ORBIMED ADVISORS LLC

CIK

1055951

Location

New York, NY

Portfolio Value

Mid $5,383,699,416

Diversification

Diversified

Filing Date

Global Rank

#636 / 8,605 ▲ 108 · as of Mar 2026

Top Industry

Biotechnology 53.5%

3Y Alpha vs SPY

+2.3%

Period ended 3 months ago

Filed May 15, 2026 · 55d

25 quarters · since Mar 2020

Clone Performance

Jul 2023–Jul 2026 · vs SPY

Hypothetical growth of cloning every reported 13F position and rebalancing on each filing, indexed to the same start.

Cloned portfolio

+88.4%

SPY

+76.5%

Annualised alpha

+2.7%

Max drawdown

−37.2%

Estimate. 13F holdings are quarter-lagged and long-only, so the clone rebalances about 45 days after each period end — when the filing becomes public — and excludes options and short positions. Past performance does not predict future results.

Portfolio Concentration

107 positions · as of Mar 31, 2026 · Δ vs Dec 31, 2025

Top Position

10.4%

+2.0 pts

Top 5

36.3%

+8.6 pts

Top 10

50.2%

+8.0 pts

HHI

374

Diversified+90

Portfolio Trend

25 quarters · across all stocks

Sector Breakdown

As of Mar 31, 2026

Sector	% Portfolio	Value	Positions
Healthcare	100.0%	$5,383,699,416	107

Last Quarter's Activity

Export CSV

Mar 31, 2026 vs Dec 31, 2025

Added To

Positions the filer increased

24 positions

Ticker	Company	Δ Shares	Shares	Value
ESPR	Esperion Therapeutics, Inc.	+4,604,802	10,570,300	$28,962,622
RLMD	Relmada Therapeutics, Inc.	+2,105,264	4,715,864	$32,822,413
LXEO	Lexeo Therapeutics, Inc.	+1,477,450	3,602,450	$20,678,063
QURE	uniQure N.V.	+1,398,749	2,136,149	$34,926,036
MLYS	Mineralys Therapeutics, Inc.	+1,072,500	2,052,900	$55,613,061
DYN	Dyne Therapeutics, Inc.	+715,700	2,917,884	$52,901,236
XENE	Xenon Pharmaceuticals Inc.	+612,771	1,059,971	$61,637,313
PALI	Palisade Bio, Inc.	+461,580	2,333,000	$4,082,750
BCAX	Bicara Therapeutics Inc.	+458,200	667,300	$13,272,597
GPCR	Structure Therapeutics Inc.	+313,600	1,475,403	$71,114,424
PFE	Pfizer Inc	+293,600	1,946,500	$54,657,720
BMY	Bristol Myers Squibb Co	+150,000	925,000	$56,101,250
CRBP	Corbus Pharmaceuticals Holdings, Inc.	+140,000	1,737,287	$16,313,124
ABVX	Abivax S.A.	+97,800	465,700	$51,855,695
PRAX	Praxis Precision Medicines, Inc.	+78,000	172,500	$55,577,775
RYTM	Rhythm Pharmaceuticals, Inc.	+74,300	314,100	$27,317,277
ANRO	Alto Neuroscience, Inc.	+42,500	167,500	$3,765,400
RVMD	Revolution Medicines, Inc.	+26,100	52,000	$5,057,000
PTCT	Ptc Therapeutics, Inc.	+25,900	49,100	$3,345,183
PTGX	Protagonist Therapeutics, Inc	+20,400	42,100	$4,437,340
VERA	Vera Therapeutics, Inc.	+16,096	369,596	$14,868,847
ELV	Elevance Health, Inc.	+15,600	114,700	$33,578,425
ASND	Ascendis Pharma A/S	+10,000	181,977	$41,623,599
BTSG	BrightSpring Health Services, Inc.	+9,300	497,800	$21,211,258
No positions match the current search.

Trimmed

Positions the filer reduced

25 positions

Ticker	Company	Δ Shares	Shares	Value
ADCT	ADC Therapeutics SA	−4,504,828	1,318,026	$4,942,597
EYPT	EyePoint, Inc.	−1,399,167	1,069,147	$13,781,304
JANX	Janux Therapeutics, Inc.	−970,826	983,600	$13,672,040
ORIC	Oric Pharmaceuticals, Inc.	−947,827	2,693,929	$34,132,080
EW	Edwards Lifesciences Corp	−762,300	1,230,600	$98,546,448
TRVI	Trevi Therapeutics, Inc.	−736,300	2,454,400	$29,280,992
AVTX	Avalo Therapeutics, Inc.	−712,135	475,165	$7,094,213
CGON	CG Oncology, Inc.	−568,283	948,267	$64,178,710
ALMS	Alumis Inc.	−554,567	548,163	$12,076,030
CCCC	C4 Therapeutics, Inc.	−548,549	856,353	$2,252,208
TECX	Tectonic Therapeutic, Inc.	−348,000	226,600	$7,004,206
JBIO	Jade Biosciences, Inc.	−346,152	185,011	$2,599,404
BCRX	Biocryst Pharmaceuticals Inc	−316,600	1,425,200	$13,567,904
NPCE	NeuroPace Inc	−309,808	2,096,527	$27,569,330
CAI	Caris Life Sciences, Inc.	−309,200	2,806,811	$50,185,780
MBX	MBX Biosciences, Inc.	−297,316	3,637,887	$108,590,926
KALV	KalVista Pharmaceuticals, Inc.	−288,000	94,400	$1,900,272
ALNY	Alnylam Pharmaceuticals, Inc.	−169,800	119,000	$39,373,530
SYK	Stryker Corp	−142,500	182,500	$59,967,675
NTRA	Natera, Inc.	−103,800	262,000	$52,397,380
BIOA	BioAge Labs, Inc.	−79,090	711,811	$12,449,574
LLY	ELI LILLY & Co	−64,400	236,800	$217,801,536
ISRG	Intuitive Surgical Inc	−54,700	208,700	$96,208,613
KRYS	Krystal Biotech, Inc.	−50,700	69,100	$17,849,912
COGT	Cogent Biosciences, Inc.	−48,900	322,100	$12,397,629
No positions match the current search.

New Positions

Positions the filer opened this quarter

25 positions

Ticker	Company	Shares	Value
MYGN	Myriad Genetics Inc	125,000,000	$562,500,000
RCEL	AVITA Medical, Inc.	82,010,995	$303,440,681
MDXH	MDxHealth SA	124,306,000	$285,903,800
AZN	Astrazeneca PLC	670,200	$132,176,844
MRK	Merck & Co., Inc.	663,400	$79,800,386
GH	Guardant Health, Inc.	435,200	$40,199,424
PVLA	Palvella Therapeutics, Inc.	184,600	$23,010,390
SNDX	Syndax Pharmaceuticals Inc	962,300	$22,479,328
STRO	Sutro Biopharma, Inc.	801,144	$19,956,497
NKTR	Nektar Therapeutics	275,000	$19,786,250
DFTX	Definium Therapeutics, Inc.	804,000	$15,195,600
AMGN	Amgen Inc	39,900	$14,038,815
ALHC	Alignment Healthcare, Inc.	791,000	$13,937,420
REGN	Regeneron Pharmaceuticals, Inc.	14,700	$11,357,808
BIIB	Biogen Inc.	61,600	$11,293,128
QGEN	Qiagen N.V.	250,000	$10,010,000
GILD	Gilead Sciences, Inc.	59,600	$8,306,452
HRTX	Heron Therapeutics, Inc. /De/	9,816,940	$7,853,552
CMPS	COMPASS Pathways plc	1,150,646	$6,363,072
ALXO	Alx Oncology Holdings Inc	2,866,256	$5,746,843
AORT	Artivion, Inc.	151,000	$5,529,620
SVRA	Savara Inc	635,000	$3,467,100
SLNO	Soleno Therapeutics Inc	100,000	$3,348,000
LFST	LifeStance Health Group, Inc.	500,000	$3,185,000
DRUG	Bright Minds Biosciences Inc.	40,000	$2,918,800
No positions match the current search.

Sold Out

Positions the filer fully exited

17 positions

Ticker	Company	Shares	Value
TERN	Terns Pharmaceuticals, Inc.	2,153,300	$86,993,320
APLS	Apellis Pharmaceuticals, Inc.	2,429,868	$61,038,284
CI	Cigna Group	205,000	$56,422,150
UTHR	UNITED THERAPEUTICS Corp	105,200	$51,258,700
ROIV	Roivant Sciences Ltd.	2,190,907	$47,542,681
NBIX	Neurocrine Biosciences Inc	314,240	$44,568,659
EXAS	EXACT SCIENCES CORP	351,716	$35,720,276
BRKR	Bruker Corp	555,789	$26,183,219
CTMX	CytomX Therapeutics, Inc.	3,525,650	$15,019,269
VIR	Vir Biotechnology, Inc.	2,380,715	$14,355,711
TARS	Tarsus Pharmaceuticals, Inc.	154,400	$12,642,272
FOLD	AMICUS THERAPEUTICS, INC.	729,900	$10,393,776
CELC	Celcuity Inc.	85,664	$8,544,127
PMVP	PMV Pharmaceuticals, Inc.	4,975,291	$6,219,113
INSM	INSMED Inc	25,400	$4,420,616
OCUL	Ocular Therapeutix, Inc	157,300	$1,909,622
MPLT	MapLight Therapeutics, Inc.	56,000	$983,640
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

107 positions · $5,383,699,416 total · as of Mar 31, 2026

All sectors Healthcare

Showing 1–50 of 107 positions by value · page 1 of 3

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
MYGN	Myriad Genetics Inc Healthcare	NEW	125,000,000	NEW	$562,500,000	NEW	10.45%
EWTX	Edgewise Therapeutics, Inc. Healthcare	Held	15,518,492	0	$488,832,498	+26.9%	9.08%
ELVN	Enliven Therapeutics, Inc. Healthcare	Held	7,959,538	0	$312,013,889	+154.5%	5.80%
RCEL	AVITA Medical, Inc. Healthcare	NEW	82,010,995	NEW	$303,440,681	NEW	5.64%
MDXH	MDxHealth SA Healthcare	NEW	124,306,000	NEW	$285,903,800	NEW	5.31%
LLY	ELI LILLY & Co Healthcare	Reduced	236,800	-64,400	$217,801,536	−32.7%	4.05%
BSX	Boston Scientific Corp Healthcare	Reduced	2,382,100	-37,200	$149,476,775	−35.2%	2.78%
SION	Sionna Therapeutics, Inc. Healthcare	Reduced	3,530,702	-30,953	$141,545,843	−3.4%	2.63%
AZN	Astrazeneca PLC Healthcare	NEW	670,200	NEW	$132,176,844	NEW	2.46%
MBX	MBX Biosciences, Inc. Healthcare	Reduced	3,637,887	-297,316	$108,590,926	−12.5%	2.02%
CRVS	Corvus Pharmaceuticals, Inc. Healthcare	Held	7,165,006	0	$104,824,037	+90.0%	1.95%
ARGX	Argenx SE Healthcare	Reduced	136,900	-9,100	$99,971,225	−18.6%	1.86%
EW	Edwards Lifesciences Corp Healthcare	Reduced	1,230,600	-762,300	$98,546,448	−42.0%	1.83%
ISRG	Intuitive Surgical Inc Healthcare	Reduced	208,700	-54,700	$96,208,613	−35.5%	1.79%
CMPX	Compass Therapeutics, Inc. Healthcare	Held	15,219,994	0	$80,513,768	−1.5%	1.50%
MRK	Merck & Co., Inc. Healthcare	NEW	663,400	NEW	$79,800,386	NEW	1.48%
GPCR	Structure Therapeutics Inc. Healthcare	Added	1,475,403	+313,600	$71,114,424	−12.0%	1.32%
AVBP	ArriVent BioPharma, Inc. Healthcare	Held	3,027,328	0	$69,840,456	+14.7%	1.30%
IRON	Disc Medicine, Inc. Healthcare	Held	1,067,550	0	$68,259,147	−19.5%	1.27%
SPRY	ARS Pharmaceuticals, Inc. Healthcare	Held	8,288,510	0	$66,556,735	−31.1%	1.24%
CGON	CG Oncology, Inc. Healthcare	Reduced	948,267	-568,283	$64,178,710	+1.9%	1.19%
XENE	Xenon Pharmaceuticals Inc. Healthcare	Added	1,059,971	+612,771	$61,637,313	+207.5%	1.14%
SYK	Stryker Corp Healthcare	Reduced	182,500	-142,500	$59,967,675	−47.5%	1.11%
BMY	Bristol Myers Squibb Co Healthcare	Added	925,000	+150,000	$56,101,250	+34.2%	1.04%
MLYS	Mineralys Therapeutics, Inc. Healthcare	Added	2,052,900	+1,072,500	$55,613,061	+56.3%	1.03%
PRAX	Praxis Precision Medicines, Inc. Healthcare	Added	172,500	+78,000	$55,577,775	+99.5%	1.03%
PFE	Pfizer Inc Healthcare	Added	1,946,500	+293,600	$54,657,720	+32.8%	1.02%
DYN	Dyne Therapeutics, Inc. Healthcare	Added	2,917,884	+715,700	$52,901,236	+22.8%	0.98%
NTRA	Natera, Inc. Healthcare	Reduced	262,000	-103,800	$52,397,380	−37.5%	0.97%
ABVX	Abivax S.A. Healthcare	Added	465,700	+97,800	$51,855,695	+4.5%	0.96%
UPB	Upstream Bio, Inc. Healthcare	Held	5,693,589	0	$51,242,301	−66.9%	0.95%
DHR	Danaher Corp /De/ Healthcare	Reduced	265,800	-34,000	$50,395,680	−26.6%	0.94%
CAI	Caris Life Sciences, Inc. Healthcare	Reduced	2,806,811	-309,200	$50,185,780	−40.3%	0.93%
ASND	Ascendis Pharma A/S Healthcare	Added	181,977	+10,000	$41,623,599	+13.5%	0.77%
STTK	Shattuck Labs, Inc. Healthcare	Held	6,306,127	0	$40,548,396	+76.2%	0.75%
GH	Guardant Health, Inc. Healthcare	NEW	435,200	NEW	$40,199,424	NEW	0.75%
ALNY	Alnylam Pharmaceuticals, Inc. Healthcare	Reduced	119,000	-169,800	$39,373,530	−65.7%	0.73%
PRLD	Prelude Therapeutics Inc Healthcare	Held	10,909,256	0	$37,309,655	+17.9%	0.69%
CRNX	Crinetics Pharmaceuticals, Inc. Healthcare	Held	999,000	0	$36,283,680	−22.0%	0.67%
AXSM	Axsome Therapeutics, Inc. Healthcare	Reduced	213,921	-39,200	$36,156,927	−21.8%	0.67%
QURE	uniQure N.V. Healthcare	Added	2,136,149	+1,398,749	$34,926,036	+97.9%	0.65%
ORIC	Oric Pharmaceuticals, Inc. Healthcare	Reduced	2,693,929	-947,827	$34,132,080	+14.6%	0.63%
ELV	Elevance Health, Inc. Healthcare	Added	114,700	+15,600	$33,578,425	−3.3%	0.62%
RLMD	Relmada Therapeutics, Inc. Healthcare	Added	4,715,864	+2,105,264	$32,822,413	+160.3%	0.61%
FBRX	Forte Biosciences, Inc. Healthcare	Held	1,196,955	0	$31,001,134	−5.0%	0.58%
TRVI	Trevi Therapeutics, Inc. Healthcare	Reduced	2,454,400	-736,300	$29,280,992	−26.7%	0.54%
ESPR	Esperion Therapeutics, Inc. Healthcare	Added	10,570,300	+4,604,802	$28,962,622	+31.2%	0.54%
NPCE	NeuroPace Inc Healthcare	Reduced	2,096,527	-309,808	$27,569,330	−25.8%	0.51%
RYTM	Rhythm Pharmaceuticals, Inc. Healthcare	Added	314,100	+74,300	$27,317,277	+6.4%	0.51%
PVLA	Palvella Therapeutics, Inc. Healthcare	NEW	184,600	NEW	$23,010,390	NEW	0.43%