SION · Sionna Therapeutics, Inc. · Holdings
The latest filing states the doubt was alleviated.
“The Company has evaluated whether there are conditions and events, considered in the aggregate, that raise substantial doubt about the Company’s ability to continue as a going concern within one year after the date that these condensed consolidated financial statements are issued. The Company believes that its existing cash, cash equivalents and marketable securities of $268.3 million as of June 30, 2026, will be sufficient to allow the Company to fund operations beyond twelve months from the date that the financial statements are issued.”View the 10-Q filed Aug 6, 2026
Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.
Institutional Ownership Trend
Superinvestors Holding SION
All superinvestors →Holder Concentration
Across 150 13F filersWho Holds SION
Last 7 quarters through Sep 30, 2026 (filing window open)Each kind of 13F filer's share of the common shares 13F filers report. Holder type comes from regulatory records, never the filer's name; style, turnover and horizon are measured from each filer's own 13F book. The quarter selector does not change this card.
Jun 30, 2026, the newest closed quarter: 146 filers, like-for-like change +5.9%; actively managed books +5.0%; index-like books +13.6%.
| Holder type | Share | Filers | Change |
|---|---|---|---|
| Registered adviser | 56.6% | 67 | +5.0% |
| Exempt adviser | 0.7% | 3 | +46.2% |
| Adviser | 1.1% | 4 | -8.9% |
| Bank | 6.3% | 13 | +16.6% |
| Benefit plan | 0.0% | 3 | +525.5% |
| Non-US | 0.3% | 4 | +2.2% |
| Holding company | 5.4% | 7 | +9.9% |
| Insurer | 0.0% | 0 | — |
| Unknown | 29.5% | 45 | +4.7% |
| Style | Share | Filers | Change |
|---|---|---|---|
| Index-like | 11.3% | 26 | +13.6% |
| Systematic-like | 4.1% | 13 | +18.8% |
| Concentrated | 48.2% | 18 | +1.4% |
| Diversified active | 36.4% | 89 | +8.6% |
| Not measured | 0.0% | 0 | — |
| Unknown | 0.0% | 0 | — |
| Turnover | Share | Filers | Change |
|---|---|---|---|
| Low turnover | 65.4% | 70 | +2.5% |
| Medium turnover | 17.9% | 34 | +18.8% |
| High turnover | 12.5% | 30 | +4.8% |
| Unknown | 4.1% | 12 | +16.5% |
| Not measured | 0.0% | 0 | — |
| Holding horizon | Share | Filers | Change |
|---|---|---|---|
| Short horizon | 5.3% | 24 | +13.4% |
| Medium horizon | 24.2% | 25 | +5.1% |
| Long horizon | 52.9% | 81 | +9.6% |
| Unknown | 17.5% | 16 | -4.7% |
| Not measured | 0.0% | 0 | — |
| 13F book size | Share | Filers | Change |
|---|---|---|---|
| Under $1B | 13.6% | 27 | -0.2% |
| $1B to $10B | 27.2% | 29 | -1.3% |
| $10B to $100B | 35.5% | 42 | +11.9% |
| $100B or more | 23.7% | 48 | +10.3% |
| Not measured | 0.0% | 0 | — |
| Client base | Share | Filers | Change |
|---|---|---|---|
| Individuals and high net worth | 0.0% | 12 | -26.6% |
| Pooled investment vehicles | 46.2% | 27 | +5.0% |
| Registered funds and BDCs | 8.7% | 13 | -9.2% |
| Pension and profit sharing plans | 0.0% | 1 | new |
| Insurance companies | 0.0% | 2 | +28.2% |
| Governments and sovereign funds | 0.3% | 3 | +755.4% |
| Other investment advisers | 0.0% | 1 | +2.5% |
| Diversified | 1.3% | 8 | +344.4% |
| Corporations | 0.0% | 0 | — |
| Unknown | 43.4% | 79 | +7.1% |
| Private funds | Share | Filers | Change |
|---|---|---|---|
| Hedge funds | 20.6% | 29 | +31.9% |
| Private equity funds | 0.0% | 1 | +27.7% |
| Venture capital funds | 21.6% | 3 | -1.6% |
| Real estate funds | 0.0% | 3 | +90.0% |
| Securitized asset funds | 0.0% | 1 | +9056.9% |
| Other private funds | 9.7% | 8 | -24.7% |
| Mixed private funds | 1.0% | 3 | +410.2% |
| Private funds, type not stated | 0.0% | 2 | +40.2% |
| No private funds | 4.3% | 20 | +16.9% |
| Unknown | 42.7% | 76 | +6.7% |
| Location | Share | Filers | Change |
|---|---|---|---|
| United States | 97.5% | 117 | +6.4% |
| Outside the US | 2.5% | 29 | -10.7% |
The Sep 30, 2026 filing window is still open, so its bar carries the Jun 30, 2026 positions of filers that have not filed yet.
How the mix is measured
Shares are 13F common shares restated to today's split basis; options and principal amounts are left out. The change compares only filers with a 13F in both quarters and keeps each filer in its bucket of the later quarter on both sides; a filer that continues under a new CIK is compared through its successor. Holder type comes from each filer's current regulatory profile; client base and private funds come from the Form ADV roster current at each quarter end (rosters from December 2019, so an earlier quarter reads Unknown). Style, turnover, horizon and book size are measured from each filer's 13F book in the newest measured quarter, and Not measured means none was. Actively managed books are those measured systematic-like, concentrated or diversified active.
Excluded 1 holder with no observed 2026-06-30 13F. Compared across CIK changes: JANUS HENDERSON GROUP PLC continues as Jupiter Topco LLC.
Conviction and Crowding
146 13F filers, quarter ended Jun 30, 2026Measured across every 13F filer's common-share book once the quarter's filing window closed. Crowding counts filers with high turnover or that advise private funds on Form ADV.
Managers in the top fifth by current three-year FundScore alpha were net buyers of $0 (0 buying, 0 selling).
Estimated Holder Cost Basis
Quarter ended Jun 30, 2026, on that quarter's share basisEstimated, never filed: each 13F buy is costed at its quarter's average traded price and each sale keeps the average cost, so this is what holders paid on average if they traded evenly through each quarter.
Estimated cost covers 96.5% of the 13F shares; positions already held when a filer's 13F history starts, or bought in a quarter without a trusted average price, have no estimate.
Shared Holders
Companies SION's active holders also own, quarter ended Jun 30, 2026| # | Company | Shared holders |
|---|---|---|
| 1 | TYRA Tyra Biosciences, Inc. | 8 |
| 2 | RAPP Rapport Therapeutics, Inc. | 7 |
| 3 | AVLN Avalyn Pharma Inc. | 8 |
| 4 | PRAX Praxis Precision Medicines, Inc. | 12 |
| 5 | XENE Xenon Pharmaceuticals Inc. | 12 |
| 6 | ELVN Enliven Therapeutics, Inc. | 11 |
| 7 | MNPR Monopar Therapeutics | 6 |
| 8 | ERAS Erasca, Inc. | 10 |
| 9 | IRON Disc Medicine, Inc. | 9 |
| 10 | SYRE Spyre Therapeutics, Inc. | 11 |
Shareholder Targets
13F filers that own its peers but not SION, quarter ended Jun 30, 2026Found through its holder-overlap peers: TYRA, RAPP, AVLN, PRAX, XENE, ELVN, MNPR, ERAS, IRON, SYRE, TARA, EWTX, RYTM, ORKA, ORIC, PBLS, MOBI, PRLD, SEPN, SRRK. 600 filers in all.
| # | Filer | In peers | Largest peers |
|---|---|---|---|
| 1 | Polar Capital Holdings Plc Registered adviser, Diversified active | $1,275,245,383 9 held | ELVN, XENE, RYTM |
| 2 | Paradigm Biocapital Advisors LP Registered adviser, Concentrated | $1,193,494,452 5 held | EWTX, SYRE, ORKA |
| 3 | Venrock Adviser, LLC Registered adviser, Concentrated | $1,078,232,562 6 held | ORKA, ERAS, SYRE |
| 4 | RTW INVESTMENTS, LP Registered adviser, Diversified active | $1,007,212,422 4 held | SYRE, ERAS, ORKA |
| 5 | Orbis Allan Gray Ltd Unknown, Diversified active | $838,502,039 2 held | PRAX, SRRK |
| 6 | T. Rowe Price Investment Management, Inc. Adviser, Diversified active | $762,206,661 7 held | ERAS, XENE, ORKA |
| 7 | Cormorant Asset Management, LP Registered adviser, Diversified active | $741,581,067 8 held | PRAX, PBLS, RAPP |
| 8 | Capital World Investors Adviser, Diversified active | $705,691,820 7 held | ORKA, SYRE, SRRK |
| 9 | Frazier Life Sciences Management, L.P. Registered adviser, Concentrated | $609,211,751 3 held | ERAS, IRON, PBLS |
| 10 | Pictet Asset Management Holding SA Unknown, Diversified active | $535,304,723 11 held | RYTM, PRAX, XENE |
Fund Ownership of SION by Fund Type
Registered funds' Form N-PORT reports for the quarter ended Jun 30, 2026Index funds and index ETFs hold 7.74% of shares outstanding.
| Fund type | Of shares outstanding | Shares |
|---|---|---|
| Index funds | 1.30% | 589,199 |
| Index ETFs | 6.44% | 2,910,114 |
| Active ETFs | 0.13% | 58,706 |
| Active funds | 6.43% | 2,905,702 |
| Unclassified | 0.24% | 106,290 |
| All registered funds | 14.53% | 6,570,011 |
How fund types are measured
Each fund series counts once, with its latest Form N-PORT report dated inside the quarter; only long share positions count, restated to today's split basis. The fund type is the series' latest Form N-CEN answer on or before the quarter end (the index-fund box and the exchange-traded flag), never its name. Unclassified funds have no usable N-CEN; unit investment trusts are among them, so index ownership is a floor. Funds sit inside their advisers' 13F reports, so these shares overlap the 13F figures and are never added to them.
| Holder | Value (USD) | % of 13F | Shares | Type | Filed | Open |
|---|---|---|---|---|---|---|
| Large RA CAPITAL MANAGEMENT, L.P. Registered adviser | $435,722,929 | 20.47% | 9,905,045 | Shares | 2026-08-14 | |
| Mid TPG GP A, LLC | $285,713,378 | 13.42% | 6,494,962 | Shares | 2026-08-14 | |
| Large VIKING GLOBAL INVESTORS LP Registered adviser | $140,556,012 | 6.60% | 3,195,181 | Shares | 2026-08-14 | |
| Small Atlas Venture Life Science Advisors, LLC | $131,776,531 | 6.19% | 2,995,602 | Shares | 2026-08-13 | |
| Mid ORBIMED ADVISORS LLC Registered adviser | $112,433,029 | 5.28% | 2,555,877 | Shares | 2026-08-14 | |
| Small ENAVATE SCIENCES GP, LLC | $109,008,539 | 5.12% | 2,478,030 | Shares | 2026-08-14 | |
| Large ADAGE CAPITAL PARTNERS GP, L.L.C. Registered adviser | $70,384,000 | 3.31% | 1,600,000 | Shares | 2026-08-14 | |
| Mega JPMORGAN CHASE & CO Bank | $65,567,443 | 3.08% | 1,490,508 | Shares | 2026-08-12 | |
| Mega BlackRock, Inc. Holding company | $64,875,084 | 3.05% | 1,474,769 | Shares | 2026-08-07 | |
| Mega JENNISON ASSOCIATES LLC Registered adviser | $51,562,130 | 2.42% | 1,172,133 | Shares | 2026-08-03 | |
| Mega CITADEL ADVISORS LLC Registered adviser | $50,484,507 | 2.37% | 1,147,636 | Shares | 2026-09-02 | |
| Mega VANGUARD CAPITAL MANAGEMENT LLC Registered adviser | $49,796,723 | 2.34% | 1,132,001 | Shares | 2026-08-13 | |
| Mega STATE STREET CORP Bank | $44,937,280 | 2.11% | 1,021,534 | Shares | 2026-09-22 | |
| Mid PERCEPTIVE ADVISORS LLC Registered adviser | $39,810,950 | 1.87% | 905,000 | Shares | 2026-08-14 | |
| Mid DEERFIELD MANAGEMENT COMPANY, L.P. Registered adviser | $29,953,494 | 1.41% | 680,916 | Shares | 2026-08-14 | |
| Mid Siren, L.L.C. | $26,856,554 | 1.26% | 610,515 | Shares | 2026-08-13 | |
| Mega PRICE T ROWE ASSOCIATES INC /MD/ Registered adviser | $21,027,923 | 0.99% | 478,016 | Shares | 2026-08-14 | |
| Mid EVENTIDE ASSET MANAGEMENT, LLC Registered adviser | $20,894,414 | 0.98% | 474,981 | Shares | 2026-08-14 | |
| Mega GEODE CAPITAL MANAGEMENT, LLC Registered adviser | $20,109,808 | 0.94% | 457,145 | Shares | 2026-08-12 | |
| Mid Casdin Capital, LLC Registered adviser | $17,596,000 | 0.83% | 400,000 | Shares | 2026-08-14 | |
| Large BAKER BROS. ADVISORS LP Registered adviser | $17,596,000 | 0.83% | 400,000 | Shares | 2026-08-14 | |
| Mega GOLDMAN SACHS GROUP INC Holding company | $17,103,751 | 0.80% | 388,810 | Shares | 2026-08-14 | |
| Large Driehaus Capital Management LLC Registered adviser | $16,955,813 | 0.80% | 385,447 | Shares | 2026-08-14 | |
| Mega FRANKLIN RESOURCES INC Adviser | $12,762,070 | 0.60% | 290,113 | Shares | 2026-08-13 | |
| Large Aberdeen Group plc Holding company | $12,499,230 | 0.59% | 284,138 | Shares | 2026-07-31 | |
| Mega FMR LLC Holding company | $12,242,065 | 0.58% | 278,292 | Shares | 2026-08-13 | |
| Mega MILLENNIUM MANAGEMENT LLC Registered adviser | $12,173,484 | 0.57% | 276,733 | Shares | 2026-08-14 | |
| Large Candriam S.C.A. Registered adviser | $10,258,819 | 0.48% | 233,208 | Shares | 2026-08-13 | |
| Mega VANGUARD PORTFOLIO MANAGEMENT LLC Registered adviser | $9,807,526 | 0.46% | 222,949 | Shares | 2026-08-13 | |
| Small Kalehua Capital Management LLC Exempt adviser | $8,669,197 | 0.41% | 197,072 | Shares | 2026-08-19 | |
| Mid Longaeva Partners L.P. | $8,637,524 | 0.41% | 196,352 | Shares | 2026-08-14 | |
| Large Artisan Partners Limited Partnership Registered adviser | $8,336,017 | 0.39% | 189,498 | Shares | 2026-08-13 | |
| Large Ensign Peak Advisors, Inc | $8,117,562 | 0.38% | 184,532 | Shares | 2026-08-14 | |
| Mid Soleus Capital Management, L.P. | $7,816,451 | 0.37% | 177,687 | Shares | 2026-08-11 | |
| Mega NORTHERN TRUST CORP Bank | $6,795,398 | 0.32% | 154,476 | Shares | 2026-08-13 | |
| Mega MORGAN STANLEY Holding company | $6,644,554 | 0.31% | 151,047 | Shares | 2026-08-13 | |
| Mid Sofinnova Investments, Inc. | $6,353,563 | 0.30% | 144,432 | Shares | 2026-08-14 | |
| Mega Qube Research & Technologies Ltd Exempt adviser | $6,172,192 | 0.29% | 140,309 | Shares | 2026-08-14 | |
| Large Alyeska Investment Group, L.P. Registered adviser | $5,992,405 | 0.28% | 136,222 | Shares | 2026-08-14 | |
| Small GordonMD Global Investments LP | $5,982,640 | 0.28% | 136,000 | Shares | 2026-08-14 | |
| Mega CHARLES SCHWAB INVESTMENT MANAGEMENT INC Registered adviser | $5,707,834 | 0.27% | 129,753 | Shares | 2026-08-14 | |
| Small Sio Capital Management, LLC Adviser | $5,622,273 | 0.26% | 127,808 | Shares | 2026-08-14 | |
| Mid Y-Intercept (Hong Kong) Ltd Exempt adviser | $5,559,215 | 0.26% | 1,056,885 | Shares | 2026-10-16 | |
| Small Ishara Investments LP Registered adviser | $5,410,770 | 0.25% | 123,000 | Shares | 2026-08-14 | |
| Mega VANGUARD FIDUCIARY TRUST CO | $5,342,233 | 0.25% | 121,442 | Shares | 2026-08-13 | |
| Small Artia Global Partners LP Registered adviser | $5,267,406 | 0.25% | 119,741 | Shares | 2026-08-14 | |
| Mega UBS Group AG Bank | $5,111,901 | 0.24% | 116,206 | Shares | 2026-08-13 | |
| Small First Turn Management, LLC Registered adviser | $4,860,587 | 0.23% | 110,493 | Shares | 2026-08-14 | |
| Mega CITIGROUP INC Bank | $4,846,070 | 0.23% | 110,163 | Shares | 2026-08-03 | |
| Small Ikarian Capital, LLC Registered adviser | $4,728,925 | 0.22% | 107,500 | Put | 2026-08-14 | |
| Mega D. E. Shaw & Co., Inc. | $4,471,318 | 0.21% | 101,644 | Shares | 2026-08-14 | |
| Mid Rock Springs Capital Management LP Registered adviser | $4,373,881 | 0.21% | 99,429 | Shares | 2026-08-14 | |
| Large Walleye Capital LLC Registered adviser | $4,282,294 | 0.20% | 97,347 | Shares | 2026-08-03 | |
| Mid Rhenman & Partners Asset Management AB | $4,271,429 | 0.20% | 97,100 | Shares | 2026-08-13 | |
| Mega BANK OF AMERICA CORP /DE/ Bank | $3,911,062 | 0.18% | 88,908 | Shares | 2026-08-14 | |
| Mega AMERIPRISE FINANCIAL INC Adviser | $3,617,385 | 0.17% | 82,232 | Shares | 2026-08-14 | |
| Mid Integral Health Asset Management, LLC Registered adviser | $3,299,250 | 0.15% | 75,000 | Shares | 2026-08-14 | |
| Small SUPERSTRING CAPITAL MANAGEMENT LP | $2,778,232 | 0.13% | 63,156 | Shares | 2026-08-14 | |
| Small STEMPOINT CAPITAL LP Registered adviser | $2,614,149 | 0.12% | 59,426 | Shares | 2026-08-14 | |
| Mega DEUTSCHE BANK AG\ Non-US | $2,346,998 | 0.11% | 53,353 | Shares | 2026-08-07 | |
| Mid SEVEN GRAND MANAGERS, LLC Registered adviser | $2,199,500 | 0.10% | 50,000 | Shares | 2026-08-14 | |
| Large Point72 Asset Management, L.P. Registered adviser | $2,169,938 | 0.10% | 49,328 | Shares | 2026-08-14 | |
| Mega TD Asset Management Inc | $2,084,950 | 0.10% | 47,396 | Shares | 2026-08-04 | |
| Large ALPS ADVISORS INC Registered adviser | $2,002,644 | 0.09% | 45,525 | Shares | 2026-07-29 | |
| Small SILVERARC CAPITAL MANAGEMENT, LLC Registered adviser | $1,868,607 | 0.09% | 42,478 | Shares | 2026-08-13 | |
| Mega Russell Investments Group, Ltd. | $1,858,928 | 0.09% | 42,258 | Shares | 2026-08-06 | |
| Mega Bank of New York Mellon Corp Bank | $1,829,365 | 0.09% | 41,586 | Shares | 2026-08-06 | |
| Mega Nuveen, LLC | $1,814,982 | 0.09% | 41,259 | Shares | 2026-08-11 | |
| Mid XTX Topco Ltd | $1,675,843 | 0.08% | 38,096 | Shares | 2026-08-14 | |
| Mega WELLINGTON MANAGEMENT GROUP LLP Holding company | $1,643,685 | 0.08% | 37,365 | Shares | 2026-08-14 | |
| Mega MANUFACTURERS LIFE INSURANCE COMPANY, THE Non-US | $1,558,125 | 0.07% | 35,420 | Shares | 2026-09-09 | |
| Mid BOOTHBAY FUND MANAGEMENT, LLC Registered adviser | $1,429,675 | 0.07% | 32,500 | Put | 2026-08-14 | |
| Mega BNP PARIBAS ARBITRAGE, SA Non-US | $1,399,013 | 0.07% | 31,803 | Shares | 2026-08-13 | |
| Mega MILLENNIUM MANAGEMENT LLC Registered adviser | $1,258,114 | 0.06% | 28,600 | Put | 2026-08-14 | |
| Mega Swiss National Bank | $1,187,730 | 0.06% | 27,000 | Shares | 2026-08-11 | |
| Large Quadrature Capital Ltd | $1,144,751 | 0.05% | 26,023 | Shares | 2026-08-07 | |
| Mega ALLIANCEBERNSTEIN L.P. Registered adviser | $1,119,545 | 0.05% | 25,450 | Shares | 2026-08-14 | |
| Large Trexquant Investment LP Registered adviser | $1,047,401 | 0.05% | 23,810 | Shares | 2026-08-14 | |
| Large NEW YORK STATE COMMON RETIREMENT FUND | $1,037,548 | 0.05% | 23,586 | Shares | 2026-07-29 | |
| Large TUDOR INVESTMENT CORP ET AL Registered adviser | $993,074 | 0.05% | 22,575 | Shares | 2026-08-14 | |
| Mega RHUMBLINE ADVISERS Registered adviser | $981,372 | 0.05% | 22,309 | Shares | 2026-08-12 | |
| Mega MILLENNIUM MANAGEMENT LLC Registered adviser | $879,800 | 0.04% | 20,000 | Call | 2026-08-14 | |
| Small Maven Securities LTD | $879,800 | 0.04% | 20,000 | Shares | 2026-08-14 | |
| Large LOS ANGELES CAPITAL MANAGEMENT LLC Registered adviser | $820,193 | 0.04% | 18,645 | Shares | 2026-08-13 | |
| Mid Susquehanna Portfolio Strategies, LLC | $793,315 | 0.04% | 18,034 | Shares | 2026-08-14 | |
| Large Rafferty Asset Management, LLC Registered adviser | $791,995 | 0.04% | 18,004 | Shares | 2026-08-14 | |
| Mid Shay Capital LLC | $791,820 | 0.04% | 18,000 | Shares | 2026-08-14 | |
| Mega WELLS FARGO & COMPANY/MN Bank | $739,955 | 0.03% | 16,821 | Shares | 2026-08-14 | |
| Mid Engineers Gate Manager LP | $686,375 | 0.03% | 15,603 | Shares | 2026-08-14 | |
| Mega CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM Benefit plan | $653,339 | 0.03% | 14,852 | Shares | 2026-08-24 | |
| Mid KENNEDY CAPITAL MANAGEMENT LLC Registered adviser | $555,197 | 0.03% | 12,621 | Shares | 2026-08-14 | |
| Mega MARSHALL WACE, LLP Exempt adviser | $554,230 | 0.03% | 12,599 | Shares | 2026-08-13 | |
| Mega Invesco Ltd. Adviser | $546,266 | 0.03% | 12,418 | Shares | 2026-08-14 | |
| Large MetLife Investment Management, LLC Registered adviser | $482,658 | 0.02% | 10,972 | Shares | 2026-08-14 | |
| Mega UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC Registered adviser | $467,260 | 0.02% | 10,622 | Shares | 2026-08-13 | |
| Large MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $465,502 | 0.02% | 10,582 | Shares | 2026-08-14 | |
| Large Jump Financial, LLC | $460,707 | 0.02% | 10,473 | Shares | 2026-08-13 | |
| Mega VANGUARD ASSET MANAGEMENT, Ltd | $419,444 | 0.02% | 9,535 | Shares | 2026-08-13 | |
| Mid PROFUND ADVISORS LLC Registered adviser | $402,068 | 0.02% | 9,140 | Shares | 2026-08-11 | |
| Small Virtus Investment Advisers, LLC Registered adviser | $400,704 | 0.02% | 9,109 | Shares | 2026-08-11 |
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