PRAX · Praxis Precision Medicines, Inc. · Holdings

$267.73 +7.56 (+2.90%)

Russell 2000 member Rebalance outlook locked

Market Cap

$7.26B

27.92M

Volume · Oct 20 259.69K Avg daily vol (3M) 441.55K

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Use institutional holdings through the 13F API or MCP → See every holder of PRAX: 13F, 13D and 13G, insiders and funds →

Institutional holdings are being reconciled with SEC filings. Holder totals and changes may be incomplete until reconciliation finishes.

The Sep 30, 2026 filing window is still open — showing the latest known positions. Funds that have not filed yet carry their prior-quarter positions; a fund that filed without this stock counts as sold out. Each fund's Change is measured against its own previous reported quarter, shown in the Reported column. Pick a completed quarter in the Quarter selector below to put every fund on one quarter and see the stock-wide activity breakdown.

Quarter:

Holders: 320

Total Value: $11,630,939,435

Total Shares: 34,741,839

Showing 1–100 of 334 holdings by value · page 1 of 4

Institutional Ownership Trend

24 quarters

Holder Concentration

Across 316 13F filers

Top Holder

9.8%

of institutional value

Top 5

34.0%

of institutional value

Top 10

51.7%

of institutional value

HHI

367

Broadly held

Who Holds PRAX

Last 8 quarters through Sep 30, 2026 (filing window open)

Each kind of 13F filer's share of the common shares 13F filers report. Holder type comes from regulatory records, never the filer's name; style, turnover and horizon are measured from each filer's own 13F book. The quarter selector does not change this card.

Jun 30, 2026, the newest closed quarter: 309 filers, like-for-like change +5.0%; actively managed books +6.0%; index-like books +1.8%.

Holder type	Share	Filers	Change	New	Exited
Registered adviser	47.6%	158	+10.1%	33	22
Exempt adviser	0.9%	4	+63.6%	0	1
Adviser	3.5%	9	+87.5%	1	0
Bank	6.4%	18	+9.7%	0	1
Insurer	0.1%	3	-31.9%	0	0
Broker-dealer	0.0%	2	+57.9%	0	0
Benefit plan	0.2%	5	-1.9%	0	0
Non-US	2.0%	10	+33.1%	2	1
Holding company	19.0%	10	-0.2%	0	0
Unknown	20.3%	90	-10.5%	19	13

Style	Share	Filers	Change	New	Exited
Index-like	24.4%	38	+1.8%	0	0
Systematic-like	2.2%	25	+37.3%	12	5
Concentrated	6.4%	38	-15.9%	9	7
Diversified active	67.1%	208	+8.0%	34	25
Unknown	0.0%	0	-100.0%	0	1
Not measured	0.0%	0	—	0	0

Turnover	Share	Filers	Change	New	Exited
Low turnover	42.3%	141	+8.3%	15	15
Medium turnover	33.5%	93	-0.4%	17	5
High turnover	4.3%	47	-5.4%	16	15
Unknown	19.9%	28	+11.0%	7	3
Not measured	0.0%	0	—	0	0

Holding horizon	Share	Filers	Change	New	Exited
Short horizon	19.4%	43	+9.3%	13	12
Medium horizon	12.6%	51	-0.3%	6	8
Long horizon	43.8%	178	+14.6%	28	15
Unknown	24.1%	37	-8.9%	8	3
Not measured	0.0%	0	—	0	0

13F book size	Share	Filers	Change	New	Exited
Under $1B	2.3%	57	-4.5%	15	15
$1B to $10B	15.9%	81	-7.4%	15	13
$10B to $100B	23.2%	98	-2.3%	19	8
$100B or more	58.6%	73	+13.0%	6	2
Not measured	0.0%	0	—	0	0

Client base	Share	Filers	Change	New	Exited
Individuals and high net worth	0.2%	46	+14.2%	9	7
Pooled investment vehicles	26.0%	49	-1.6%	12	10
Registered funds and BDCs	15.4%	24	+29.1%	4	0
Pension and profit sharing plans	0.0%	4	+48.7%	1	0
Insurance companies	0.6%	3	+93.4%	0	0
Governments and sovereign funds	0.5%	7	+39.0%	2	2
Other investment advisers	0.0%	5	-4.6%	0	0
Diversified	4.8%	18	+20.6%	4	3
Corporations	0.0%	0	—	0	0
Unknown	52.5%	153	+0.7%	23	16

Private funds	Share	Filers	Change	New	Exited
Hedge funds	26.5%	57	+10.5%	13	9
Private equity funds	4.6%	9	-14.0%	0	0
Venture capital funds	0.9%	3	-57.2%	0	1
Real estate funds	0.0%	3	-0.5%	0	1
Liquidity funds	0.0%	1	-4.2%	0	0
Securitized asset funds	0.1%	1	-5.1%	0	0
Other private funds	4.3%	15	+36.9%	2	1
Mixed private funds	0.4%	4	+87.6%	1	2
Private funds, type not stated	0.3%	3	+1194.0%	2	1
No private funds	11.4%	65	+27.2%	14	8
Unknown	51.5%	148	+0.1%	23	15

Location	Share	Filers	Change	New	Exited
United States	89.2%	248	+7.1%	44	31
Outside the US	10.8%	61	-10.9%	11	7

The Sep 30, 2026 filing window is still open, so its bar carries the Jun 30, 2026 positions of filers that have not filed yet.

How the mix is measured

Shares are 13F common shares restated to today's split basis; options and principal amounts are left out. The change compares only filers with a 13F in both quarters and keeps each filer in its bucket of the later quarter on both sides; a filer that continues under a new CIK is compared through its successor. Holder type comes from each filer's current regulatory profile; client base and private funds come from the Form ADV roster current at each quarter end (rosters from December 2019, so an earlier quarter reads Unknown). Style, turnover, horizon and book size are measured from each filer's 13F book in the newest measured quarter, and Not measured means none was. Actively managed books are those measured systematic-like, concentrated or diversified active.

Excluded 3 holders with no observed 2026-03-31 13F and 2 holders with no observed 2026-06-30 13F. Compared across CIK changes: JANUS HENDERSON GROUP PLC continues as Jupiter Topco LLC.

Conviction and Crowding

108 13F filers, quarter ended Sep 30, 2022

Measured across every 13F filer's common-share book once the quarter's filing window closed. Crowding counts filers with high turnover or that advise private funds on Form ADV.

Conviction holders

1.85% of filers hold it in their top 10

Jun 30, 2022: 2

Holders above 5%

median weight 0.001%

Jun 30, 2022: 2

Crowding

49.4%

of shares outstanding, 96th percentile

Jun 30, 2022: 42.1%

Private-fund advisers

47.0%

of shares outstanding

Institutional ownership

92.5%

117.5% of the estimated free float above 100%: filers can report lent or client shares more than once

Top 10 holders

61.6%

of 13F shares, Herfindahl 0.051

Active holders

+12.1%

like-for-like share change of active filers

5% stakes on record

0 13D, 0 13G

How long holders have held it value-weighted 6.7 quarters

Under 1 year 14.5% 1 to 3 years 85.5% 3 years or more 0.000% Since coverage start 0.000%

Estimated Holder Cost Basis

Quarter ended Sep 30, 2022, on that quarter's share basis

Estimated, never filed: each 13F buy is costed at its quarter's average traded price and each sale keeps the average cost, so this is what holders paid on average if they traded evenly through each quarter.

Estimated avg cost

$21.97

estimated per share

Jun 30, 2022: $23.92

Quarter-end price

$2.27

implied by 13F values

Estimated gain or loss

-89.7%

price against the estimated cost

Estimated at a loss

100.0%

of costed 13F value

Estimated cost covers 97.4% of the 13F shares; positions already held when a filer's 13F history starts, or bought in a quarter without a trusted average price, have no estimate.

Shareholder Targets

13F filers that own its peers but not PRAX, quarter ended Sep 30, 2022

PRAX has no holder-overlap peers, so these filers hold the largest Healthcare stocks: UNH, JNJ, LLY, TMO, PFE, ABBV, MRK, DHR, ABT, BMY, CVS, ELV, AMGN, MDT, CI, VRTX, REGN, ZTS, GILD, SYK. 4,535 filers in all.

#	Filer	In peers	Of book	Largest peers
1	Capital World Investors Adviser, Diversified active	$69,718,548,246 17 held	16.8%	UNH, PFE, LLY
2	WELLINGTON MANAGEMENT GROUP LLP Holding company, Diversified active	$62,465,515,432 20 held	14.3%	UNH, PFE, LLY
3	Capital International Investors Adviser, Diversified active	$42,947,325,206 17 held	13.4%	UNH, ABBV, ABT
4	Capital Research Global Investors Adviser, Diversified active	$40,983,360,134 17 held	14.1%	UNH, ABT, ABBV
5	NORGES BANK Non-US, Index-like	$34,748,389,790 20 held	9.69%	UNH, JNJ, TMO
6	LILLY ENDOWMENT INC Unknown, Unknown	$33,555,261,463 1 held	100.0%	LLY
7	MASSACHUSETTS FINANCIAL SERVICES CO /MA/ Registered adviser, Diversified active	$28,003,649,842 18 held	11.1%	TMO, JNJ, CI
8	PNC FINANCIAL SERVICES GROUP, INC. Bank, Diversified active	$22,804,939,511 20 held	32.5%	LLY, JNJ, MRK
9	STATE FARM MUTUAL AUTOMOBILE INSURANCE CO Insurer, Diversified active	$20,152,914,685 9 held	24.4%	LLY, JNJ, ZTS
10	FRANKLIN RESOURCES INC Adviser, Diversified active	$17,941,905,875 20 held	10.8%	UNH, JNJ, MDT

Fund Ownership of PRAX by Fund Type

Registered funds' Form N-PORT reports for the quarter ended Jun 30, 2026

Index funds and index ETFs hold 18.69% of shares outstanding.

Fund type	Of shares outstanding	Change	Shares	Funds
Index funds	3.24%	+0.41 pp	905,388	64
Index ETFs	15.45%	+2.30 pp	4,312,374	53
Active ETFs	0.48%	+0.07 pp	135,345	21
Active funds	19.96%	+4.17 pp	5,573,269	244
Unclassified	0.16%	+0.16 pp	44,165	14
All registered funds	39.29%	+7.11 pp	10,970,541	396

How fund types are measured

Each fund series counts once, with its latest Form N-PORT report dated inside the quarter; only long share positions count, restated to today's split basis. The fund type is the series' latest Form N-CEN answer on or before the quarter end (the index-fund box and the exchange-traded flag), never its name. Unclassified funds have no usable N-CEN; unit investment trusts are among them, so index ownership is a floor. Funds sit inside their advisers' 13F reports, so these shares overlap the 13F figures and are never added to them.

Holder type: Registered adviser 167 Exempt adviser 6 Adviser 9 Bank 18 Insurer 3 Broker-dealer 2 Benefit plan 5 Non-US 10 Holding company 10 Unknown 90

Showing 100 of 334

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

Jupiter Topco LLC

$1,145,441,799

9.85%

3,421,374

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JANUS HENDERSON INVESTORS UK Ltd	63,475	$21,250,795	1.9%	Defined
JANUS HENDERSON INVESTORS US LLC	3,330,559	$1,115,037,847	97.3%	Defined
Held directly	27,340	$9,153,157	0.8%	Defined

FMR LLC

$775,677,292

6.67%

2,316,907

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	1,974,768	$661,132,578	85.2%	Defined
FIDELITY MANAGEMENT TRUST CO	163,365	$54,692,968	7.1%	Defined
STRATEGIC ADVISERS LLC	1,179	$394,717	0.1%	Defined
Fidelity Institutional Asset Management Trust Co	37,912	$12,692,558	1.6%	Defined
FIAM LLC	139,683	$46,764,471	6.0%	Defined

BlackRock, Inc.

$767,534,525

6.60%

2,292,585

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	33,396	$11,180,646	1.5%	Sole
BlackRock Investment Management (Australia) Ltd	41	$13,726	0.0%	Sole
BlackRock Asset Management Canada Ltd	3,419	$1,144,647	0.1%	Sole
BlackRock Investment Management, LLC	74,626	$24,984,038	3.3%	Sole
BLACKROCK ADVISORS LLC	107,989	$36,153,637	4.7%	Sole
BlackRock Fund Advisors	1,159,165	$388,076,850	50.6%	Sole
BlackRock Institutional Trust Company, N.A.	817,983	$273,852,528	35.7%	Sole
BlackRock Japan Co. Ltd	895	$299,637	0.0%	Sole
BlackRock Fund Managers Ltd.	4,084	$1,367,282	0.2%	Sole
BlackRock Investment Management (UK) Ltd.	10,315	$3,453,358	0.4%	Sole
BlackRock (Netherlands) B.V.	1,127	$377,308	0.0%	Sole
BlackRock Asset Management Ireland Ltd	51,298	$17,174,057	2.2%	Sole
BlackRock (Luxembourg) S.A.	202	$67,627	0.0%	Sole
BlackRock Asset Management Schweiz AG	4,065	$1,360,921	0.2%	Sole
Aperio Group, LLC	23,950	$8,018,220	1.0%	Sole
SpiderRock Advisors, LLC	30	$10,043	0.0%	Sole

PERCEPTIVE ADVISORS LLC

$681,627,752

5.86%

2,035,986

BAKER BROS. ADVISORS LP

$586,953,158

5.05%

1,753,198

Orbis Allan Gray Ltd

$512,157,724

4.40%

1,529,788

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
ORBIS INVESTMENT MANAGEMENT LTD	1,526,680	$511,117,197	99.8%	Defined
Held directly	3,108	$1,040,527	0.2%	Defined

VANGUARD PORTFOLIO MANAGEMENT LLC

$447,006,586

3.84%

1,335,185

VANGUARD CAPITAL MANAGEMENT LLC

$413,565,752

3.56%

1,235,299

STATE STREET CORP

$343,642,851

2.95%

1,026,443

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STATE STREET GLOBAL ADVISORS EUROPE LIMITED joint	1,026,443	$343,642,851	100.0%	Defined

ADAGE CAPITAL PARTNERS GP, L.L.C.

$339,972,549

2.92%

1,015,480

DEERFIELD MANAGEMENT COMPANY, L.P.

$322,520,281

2.77%

963,351

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Deerfield UGP, LLC	963,351	$322,520,281	100.0%	Defined

Driehaus Capital Management LLC

$321,079,679

2.76%

959,048

PRICE T ROWE ASSOCIATES INC /MD/

$315,706,634

2.71%

942,999

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T. Rowe Price International Ltd	37,817	$12,660,753	4.0%	Defined
Held directly	905,182	$303,045,881	96.0%	Sole

MORGAN STANLEY

$285,948,152

2.46%

854,112

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	296	$99,097	0.0%	Defined
MORGAN STANLEY & CO. LLC	37,694	$12,619,574	4.4%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	792,302	$265,254,786	92.8%	Defined
MORGAN STANLEY SMITH BARNEY LLC	2,571	$860,744	0.3%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	21,249	$7,113,951	2.5%	Defined

GEODE CAPITAL MANAGEMENT, LLC

$250,435,976

2.15%

748,039

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	95,325	$31,913,856	12.7%	Defined
Held directly	652,714	$218,522,120	87.3%	Defined

Cormorant Asset Management, LP

$214,265,600

1.84%

640,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Chen Bihua	640,000	$214,265,600	100.0%	Defined

GOLDMAN SACHS GROUP INC

$183,742,793

1.58%

548,830

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	354,073	$118,540,099	64.5%	Defined
GOLDMAN SACHS ASSET MANAGEMENT, L.P.	191,220	$64,018,543	34.8%	Defined
GOLDMAN SACHS INTERNATIONAL	647	$216,609	0.1%	Defined
Goldman Sachs Trust Company, N.A. joint	2,890	$967,542	0.5%	Defined

BANK OF AMERICA CORP /DE/

$183,106,693

1.57%

546,930

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	521,771	$174,683,713	95.4%	Defined
BOFA SECURITIES, INC.	8,061	$2,698,742	1.5%	Defined
MANAGED ACCOUNT ADVISORS LLC joint	17,098	$5,724,238	3.1%	Defined

Invesco Ltd.

$179,965,691

1.55%

537,548

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invesco Advisers, Inc. joint	518,711	$173,659,253	96.5%	Defined
Invesco Trust Co joint	10,027	$3,356,939	1.9%	Defined
Invesco Capital Management LLC	8,810	$2,949,499	1.6%	Defined

Hood River Capital Management LLC

$142,341,659

1.22%

425,167

NORGES BANK

$116,161,751

1.00%

346,969

FRANKLIN RESOURCES INC

$109,517,842

0.94%

327,124

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
FIDUCIARY TRUST INTERNATIONAL LLC	58	$19,417	0.0%	Defined
FRANKLIN ADVISERS INC	250,813	$83,969,684	76.7%	Defined
PUTNAM INVESTMENT MANAGEMENT LLC	48,223	$16,144,578	14.7%	Defined
PUTNAM ADVISORY CO LLC	28,030	$9,384,163	8.6%	Defined

Pictet Asset Management Holding SA

$97,654,560

0.84%

291,689

Polar Capital Holdings Plc

$93,450,267

0.80%

279,131

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Polar Capital LLP	279,131	$93,450,267	100.0%	Defined

Vivo Capital, LLC

$90,766,925

0.78%

271,116

Logos Global Management LP

$87,045,400

0.75%

260,000

NORTHERN TRUST CORP

$80,646,556

0.69%

240,887

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	220,857	$73,940,714	91.7%	Defined
NORTHERN TRUST GLOBAL INVESTMENTS LTD	16,128	$5,399,492	6.7%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC joint	3,902	$1,306,350	1.6%	Other

AMERICAN CENTURY COMPANIES INC

$79,450,688

0.68%

237,315

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
AMERICAN CENTURY INVESTMENT MANAGEMENT INC	237,315	$79,450,688	100.0%	Defined

ORBIMED ADVISORS LLC

$77,035,179

0.66%

230,100

Caption Management, LLC

$75,260,792

0.65%

224,800

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$73,656,478

0.63%

220,008

WESTFIELD CAPITAL MANAGEMENT CO LP

$73,284,861

0.63%

218,898

Verition Fund Management LLC

$67,326,269

0.58%

201,100

Woodline Partners LP

$66,962,352

0.58%

200,013

BNP PARIBAS ARBITRAGE, SA

$63,077,449

0.54%

188,409

VANGUARD FIDUCIARY TRUST CO

$62,994,421

0.54%

188,161

Affinity Asset Advisors, LLC

$61,936,150

0.53%

185,000

Soleus Capital Management, L.P.

$59,430,916

0.51%

177,517

Aberdeen Group plc

$55,708,721

0.48%

166,399

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
abrdn Inc.	166,399	$55,708,721	100.0%	Defined

T. Rowe Price Investment Management, Inc.

$53,726,094

0.46%

160,477

Qube Research & Technologies Ltd

$51,047,105

0.44%

152,475

MARSHALL WACE, LLP

$45,868,908

0.39%

137,008

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Marshall Wace North America L.P. joint	137,008	$45,868,908	100.0%	Other

UBS Group AG

$43,872,888

0.38%

131,046

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Financial Services Inc	267	$89,388	0.2%	Defined
UBS AG	128,264	$42,941,504	97.9%	Defined
UBS Switzerland AG	2,478	$829,609	1.9%	Defined
UBS Securities LLC	37	$12,387	0.0%	Defined

WELLINGTON MANAGEMENT GROUP LLP

$42,139,010

0.36%

125,867

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Wellington Management Company LLP	64,605	$21,629,107	51.3%	Defined
Wellington Managment Canada LLC	3,313	$1,109,159	2.6%	Defined
Wellington Management Singapore Pte. Ltd.	2,207	$738,881	1.8%	Defined
Wellington Management International Ltd	1,904	$637,440	1.5%	Defined
Wellington Trust Company, NA joint	49,471	$16,562,396	39.3%	Defined
Wellington Management Australia Pty Ltd	3,769	$1,261,823	3.0%	Defined
Wellington Management Europe GmbH	598	$200,204	0.5%	Defined

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$41,882,229

0.36%

125,100

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	125,100	$41,882,229	100.0%	Other

VOYA INVESTMENT MANAGEMENT LLC

$40,920,376

0.35%

122,227

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Voya Investment Management Co. LLC joint	122,227	$40,920,376	100.0%	Defined

683 Capital Management, LLC

$36,960,816

0.32%

110,400

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
683 Capital Partners, LP	110,400	$36,960,816	100.0%	Defined

Nuveen, LLC

$36,168,032

0.31%

108,032

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Nuveen Asset Management, LLC joint	16,546	$5,539,435	15.3%	Defined
TIAA CREF INVESTMENT MANAGEMENT LLC joint	12,773	$4,276,272	11.8%	Defined
TEACHERS ADVISORS, LLC joint	78,713	$26,352,325	72.9%	Defined

MASSACHUSETTS FINANCIAL SERVICES CO /MA/

$35,959,458

0.31%

107,409

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MFS Heritage Trust CO	1,741	$582,869	1.6%	Defined
Held directly	105,668	$35,376,589	98.4%	Sole

Nantahala Capital Management, LLC

$33,479,000

0.29%

100,000

MetLife Investment Management, LLC

$30,312,890

0.26%

90,543

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
METLIFE INC	90,543	$30,312,890	100.0%	Defined

NEUBERGER BERMAN GROUP LLC

$29,952,991

0.26%

89,468

Velan Capital Investment Management LP

$29,722,990

0.26%

88,781

Bank of New York Mellon Corp

$28,583,026

0.25%

85,376

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BNY Mellon Trust of Delaware	3	$1,004	0.0%	Defined
Mellon Investments Corporation joint	37,161	$12,441,130	43.5%	Defined
The Bank of New York Mellon	45,557	$15,252,028	53.4%	Defined
BNY Mellon, NA joint	1,960	$656,187	2.3%	Defined
BNY Mellon Advisors, Inc. joint	694	$232,343	0.8%	Other
Held directly	1	$334	0.0%	Defined

First Turn Management, LLC

$27,964,339

0.24%

83,528

ACUTA CAPITAL PARTNERS, LLC

$27,719,272

0.24%

82,796

Alyeska Investment Group, L.P.

$27,066,432

0.23%

80,846

ADAR1 Capital Management, LLC

$24,859,161

0.21%

74,253

FRONTIER CAPITAL MANAGEMENT CO LLC

$24,843,761

0.21%

74,207

Ensign Peak Advisors, Inc

$24,423,600

0.21%

72,952

Ikarian Capital, LLC

$24,386,773

0.21%

72,842

ALLIANCEBERNSTEIN L.P.

$23,943,511

0.21%

71,518

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Equitable Holdings, Inc.	71,518	$23,943,511	100.0%	Defined

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$23,334,863

0.20%

69,700

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	69,700	$23,334,863	100.0%	Other

72 Investment Holdings, LLC

$22,073,709

0.19%

65,933

SILVERARC CAPITAL MANAGEMENT, LLC

$21,988,672

0.19%

65,679

AMERIPRISE FINANCIAL INC

$21,525,322

0.19%

64,295

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Columbia Management Investment Advisers, LLC	61,695	$20,654,869	96.0%	Defined
Ameriprise Trust Co	2,565	$858,736	4.0%	Defined
Ameriprise Financial Services, LLC	35	$11,717	0.1%	Defined

DEUTSCHE BANK AG\

$21,514,608

0.18%

64,263

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DWS Investment GmbH	30,774	$10,302,827	47.9%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC	5,712	$1,912,320	8.9%	Defined
DWS Investments UK Ltd	27,777	$9,299,461	43.2%	Defined

RAYMOND JAMES FINANCIAL INC

$20,750,281

0.18%

61,980

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RAYMOND JAMES & ASSOCIATES	2,577	$862,753	4.2%	Defined
Raymond James Financial Services Advisors, Inc.	2,111	$706,741	3.4%	Defined
ClariVest Asset Management LLC joint	2	$669	0.0%	Defined
EAGLE ASSET MANAGEMENT INC joint	57,290	$19,180,118	92.4%	Defined

Candriam S.C.A.

$20,373,980

0.18%

60,856

AQR CAPITAL MANAGEMENT LLC

$19,567,133

0.17%

58,446

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RF&L WEALTH MANAGEMENT, LLC	3	$1,004	0.0%	Other
Prism Planning Partners LLC	1	$334	0.0%	Other
Compound Planning, Inc.	3	$1,004	0.0%	Other
Arax Advisory Partners	101	$33,813	0.2%	Other
HALBERT HARGROVE GLOBAL ADVISORS, LLC	142	$47,540	0.2%	Other
Stokes Family Office, LLC	100	$33,479	0.2%	Other
Held directly	58,096	$19,449,959	99.4%	Defined

HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND

$19,029,463

0.16%

56,840

Russell Investments Group, Ltd.

$17,085,336

0.15%

51,033

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Russell Investment Management, LLC	31,391	$10,509,392	61.5%	Defined
Russell Investments Capital, LLC	9,942	$3,328,482	19.5%	Defined
Russell Investments France SAS	2,847	$953,147	5.6%	Defined
Russell Investments Implementation Services, LLC	1,525	$510,554	3.0%	Defined
Russell Investments Trust Company	5,328	$1,783,761	10.4%	Defined

Universal- Beteiligungs- und Servicegesellschaft mbH

$16,109,425

0.14%

48,118

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Universal-Investment-Gesellschaft mbH joint	48,118	$16,109,425	100.0%	Defined

Boxer Capital Management, LLC

$15,553,339

0.13%

46,457

Swiss National Bank

$15,433,819

0.13%

46,100

ArrowMark Colorado Holdings LLC

$15,410,383

0.13%

46,030

California Public Employees Retirement System

$15,189,422

0.13%

45,370

JPMORGAN CHASE & CO

$14,759,214

0.13%

44,085

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
J.P. Morgan Trust Co of Delaware	415	$138,937	0.9%	Other
JPMorgan Chase Bank, N.A.	12,721	$4,258,863	28.9%	Defined
J.P. Morgan Investment Management Inc.	30,326	$10,152,841	68.8%	Defined
J.P. Morgan Securities LLC	6	$2,008	0.0%	Defined
J.P. Morgan Securities plc	260	$87,045	0.6%	Defined
J.P. MORGAN MANSART MANAGEMENT Ltd	357	$119,520	0.8%	Defined

JANE STREET GROUP, LLC

$14,630,323

0.13%

43,700

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	43,700	$14,630,323	100.0%	Defined

KVP Capital Advisors, LP

$14,362,491

0.12%

42,900

SEB Asset Management AB

$14,297,206

0.12%

42,705

Squarepoint Ops LLC

$14,228,909

0.12%

42,501

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Squarepoint Capital LLP	42,501	$14,228,909	100.0%	Defined

SEI INVESTMENTS CO

$13,430,769

0.12%

40,117

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SEI INVESTMENTS MANAGEMENT CORP	135	$45,196	0.3%	Sole
SEI TRUST CO	39,982	$13,385,573	99.7%	Sole

Integral Health Asset Management, LLC

$13,391,600

0.12%

40,000

EVENTIDE ASSET MANAGEMENT, LLC

$12,951,016

0.11%

38,684

PFM Health Sciences, LP

$12,914,524

0.11%

38,575

STEMPOINT CAPITAL LP

$12,468,583

0.11%

37,243

UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC

$12,115,042

0.10%

36,187

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Group AG	408	$136,594	1.1%	Defined
UBS Asset Management Switzerland AG	30,294	$10,142,128	83.7%	Sole
UBS Asset Management (UK) Ltd.	3,281	$1,098,444	9.1%	Defined
Held directly	2,204	$737,876	6.1%	Defined

Burkehill Global Management, LP

$11,717,650

0.10%

35,000

University of Wisconsin Foundation

$11,627,256

0.10%

34,730

B Group, Inc.

$11,127,415

0.10%

33,237

RHUMBLINE ADVISERS

$10,829,452

0.09%

32,347

DIMENSIONAL FUND ADVISORS LP

$10,570,659

0.09%

31,574

HighVista Strategies LLC

$10,114,005

0.09%

30,210

LORD, ABBETT & CO. LLC

$9,930,540

0.09%

29,662

Clearbridge Investments, LLC

$9,367,758

0.08%

27,981

WELLS FARGO & COMPANY/MN

$9,336,955

0.08%

27,889

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO BANK N A	23,862	$7,988,758	85.6%	Defined
WELLS FARGO ADVISORS FINANCIAL NETWORK, LLC	958	$320,728	3.4%	Defined
WELLS FARGO CLEARING SERVICES, LLC	3,050	$1,021,109	10.9%	Defined
Wells Fargo Securities, LLC	8	$2,678	0.0%	Defined
WELLS FARGO INVESTMENT INSTITUTE, INC.	11	$3,682	0.0%	Defined

JANE STREET GROUP, LLC

$9,139,767

0.08%

27,300

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	27,300	$9,139,767	100.0%	Defined

Exome Asset Management LLC

$9,107,961

0.08%

27,205

MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.

$9,101,265

0.08%

27,185

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Global X Management CO LLC joint	25,853	$8,655,325	95.1%	Defined
Global X Management (AUS) Ltd joint	1,332	$445,940	4.9%	Defined

Showing the top 100 of 334 holders. Create a free account to see every holder, past quarters, search, filters and CSV export.

Key facts CIK 1689548 CUSIP 74006W207 13F (30d) 18 filings 18 filers Visit website Investor relations