GPCR · Structure Therapeutics Inc. · Holdings

$41.23 +0.85 (+2.11%) At close · Sep 9

Market Cap

$3.17B

71.31M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Use institutional holdings through the 13F API or MCP →

Quarter:

Holders: 193

Total Value: $3,654,510,739

Total Shares: 68,092,268

Showing 1–100 of 199 holdings by value · page 1 of 2

Institutional Ownership Trend

14 quarters

Holder Concentration

Across 193 13F filers · Δ vs Mar 31, 2026

Top Holder

11.5%

−1.0 pts

Top 5

46.5%

−0.6 pts

Top 10

63.9%

+0.4 pts

HHI

551

Broadly held−10

Quarterly Activity

vs Mar 31, 2026

New

Increased

Decreased

Sold Out

Unchanged

Holder count: -6

Institutional value: +12.2%

Shares held: +0.7%

Top Buyers

vs Mar 31, 2026

Institution	Added	Now Holds
Mid ORBIMED ADVISORS LLC	+733,997	2,209,400
Mega MORGAN STANLEY	+501,183	2,806,640
Mid Deep Track Capital, LP	+460,224	4,740,072
Mega BANK OF AMERICA CORP /DE/	+336,290	563,422
Small Davern Capital Partners, LP	+319,598	446,059

Top Sellers

vs Mar 31, 2026

Institution	Sold	Now Holds
Mega PRICE T ROWE ASSOCIATES INC /MD/	−1,155,164	845,532
Mega FMR LLC	−593,143	7,810,306
Mid Siren, L.L.C.	−455,731	872,967
Mega JPMORGAN CHASE & CO	−208,819	3,984
Small STEMPOINT CAPITAL LP	−162,089	38,178

Top New Positions

vs Mar 31, 2026

Institution	Acquired	Value (USD)
Mega Jupiter Topco LLC	5,204,212	$279,310,056
Large RTW INVESTMENTS, LP	1,607,507	$86,274,900
Large ExodusPoint Capital Management, LP	78,266	$4,200,536
Large ADAGE CAPITAL PARTNERS GP, L.L.C.	75,000	$4,025,250
Small SCOGGIN MANAGEMENT LP	50,000	$2,683,500

Top Sold-Out Positions

vs Mar 31, 2026

Institution	Previously Held	Last Value (USD)
Mega JANUS HENDERSON GROUP PLC	5,354,981	$258,110,082
Mid Paradigm Biocapital Advisors LP	545,287	$26,282,833
Large Balyasny Asset Management L.P.	304,934	$14,697,818
Large Pentwater Capital Management LP	245,000	$11,809,000
Small Sio Capital Management, LLC	209,093	$10,078,282

Filter: New 28 Increased 75 Reduced 54 Sold out 34 Unchanged 36

Showing 100 of 199

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

FMR LLC

$419,179,120

11.47%

7,810,306

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC joint	6,434,598	$345,344,874	82.4%	Defined
FIDELITY MANAGEMENT TRUST CO	425,930	$22,859,663	5.5%	Defined
Impresa Management LLC	34,907	$1,873,458	0.4%	Defined
Fidelity Institutional Asset Management Trust Co	413,595	$22,197,643	5.3%	Defined
FIAM LLC	501,276	$26,903,482	6.4%	Defined

WELLINGTON MANAGEMENT GROUP LLP

$396,054,165

10.84%

7,379,433

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Wellington Management Company LLP	6,347,592	$340,675,262	86.0%	Defined
Wellington Managment Canada LLC	81,990	$4,400,403	1.1%	Defined
Wellington Management Japan Pte Ltd	82,466	$4,425,950	1.1%	Defined
Wellington Management Singapore Pte. Ltd.	68,061	$3,652,833	0.9%	Defined
Wellington Management International Ltd	161,723	$8,679,673	2.2%	Defined
Wellington Trust Company, NA joint	556,354	$29,859,519	7.5%	Defined
Wellington Management Australia Pty Ltd	13,364	$717,245	0.2%	Defined
Wellington Management Europe GmbH	67,883	$3,643,280	0.9%	Defined

Avoro Capital Advisors LLC

$351,836,636

9.63%

6,555,555

Jupiter Topco LLC

$279,310,056

7.64%

5,204,212

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JANUS HENDERSON INVESTORS UK Ltd	92,532	$4,966,192	1.8%	Defined
JANUS HENDERSON INVESTORS US LLC	5,049,980	$271,032,426	97.0%	Defined
Janus Henderson Investors (Singapore) Ltd	54,531	$2,926,678	1.0%	Defined
Held directly	7,169	$384,760	0.1%	Defined

Deep Track Capital, LP

$254,399,664

6.96%

4,740,072

BVF INC/IL

$180,697,390

4.94%

3,366,823

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BVF PARTNERS L P/IL	3,366,823	$180,697,390	100.0%	Defined

MORGAN STANLEY

$150,632,366

4.12%

2,806,640

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	12	$644	0.0%	Defined
MORGAN STANLEY & CO. LLC	11,981	$643,020	0.4%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	2,444,657	$131,204,741	87.1%	Defined
MORGAN STANLEY INVESTMENT MANAGEMENT INC	63,348	$3,399,887	2.3%	Defined
MORGAN STANLEY SMITH BARNEY LLC	274,160	$14,714,166	9.8%	Defined
Morgan Stanley Bank, N.A.	4,445	$238,563	0.2%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	8,037	$431,345	0.3%	Defined

ORBIMED ADVISORS LLC

$118,578,498

3.24%

2,209,400

PRINCIPAL FINANCIAL GROUP INC

$94,070,253

2.57%

1,752,753

AMERICAN CENTURY COMPANIES INC

$90,282,546

2.47%

1,682,179

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
AMERICAN CENTURY INVESTMENT MANAGEMENT INC	1,682,179	$90,282,546	100.0%	Defined

RTW INVESTMENTS, LP

$86,274,900

2.36%

1,607,507

Driehaus Capital Management LLC

$83,361,263

2.28%

1,553,219

BAKER BROS. ADVISORS LP

$76,883,831

2.10%

1,432,529

Casdin Capital, LLC

$63,062,250

1.73%

1,175,000

DEERFIELD MANAGEMENT COMPANY, L.P.

$58,285,620

1.59%

1,086,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Deerfield UGP, LLC	1,086,000	$58,285,620	100.0%	Defined

CAPITOLIS LIQUID GLOBAL MARKETS LLC

$55,875,837

1.53%

1,041,100

Siren, L.L.C.

$46,852,138

1.28%

872,967

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invus Group, LLC	872,967	$46,852,138	100.0%	Defined

PRICE T ROWE ASSOCIATES INC /MD/

$45,379,702

1.24%

845,532

Pacific Heights Asset Management LLC

$42,936,000

1.17%

800,000

Rock Springs Capital Management LP

$34,365,813

0.94%

640,317

Aberdeen Group plc

$34,344,238

0.94%

639,915

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
abrdn Inc.	639,915	$34,344,238	100.0%	Defined

ALLIANCEBERNSTEIN L.P.

$32,830,368

0.90%

611,708

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Equitable Holdings, Inc.	611,708	$32,830,368	100.0%	Defined

FRANKLIN RESOURCES INC

$31,066,287

0.85%

578,839

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fiduciary Trust Co International of Pennsylvania	50	$2,683	0.0%	Defined
FIDUCIARY TRUST INTERNATIONAL LLC	292	$15,671	0.1%	Defined
FRANKLIN ADVISERS INC	578,497	$31,047,933	99.9%	Defined

BANK OF AMERICA CORP /DE/

$30,238,857

0.83%

563,422

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	234,383	$12,579,335	41.6%	Defined
BOFA SECURITIES, INC.	299,799	$16,090,212	53.2%	Defined
MANAGED ACCOUNT ADVISORS LLC joint	29,240	$1,569,310	5.2%	Defined

BlackRock, Inc.

$27,433,361

0.75%

511,149

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	5,540	$297,331	1.1%	Sole
BLACKROCK ADVISORS LLC	19,786	$1,061,914	3.9%	Sole
BlackRock Fund Advisors	418,591	$22,465,778	81.9%	Sole
BlackRock Investment Management (UK) Ltd.	7,792	$418,196	1.5%	Sole
BlackRock (Netherlands) B.V.	973	$52,220	0.2%	Sole
BlackRock Asset Management Ireland Ltd	57,795	$3,101,857	11.3%	Sole
BlackRock (Luxembourg) S.A.	429	$23,024	0.1%	Sole
Aperio Group, LLC	243	$13,041	0.0%	Sole

Logos Global Management LP

$26,835,000

0.73%

500,000

Parkman Healthcare Partners LLC

$26,065,425

0.71%

485,661

Davern Capital Partners, LP

$23,939,986

0.66%

446,059

HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND

$22,476,996

0.62%

418,800

UBS Group AG

$20,340,178

0.56%

378,986

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Financial Services Inc	518	$27,801	0.1%	Defined
UBS AG	378,468	$20,312,377	99.9%	Defined

DEUTSCHE BANK AG\

$17,811,301

0.49%

331,867

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DWS Investments UK Ltd	331,867	$17,811,301	100.0%	Defined

NEXTBio Capital Management LP

$16,771,660

0.46%

312,496

Catalio Capital Management, LP

$14,842,438

0.41%

276,550

MARSHALL WACE, LLP

$14,361,662

0.39%

267,592

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Marshall Wace North America L.P. joint	267,592	$14,361,662	100.0%	Other

HSG Holding Ltd

$14,279,547

0.39%

266,062

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SNP China Enterprises Ltd	266,062	$14,279,547	100.0%	Defined

SEB Asset Management AB

$13,151,457

0.36%

245,043

GOLDMAN SACHS GROUP INC

$13,030,538

0.36%

242,790

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	233,294	$12,520,888	96.1%	Defined
GOLDMAN SACHS ASSET MANAGEMENT, L.P.	9,496	$509,650	3.9%	Defined

AMERIPRISE FINANCIAL INC

$12,371,684

0.34%

230,514

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Columbia Management Investment Advisers, LLC	39,457	$2,117,657	17.1%	Defined
Threadneedle Asset Management Holdings LTD	185,094	$9,933,994	80.3%	Defined
Ameriprise Financial Services, LLC	305	$16,369	0.1%	Defined
Columbia Threadneedle Management Ltd	5,658	$303,664	2.5%	Defined

NATIONAL BANK OF CANADA /FI/

$11,581,986

0.32%

215,800

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NBC Global Finance Ltd	215,800	$11,581,986	100.0%	Defined

TWO SIGMA INVESTMENTS, LP

$10,957,052

0.30%

204,156

Eversept Partners, LP

$10,535,528

0.29%

196,302

Schonfeld Strategic Advisors LLC

$10,234,063

0.28%

190,685

Woodline Partners LP

$8,254,875

0.23%

153,808

NOMURA ASSET MANAGEMENT INTERNATIONAL INC.

$8,217,896

0.22%

153,119

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NOMURA HOLDINGS INC joint	153,119	$8,217,896	100.0%	Defined

ArrowMark Colorado Holdings LLC

$8,081,574

0.22%

150,579

Susquehanna Portfolio Strategies, LLC

$7,994,039

0.22%

148,948

CenterBook Partners LP

$7,944,770

0.22%

148,030

Rhenman & Partners Asset Management AB

$7,787,517

0.21%

145,100

GOLDMAN SACHS GROUP INC

$7,782,150

0.21%

145,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	145,000	$7,782,150	100.0%	Defined

B Group, Inc.

$7,513,800

0.21%

140,000

HighVista Strategies LLC

$7,019,177

0.19%

130,784

Universal- Beteiligungs- und Servicegesellschaft mbH

$6,745,728

0.18%

125,689

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Universal-Investment-Gesellschaft mbH joint	125,689	$6,745,728	100.0%	Defined

Squarepoint Ops LLC

$6,739,610

0.18%

125,575

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Squarepoint Capital LLP	125,575	$6,739,610	100.0%	Defined

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$6,566,202

0.18%

122,344

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	122,344	$6,566,202	100.0%	Other

D. E. Shaw & Co., Inc.

$6,188,151

0.17%

115,300

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
D. E. SHAW & CO, L.P.	115,300	$6,188,151	100.0%	Defined

VOLORIDGE INVESTMENT MANAGEMENT, LLC

$6,027,141

0.16%

112,300

Soleus Capital Management, L.P.

$5,742,690

0.16%

107,000

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$5,302,596

0.15%

98,800

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	98,800	$5,302,596	100.0%	Other

Avidity Partners Management LP

$5,259,660

0.14%

98,000

GEODE CAPITAL MANAGEMENT, LLC

$5,215,811

0.14%

97,183

Qube Research & Technologies Ltd

$5,012,939

0.14%

93,403

PEREGRINE CAPITAL MANAGEMENT LLC

$4,949,930

0.14%

92,229

PFM Health Sciences, LP

$4,913,488

0.13%

91,550

PLATINUM INVESTMENT MANAGEMENT LTD

$4,849,782

0.13%

90,363

MILLENNIUM MANAGEMENT LLC

$4,807,114

0.13%

89,568

ExodusPoint Capital Management, LP

$4,200,536

0.11%

78,266

Boxer Capital Management, LLC

$4,025,250

0.11%

75,000

Cormorant Asset Management, LP

$4,025,250

0.11%

75,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Chen Bihua	75,000	$4,025,250	100.0%	Defined

ADAGE CAPITAL PARTNERS GP, L.L.C.

$4,025,250

0.11%

75,000

CITADEL ADVISORS LLC

$4,014,516

0.11%

74,800

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	74,800	$4,014,516	100.0%	Defined

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$3,869,607

0.11%

72,100

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	72,100	$3,869,607	100.0%	Other

ALPS ADVISORS INC

$3,855,277

0.11%

71,833

TD Asset Management Inc

$3,701,190

0.10%

68,962

Brevan Howard Capital Management LP

$3,238,233

0.09%

60,336

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Brevan Howard Investment Products Ltd	60,336	$3,238,233	100.0%	Defined

Burkehill Global Management, LP

$3,220,200

0.09%

60,000

RAYMOND JAMES FINANCIAL INC

$3,185,689

0.09%

59,357

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RAYMOND JAMES & ASSOCIATES	438	$23,507	0.7%	Defined
Raymond James Financial Services Advisors, Inc.	3,235	$173,622	5.5%	Defined
CHARTWELL INVESTMENT PARTNERS, LLC	55,684	$2,988,560	93.8%	Defined

JANE STREET GROUP, LLC

$3,026,988

0.08%

56,400

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	56,400	$3,026,988	100.0%	Defined

CITADEL ADVISORS LLC

$2,908,914

0.08%

54,200

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	54,200	$2,908,914	100.0%	Defined

TUDOR INVESTMENT CORP ET AL

$2,879,717

0.08%

53,656

ANTIPODES PARTNERS Ltd

$2,751,231

0.08%

51,262

Buckland Partners Management Co LLC

$2,683,500

0.07%

50,000

SCOGGIN MANAGEMENT LP

$2,683,500

0.07%

50,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Scoggin GP LLC	50,000	$2,683,500	100.0%	Defined

SEVEN GRAND MANAGERS, LLC

$2,683,500

0.07%

50,000

DAFNA Capital Management LLC

$2,495,655

0.07%

46,500

Mariner, LLC

$2,484,115

0.07%

46,285

OSAIC HOLDINGS, INC.

$2,403,664

0.07%

44,786

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
OSAIC WEALTH, INC.	39,414	$2,115,349	88.0%	Defined
CW Advisors, LLC	5,372	$288,315	12.0%	Sole

STATE STREET CORP

$2,395,238

0.07%

44,629

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STATE STREET GLOBAL ADVISORS EUROPE LIMITED joint	44,629	$2,395,238	100.0%	Defined

VOYA INVESTMENT MANAGEMENT LLC

$2,383,484

0.07%

44,410

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Voya Investment Management Co. LLC joint	44,410	$2,383,484	100.0%	Defined

BANQUE PICTET & CIE SA

$2,325,628

0.06%

43,332

Jump Financial, LLC

$2,289,454

0.06%

42,658

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Leap GP LLC joint	42,658	$2,289,454	100.0%	Defined

BANK OF MONTREAL /CAN/

$2,284,730

0.06%

42,570

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BMO Bank N.A.	7	$375	0.0%	Defined
BMO NESBITT BURNS INC.	42,413	$2,276,305	99.6%	Defined
BMO NESBITT BURNS SECURITIES LTD.	150	$8,050	0.4%	Defined

Cinctive Capital Management LP

$2,193,868

0.06%

40,877

Jefferies Financial Group Inc.

$2,180,343

0.06%

40,625

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jefferies Financial Services, Inc.	40,625	$2,180,343	100.0%	Defined

Jones Hill Capital LP

$2,177,230

0.06%

40,567

STEMPOINT CAPITAL LP

$2,049,013

0.06%

38,178

MANUFACTURERS LIFE INSURANCE COMPANY, THE

$2,045,256

0.06%

38,108

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MANULIFE FINANCIAL CORP joint	38,108	$2,045,256	100.0%	Defined

CAPITAL FUND MANAGEMENT S.A.

$2,000,871

0.05%

37,281

PSquared Asset Management AG

$1,996,524

0.05%

37,200

FLAX POND CAPITAL, LLC

$1,932,120

0.05%

36,000

TrueMark Investments, LLC

$1,803,312

0.05%

33,600

Key facts CIK 1888886 CUSIP 86366E106 13F (30d) 134 filings 134 filers Visit website Investor relations