LXRX · Lexicon Pharmaceuticals, Inc.

$2.32 +0.01 (+0.43%) At close · Aug 27

Market Cap

$1.02B

444.96M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Quarter:

Holders: 149

Total Value: $878,995,892

Total Shares: 366,248,315

Showing 1–100 of 153 holdings by value · page 1 of 2

Institutional Ownership Trend

26 quarters

Superinvestors Holding LXRX

All superinvestors →

Joel Greenblatt $32,704

Holder Concentration

Across 149 13F filers · Δ vs Mar 31, 2026

Top Holder

47.8%

+0.2 pts

Top 5

84.0%

+0.5 pts

Top 10

92.6%

+2.2 pts

HHI

2,702

Highly concentrated+7

Quarterly Activity

vs Mar 31, 2026

New

Increased

Decreased

Sold Out

Unchanged

Holder count: +12

Institutional value: +73.3%

Shares held: +12.6%

Top Buyers

vs Mar 31, 2026

Institution	Added	Now Holds
Small Artal Group S.A.	+20,421,735	175,156,062
Mega BlackRock, Inc.	+14,026,522	17,348,741
Mega FMR LLC	+6,725,707	51,782,045
Mega STATE STREET CORP	+3,953,731	4,917,769
Mega GEODE CAPITAL MANAGEMENT, LLC	+3,075,261	6,244,372

Top Sellers

vs Mar 31, 2026

Institution	Sold	Now Holds
Mega MILLENNIUM MANAGEMENT LLC	−3,810,502	1,134,229
Mega JANE STREET GROUP, LLC	−2,656,038	582,900
Mega UBS Group AG	−1,798,469	684,713
Large CIBC Bancorp USA Inc.	−1,786,260	13,740
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP	−1,383,088	1,383,176

Top New Positions

vs Mar 31, 2026

Institution	Acquired	Value (USD)
Mega Nuveen, LLC	586,664	$1,407,992
Large Janney Montgomery Scott LLC	295,548	$709,315
Mega CANADA PENSION PLAN INVESTMENT BOARD	257,900	$618,960
Mega DEUTSCHE BANK AG\	247,528	$594,066
Mega PRICE T ROWE ASSOCIATES INC /MD/	204,391	$490,538

Top Sold-Out Positions

vs Mar 31, 2026

Institution	Previously Held	Last Value (USD)
Large MARSHALL WACE, LLP	2,376,304	$3,707,033
Mid Hennion & Walsh Asset Management, Inc.	848,138	$1,323,095
Mid TANG CAPITAL MANAGEMENT LLC	399,700	$623,532
Mid Catalyst Funds Management Pty Ltd	207,900	$324,324
Mid Brevan Howard Capital Management LP	160,499	$250,378

Filter: New 43 Increased 37 Reduced 37 Sold out 31 Unchanged 32

Showing 100 of 153

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

Artal Group S.A.

$420,374,548

47.82%

175,156,062

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Stichting Administratiekantoor Westend joint	175,156,062	$420,374,548	100.0%	Defined

FMR LLC

$124,276,907

14.14%

51,782,045

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	27,107,108	$65,057,059	52.3%	Defined
FIDELITY MANAGEMENT TRUST CO	24,673,450	$59,216,280	47.6%	Defined
STRATEGIC ADVISERS LLC	1,487	$3,568	0.0%	Defined

Siren, L.L.C.

$106,328,443

12.10%

44,303,518

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invus Group, LLC	44,303,518	$106,328,443	100.0%	Defined

Sessa Capital IM, L.P.

$45,506,006

5.18%

18,960,836

BlackRock, Inc.

$41,636,977

4.74%

17,348,741

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	118,515	$284,436	0.7%	Sole
BlackRock Investment Management, LLC	734,246	$1,762,190	4.2%	Sole
BLACKROCK ADVISORS LLC	563,290	$1,351,896	3.2%	Sole
BlackRock Fund Advisors	9,436,515	$22,647,636	54.4%	Sole
BlackRock Institutional Trust Company, N.A.	6,477,052	$15,544,924	37.3%	Sole
BlackRock Investment Management (UK) Ltd.	1,973	$4,735	0.0%	Sole
Aperio Group, LLC	17,150	$41,160	0.1%	Sole

VANGUARD CAPITAL MANAGEMENT LLC

$23,762,899

2.70%

9,901,208

Point72 Asset Management, L.P.

$19,803,180

2.25%

8,251,325

GEODE CAPITAL MANAGEMENT, LLC

$14,986,492

1.70%

6,244,372

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	851,347	$2,043,232	13.6%	Defined
Held directly	5,393,025	$12,943,260	86.4%	Defined

STATE STREET CORP

$11,802,645

1.34%

4,917,769

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STATE STREET GLOBAL ADVISORS EUROPE LIMITED joint	4,917,769	$11,802,645	100.0%	Defined

VANGUARD PORTFOLIO MANAGEMENT LLC

$5,658,597

0.64%

2,357,749

NORTHERN TRUST CORP

$4,724,684

0.54%

1,968,619

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	1,929,538	$4,630,890	98.0%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC joint	39,081	$93,794	2.0%	Other

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$4,696,260

0.53%

1,956,775

VANGUARD FIDUCIARY TRUST CO

$3,922,970

0.45%

1,634,571

CITADEL ADVISORS LLC

$3,842,836

0.44%

1,601,182

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	1,039,210	$2,494,104	64.9%	Defined
Held directly	561,972	$1,348,732	35.1%	Defined

Ishara Investments LP

$3,050,400

0.35%

1,271,000

MILLENNIUM MANAGEMENT LLC

$2,722,149

0.31%

1,134,229

RENAISSANCE TECHNOLOGIES LLC

$2,704,800

0.31%

1,127,000

MACKENZIE FINANCIAL CORP

$2,312,049

0.26%

963,354

ADAR1 Capital Management, LLC

$1,800,000

0.20%

750,000

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$1,672,262

0.19%

696,776

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	683,213	$1,639,711	98.1%	Other
G1 EXECUTION SERVICES, LLC	13,563	$32,551	1.9%	Other

ACADIAN ASSET MANAGEMENT LLC

$1,671,880

0.19%

696,617

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Acadian Inc	696,617	$1,671,880	100.0%	Defined

UBS Group AG

$1,643,309

0.19%

684,713

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Financial Services Inc	2,049	$4,917	0.3%	Defined
UBS AG	625,187	$1,500,448	91.3%	Defined
UBS Switzerland AG	57,477	$137,944	8.4%	Defined

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$1,604,400

0.18%

668,500

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	668,500	$1,604,400	100.0%	Other

TWO SIGMA INVESTMENTS, LP

$1,544,265

0.18%

643,444

Nuveen, LLC

$1,407,992

0.16%

586,664

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Nuveen Asset Management, LLC joint	63,937	$153,448	10.9%	Defined
TEACHERS ADVISORS, LLC joint	522,727	$1,254,544	89.1%	Defined

JANE STREET GROUP, LLC

$1,398,960

0.16%

582,900

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	582,900	$1,398,960	100.0%	Defined

Bank of New York Mellon Corp

$1,364,893

0.16%

568,706

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Investments Corporation	143,878	$345,307	25.3%	Defined
The Bank of New York Mellon	424,826	$1,019,582	74.7%	Defined
Held directly	2	$4	0.0%	Defined

Invesco Ltd.

$1,219,369

0.14%

508,071

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invesco Advisers, Inc. joint	35,828	$85,987	7.1%	Defined
Invesco Trust Co joint	99,246	$238,190	19.5%	Defined
Invesco Capital Management LLC	372,997	$895,192	73.4%	Defined

GOLDMAN SACHS GROUP INC

$1,165,310

0.13%

485,546

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	302,421	$725,810	62.3%	Defined
GOLDMAN SACHS ASSET MANAGEMENT, L.P.	183,125	$439,500	37.7%	Defined

Compagnie Lombard Odier SCmA

$1,152,000

0.13%

480,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Bank Lombard Odier & Co Ltd	480,000	$1,152,000	100.0%	Defined

BANK OF AMERICA CORP /DE/

$1,011,116

0.12%

421,299

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	143,467	$344,320	34.1%	Defined
BOFA SECURITIES, INC.	152,521	$366,050	36.2%	Defined
MERRILL LYNCH INTERNATIONAL	125,311	$300,746	29.7%	Defined

GSA CAPITAL PARTNERS LLP

$953,325

0.11%

397,219

BARCLAYS PLC

$929,959

0.11%

387,483

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BARCLAYS BANK PLC	371,098	$890,635	95.8%	Defined
BARCLAYS CAPITAL INC.	16,385	$39,324	4.2%	Defined

CITADEL ADVISORS LLC

$886,320

0.10%

369,300

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	369,300	$886,320	100.0%	Defined

XTX Topco Ltd

$858,904

0.10%

357,877

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
XTX EXECUTION SERVICES LLC joint	357,877	$858,904	100.0%	Defined

Janney Montgomery Scott LLC

$709,315

0.08%

295,548

CANADA PENSION PLAN INVESTMENT BOARD

$618,960

0.07%

257,900

RHUMBLINE ADVISERS

$616,524

0.07%

256,885

DEUTSCHE BANK AG\

$594,066

0.07%

247,528

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DWS INVESTMENT MANAGEMENT AMERICAS, INC	4,709	$11,301	1.9%	Defined
DWS Investments UK Ltd	242,819	$582,765	98.1%	Defined

WELLS FARGO & COMPANY/MN

$553,127

0.06%

230,470

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO BANK N A	227,027	$544,864	98.5%	Defined
WELLS FARGO CLEARING SERVICES, LLC	3,443	$8,263	1.5%	Defined

PRICE T ROWE ASSOCIATES INC /MD/

$490,538

0.06%

204,391

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T. Rowe Price International Ltd	204,391	$490,538	100.0%	Defined

WELLINGTON MANAGEMENT GROUP LLP

$431,280

0.05%

179,700

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Wellington Management Company LLP	60,000	$144,000	33.4%	Defined
Wellington Trust Company, NA joint	119,700	$287,280	66.6%	Defined

CITIGROUP INC

$420,491

0.05%

175,205

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citigroup Financial Products Inc. joint	175,205	$420,491	100.0%	Defined

GROUP ONE TRADING LLC

$420,031

0.05%

175,013

Virtus Investment Advisers, LLC

$408,996

0.05%

170,415

Headlands Technologies LLC

$401,275

0.05%

167,198

Ikarian Capital, LLC

$395,217

0.04%

164,674

Quarry LP

$374,846

0.04%

156,186

MetLife Investment Management, LLC

$351,384

0.04%

146,410

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
METLIFE INC	146,410	$351,384	100.0%	Defined

MORGAN STANLEY

$318,963

0.04%

132,902

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	1,040	$2,496	0.8%	Defined
MORGAN STANLEY & CO. LLC	67,403	$161,767	50.7%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	47,912	$114,988	36.1%	Defined
MORGAN STANLEY SMITH BARNEY LLC	14,138	$33,931	10.6%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	2,409	$5,781	1.8%	Defined

PANAGORA ASSET MANAGEMENT INC

$316,900

0.04%

132,042

State of Wyoming

$285,816

0.03%

119,090

MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.

$273,873

0.03%

114,114

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Global X Management CO LLC joint	114,114	$273,873	100.0%	Defined

Cornerstone Investment Partners, LLC

$272,973

0.03%

113,739

JPMORGAN CHASE & CO

$263,613

0.03%

109,839

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JPMorgan Chase Bank, N.A.	103,175	$247,620	93.9%	Defined
J.P. Morgan Securities plc	6,664	$15,993	6.1%	Defined

Cerity Partners LLC

$236,159

0.03%

98,400

ALGERT GLOBAL LLC

$221,160

0.03%

92,150

BANK OF NOVA SCOTIA

$207,856

0.02%

86,607

LPL Financial LLC

$203,798

0.02%

84,916

Vanguard Global Advisers, LLC

$187,070

0.02%

77,946

AQR CAPITAL MANAGEMENT LLC

$180,551

0.02%

75,230

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
HALBERT HARGROVE GLOBAL ADVISORS, LLC	163	$391	0.2%	Other
Stokes Family Office, LLC	25	$60	0.0%	Other
Held directly	75,042	$180,100	99.8%	Defined

Police & Firemen's Retirement System of New Jersey

$176,164

0.02%

73,402

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Capital	73,402	$176,164	100.0%	Defined

UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO

$171,424

0.02%

71,427

PRUDENTIAL FINANCIAL INC

$171,228

0.02%

71,345

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
PGIM Quantitative Solutions LLC	71,345	$171,228	100.0%	Defined

MANUFACTURERS LIFE INSURANCE COMPANY, THE

$167,392

0.02%

69,747

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MANULIFE FINANCIAL CORP joint	69,747	$167,392	100.0%	Defined

NEW YORK STATE COMMON RETIREMENT FUND

$164,160

0.02%

68,400

ALLIANCEBERNSTEIN L.P.

$162,720

0.02%

67,800

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Equitable Holdings, Inc.	67,800	$162,720	100.0%	Defined

TWO SIGMA SECURITIES, LLC

$159,300

0.02%

66,375

SEI INVESTMENTS CO

$153,448

0.02%

63,937

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SEI TRUST CO	63,937	$153,448	100.0%	Sole

Straight Path Wealth Management

$150,398

0.02%

62,666

R Squared Ltd

$131,964

0.02%

54,985

Vanguard Personalized Indexing Management, LLC

$130,401

0.01%

54,334

Fortis Group Advisors, LLC

$120,000

0.01%

50,000

Schonfeld Strategic Advisors LLC

$118,644

0.01%

49,435

SCOTIA CAPITAL INC.

$117,290

0.01%

48,871

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF NOVA SCOTIA	48,871	$117,290	100.0%	Defined

PROFUND ADVISORS LLC

$116,606

0.01%

48,586

VOYA INVESTMENT MANAGEMENT LLC

$114,650

0.01%

47,771

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Voya Investment Management Co. LLC joint	47,771	$114,650	100.0%	Defined

AXQ CAPITAL, LP

$109,744

0.01%

45,727

BOOTHBAY FUND MANAGEMENT, LLC

$106,356

0.01%

44,315

WINTON GROUP Ltd

$103,680

0.01%

43,200

INTECH INVESTMENT MANAGEMENT LLC

$101,978

0.01%

42,491

LMR Partners LLP

$98,618

0.01%

41,091

BANK OF MONTREAL /CAN/

$96,000

0.01%

40,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BMO PRIVATE INVESTMENT COUNSEL INC.	40,000	$96,000	100.0%	Defined

BNP PARIBAS ARBITRAGE, SA

$90,672

0.01%

37,780

Rafferty Asset Management, LLC

$81,816

0.01%

34,090

ProShare Advisors LLC

$78,211

0.01%

32,588

Leonteq Securities AG

$72,000

0.01%

30,000

Pathstone Holdings, LLC

$71,925

0.01%

29,969

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
ADVISOR PARTNERS II, LLC	29,774	$71,457	99.3%	Defined
Held directly	195	$468	0.7%	Sole

PINNACLE ASSOCIATES LTD

$69,636

0.01%

29,015

VICTORY CAPITAL MANAGEMENT INC

$58,135

0.01%

24,223

Legal & General Group Plc

$58,044

0.01%

24,185

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Legal & General Investment Management America Inc	24,185	$58,044	100.0%	Defined

XPONANCE LLC

$57,031

0.01%

23,763

Graham Capital Management, L.P.

$56,498

0.01%

23,541

Ameritas Investment Partners, Inc.

$55,166

0.01%

22,986

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
EATON VANCE MANAGEMENT	22,586	$54,206	98.3%	Other
Held directly	400	$960	1.7%	Sole

D. E. Shaw & Co., Inc.

$53,280

0.01%

22,200

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
D. E. Shaw Investment Management, L.L.C. joint	22,200	$53,280	100.0%	Defined

Quadrature Capital Ltd

$52,795

0.01%

21,998

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Quadrature US Inc.	21,998	$52,795	100.0%	Other

DIKER MANAGEMENT LLC

$48,000

0.01%

20,000

Invera Wealth Advisors, LLC

$48,000

0.01%

20,000

WEDBUSH SECURITIES INC

$48,000

0.01%

20,000

TIAA-CREF INDIVIDUAL & INSTITUTIONAL SERVICES, LLC

$48,000

0.01%

20,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
TEACHERS INSURANCE & ANNUITY ASSOCIATION OF AMERICA	20,000	$48,000	100.0%	Defined

Key facts CIK 1062822 CUSIP 528872302 13F (30d) 134 filings 133 filers Visit website Investor relations