PERCEPTIVE ADVISORS LLC

CIK

1224962

Location

NEW YORK, NY

Portfolio Value

Mid $5,091,752,531

Diversification

Diversified

Filing Date

Global Rank

#657 / 8,603 ▼ 2 · as of Mar 2026

Top Industry

Biotechnology 90.8%

3Y Alpha vs SPY

+2.6%

Period ended 3 months ago

Filed May 29, 2026 · 41d

25 quarters · since Mar 2020

Clone Performance

Jul 2023–Jul 2026 · vs SPY

Hypothetical growth of cloning every reported 13F position and rebalancing on each filing, indexed to the same start.

Cloned portfolio

+92.5%

SPY

+76.0%

Annualised alpha

+3.7%

Max drawdown

−46.0%

Estimate. 13F holdings are quarter-lagged and long-only, so the clone rebalances about 45 days after each period end — when the filing becomes public — and excludes options and short positions. Past performance does not predict future results.

Portfolio Concentration

90 positions · as of Mar 31, 2026 · Δ vs Dec 31, 2025

Top Position

12.9%

+1.8 pts

Top 5

35.4%

+5.6 pts

Top 10

51.6%

+7.8 pts

HHI

414

Diversified+95

Portfolio Trend

25 quarters · across all stocks

Sector Breakdown

As of Mar 31, 2026

Sector	% Portfolio	Value	Positions
Healthcare	100.0%	$5,091,752,531	90

Last Quarter's Activity

Export CSV

Mar 31, 2026 vs Dec 31, 2025

Added To

Positions the filer increased

23 positions

Ticker	Company	Δ Shares	Shares	Value
RLAY	Relay Therapeutics, Inc.	+7,847,896	9,751,141	$97,023,852
SABS	SAB Biotherapeutics, Inc.	+5,628,533	6,431,743	$24,633,575
BCRX	Biocryst Pharmaceuticals Inc	+4,271,504	7,434,033	$70,771,994
CNTA	Centessa Pharmaceuticals plc	+2,341,269	5,258,903	$208,883,627
AVR	Anteris Technologies Global Corp.	+1,750,000	3,425,476	$19,011,391
CRVS	Corvus Pharmaceuticals, Inc.	+1,600,000	2,292,441	$33,538,411
DYN	Dyne Therapeutics, Inc.	+1,189,895	4,668,839	$84,646,051
TENX	Tenax Therapeutics, Inc.	+1,008,640	1,447,782	$23,150,034
SYRE	Spyre Therapeutics, Inc.	+714,000	3,783,225	$190,825,869
ASND	Ascendis Pharma A/S	+450,000	1,531,421	$350,281,925
XFOR	X4 Pharmaceuticals, Inc	+423,196	6,737,648	$27,826,486
CTMX	CytomX Therapeutics, Inc.	+418,639	10,098,824	$47,464,472
ROIV	Roivant Sciences Ltd.	+300,000	8,285,461	$229,507,269
TNGX	Tango Therapeutics, Inc.	+295,118	808,153	$16,906,560
ZYME	Zymeworks Inc.	+248,228	3,510,078	$87,892,353
BBNX	Beta Bionics, Inc.	+240,000	842,944	$8,446,298
ANRO	Alto Neuroscience, Inc.	+225,500	2,009,893	$45,182,394
NRIX	Nurix Therapeutics, Inc.	+155,000	3,710,877	$57,518,593
GH	Guardant Health, Inc.	+140,000	300,000	$27,711,000
SLDB	Solid Biosciences Inc.	+73,107	11,906,646	$85,727,851
PRAX	Praxis Precision Medicines, Inc.	+40,000	2,035,986	$655,974,329
BLLN	BillionToOne, Inc.	+19,000	91,812	$7,247,639
AXSM	Axsome Therapeutics, Inc.	+1,050	149,950	$25,344,549
No positions match the current search.

Trimmed

Positions the filer reduced

25 positions

Ticker	Company	Δ Shares	Shares	Value
PALI	Palisade Bio, Inc.	−3,121,851	8,928,149	$15,624,260
IKT	Inhibikase Therapeutics, Inc.	−3,106,568	2,315,000	$3,889,200
IRD	Opus Genetics, Inc.	−2,489,158	1,835,842	$8,353,081
VRDN	Viridian Therapeutics, Inc.\DE	−1,871,874	1,170,829	$22,901,415
OMDA	Omada Health, Inc.	−1,610,000	786,330	$9,884,168
IVVD	Invivyd, Inc.	−925,863	20,859,303	$27,117,093
APGE	Apogee Therapeutics, Inc.	−790,267	1,540,384	$129,654,121
SION	Sionna Therapeutics, Inc.	−520,659	658,439	$26,396,819
ADMA	Adma Biologics, Inc.	−416,235	467,233	$4,209,769
IMVT	Immunovant, Inc.	−397,507	1,597,383	$39,678,993
NBIX	Neurocrine Biosciences Inc	−266,000	65,050	$8,569,687
BLTE	Belite Bio, Inc	−262,260	151,979	$24,231,531
CBIO	Crescent Biopharma, Inc.	−246,744	206,942	$3,801,524
CTNM	Contineum Therapeutics, Inc.	−209,000	1,255,592	$16,398,031
RYTM	Rhythm Pharmaceuticals, Inc.	−172,596	2,373,795	$206,448,951
CPIX	Cumberland Pharmaceuticals Inc	−144,109	196,978	$640,178
TVTX	Travere Therapeutics, Inc.	−135,629	4,142,551	$123,075,190
ABVX	Abivax S.A.	−129,459	328,884	$36,621,233
PTGX	Protagonist Therapeutics, Inc	−119,546	1,230,879	$129,734,646
OBIO	Orchestra BioMed Holdings, Inc.	−89,350	5,037,906	$21,411,100
AXGN	Axogen, Inc.	−86,828	697,312	$23,101,946
AORT	Artivion, Inc.	−85,000	1,637,290	$59,957,559
NUVL	Nuvalent, Inc.	−84,600	1,580,505	$161,922,737
ORKA	Oruka Therapeutics, Inc.	−81,000	1,395,501	$68,449,324
DRUG	Bright Minds Biosciences Inc.	−71,746	377,544	$27,549,385
No positions match the current search.

New Positions

Positions the filer opened this quarter

19 positions

Ticker	Company	Shares	Value
MRNA	Moderna, Inc.	1,000,000	$50,800,000
IONS	Ionis Pharmaceuticals Inc	504,000	$37,845,360
DAWN	Day One Biopharmaceuticals, Inc.	1,755,799	$37,644,330
DMRA	Damora Therapeutics, Inc.	1,223,000	$31,675,700
RVMD	Revolution Medicines, Inc.	258,600	$25,148,850
DBVT	DBV Technologies S.A.	964,391	$20,146,127
STRO	Sutro Biopharma, Inc.	715,307	$17,818,297
EVMN	Evommune, Inc.	448,350	$10,307,566
PHAT	Phathom Pharmaceuticals, Inc.	925,000	$10,276,750
TWST	Twist Bioscience Corp	150,000	$7,128,000
SRZN	Surrozen, Inc./DE	229,393	$6,682,218
AGMB	Agomab Therapeutics NV	600,000	$6,294,000
EOLS	Evolus, Inc.	1,286,862	$5,289,002
OCUL	Ocular Therapeutix, Inc	500,000	$4,235,000
APLS	Apellis Pharmaceuticals, Inc.	80,956	$3,256,859
EDSA	Edesa Biotech, Inc.	563,239	$2,945,739
ADPT	Adaptive Biotechnologies Corp	152,500	$2,116,700
CORT	Corcept Therapeutics Inc	50,000	$2,015,500
XGN	Exagen Inc.	114,893	$344,679
No positions match the current search.

Sold Out

Positions the filer fully exited

25 positions

Ticker	Company	Shares	Value
EXAS	EXACT SCIENCES CORP	1,200,487	$121,921,459
ACLX	Arcellx, Inc.	1,466,071	$95,587,829
BSX	Boston Scientific Corp	979,000	$93,347,650
FOLD	AMICUS THERAPEUTICS, INC.	6,370,851	$90,720,918
DHR	Danaher Corp /De/	200,000	$45,784,000
IRON	Disc Medicine, Inc.	450,743	$35,793,501
PEN	Penumbra Inc	110,529	$34,364,571
CAI	Caris Life Sciences, Inc.	1,136,206	$30,654,837
PVLA	Palvella Therapeutics, Inc.	266,287	$27,872,260
KOD	Kodiak Sciences Inc.	848,900	$23,735,244
BIIB	Biogen Inc.	124,000	$21,822,760
ALDX	Aldeyra Therapeutics, Inc.	4,185,632	$21,681,573
MIRM	Mirum Pharmaceuticals, Inc.	259,545	$20,501,459
GRAL	GRAIL, Inc.	237,342	$20,314,101
CVS	CVS HEALTH Corp	220,000	$17,459,200
GKOS	GLAUKOS Corp	140,000	$15,807,400
DXCM	Dexcom Inc	225,758	$14,983,558
SVRA	Savara Inc	2,400,000	$14,472,000
SEPN	Septerna, Inc.	433,160	$12,076,500
GOSS	Gossamer Bio, Inc.	3,139,669	$9,732,973
MPLT	MapLight Therapeutics, Inc.	550,000	$9,660,750
XENE	Xenon Pharmaceuticals Inc.	200,791	$8,999,452
KMTS	Kestra Medical Technologies, Ltd.	285,000	$7,558,200
CAPR	Capricor Therapeutics, Inc.	242,100	$6,987,006
BHVN	Biohaven Ltd.	500,000	$5,645,000
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

90 positions · $5,091,752,531 total · as of Mar 31, 2026

All sectors Healthcare

Showing 1–50 of 90 positions by value · page 1 of 2

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
PRAX	Praxis Precision Medicines, Inc. Healthcare	Added	2,035,986	+40,000	$655,974,329	+11.5%	12.88%
CELC	Celcuity Inc. Healthcare	Reduced	3,127,200	-33,000	$356,938,608	+13.2%	7.01%
ASND	Ascendis Pharma A/S Healthcare	Added	1,531,421	+450,000	$350,281,925	+51.9%	6.88%
ROIV	Roivant Sciences Ltd. Healthcare	Added	8,285,461	+300,000	$229,507,269	+32.4%	4.51%
CNTA	Centessa Pharmaceuticals plc Healthcare	Added	5,258,903	+2,341,269	$208,883,627	+186.3%	4.10%
RYTM	Rhythm Pharmaceuticals, Inc. Healthcare	Reduced	2,373,795	-172,596	$206,448,951	−24.3%	4.05%
SYRE	Spyre Therapeutics, Inc. Healthcare	Added	3,783,225	+714,000	$190,825,869	+89.8%	3.75%
NUVL	Nuvalent, Inc. Healthcare	Reduced	1,580,505	-84,600	$161,922,737	−3.3%	3.18%
EWTX	Edgewise Therapeutics, Inc. Healthcare	Reduced	4,423,974	-34,000	$139,355,181	+26.0%	2.74%
PTGX	Protagonist Therapeutics, Inc Healthcare	Reduced	1,230,879	-119,546	$129,734,646	+10.0%	2.55%
APGE	Apogee Therapeutics, Inc. Healthcare	Reduced	1,540,384	-790,267	$129,654,121	−26.3%	2.55%
TVTX	Travere Therapeutics, Inc. Healthcare	Reduced	4,142,551	-135,629	$123,075,190	−24.7%	2.42%
AMLX	Amylyx Pharmaceuticals, Inc. Healthcare	Held	8,284,882	0	$115,159,859	+15.1%	2.26%
IMTX	Immatics N.V. Healthcare	Held	10,383,456	0	$102,173,207	−6.3%	2.01%
RLAY	Relay Therapeutics, Inc. Healthcare	Added	9,751,141	+7,847,896	$97,023,852	+502.6%	1.91%
INBX	Inhibrx Biosciences, Inc. Healthcare	Reduced	1,442,707	-10,000	$96,993,191	−15.5%	1.90%
MGTX	MeiraGTx Holdings plc Healthcare	Held	10,326,103	0	$89,424,051	+8.9%	1.76%
ZYME	Zymeworks Inc. Healthcare	Added	3,510,078	+248,228	$87,892,353	+2.3%	1.73%
SLDB	Solid Biosciences Inc. Healthcare	Added	11,906,646	+73,107	$85,727,851	+28.4%	1.68%
DYN	Dyne Therapeutics, Inc. Healthcare	Added	4,668,839	+1,189,895	$84,646,051	+24.4%	1.66%
BCRX	Biocryst Pharmaceuticals Inc Healthcare	Added	7,434,033	+4,271,504	$70,771,994	+186.9%	1.39%
ORKA	Oruka Therapeutics, Inc. Healthcare	Reduced	1,395,501	-81,000	$68,449,324	+53.0%	1.34%
AORT	Artivion, Inc. Healthcare	Reduced	1,637,290	-85,000	$59,957,559	−23.7%	1.18%
NRIX	Nurix Therapeutics, Inc. Healthcare	Added	3,710,877	+155,000	$57,518,593	−14.7%	1.13%
MRNA	Moderna, Inc. Healthcare	NEW	1,000,000	NEW	$50,800,000	NEW	1.00%
NAUT	Nautilus Biotechnology, Inc. Healthcare	Held	12,594,211	0	$48,865,538	+99.0%	0.96%
CTMX	CytomX Therapeutics, Inc. Healthcare	Added	10,098,824	+418,639	$47,464,472	+15.1%	0.93%
ANRO	Alto Neuroscience, Inc. Healthcare	Added	2,009,893	+225,500	$45,182,394	+42.3%	0.89%
ENGN	enGene Therapeutics Inc. Healthcare	Reduced	5,827,506	-41,570	$39,685,315	−25.1%	0.78%
IMVT	Immunovant, Inc. Healthcare	Reduced	1,597,383	-397,507	$39,678,993	−21.8%	0.78%
ISRG	Intuitive Surgical Inc Healthcare	Reduced	85,419	-2,500	$39,377,304	−20.9%	0.77%
IONS	Ionis Pharmaceuticals Inc Healthcare	NEW	504,000	NEW	$37,845,360	NEW	0.74%
DAWN	Day One Biopharmaceuticals, Inc. Healthcare	NEW	1,755,799	NEW	$37,644,330	NEW	0.74%
ABVX	Abivax S.A. Healthcare	Reduced	328,884	-129,459	$36,621,233	−40.8%	0.72%
CRVS	Corvus Pharmaceuticals, Inc. Healthcare	Added	2,292,441	+1,600,000	$33,538,411	+529.0%	0.66%
RGEN	Repligen Corp Healthcare	Reduced	280,541	-35,000	$33,053,340	−36.1%	0.65%
JAZZ	Jazz Pharmaceuticals plc Healthcare	Held	170,000	0	$32,138,500	+11.2%	0.63%
DMRA	Damora Therapeutics, Inc. Healthcare	NEW	1,223,000	NEW	$31,675,700	NEW	0.62%
XFOR	X4 Pharmaceuticals, Inc Healthcare	Added	6,737,648	+423,196	$27,826,486	+10.2%	0.55%
GH	Guardant Health, Inc. Healthcare	Added	300,000	+140,000	$27,711,000	+69.6%	0.54%
DRUG	Bright Minds Biosciences Inc. Healthcare	Reduced	377,544	-71,746	$27,549,385	−21.4%	0.54%
IVVD	Invivyd, Inc. Healthcare	Reduced	20,859,303	-925,863	$27,117,093	−49.6%	0.53%
SION	Sionna Therapeutics, Inc. Healthcare	Reduced	658,439	-520,659	$26,396,819	−45.6%	0.52%
AXSM	Axsome Therapeutics, Inc. Healthcare	Added	149,950	+1,050	$25,344,549	−6.8%	0.50%
RVMD	Revolution Medicines, Inc. Healthcare	NEW	258,600	NEW	$25,148,850	NEW	0.49%
SABS	SAB Biotherapeutics, Inc. Healthcare	Added	6,431,743	+5,628,533	$24,633,575	+720.0%	0.48%
BLTE	Belite Bio, Inc Healthcare	Reduced	151,979	-262,260	$24,231,531	−63.4%	0.48%
TENX	Tenax Therapeutics, Inc. Healthcare	Added	1,447,782	+439,332	$23,150,034	+88.3%	0.45%
AXGN	Axogen, Inc. Healthcare	Reduced	697,312	-86,828	$23,101,946	−10.0%	0.45%
VRDN	Viridian Therapeutics, Inc.\DE Healthcare	Reduced	1,170,829	-1,871,874	$22,901,415	−75.8%	0.45%