ORBIMED ADVISORS LLC

CIK

1055951

Location

New York, NY

Portfolio Value

Mid $5,124,541,261

Diversification

Diversified

Reports for

ORBIMED CAPITAL LLC

Filing Date

Global Rank

#732 / 8,700 ▲ 86

Top Industry

Biotechnology 72.2%

Period ended 2 months ago

Filed Aug 14, 2026 · 30d

26 quarters · since Mar 2020

Portfolio Concentration

116 tracked positions · as of Jun 30, 2026 · Δ vs Mar 31, 2026

Top Position

12.3%

+2.1 pts

Top 5

32.1%

+0.9 pts

Top 10

42.7%

−2.1 pts

HHI

337

Diversified+21

Portfolio Trend

26 quarters · across all stocks

Sector Breakdown

As of Jun 30, 2026

Sector	% Portfolio	Value	Positions
Healthcare	100.0%	$5,124,541,261	116

Last Quarter's Activity

Export CSV

Jun 30, 2026 vs Mar 31, 2026

Added To

Positions the filer increased

25 positions

Ticker	Company	Δ Shares	Shares	Value
SVRA	Savara Inc	+3,324,900	3,959,900	$24,392,984
PRLD	Prelude Therapeutics Inc	+2,815,315	13,724,571	$73,151,963
QTTB	Q32 Bio Inc.	+1,875,000	4,127,987	$52,590,554
COGT	Cogent Biosciences, Inc.	+1,359,200	1,681,300	$65,066,310
GPCR	Structure Therapeutics Inc.	+733,997	2,209,400	$118,578,498
TRAW	Traws Pharma, Inc.	+597,729	1,203,260	$1,010,738
SNDX	Syndax Pharmaceuticals Inc	+579,700	1,542,000	$33,708,120
IMA	ImageneBio, Inc.	+530,713	909,269	$5,364,687
ATAI	AtaiBeckley Inc.	+450,500	797,500	$4,202,825
LFST	LifeStance Health Group, Inc.	+447,400	947,400	$10,146,654
BCRX	Biocryst Pharmaceuticals Inc	+426,800	1,852,000	$18,520,000
—		+380,750	1,577,705	$33,526,231
LXEO	Lexeo Therapeutics, Inc.	+345,400	3,947,850	$18,377,241
DYN	Dyne Therapeutics, Inc.	+317,800	3,235,684	$71,864,541
ABVX	Abivax S.A.	+280,822	746,522	$99,481,521
AZN	Astrazeneca PLC	+245,500	915,700	$173,635,034
KNSA	Kiniksa Pharmaceuticals International, plc	+240,001	420,600	$26,897,370
NKTR	Nektar Therapeutics	+190,346	465,346	$32,485,804
PTGX	Protagonist Therapeutics, Inc	+150,000	192,100	$23,547,618
GH	Guardant Health, Inc.	+148,500	583,700	$87,572,511
PVLA	Palvella Therapeutics, Inc.	+147,760	332,360	$50,791,255
ANRO	Alto Neuroscience, Inc.	+90,352	257,852	$6,804,714
RVMD	Revolution Medicines, Inc.	+68,500	120,500	$22,567,240
ASND	Ascendis Pharma A/S	+62,479	244,456	$65,201,304
PRAX	Praxis Precision Medicines, Inc.	+57,600	230,100	$77,035,179
No positions match the current search.

Trimmed

Positions the filer reduced

25 positions

Ticker	Company	Δ Shares	Shares	Value
ELVN	Enliven Therapeutics, Inc.	−1,182,906	6,776,632	$343,914,074
RLMD	Relmada Therapeutics, Inc.	−1,084,669	3,631,195	$25,127,869
TRVI	Trevi Therapeutics, Inc.	−1,024,107	1,430,293	$26,674,964
SION	Sionna Therapeutics, Inc.	−974,825	2,555,877	$112,433,029
BSX	Boston Scientific Corp	−898,900	1,483,200	$63,302,976
IRON	Disc Medicine, Inc.	−710,015	357,535	$26,150,109
ORIC	Oric Pharmaceuticals, Inc.	−678,929	2,015,000	$21,822,450
NPCE	NeuroPace Inc	−591,402	1,505,125	$23,916,436
HELP	Cybin Inc.	−561,443	3,271,400	$21,623,954
BCAX	Bicara Therapeutics Inc.	−476,200	191,100	$5,673,759
JANX	Janux Therapeutics, Inc.	−458,900	524,700	$8,059,392
DFTX	Definium Therapeutics, Inc.	−438,600	365,400	$17,188,416
EW	Edwards Lifesciences Corp	−395,700	834,900	$75,525,054
QURE	uniQure N.V.	−328,663	1,807,486	$83,252,805
WHWK	Whitehawk Therapeutics, Inc.	−231,704	3,934,296	$18,019,075
MBX	MBX Biosciences, Inc.	−209,151	3,428,736	$189,266,227
URGN	UroGen Pharma Ltd.	−199,300	676,187	$24,883,681
ACET	Adicet Bio, Inc.	−183,157	844,787	$7,298,959
XENE	Xenon Pharmaceuticals Inc.	−167,500	892,471	$53,869,549
ALNY	Alnylam Pharmaceuticals, Inc.	−102,000	17,000	$5,117,510
AXSM	Axsome Therapeutics, Inc.	−96,343	117,578	$28,779,567
STRO	Sutro Biopharma, Inc.	−57,200	743,944	$24,698,940
ISRG	Intuitive Surgical Inc	−50,800	157,900	$62,793,672
ARGX	Argenx SE	−44,020	92,880	$86,171,277
SYK	Stryker Corp	−23,400	159,100	$50,091,044
No positions match the current search.

New Positions

Positions the filer opened this quarter

25 positions

Ticker	Company	Shares	Value
UNH	Unitedhealth Group Inc	171,100	$71,114,293
HUM	Humana Inc	164,100	$65,183,802
ODTX	Odyssey Therapeutics, Inc.	3,001,198	$56,152,414
ARQT	Arcutis Biotherapeutics, Inc.	2,042,000	$53,541,240
WST	West Pharmaceutical Services Inc	70,600	$25,345,400
AURA	Aura Biosciences, Inc.	3,333,333	$23,666,664
SYRE	Spyre Therapeutics, Inc.	186,145	$16,525,953
WAT	Waters Corp /De/	40,300	$15,114,112
MNPR	Monopar Therapeutics	157,423	$14,575,795
TVTX	Travere Therapeutics, Inc.	253,000	$14,372,930
TSHA	Taysha Gene Therapies, Inc.	2,000,000	$13,620,000
DNTH	Dianthus Therapeutics, Inc. /DE/	115,000	$11,210,200
SPRB	Spruce Biosciences, Inc.	200,000	$10,800,000
ERAS	Erasca, Inc.	495,900	$9,084,888
TARA	Protara Therapeutics, Inc.	2,220,000	$8,480,400
ZNTL	Zentalis Pharmaceuticals, Inc.	1,390,576	$6,744,293
XLO	Xilio Therapeutics, Inc.	592,300	$5,674,234
NMRA	Neumora Therapeutics, Inc.	2,139,882	$3,637,799
ACAD	Acadia Pharmaceuticals Inc	137,000	$3,466,100
AMLX	Amylyx Pharmaceuticals, Inc.	183,400	$3,293,864
TYRA	Tyra Biosciences, Inc.	102,000	$3,257,880
RAPP	Rapport Therapeutics, Inc.	76,616	$3,192,588
AGMB	Agomab Therapeutics NV	192,740	$2,501,765
TARS	Tarsus Pharmaceuticals, Inc.	35,581	$2,239,468
ACRS	Aclaris Therapeutics, Inc.	421,500	$2,229,735
No positions match the current search.

Sold Out

Positions the filer fully exited

23 positions

Ticker	Company	Shares	Value
MDXH	MDxHealth SA	124,306,000	$285,903,800
RCEL	AVITA Medical, Inc.	82,010,995	$194,090,681
MYGN	Myriad Genetics Inc	125,000,000	$122,875,000
PFE	Pfizer Inc	1,946,500	$54,657,720
DHR	Danaher Corp /De/	265,800	$50,395,680
BTSG	BrightSpring Health Services, Inc.	497,800	$21,211,258
AMGN	Amgen Inc	39,900	$14,038,815
ALHC	Alignment Healthcare, Inc.	791,000	$13,937,420
REGN	Regeneron Pharmaceuticals, Inc.	14,700	$11,357,808
CARL	Carlsmed, Inc.	1,252,600	$11,336,030
QGEN	Qiagen N.V.	250,000	$10,010,000
GILD	Gilead Sciences, Inc.	59,600	$8,306,452
HRTX	Heron Therapeutics, Inc. /De/	9,816,940	$7,853,552
AVTX	Avalo Therapeutics, Inc.	475,165	$7,094,213
CMPS	COMPASS Pathways plc	1,150,646	$6,363,072
ADCT	ADC Therapeutics SA	1,318,026	$4,942,597
CGEM	Cullinan Therapeutics, Inc.	243,006	$3,453,115
JBIO	Jade Biosciences, Inc.	185,011	$2,599,404
CCCC	C4 Therapeutics, Inc.	856,353	$2,252,208
VTGN	Vistagen Therapeutics, Inc.	3,060,000	$1,744,200
—		100,000	$0
—		94,400	$0
—		10,570,300	$0
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

116 tracked positions · $5,124,541,261 total · filing declares 129 positions · $5,396,779,685 · as of Jun 30, 2026

All sectors Healthcare

Showing 1–50 of 116 positions by value · page 1 of 3

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
EWTX	Edgewise Therapeutics, Inc. Healthcare	Held	15,518,492	0	$630,516,329	+29.0%	12.30%
ELVN	Enliven Therapeutics, Inc. Healthcare	Reduced	6,776,632	-1,182,906	$343,914,074	+10.2%	6.71%
LLY	ELI LILLY & Co Healthcare	Added	257,900	+21,100	$309,333,022	+42.0%	6.04%
MBX	MBX Biosciences, Inc. Healthcare	Reduced	3,428,736	-209,151	$189,266,227	+74.3%	3.69%
AZN	Astrazeneca PLC Healthcare	Added	915,700	+245,500	$173,635,034	+31.4%	3.39%
GPCR	Structure Therapeutics Inc. Healthcare	Added	2,209,400	+733,997	$118,578,498	+66.7%	2.31%
SION	Sionna Therapeutics, Inc. Healthcare	Reduced	2,555,877	-974,825	$112,433,029	−20.6%	2.19%
CRVS	Corvus Pharmaceuticals, Inc. Healthcare	Held	7,165,006	0	$107,045,189	+2.1%	2.09%
AVBP	ArriVent BioPharma, Inc. Healthcare	Held	3,027,328	0	$105,169,374	+50.6%	2.05%
ABVX	Abivax S.A. CALL + SHARES Healthcare	Added	746,522	+280,822	$99,481,521	+91.8%	1.94%
GH	Guardant Health, Inc. Healthcare	Added	583,700	+148,500	$87,572,511	+117.8%	1.71%
ARGX	Argenx SE Healthcare	Reduced	92,880	-44,020	$86,171,277	−13.8%	1.68%
MRK	Merck & Co., Inc. Healthcare	Held	663,400	0	$85,246,900	+6.8%	1.66%
QURE	uniQure N.V. Healthcare	Reduced	1,807,486	-328,663	$83,252,805	+138.4%	1.62%
PRAX	Praxis Precision Medicines, Inc. Healthcare	Added	230,100	+57,600	$77,035,179	+38.6%	1.50%
EW	Edwards Lifesciences Corp Healthcare	Reduced	834,900	-395,700	$75,525,054	−23.4%	1.47%
PRLD	Prelude Therapeutics Inc Healthcare	Added	13,724,571	+2,815,315	$73,151,963	+96.1%	1.43%
DYN	Dyne Therapeutics, Inc. Healthcare	Added	3,235,684	+317,800	$71,864,541	+35.8%	1.40%
NTRA	Natera, Inc. Healthcare	Held	262,000	0	$71,119,900	+35.7%	1.39%
UNH	Unitedhealth Group Inc CALL + SHARES Healthcare	NEW	171,100	NEW	$71,114,293	NEW	1.39%
CGON	CG Oncology, Inc. Healthcare	Added	972,800	+24,533	$69,117,440	+7.7%	1.35%
SPRY	ARS Pharmaceuticals, Inc. Healthcare	Held	8,288,510	0	$66,390,965	−0.2%	1.30%
ASND	Ascendis Pharma A/S Healthcare	Added	244,456	+62,479	$65,201,304	+56.6%	1.27%
HUM	Humana Inc Healthcare	NEW	164,100	NEW	$65,183,802	NEW	1.27%
COGT	Cogent Biosciences, Inc. Healthcare	Added	1,681,300	+1,359,200	$65,066,310	+424.8%	1.27%
BSX	Boston Scientific Corp Healthcare	Reduced	1,483,200	-898,900	$63,302,976	−57.7%	1.24%
ISRG	Intuitive Surgical Inc Healthcare	Reduced	157,900	-50,800	$62,793,672	−34.7%	1.23%
MLYS	Mineralys Therapeutics, Inc. Healthcare	Added	2,110,300	+57,400	$56,935,894	+2.4%	1.11%
ODTX	Odyssey Therapeutics, Inc. Healthcare	NEW	3,001,198	NEW	$56,152,414	NEW	1.10%
XENE	Xenon Pharmaceuticals Inc. Healthcare	Reduced	892,471	-167,500	$53,869,549	−12.6%	1.05%
ARQT	Arcutis Biotherapeutics, Inc. Healthcare	NEW	2,042,000	NEW	$53,541,240	NEW	1.04%
BMY	Bristol Myers Squibb Co Healthcare	Held	925,000	0	$53,298,500	−5.0%	1.04%
QTTB	Q32 Bio Inc. Healthcare	Added	4,127,987	+1,875,000	$52,590,554	+263.6%	1.03%
PVLA	Palvella Therapeutics, Inc. CALL + SHARES Healthcare	Added	332,360	+147,760	$50,791,255	+120.7%	0.99%
SYK	Stryker Corp Healthcare	Reduced	159,100	-23,400	$50,091,044	−16.5%	0.98%
CAI	Caris Life Sciences, Inc. Healthcare	Held	2,806,811	0	$50,017,372	−0.3%	0.98%
ELV	Elevance Health, Inc. CALL + SHARES Healthcare	Added	124,700	+10,000	$48,225,231	+43.6%	0.94%
TMO	Thermo Fisher Scientific Inc. Healthcare	Added	90,700	+44,200	$45,473,352	+99.0%	0.89%
STTK	Shattuck Labs, Inc. Healthcare	Held	6,306,127	0	$43,764,521	+7.9%	0.85%
UPB	Upstream Bio, Inc. Healthcare	Held	5,693,589	0	$39,399,635	−23.1%	0.77%
		Held	999,000	0	$37,382,580	+3.0%	0.73%
RYTM	Rhythm Pharmaceuticals, Inc. Healthcare	Added	322,900	+8,800	$35,851,587	+31.2%	0.70%
SNDX	Syndax Pharmaceuticals Inc Healthcare	Added	1,542,000	+579,700	$33,708,120	+50.0%	0.66%
		Added	1,577,705	+380,750	$33,526,231	+8.1%	0.65%
CMPX	Compass Therapeutics, Inc. Healthcare	Held	15,219,994	0	$33,331,786	−58.6%	0.65%
NKTR	Nektar Therapeutics Healthcare	Added	465,346	+190,346	$32,485,804	+64.2%	0.63%
KRYS	Krystal Biotech, Inc. Healthcare	Added	83,200	+14,100	$30,922,944	+73.2%	0.60%
AXSM	Axsome Therapeutics, Inc. Healthcare	Reduced	117,578	-96,343	$28,779,567	−20.4%	0.56%
KNSA	Kiniksa Pharmaceuticals International, plc Healthcare	Added	420,600	+240,001	$26,897,370	+209.3%	0.52%
TRVI	Trevi Therapeutics, Inc. Healthcare	Reduced	1,430,293	-1,024,107	$26,674,964	−8.9%	0.52%

Covers the securities this platform tracks: U.S.-listed common stock and the put/call positions reported on it. A 13F can also report security types outside that coverage — preferred shares, bonds, warrants, untracked share classes — so the filing's own declared total can exceed the figures above. The source filing is linked at the top of this table.