TSHA · Taysha Gene Therapies, Inc. · Shareholders & Ownership

$4.25 +0.24 (+5.99%) At close · Oct 27 Q2 2026 earnings call transcript

Russell 2000 member Rebalance outlook locked

Market Cap

$1.36B

325.83M

Volume · Oct 27 2.82M Avg daily vol (3M) 3.55M

Every disclosed holder of TSHA in one list: 13F institutions, Schedule 13D and 13G filers, insiders (Forms 3, 4 and 5) and registered funds, each from its own latest filing. Holders nest by CIK and SEC reporting links, never by name, and each is summed once.

How the holder list picks a filing →

Who Owns TSHA

13F quarter Sep 30, 2026, combined view: filers that have not filed yet carry their Jun 30, 2026 positions

No chart: the summed disclosures exceed shares outstanding, so they are not parts of one whole.

Holder group	Holders	Shares	% Out	Summed
Institutional (13F)	212	299,640,608	91.96%	Yes
Insiders (Forms 3, 4, 5)	8	34,979,947	10.74%	Yes
13D/G-only blocks	2	11,912,861	3.66%	Yes
Remaining	—	20,699,871	-6.35%	Negative
Registered funds (N-PORT, not summed)	165	57,530,480	17.66%	No

Shares outstanding: 325,833,545, the issuer's latest cover-page count restated onto today's split basis.

Remaining is negative: the summed disclosures exceed shares outstanding, as when filings are dated at different times or holders that do not disclose their links count the same shares. It is flagged, not clipped.

13D/G-only counts each filer's latest 13D or 13G that no 13F report of the listing contains, that names no 13F filer and that no counted insider files. Funds are never summed: their shares sit inside their advisers' 13F reports.

Holders of TSHA

One row per holder Every filing By ultimate parent

All 13F Funds Insiders 13D/G Non-US

#	Holder	Shares	% Out	Change	As of	Notes
1	Paul B Manning 13D CIK 1494695 · Registered fund · May 30, 2025 Item 4 purpose: not restated by this amendment, the earlier 13D's purpose stands not summed	25,601,111	7.86%	—	May 30, 2025	not summed
1.1	Manning Paul B Insider CIK 1494695 · May 30, 2025 10% Owner, issuer-wide	25,601,110	7.86%	+749,999	May 30, 2025	10% Owner, issuer-wide
2	Avoro Capital Advisors LLC 13F CIK 1633313 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	23,888,888	7.33%	+2,188,888	Jun 30, 2026	carried, not yet filed for the newest quarter
3	RA CAPITAL MANAGEMENT, L.P. 13F CIK 1346824 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	23,555,648	7.23%	0	Jun 30, 2026	carried, not yet filed for the newest quarter
3.1	RA CAPITAL MANAGEMENT, L.P. 13G CIK 1346824 · Registered investment adviser · Jun 30, 2026 Rule 13d-1(c), passive investor, not summed	32,886,242	10.09%	+5,223,761	Jun 30, 2026	Rule 13d-1(c), passive investor, not summed
4	GOLDMAN SACHS GROUP INC 13F CIK 886982 · Holding company · Jun 30, 2026 carried, not yet filed for the newest quarter	22,713,118	6.97%	+343,473	Jun 30, 2026	carried, not yet filed for the newest quarter
4.1	Goldman Sachs ActiveBeta(R) U.S. Small Cap Equity ETF Fund S000048296 · Registered fund · Aug 31, 2026 Goldman Sachs ETF Trust, not summed	52,451	0.02%	-12,529	Aug 31, 2026	Goldman Sachs ETF Trust, not summed
4.2	Goldman Sachs Innovate Equity ETF Fund S000068597 · Registered fund · Aug 31, 2026 Goldman Sachs ETF Trust, not summed	21,974	0.01%	-1,374	Aug 31, 2026	Goldman Sachs ETF Trust, not summed
4.3	Goldman Sachs Absolute Return Tracker Fund Fund S000020314 · Registered fund · Aug 31, 2026 GOLDMAN SACHS TRUST, not summed	3,572	0.00%	-14,140	Aug 31, 2026	GOLDMAN SACHS TRUST, not summed
5	BlackRock, Inc. 13F CIK 2012383 · Holding company · Jun 30, 2026 carried, not yet filed for the newest quarter	20,691,927	6.35%	+2,326,319	Jun 30, 2026	carried, not yet filed for the newest quarter
5.1	iShares Russell 2000 ETF Fund S000004344 · Registered fund · Jun 30, 2026 iShares Trust, not summed	6,245,134	1.92%	+834,135	Jun 30, 2026	iShares Trust, not summed
5.2	iShares Russell 2000 Growth ETF Fund S000004343 · Registered fund · Jun 30, 2026 iShares Trust, not summed	2,213,229	0.68%	+419,324	Jun 30, 2026	iShares Trust, not summed
5.3	iShares Biotechnology ETF Fund S000004350 · Registered fund · Jun 30, 2026 iShares Trust, not summed	1,687,467	0.52%	+15,287	Jun 30, 2026	iShares Trust, not summed
5.4	Master Small Cap Index Series Fund S000002716 · Registered fund · Jun 30, 2026 Quantitative Master Series LLC, not summed	448,224	0.14%	+108,042	Jun 30, 2026	Quantitative Master Series LLC, not summed
5.5	iShares Core S&P Total U.S. Stock Market ETF Fund S000004317 · Registered fund · Jun 30, 2026 iShares Trust, not summed	329,792	0.10%	+7,888	Jun 30, 2026	iShares Trust, not summed
6	Vestal Point Capital, LP 13F CIK 1974915 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	19,415,000	5.96%	+1,415,000	Jun 30, 2026	carried, not yet filed for the newest quarter
7	MORGAN STANLEY 13F CIK 895421 · Holding company · Jun 30, 2026 carried, not yet filed for the newest quarter	16,487,479	5.06%	-1,477,892	Jun 30, 2026	carried, not yet filed for the newest quarter
7.1	MORGAN STANLEY 13G CIK 895421 · Holding company · Jun 30, 2026 Rule 13d-1(b), qualified institution, not summed	16,244,339	4.99%	-614,305	Jun 30, 2026	Rule 13d-1(b), qualified institution, not summed
8	RTW INVESTMENTS, LP 13F CIK 1493215 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	13,560,258	4.16%	-119,990	Jun 30, 2026	carried, not yet filed for the newest quarter
9	FMR LLC 13F CIK 315066 · Holding company · Jun 30, 2026 carried, not yet filed for the newest quarter	13,336,413	4.09%	-984,842	Jun 30, 2026	carried, not yet filed for the newest quarter
9.1	Fidelity Growth Company Fund Fund S000007119 · Registered fund · Aug 31, 2026 Fidelity Mt. Vernon Street Trust, not summed	4,170,948	1.28%	-5,155	Aug 31, 2026	Fidelity Mt. Vernon Street Trust, not summed
9.2	Fidelity Small Cap Index Fund Fund S000033638 · Registered fund · Jul 31, 2026 Fidelity Salem Street Trust, not summed	2,622,724	0.80%	+438,383	Jul 31, 2026	Fidelity Salem Street Trust, not summed
9.3	Fidelity Extended Market Index Fund Fund S000006021 · Registered fund · Aug 31, 2026 Fidelity Concord Street Trust, not summed	1,298,407	0.40%	+150,799	Aug 31, 2026	Fidelity Concord Street Trust, not summed
9.4	Fidelity Growth Company K6 Fund Fund S000065696 · Registered fund · Aug 31, 2026 Fidelity Mt. Vernon Street Trust, not summed	1,103,258	0.34%	+5,155	Aug 31, 2026	Fidelity Mt. Vernon Street Trust, not summed
9.5	Select Biotechnology Portfolio Fund S000007486 · Registered fund · Aug 31, 2026 Fidelity Select Portfolios, not summed	940,476	0.29%	0	Aug 31, 2026	Fidelity Select Portfolios, not summed
10	VANGUARD CAPITAL MANAGEMENT LLC 13F CIK 2100119 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	12,478,595	3.83%	+2,247,093	Jun 30, 2026	carried, not yet filed for the newest quarter
11	STATE STREET CORP 13F CIK 93751 · Bank · Jun 30, 2026 carried, not yet filed for the newest quarter	11,421,920	3.51%	+212,842	Jun 30, 2026	carried, not yet filed for the newest quarter
11.1	State Street(R) SPDR(R) S&P(R) Biotech ETF Fund S000010018 · Registered fund · Jun 30, 2026 SPDR SERIES TRUST, not summed	5,565,638	1.71%	-73,273	Jun 30, 2026	SPDR SERIES TRUST, not summed
11.2	State Street(R) SPDR(R) S&P Kensho New Economies Composite ETF Fund S000063362 · Registered fund · Jun 30, 2026 SPDR SERIES TRUST, not summed	427,344	0.13%	-171,415	Jun 30, 2026	SPDR SERIES TRUST, not summed
11.3	STATE STREET SMALL/MID CAP EQUITY INDEX PORTFOLIO Fund S000050332 · Registered fund · Jun 30, 2026 STATE STREET INSTITUTIONAL INVESTMENT TRUST, not summed	78,900	0.02%	+2,800	Jun 30, 2026	STATE STREET INSTITUTIONAL INVESTMENT TRUST, not summed
11.4	State Street Total Return V.I.S. Fund Fund S000001637 · Registered fund · Jun 30, 2026 STATE STREET VARIABLE INSURANCE SERIES FUNDS INC, not summed	6,053	0.00%	+896	Jun 30, 2026	STATE STREET VARIABLE INSURANCE SERIES FUNDS INC, not summed
11.5	State Street Balanced Index Fund Fund S000082802 · Registered fund · Jun 30, 2026 STATE STREET INSTITUTIONAL INVESTMENT TRUST, not summed	1,415	0.00%	0	Jun 30, 2026	STATE STREET INSTITUTIONAL INVESTMENT TRUST, not summed
12	Siren, L.L.C. 13F CIK 2005245 · Unknown · Jun 30, 2026 carried, not yet filed for the newest quarter	9,846,579	3.02%	+1,016,666	Jun 30, 2026	carried, not yet filed for the newest quarter
13	Octagon Capital Advisors LP 13F CIK 1839435 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	9,693,244	2.97%	+833,333	Jun 30, 2026	carried, not yet filed for the newest quarter
14	VANGUARD TOTAL STOCK MARKET INDEX FUND Fund S000002848 · Registered fund · Jun 30, 2026 VANGUARD INDEX FUNDS, not summed	9,138,043	2.80%	+1,624,093	Jun 30, 2026	VANGUARD INDEX FUNDS, not summed
15	Venrock Healthcare Capital Partners III, L.P. 13G CIK 1738048 · Unknown · Sep 30, 2024 Rule 13d-1(c), passive investor	9,000,000	2.76%	-1,412,872	Sep 30, 2024	Rule 13d-1(c), passive investor
16	GEODE CAPITAL MANAGEMENT, LLC 13F CIK 1214717 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	6,560,394	2.01%	+1,028,439	Jun 30, 2026	carried, not yet filed for the newest quarter
17	Polar Capital Holdings Plc 13F CIK 1837309 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	5,117,133	1.57%	-537,207	Jun 30, 2026	carried, not yet filed for the newest quarter
18	MPM BIOIMPACT LLC 13F CIK 1687078 · Investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	4,500,000	1.38%	+4,500,000	Jun 30, 2026	carried, not yet filed for the newest quarter
19	Nolan Sean P. Insider CIK 1569926 · Jan 26, 2026 Director, Chief Executive Officer, issuer-wide	4,443,802	1.36%	-178,101	Jan 26, 2026	Director, Chief Executive Officer, issuer-wide
20	D. E. Shaw & Co., Inc. 13F CIK 1009207 · Unknown · Jun 30, 2026 carried, not yet filed for the newest quarter	4,398,652	1.35%	-28,649	Jun 30, 2026	carried, not yet filed for the newest quarter
21	BAKER BROS. ADVISORS LP 13F CIK 1263508 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	4,004,756	1.23%	0	Jun 30, 2026	carried, not yet filed for the newest quarter
22	WELLINGTON MANAGEMENT GROUP LLP 13F CIK 902219 · Holding company · Jun 30, 2026 carried, not yet filed for the newest quarter	3,975,605	1.22%	+3,349,244	Jun 30, 2026	carried, not yet filed for the newest quarter
23	HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND 13F CIK 1535845 · Non-US institution · Jun 30, 2026 carried, not yet filed for the newest quarter	3,885,501	1.19%	+1,002,200	Jun 30, 2026	carried, not yet filed for the newest quarter
24	Casdin Capital, LLC 13F CIK 1534261 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	3,250,000	1.00%	0	Jun 30, 2026	carried, not yet filed for the newest quarter
25	VANGUARD PORTFOLIO MANAGEMENT LLC 13F CIK 2100121 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	3,140,009	0.96%	+1,117,511	Jun 30, 2026	carried, not yet filed for the newest quarter
26	VANGUARD EXTENDED MARKET INDEX FUND Fund S000002841 · Registered fund · Jun 30, 2026 VANGUARD INDEX FUNDS, not summed	3,044,554	0.93%	+565,632	Jun 30, 2026	VANGUARD INDEX FUNDS, not summed
27	ADAR1 Capital Management, LLC 13F CIK 1940272 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	3,040,466	0.93%	+61,037	Jun 30, 2026	carried, not yet filed for the newest quarter
28	TCG Crossover GP I, LLC 13G CIK 1839947 · Unknown · Dec 31, 2023 Rule 13d-1(c), passive investor	2,912,861	0.89%	—	Dec 31, 2023	Rule 13d-1(c), passive investor
29	Pictet Asset Management Holding SA 13F CIK 1993888 · Unknown · Jun 30, 2026 carried, not yet filed for the newest quarter	2,770,701	0.85%	+2,751,383	Jun 30, 2026	carried, not yet filed for the newest quarter
30	Aberdeen Group plc 13F CIK 1716774 · Holding company · Jun 30, 2026 carried, not yet filed for the newest quarter	2,327,152	0.71%	+1,306,089	Jun 30, 2026	carried, not yet filed for the newest quarter
31	FARALLON CAPITAL MANAGEMENT LLC 13F CIK 909661 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	2,250,000	0.69%	+2,250,000	Jun 30, 2026	carried, not yet filed for the newest quarter
32	NORGES BANK 13F CIK 1374170 · Non-US institution · Jun 30, 2026 carried, not yet filed for the newest quarter	2,233,600	0.69%	—	Jun 30, 2026	carried, not yet filed for the newest quarter
33	NORTHERN TRUST CORP 13F CIK 73124 · Bank · Jun 30, 2026 carried, not yet filed for the newest quarter	2,226,210	0.68%	+411,892	Jun 30, 2026	carried, not yet filed for the newest quarter
33.1	Small Cap Index Fund Fund S000001245 · Registered fund · Jun 30, 2026 Northern Funds, not summed	121,181	0.04%	+21,543	Jun 30, 2026	Northern Funds, not summed
33.2	Small Cap Core Fund Fund S000001244 · Registered fund · Jun 30, 2026 Northern Funds, not summed	26,939	0.01%	—	Jun 30, 2026	Northern Funds, not summed
33.3	FlexShares Morningstar US Market Factor Tilt Index Fund Fund S000033312 · Registered fund · Jul 31, 2026 FlexShares Trust, not summed	9,954	0.00%	—	Jul 31, 2026	FlexShares Trust, not summed
34	CHARLES SCHWAB INVESTMENT MANAGEMENT INC 13F CIK 884546 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	2,200,695	0.68%	+392,096	Jun 30, 2026	carried, not yet filed for the newest quarter
34.1	Schwab U.S. Small-Cap ETF Fund S000026636 · Registered fund · Aug 31, 2026 SCHWAB STRATEGIC TRUST, not summed	1,267,552	0.39%	+197,597	Aug 31, 2026	SCHWAB STRATEGIC TRUST, not summed
34.2	Schwab Small-Cap Index Fund Fund S000005912 · Registered fund · Jul 31, 2026 SCHWAB CAPITAL TRUST, not summed	582,403	0.18%	+99,463	Jul 31, 2026	SCHWAB CAPITAL TRUST, not summed
34.3	Schwab Total Stock Market Index Fund Fund S000005913 · Registered fund · Jul 31, 2026 SCHWAB CAPITAL TRUST, not summed	167,251	0.05%	+44,899	Jul 31, 2026	SCHWAB CAPITAL TRUST, not summed
34.4	Schwab U.S. Broad Market ETF Fund S000026631 · Registered fund · Aug 31, 2026 SCHWAB STRATEGIC TRUST, not summed	158,994	0.05%	+27,214	Aug 31, 2026	SCHWAB STRATEGIC TRUST, not summed
35	MILLENNIUM MANAGEMENT LLC 13F CIK 1273087 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	2,126,838	0.65%	-1,154,982	Jun 30, 2026	carried, not yet filed for the newest quarter
36	Stalfort John A III Insider CIK 1709418 · Jun 1, 2026 Director, issuer-wide	2,060,849	0.63%	+21,335	Jun 1, 2026	Director, issuer-wide
37	ORBIMED ADVISORS LLC 13F CIK 1055951 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	2,000,000	0.61%	+2,000,000	Jun 30, 2026	carried, not yet filed for the newest quarter
38	RICE HALL JAMES & ASSOCIATES, LLC 13F CIK 1230765 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	1,992,229	0.61%	+47,558	Jun 30, 2026	carried, not yet filed for the newest quarter
39	VANGUARD FIDUCIARY TRUST CO 13F CIK 933478 · Unknown · Jun 30, 2026 carried, not yet filed for the newest quarter	1,896,474	0.58%	+366,013	Jun 30, 2026	carried, not yet filed for the newest quarter
40	B Group, Inc. 13F CIK 2043476 · Unknown · Jun 30, 2026 carried, not yet filed for the newest quarter	1,800,556	0.55%	0	Jun 30, 2026	carried, not yet filed for the newest quarter
41	Affinity Asset Advisors, LLC 13F CIK 1773195 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	1,750,000	0.54%	+750,000	Jun 30, 2026	carried, not yet filed for the newest quarter
42	BARCLAYS PLC 13F CIK 312069 · Bank · Jun 30, 2026 carried, not yet filed for the newest quarter	1,630,659	0.50%	-1,181,351	Jun 30, 2026	carried, not yet filed for the newest quarter
43	CITADEL ADVISORS LLC 13F CIK 1423053 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	1,535,287	0.47%	+1,124,152	Jun 30, 2026	carried, not yet filed for the newest quarter
44	Seven Fleet Capital Management LP 13F CIK 2092021 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	1,504,400	0.46%	+878,692	Jun 30, 2026	carried, not yet filed for the newest quarter
45	HEIGHTS CAPITAL MANAGEMENT, INC 13F CIK 1081698 · Unknown · Jun 30, 2026 carried, not yet filed for the newest quarter	1,500,000	0.46%	+1,500,000	Jun 30, 2026	carried, not yet filed for the newest quarter
46	abrdn Life Sciences Investors Fund · Registered fund · Jun 30, 2026 abrdn Life Sciences Investors, not summed	1,496,652	0.46%	—	Jun 30, 2026	abrdn Life Sciences Investors, not summed
46.1	abrdn Healthcare Investors Fund · Registered fund · Jun 30, 2026 abrdn Healthcare Investors, not summed	830,500	0.25%	—	Jun 30, 2026	abrdn Healthcare Investors, not summed
46.2	Guggenheim Active Allocation Fund Fund · Registered fund · May 29, 2026 Guggenheim Active Allocation Fund, not summed	133	0.00%	—	May 29, 2026	Guggenheim Active Allocation Fund, not summed
47	Alam Kamran Insider CIK 1793412 · Feb 4, 2026 CHIEF FINANCIAL OFFICER, issuer-wide	1,442,131	0.44%	-1,655	Feb 4, 2026	CHIEF FINANCIAL OFFICER, issuer-wide
48	Palo Alto Investors LP 13F CIK 1306923 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	1,391,382	0.43%	0	Jun 30, 2026	carried, not yet filed for the newest quarter
49	BANK OF AMERICA CORP /DE/ 13F CIK 70858 · Bank · Jun 30, 2026 carried, not yet filed for the newest quarter	1,372,845	0.42%	-304,201	Jun 30, 2026	carried, not yet filed for the newest quarter
50	Granahan Investment Management, LLC 13F CIK 1026710 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	1,305,177	0.40%	+421,936	Jun 30, 2026	carried, not yet filed for the newest quarter

27 more nested rows are not shown here; Every filing lists them all.

Shares are restated onto today's split basis. Change compares each row with the same holder's previous filing in the same source; a dash means there is none to compare. Nested 13D/G, insider and fund rows are not summed, since a 13F report already holds them.

Showing 1–50 of 287 holders

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Key facts CIK 1806310 CUSIP 877619106 13F (30d) 24 filings 23 filers Visit website Investor relations