,923	$857,535	97.8%	Defined

Key facts CIK 1806310 CUSIP 877619106 13F (30d) 111 filings 111 filers Visit website Investor relations