EWTX · Edgewise Therapeutics, Inc.

$44.18 +0.89 (+2.06%) At close · Aug 21

Market Cap

$4.72B

108.60M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Quarter:

Holders: 225

Total Value: $4,856,852,066

Total Shares: 119,618,532

Institutional Ownership Trend

22 quarters

Holder Concentration

Across 225 13F filers · Δ vs Mar 31, 2026

Top Holder

13.0%

−0.0 pts

Top 5

39.2%

+0.3 pts

Top 10

59.1%

−0.4 pts

HHI

479

Broadly held+1

Quarterly Activity

vs Mar 31, 2026

New

Increased

Decreased

Sold Out

Unchanged

Holder count: +8

Institutional value: +29.1%

Shares held: +0.2%

Top Buyers

vs Mar 31, 2026

Institution	Added	Now Holds
Mega FMR LLC	+4,472,083	5,489,135
Mid Paradigm Biocapital Advisors LP	+2,850,417	10,215,455
Mega PRICE T ROWE ASSOCIATES INC /MD/	+747,091	816,518
Mega Qube Research & Technologies Ltd	+426,597	1,252,507
Mid Integral Health Asset Management, LLC	+400,000	2,000,000

Top Sellers

vs Mar 31, 2026

Institution	Sold	Now Holds
Large BAKER BROS. ADVISORS LP	−2,874,221	3,701,719
Large RA CAPITAL MANAGEMENT, L.P.	−2,035,707	8,392,730
Mid Siren, L.L.C.	−1,245,634	3,184,629
Mega UBS Group AG	−1,136,158	174,967
Mid Soleus Capital Management, L.P.	−999,026	450,889

Top New Positions

vs Mar 31, 2026

Institution	Acquired	Value (USD)
Mega Jupiter Topco LLC	6,075,331	$246,840,697
Small Tyro Capital Management LLC	612,965	$24,904,767
Mega NORGES BANK	510,140	$20,726,988
Large ADAGE CAPITAL PARTNERS GP, L.L.C.	462,000	$18,771,060
Small KINGDON CAPITAL MANAGEMENT, L.L.C.	100,000	$4,063,000

Top Sold-Out Positions

vs Mar 31, 2026

Institution	Previously Held	Last Value (USD)
Mega JANUS HENDERSON GROUP PLC	5,915,556	$186,340,013
Mid Bellevue Group AG	1,528,518	$48,148,317
Large Candriam S.C.A.	447,416	$14,093,604
Mega MILLENNIUM MANAGEMENT LLC	342,867	$10,800,310
Small STEMPOINT CAPITAL LP	290,864	$9,162,216

Filter: New 40 Increased 84 Reduced 74 Sold out 32 Unchanged 27

Showing 100 of 232

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

ORBIMED ADVISORS LLC

$630,516,329

12.98%

15,518,492

Paradigm Biocapital Advisors LP

$415,053,936

8.55%

10,215,455

RA CAPITAL MANAGEMENT, L.P.

$340,996,619

7.02%

8,392,730

BlackRock, Inc.

$268,415,424

5.53%

6,606,336

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	90,279	$3,668,035	1.4%	Sole
BlackRock Investment Management (Australia) Ltd	194	$7,882	0.0%	Sole
BlackRock Asset Management Canada Ltd	14,171	$575,767	0.2%	Sole
BlackRock Investment Management, LLC	198,963	$8,083,866	3.0%	Sole
BLACKROCK ADVISORS LLC	266,519	$10,828,666	4.0%	Sole
BlackRock Fund Advisors	3,503,650	$142,353,299	53.0%	Sole
BlackRock Institutional Trust Company, N.A.	2,257,615	$91,726,897	34.2%	Sole
BlackRock Fund Managers Ltd.	8,441	$342,957	0.1%	Sole
BlackRock Investment Management (UK) Ltd.	25,715	$1,044,800	0.4%	Sole
BlackRock (Netherlands) B.V.	2,537	$103,078	0.0%	Sole
BlackRock Asset Management Ireland Ltd	148,011	$6,013,686	2.2%	Sole
BlackRock Asset Management Schweiz AG	8,053	$327,193	0.1%	Sole
Aperio Group, LLC	82,188	$3,339,298	1.2%	Sole

Jupiter Topco LLC

$246,840,697

5.08%

6,075,331

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JANUS HENDERSON INVESTORS UK Ltd	111,193	$4,517,771	1.8%	Defined
JANUS HENDERSON INVESTORS US LLC	5,955,456	$241,970,177	98.0%	Defined
Held directly	8,682	$352,749	0.1%	Defined

FMR LLC

$223,023,553

4.59%

5,489,135

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	2,655,966	$107,911,898	48.4%	Defined
STRATEGIC ADVISERS LLC	44	$1,787	0.0%	Defined
Fidelity Institutional Asset Management Trust Co	20,990	$852,823	0.4%	Defined
FIAM LLC	2,812,135	$114,257,045	51.2%	Defined

NOVO HOLDINGS A/S

$217,370,500

4.48%

5,350,000

Driehaus Capital Management LLC

$192,123,952

3.96%

4,728,623

PERCEPTIVE ADVISORS LLC

$177,714,563

3.66%

4,373,974

VANGUARD CAPITAL MANAGEMENT LLC

$156,859,022

3.23%

3,860,670

BAKER BROS. ADVISORS LP

$150,400,842

3.10%

3,701,719

Siren, L.L.C.

$129,391,476

2.66%

3,184,629

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invus Group, LLC	3,184,629	$129,391,476	100.0%	Defined

Cormorant Asset Management, LP

$101,981,300

2.10%

2,510,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Chen Bihua	2,510,000	$101,981,300	100.0%	Defined

GEODE CAPITAL MANAGEMENT, LLC

$88,331,692

1.82%

2,174,051

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	272,970	$11,090,771	12.6%	Defined
Held directly	1,901,081	$77,240,921	87.4%	Defined

ALLIANCEBERNSTEIN L.P.

$86,095,945

1.77%

2,119,024

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Equitable Holdings, Inc.	2,119,024	$86,095,945	100.0%	Defined

Integral Health Asset Management, LLC

$81,260,000

1.67%

2,000,000

BRAIDWELL LP

$81,136,687

1.67%

1,996,965

MORGAN STANLEY

$79,171,493

1.63%

1,948,597

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	1,873	$76,099	0.1%	Defined
MORGAN STANLEY & CO. LLC	263,527	$10,707,102	13.5%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	1,615,742	$65,647,597	82.9%	Defined
MORGAN STANLEY SMITH BARNEY LLC	13,356	$542,654	0.7%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	54,099	$2,198,041	2.8%	Defined

STATE STREET CORP

$74,268,674

1.53%

1,827,927

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STATE STREET GLOBAL ADVISORS EUROPE LIMITED joint	1,827,927	$74,268,674	100.0%	Defined

MPM BIOIMPACT LLC

$65,852,291

1.36%

1,620,780

BANK OF AMERICA CORP /DE/

$63,312,102

1.30%

1,558,260

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	1,400,102	$56,886,144	89.9%	Defined
BOFA SECURITIES, INC.	59,800	$2,429,674	3.8%	Defined
MANAGED ACCOUNT ADVISORS LLC joint	98,358	$3,996,284	6.3%	Defined

Qube Research & Technologies Ltd

$50,889,359

1.05%

1,252,507

DIMENSIONAL FUND ADVISORS LP

$46,307,064

0.95%

1,139,726

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Dimensional Fund Advisors Ltd.	14,725	$598,276	1.3%	Defined
DFA Australia Ltd.	13,765	$559,271	1.2%	Defined
Dimensional Fund Advisors Pte. Ltd.	546	$22,183	0.0%	Defined
Dimensional Ireland Ltd	42,916	$1,743,677	3.8%	Defined
Held directly	1,067,774	$43,383,657	93.7%	Sole

AMERICAN CENTURY COMPANIES INC

$45,793,179

0.94%

1,127,078

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
AMERICAN CENTURY INVESTMENT MANAGEMENT INC	1,127,078	$45,793,179	100.0%	Defined

First Light Asset Management, LLC

$44,496,797

0.92%

1,095,171

VICTORY CAPITAL MANAGEMENT INC

$36,683,608

0.76%

902,870

PRICE T ROWE ASSOCIATES INC /MD/

$33,175,126

0.68%

816,518

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T. Rowe Price International Ltd	88,851	$3,610,016	10.9%	Defined
Held directly	727,667	$29,565,110	89.1%	Sole

VANGUARD PORTFOLIO MANAGEMENT LLC

$31,953,707

0.66%

786,456

NORTHERN TRUST CORP

$27,273,697

0.56%

671,270

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	630,953	$25,635,619	94.0%	Defined
NORTHERN TRUST GLOBAL INVESTMENTS LTD	29,224	$1,187,370	4.4%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC joint	11,093	$450,708	1.7%	Other

Aberdeen Group plc

$26,325,233

0.54%

647,926

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
abrdn Inc.	647,926	$26,325,233	100.0%	Defined

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$25,212,215

0.52%

620,532

Tyro Capital Management LLC

$24,904,767

0.51%

612,965

GOLDMAN SACHS GROUP INC

$24,356,425

0.50%

599,469

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	389,816	$15,838,224	65.0%	Defined
GOLDMAN SACHS ASSET MANAGEMENT, L.P.	209,653	$8,518,201	35.0%	Defined

Parkman Healthcare Partners LLC

$23,444,972

0.48%

577,036

Artisan Partners Limited Partnership

$23,359,202

0.48%

574,925

VANGUARD FIDUCIARY TRUST CO

$22,276,819

0.46%

548,285

NORGES BANK

$20,726,988

0.43%

510,140

Opaleye Management Inc.

$20,315,000

0.42%

500,000

CITADEL ADVISORS LLC

$19,084,194

0.39%

469,707

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	136,479	$5,545,141	29.1%	Defined
Held directly	333,228	$13,539,053	70.9%	Defined

ADAGE CAPITAL PARTNERS GP, L.L.C.

$18,771,060

0.39%

462,000

Soleus Capital Management, L.P.

$18,319,620

0.38%

450,889

Nuveen, LLC

$16,849,503

0.35%

414,706

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Nuveen Asset Management, LLC joint	108,392	$4,403,966	26.1%	Defined
TIAA CREF INVESTMENT MANAGEMENT LLC joint	146,662	$5,958,877	35.4%	Defined
TEACHERS ADVISORS, LLC joint	159,652	$6,486,660	38.5%	Defined

Sofinnova Investments, Inc.

$15,476,901

0.32%

380,923

HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND

$13,570,988

0.28%

334,014

RAYMOND JAMES FINANCIAL INC

$12,902,664

0.27%

317,565

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RAYMOND JAMES & ASSOCIATES	20,874	$848,110	6.6%	Defined
Raymond James Financial Services Advisors, Inc.	10,801	$438,844	3.4%	Defined
EAGLE ASSET MANAGEMENT INC joint	285,890	$11,615,710	90.0%	Defined

Squadron Capital Management LLC

$11,782,700

0.24%

290,000

Universal- Beteiligungs- und Servicegesellschaft mbH

$11,511,819

0.24%

283,333

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Universal-Investment-Gesellschaft mbH joint	283,333	$11,511,819	100.0%	Defined

DIADEMA PARTNERS LP

$11,060,054

0.23%

272,214

PRUDENTIAL FINANCIAL INC

$10,593,256

0.22%

260,725

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
PGIM Quantitative Solutions LLC	222,825	$9,053,379	85.5%	Defined
Prudential Trust Co	37,900	$1,539,877	14.5%	Defined

KENNEDY CAPITAL MANAGEMENT LLC

$10,425,983

0.21%

256,608

Schonfeld Strategic Advisors LLC

$10,368,857

0.21%

255,202

DEUTSCHE BANK AG\

$9,954,146

0.20%

244,995

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DWS Investment GmbH	172,000	$6,988,360	70.2%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC	1,347	$54,728	0.5%	Defined
DWS Investments UK Ltd	71,648	$2,911,058	29.2%	Defined

DAFNA Capital Management LLC

$9,215,655

0.19%

226,819

Woodline Partners LP

$9,112,902

0.19%

224,290

Bank of New York Mellon Corp

$8,627,657

0.18%

212,347

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Investments Corporation joint	71,501	$2,905,085	33.7%	Defined
The Bank of New York Mellon	139,770	$5,678,855	65.8%	Defined
BNY Mellon, NA joint	1,074	$43,636	0.5%	Defined
Held directly	2	$81	0.0%	Defined

JPMORGAN CHASE & CO

$8,254,021

0.17%

203,151

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
J.P. Morgan Trust Co of Delaware	731	$29,699	0.4%	Other
JPMorgan Chase Bank, N.A.	40,828	$1,658,841	20.1%	Defined
J.P. Morgan Investment Management Inc.	152,841	$6,209,929	75.2%	Defined
J.P. Morgan Securities LLC	79	$3,209	0.0%	Defined
J.P. Morgan Securities plc	8,662	$351,937	4.3%	Defined
55I, LLC	10	$406	0.0%	Defined

PEREGRINE CAPITAL MANAGEMENT LLC

$8,067,899

0.17%

198,570

SEB Asset Management AB

$7,884,779

0.16%

194,063

Granahan Investment Management, LLC

$7,873,200

0.16%

193,778

NEUBERGER BERMAN GROUP LLC

$7,768,252

0.16%

191,195

BARCLAYS PLC

$7,728,028

0.16%

190,205

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BARCLAYS BANK PLC	189,391	$7,694,956	99.6%	Defined
BARCLAYS CAPITAL INC.	640	$26,003	0.3%	Defined
BARCLAYS CAPITAL SECURITIES LTD	174	$7,069	0.1%	Defined

D. E. Shaw & Co., Inc.

$7,683,741

0.16%

189,115

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
D. E. SHAW & CO, L.P.	162,836	$6,616,026	86.1%	Defined
D. E. Shaw Investment Management, L.L.C. joint	26,279	$1,067,715	13.9%	Defined

UBS Group AG

$7,108,908

0.15%

174,967

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Financial Services Inc	688	$27,953	0.4%	Defined
UBS AG	170,916	$6,944,317	97.7%	Defined
UBS Switzerland AG	3,363	$136,638	1.9%	Defined

Caption Management, LLC

$6,480,485

0.13%

159,500

ADAR1 Capital Management, LLC

$5,818,175

0.12%

143,199

KVP Capital Advisors, LP

$5,403,790

0.11%

133,000

Invesco Ltd.

$4,913,465

0.10%

120,932

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invesco Advisers, Inc. joint	10,900	$442,866	9.0%	Defined
Invesco Trust Co joint	28,503	$1,158,076	23.6%	Defined
Invesco Capital Management LLC	81,529	$3,312,523	67.4%	Defined

UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC

$4,802,829

0.10%

118,209

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Group AG	1,415	$57,491	1.2%	Defined
UBS Asset Management Switzerland AG	100,261	$4,073,604	84.8%	Sole
UBS Asset Management (UK) Ltd.	10,122	$411,256	8.6%	Defined
Held directly	6,411	$260,478	5.4%	Defined

Point72 Asset Management, L.P.

$4,764,355

0.10%

117,262

Quantum Private Wealth, LLC

$4,606,629

0.09%

113,380

ALPS ADVISORS INC

$4,420,340

0.09%

108,795

Moody Aldrich Partners LLC

$4,264,199

0.09%

104,952

KINGDON CAPITAL MANAGEMENT, L.L.C.

$4,063,000

0.08%

100,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Manager 1 joint	100,000	$4,063,000	100.0%	Defined

Artia Global Partners LP

$4,014,244

0.08%

98,800

Swiss National Bank

$3,932,984

0.08%

96,800

VOYA INVESTMENT MANAGEMENT LLC

$3,846,481

0.08%

94,671

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Voya Investment Management Co. LLC joint	94,671	$3,846,481	100.0%	Defined

HSBC HOLDINGS PLC

$3,723,251

0.08%

91,638

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
HSBC Global Asset Management (UK) Ltd	1,638	$66,551	1.8%	Defined
HSBC GLOBAL ASSET MANAGEMENT (FRANCE)	90,000	$3,656,700	98.2%	Defined

HighVista Strategies LLC

$3,697,167

0.08%

90,996

RHUMBLINE ADVISERS

$3,666,126

0.08%

90,232

Ally Bridge Group (NY) LLC

$3,384,479

0.07%

83,300

BOOTHBAY FUND MANAGEMENT, LLC

$3,361,482

0.07%

82,734

NEW YORK STATE COMMON RETIREMENT FUND

$3,258,404

0.07%

80,197

WELLS FARGO & COMPANY/MN

$3,205,623

0.07%

78,898

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO BANK N A	65,249	$2,651,066	82.7%	Defined
WELLS FARGO ADVISORS FINANCIAL NETWORK, LLC	1,710	$69,477	2.2%	Defined
WELLS FARGO CLEARING SERVICES, LLC	11,871	$482,318	15.0%	Defined
WELLS FARGO INVESTMENT INSTITUTE, INC.	68	$2,762	0.1%	Defined

Russell Investments Group, Ltd.

$3,158,288

0.07%

77,733

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Russell Investment Management, LLC	46,434	$1,886,612	59.7%	Defined
Russell Investments Capital, LLC	14,969	$608,190	19.3%	Defined
Russell Investments France SAS	5,784	$235,003	7.4%	Defined
Russell Investments Trust Company	10,546	$428,483	13.6%	Defined

Centiva Capital, LP

$3,047,250

0.06%

75,000

Jefferies Financial Group Inc.

$2,900,535

0.06%

71,389

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jefferies Financial Services, Inc.	71,389	$2,900,535	100.0%	Defined

Persistent Asset Partners Ltd

$2,821,387

0.06%

69,441

NOMURA ASSET MANAGEMENT INTERNATIONAL INC.

$2,637,618

0.05%

64,918

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NOMURA HOLDINGS INC joint	64,918	$2,637,618	100.0%	Defined

CITIGROUP INC

$2,420,044

0.05%

59,563

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citigroup Financial Products Inc. joint	59,563	$2,420,044	100.0%	Defined

TUDOR INVESTMENT CORP ET AL

$2,313,228

0.05%

56,934

STATE OF WISCONSIN INVESTMENT BOARD

$2,312,253

0.05%

56,910

CITADEL ADVISORS LLC

$2,263,091

0.05%

55,700

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	55,700	$2,263,091	100.0%	Defined

HighMark Wealth Management LLC

$2,160,662

0.04%

53,179

TWO SIGMA INVESTMENTS, LP

$2,013,135

0.04%

49,548

SEI INVESTMENTS CO

$1,931,671

0.04%

47,543

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SEI INVESTMENTS MANAGEMENT CORP	71	$2,884	0.1%	Sole
SEI TRUST CO	47,472	$1,928,787	99.9%	Sole

ALGERT GLOBAL LLC

$1,919,361

0.04%

47,240

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$1,913,673

0.04%

47,100

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	47,100	$1,913,673	100.0%	Other

XTX Topco Ltd

$1,862,154

0.04%

45,832

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
XTX EXECUTION SERVICES LLC joint	45,832	$1,862,154	100.0%	Defined

Legal & General Group Plc

$1,815,672

0.04%

44,688

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Legal & General Investment Management America Inc	6,945	$282,175	15.5%	Defined
Legal & General Investment Management Ltd joint	37,743	$1,533,497	84.5%	Defined

GSA CAPITAL PARTNERS LLP

$1,806,653

0.04%

44,466

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
METLIFE INC	41,804	$1,698,496	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MANULIFE FINANCIAL CORP joint	40,757	$1,655,956	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
CREATIVE PLANNING TRUST Co LLC	2,899	$117,786	7.4%	Defined
Held directly	36,299	$1,474,828	92.6%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	38,600	$1,568,318	100.0%	Other

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
FIDUCIARY TRUST INTERNATIONAL LLC	209	$8,491	0.6%	Defined
FRANKLIN ADVISERS INC	37,396	$1,519,399	99.4%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Global X Management CO LLC joint	32,939	$1,338,311	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	29,010	$1,178,676	96.9%	Defined
Jane Street Global Trading, LLC	924	$37,542	3.1%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Brevan Howard US Investment Management, LP	26,566	$1,079,376	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Wellington Management Company LLP	12,972	$527,052	50.6%	Defined
Wellington Managment Canada LLC	724	$29,416	2.8%	Defined
Wellington Trust Company, NA joint	10,305	$418,692	40.2%	Defined
Wellington Management Europe GmbH	1,658	$67,364	6.5%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Capital	21,096	$857,130	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Wabon Partners, L.P.	20,000	$812,600	100.0%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Balyasny Asset Management L.P.	18,790	$763,437	100.0%	Other

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RF&L WEALTH MANAGEMENT, LLC	4	$162	0.0%	Other
Compound Planning, Inc.	4	$162	0.0%	Other
Arax Advisory Partners	30	$1,218	0.2%	Other
HALBERT HARGROVE GLOBAL ADVISORS, LLC	17	$690	0.1%	Other
Stokes Family Office, LLC	3	$121	0.0%	Other
Held directly	18,398	$747,510	99.7%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	14,500	$589,135	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GUGGENHEIM FUNDS DISTRIBUTORS, LLC	12,961	$526,605	95.0%	Defined
SECURITY INVESTORS LLC	688	$27,953	5.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Institutional Asset Management Trust Co	2	$81	0.0%	Other
Held directly	12,207	$495,970	100.0%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Orion Porfolio Solutions, LLC	9,824	$399,149	100.0%	Other

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
OSAIC WEALTH, INC.	404	$16,414	4.6%	Defined
CW Advisors, LLC	6,283	$255,278	72.3%	Sole
Osaic Advisory Services, LLC	2,007	$81,544	23.1%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
EATON VANCE MANAGEMENT	6,491	$263,729	100.0%	Other

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Marex Financial	6,274	$254,912	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Marshall Wace North America L.P. joint	6,100	$247,843	100.0%	Other

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	5,692	$231,265	100.0%	Other

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Squarepoint Capital LLP	5,655	$229,762	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	5,400	$219,402	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RBC CMA LTD.	2,169	$88,126	57.7%	Defined
RBC Capital Markets, LLC	1,462	$59,401	38.9%	Defined
RBC Dominion Securities Inc.	37	$1,503	1.0%	Defined
Held directly	94	$3,819	2.5%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
US BANK NATIONAL ASSOCIATION	3,386	$137,572	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Tower Research Capital Investments LLC	28	$1,137	1.0%	Other
Latour Trading LLC (Latour)	2,784	$113,113	99.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Acadian Inc	1,669	$67,811	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
KBC Bank NV joint	1,560	$63,382	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
FEDERATED MDTA LLC	1,138	$46,236	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BNP PARIBAS ASSET MANAGEMENT Europe	782	$31,772	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BESSEMER TRUST Co NATIONAL ASSOCIATION	426	$17,308	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Optiver VOF	369	$14,992	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Nykredit Bank A/S	356	$14,464	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
ROCKEFELLER & CO. LLC	137	$5,566	42.3%	Defined
ROCKEFELLER TRUST COMPANY, N.A.	187	$7,597	57.7%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fifth Third Bank, National Association	193	$7,841	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
PNC Bank, National Association	176	$7,149	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BMSS Wesson Wealth Solutions, LLC	14	$568	19.7%	Sole
Held directly	57	$2,315	80.3%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Deka Vermoegensmanagement GmbH	80,000	$2,522	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Edward D. Jones & Co., L.P.	22	$893	100.0%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JANUS HENDERSON INVESTORS UK Ltd	114,215	$3,597,772	1.9%	Defined
JANUS HENDERSON INVESTORS US LLC joint	5,801,341	$182,742,241	98.1%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BB BIOTECH AG joint	1,528,518	$48,148,317	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Columbia Management Investment Advisers, LLC	200,261	$6,308,221	99.8%	Defined
Ameriprise Financial Services, LLC	400	$12,600	0.2%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Schroder Investment Management Limited	145,286	$4,576,509	100.0%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Dynasty Wealth Management, LLC joint	16,221	$510,961	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Hudson Bay Capital UK LLP	12,930	$407,295	100.0%	Defined

Key facts CIK 1710072 CUSIP 28036F105 13F (30d) 211 filings 207 filers Visit website Investor relations