Siren, L.L.C.

CIK

2005245

Location

New York, NY

Portfolio Value

Mid $4,941,403,582

Diversification

Diversified

Reports for

Invus Financial Advisors, LLC Invus Group, LLC

Filing Date

Global Rank

#749 / 8,700 ▲ 235

Top Industry

Biotechnology 92.3%

Period ended 2 months ago

Filed Aug 13, 2026 · 31d

8 quarters · since Sep 2024

Portfolio Concentration

116 tracked positions · as of Jun 30, 2026 · Δ vs Mar 31, 2026

Top Position

10.7%

−4.3 pts

Top 5

29.7%

−5.5 pts

Top 10

44.6%

−5.7 pts

HHI

318

Diversified−120

Portfolio Trend

8 quarters · across all stocks

Sector Breakdown

As of Jun 30, 2026

Sector	% Portfolio	Value	Positions
Healthcare	92.9%	$4,592,495,357	81
Technology	3.9%	$191,960,034	21
Communication Services	1.9%	$91,465,290	6
Financial Services	0.9%	$42,766,151	3
Consumer Cyclical	0.4%	$21,263,750	4
Real Estate	0.0%	$1,453,000	1

Last Quarter's Activity

Export CSV

Jun 30, 2026 vs Mar 31, 2026

Added To

Positions the filer increased

25 positions

Ticker	Company	Δ Shares	Shares	Value
ELVN	Enliven Therapeutics, Inc.	+1,028,185	1,774,411	$90,051,358
TSHA	Taysha Gene Therapies, Inc.	+1,016,666	9,846,579	$67,055,202
ENGN	enGene Therapeutics Inc.	+1,003,503	6,256,662	$10,824,025
IVVD	Invivyd, Inc.	+1,000,000	5,000,000	$4,360,000
CGEM	Cullinan Therapeutics, Inc.	+700,000	1,893,410	$34,478,996
ABSI	Absci Corp	+674,764	2,474,764	$28,682,514
TNGX	Tango Therapeutics, Inc.	+522,259	6,179,364	$193,166,918
DFTX	Definium Therapeutics, Inc.	+500,000	1,419,493	$66,772,950
ANNX	Annexon, Inc.	+500,000	4,458,646	$25,458,868
RYTM	Rhythm Pharmaceuticals, Inc.	+410,764	1,136,275	$126,160,613
SLN	Silence Therapeutics plc	+400,000	3,311,438	$36,359,589
SION	Sionna Therapeutics, Inc.	+310,515	610,515	$26,856,554
WHWK	Whitehawk Therapeutics, Inc.	+255,102	2,337,102	$10,703,927
AMLX	Amylyx Pharmaceuticals, Inc.	+250,586	1,480,586	$26,591,324
ERAS	Erasca, Inc.	+153,535	11,397,781	$208,807,347
COGT	Cogent Biosciences, Inc.	+150,000	1,859,279	$71,954,097
SYRE	Spyre Therapeutics, Inc.	+150,000	968,598	$85,992,130
MANE	Veradermics, Inc	+150,000	1,655,374	$203,511,679
CYTK	Cytokinetics Inc	+145,000	758,952	$64,655,120
IREN	IREN Ltd	+131,900	175,000	$8,002,750
OLMA	Olema Pharmaceuticals, Inc.	+100,000	4,856,949	$60,760,431
ARWR	Arrowhead Pharmaceuticals, Inc.	+100,000	1,715,476	$139,828,448
AEVA	Aeva Technologies, Inc.	+35,459	145,459	$4,177,582
GTLB	Gitlab Inc.	+25,000	125,000	$3,816,250
GOOGL	Alphabet Inc.	+24,297	90,000	$32,163,300
No positions match the current search.

Trimmed

Positions the filer reduced

20 positions

Ticker	Company	Δ Shares	Shares	Value
TBLA	Taboola.com Ltd.	−1,546,085	8,423,410	$42,117,050
SRRK	Scholar Rock Holding Corp	−1,250,000	9,575,013	$526,625,715
EWTX	Edgewise Therapeutics, Inc.	−1,245,634	3,184,629	$129,391,476
NBP	NovaBridge Biosciences	−995,261	2,004,739	$3,909,241
RCUS	Arcus Biosciences, Inc.	−586,647	2,420,430	$74,621,856
—		−482,848	1,420,788	$53,165,886
GPCR	Structure Therapeutics Inc.	−455,731	872,967	$46,852,138
KYMR	Kymera Therapeutics, Inc.	−251,000	2,935,830	$336,651,626
RVMD	Revolution Medicines, Inc.	−210,980	900,000	$168,552,000
BCAX	Bicara Therapeutics Inc.	−200,000	5,602,970	$166,352,179
DYN	Dyne Therapeutics, Inc.	−100,000	2,129,125	$47,287,866
IRON	Disc Medicine, Inc.	−100,000	888,401	$64,977,649
SEPN	Septerna, Inc.	−100,000	1,900,000	$63,631,000
NBIS	Nebius Group N.V.	−61,614	52,000	$14,360,840
WK	Workiva Inc	−47,500	45,000	$2,182,950
FROG	JFrog Ltd	−33,316	95,500	$8,679,040
TSLA	Tesla, Inc.	−18,000	3,500	$1,472,100
DDOG	Datadog, Inc.	−14,300	40,000	$10,414,400
AMZN	Amazon Com Inc	−14,141	32,500	$7,746,050
CRWD	CrowdStrike Holdings, Inc.	−13,070	10,000	$7,631,400
No positions match the current search.

New Positions

Positions the filer opened this quarter

25 positions

Ticker	Company	Shares	Value
PBLS	Parabilis Medicines, Inc.	2,992,259	$81,898,128
ABVX	Abivax S.A.	576,000	$76,757,760
COAG	Hemab Therapeutics Holdings, Inc.	2,086,834	$76,649,412
RLAY	Relay Therapeutics, Inc.	3,650,000	$68,291,500
KLRA	Kailera Therapeutics, Inc.	2,214,286	$48,780,720
COF	Capital One Financial Corp	171,615	$34,429,401
ORKA	Oruka Therapeutics, Inc.	250,000	$23,792,500
SPTX	Seaport Therapeutics, Inc.	1,095,316	$23,790,263
TYRA	Tyra Biosciences, Inc.	725,000	$23,156,500
ADAG	Adagene Inc.	2,666,666	$11,199,997
OCS	Oculis Holding AG	625,000	$8,668,750
DSGN	Design Therapeutics, Inc.	523,212	$7,570,877
AAPL	Apple Inc.	23,000	$6,655,280
ELOX	Eloxx Pharmaceuticals, Inc.	400,000	$5,552,000
BABA	Alibaba Group Holding Ltd	50,000	$4,799,000
OUST	Ouster, Inc.	67,500	$4,220,100
PALI	Palisade Bio, Inc.	2,000,000	$4,180,000
ODTX	Odyssey Therapeutics, Inc.	200,000	$3,742,000
ZTS	Zoetis Inc.	35,000	$2,515,100
NFLX	Netflix Inc	25,000	$1,785,000
QNT	Quantinuum Inc.	20,000	$1,634,800
ENTX	Entera Bio Ltd.	736,457	$1,303,528
LITE	Lumentum Holdings Inc.	1,055	$905,253
FOXA	Fox Corp	10,000	$521,600
T	At&T Inc.	25,000	$517,500
No positions match the current search.

Sold Out

Positions the filer fully exited

9 positions

Ticker	Company	Shares	Value
FULC	Fulcrum Therapeutics, Inc.	2,350,000	$18,024,500
WVE	Wave Life Sciences, Inc.	2,450,000	$17,762,500
QURE	uniQure N.V.	1,000,000	$16,350,000
BCYC	Bicycle Therapeutics PLC	1,560,882	$7,242,492
FPS	Forgent Power Solutions, Inc.	100,000	$2,927,000
MU	Micron Technology Inc	6,000	$2,027,040
AS	Amer Sports, Inc.	50,000	$1,646,000
PRMB	Primo Brands Corp	50,000	$941,500
CNTA	Centessa Pharmaceuticals plc	1,053,464	$0
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

116 tracked positions · $4,941,403,582 total · filing declares 119 positions · $4,941,404,255 · as of Jun 30, 2026

All sectors Communication Services Consumer Cyclical Financial Services Healthcare Real Estate Technology

Showing 1–50 of 116 positions by value · page 1 of 3

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
SRRK	Scholar Rock Holding Corp Healthcare	Reduced	9,575,013	-1,250,000	$526,625,715	−1.0%	10.66%
KYMR	Kymera Therapeutics, Inc. Healthcare	Reduced	2,935,830	-251,000	$336,651,626	+26.8%	6.81%
ERAS	Erasca, Inc. Healthcare	Added	11,397,781	+153,535	$208,807,347	+14.8%	4.23%
MANE	Veradermics, Inc Healthcare	Added	1,655,374	+150,000	$203,511,679	+114.1%	4.12%
TNGX	Tango Therapeutics, Inc. Healthcare	Added	6,179,364	+522,259	$193,166,918	+63.2%	3.91%
RVMD	Revolution Medicines, Inc. Healthcare	Reduced	900,000	-210,980	$168,552,000	+56.0%	3.41%
BCAX	Bicara Therapeutics Inc. Healthcare	Reduced	5,602,970	-200,000	$166,352,179	+44.1%	3.37%
ARWR	Arrowhead Pharmaceuticals, Inc. Healthcare	Added	1,715,476	+100,000	$139,828,448	+38.0%	2.83%
ONC	BeOne Medicines Ltd. Healthcare	Held	465,000	0	$132,511,050	−4.0%	2.68%
EWTX	Edgewise Therapeutics, Inc. Healthcare	Reduced	3,184,629	-1,245,634	$129,391,476	−7.3%	2.62%
RYTM	Rhythm Pharmaceuticals, Inc. Healthcare	Added	1,136,275	+410,764	$126,160,613	+99.9%	2.55%
LXRX	Lexicon Pharmaceuticals, Inc. Healthcare	Held	44,303,518	0	$106,328,443	+53.8%	2.15%
ELVN	Enliven Therapeutics, Inc. Healthcare	Added	1,774,411	+1,028,185	$90,051,358	+207.8%	1.82%
SYRE	Spyre Therapeutics, Inc. Healthcare	Added	968,598	+150,000	$85,992,130	+108.3%	1.74%
PBLS	Parabilis Medicines, Inc. Healthcare	NEW	2,992,259	NEW	$81,898,128	NEW	1.66%
XENE	Xenon Pharmaceuticals Inc. Healthcare	Held	1,318,564	0	$79,588,523	+3.8%	1.61%
SLDB	Solid Biosciences Inc. Healthcare	Held	7,690,405	0	$76,827,145	+38.7%	1.55%
ABVX	Abivax S.A. Healthcare	NEW	576,000	NEW	$76,757,760	NEW	1.55%
COAG	Hemab Therapeutics Holdings, Inc. Healthcare	NEW	2,086,834	NEW	$76,649,412	NEW	1.55%
RCUS	Arcus Biosciences, Inc. Healthcare	Reduced	2,420,430	-586,647	$74,621,856	+14.9%	1.51%
COGT	Cogent Biosciences, Inc. Healthcare	Added	1,859,279	+150,000	$71,954,097	+9.4%	1.46%
RLAY	Relay Therapeutics, Inc. Healthcare	NEW	3,650,000	NEW	$68,291,500	NEW	1.38%
TSHA	Taysha Gene Therapies, Inc. Healthcare	Added	9,846,579	+1,016,666	$67,055,202	+69.9%	1.36%
DFTX	Definium Therapeutics, Inc. Healthcare	Added	1,419,493	+500,000	$66,772,950	+284.2%	1.35%
STOK	Stoke Therapeutics, Inc. Healthcare	Held	1,995,347	0	$65,287,753	+0.5%	1.32%
IRON	Disc Medicine, Inc. Healthcare	Reduced	888,401	-100,000	$64,977,649	+2.8%	1.31%
CYTK	Cytokinetics Inc Healthcare	Added	758,952	+145,000	$64,655,120	+59.8%	1.31%
SEPN	Septerna, Inc. Healthcare	Reduced	1,900,000	-100,000	$63,631,000	+32.4%	1.29%
OLMA	Olema Pharmaceuticals, Inc. Healthcare	Added	4,856,949	+100,000	$60,760,431	−14.3%	1.23%
		Reduced	1,420,788	-482,848	$53,165,886	−23.1%	1.08%
KLRA	Kailera Therapeutics, Inc. Healthcare	NEW	2,214,286	NEW	$48,780,720	NEW	0.99%
DYN	Dyne Therapeutics, Inc. Healthcare	Reduced	2,129,125	-100,000	$47,287,866	+17.0%	0.96%
GPCR	Structure Therapeutics Inc. Healthcare	Reduced	872,967	-455,731	$46,852,138	−26.8%	0.95%
TBLA	Taboola.com Ltd. Communication Services	Reduced	8,423,410	-1,546,085	$42,117,050	+36.3%	0.85%
PVLA	Palvella Therapeutics, Inc. Healthcare	Held	257,485	0	$39,348,857	+22.6%	0.80%
SLN	Silence Therapeutics plc Healthcare	Added	3,311,438	+400,000	$36,359,589	+137.0%	0.74%
DNLI	Denali Therapeutics Inc. Healthcare	Held	1,396,513	0	$35,918,314	+34.0%	0.73%
RELY	Remitly Global, Inc. Technology	Held	1,543,271	0	$34,584,703	+43.0%	0.70%
CGEM	Cullinan Therapeutics, Inc. Healthcare	Added	1,893,410	+700,000	$34,478,996	+103.3%	0.70%
COF	Capital One Financial Corp Financial Services	NEW	171,615	NEW	$34,429,401	NEW	0.70%
TRVI	Trevi Therapeutics, Inc. Healthcare	Held	1,786,867	0	$33,325,069	+56.3%	0.67%
ORIC	Oric Pharmaceuticals, Inc. Healthcare	Held	2,998,192	0	$32,470,419	−14.5%	0.66%
GOOGL	Alphabet Inc. Communication Services	Added	90,000	+24,297	$32,163,300	+70.2%	0.65%
DBVT	DBV Technologies S.A. Healthcare	Held	1,857,362	0	$30,460,736	−21.5%	0.62%
ABSI	Absci Corp Healthcare	Added	2,474,764	+674,764	$28,682,514	+431.2%	0.58%
SION	Sionna Therapeutics, Inc. Healthcare	Added	610,515	+310,515	$26,856,554	+123.3%	0.54%
RAPP	Rapport Therapeutics, Inc. Healthcare	Held	641,469	0	$26,730,013	+33.2%	0.54%
AMLX	Amylyx Pharmaceuticals, Inc. Healthcare	Added	1,480,586	+250,586	$26,591,324	+55.5%	0.54%
ANNX	Annexon, Inc. Healthcare	Added	4,458,646	+500,000	$25,458,868	+16.1%	0.52%
MNPR	Monopar Therapeutics Healthcare	Held	270,118	0	$25,010,225	+69.0%	0.51%

Covers the securities this platform tracks: U.S.-listed common stock and the put/call positions reported on it. A 13F can also report security types outside that coverage — preferred shares, bonds, warrants, untracked share classes — so the filing's own declared total can exceed the figures above. The source filing is linked at the top of this table.