Sio Capital Management, LLC

CIK

1482416

Location

NEW YORK, NY

Portfolio Value

Small $697,805,888

Diversification

Diversified

Filing Date

Global Rank

#2,189 / 8,605 ▲ 106 · as of Mar 2026

Top Industry

Biotechnology 45.3%

3Y Alpha vs SPY

+3.4%

Period ended 3 months ago

Filed May 14, 2026 · 56d

25 quarters · since Mar 2020

Clone Performance

Jul 2023–Jul 2026 · vs SPY

Hypothetical growth of cloning every reported 13F position and rebalancing on each filing, indexed to the same start.

Cloned portfolio

+95.6%

SPY

+76.5%

Annualised alpha

+4.2%

Max drawdown

−37.3%

Estimate. 13F holdings are quarter-lagged and long-only, so the clone rebalances about 45 days after each period end — when the filing becomes public — and excludes options and short positions. Past performance does not predict future results.

Portfolio Concentration

72 positions · as of Mar 31, 2026 · Δ vs Dec 31, 2025

Top Position

7.1%

−0.1 pts

Top 5

26.6%

−6.6 pts

Top 10

45.1%

−6.4 pts

HHI

300

Diversified−66

Portfolio Trend

25 quarters · across all stocks

Sector Breakdown

As of Mar 31, 2026

Sector	% Portfolio	Value	Positions
Healthcare	92.5%	$645,463,593	70
Industrials	7.1%	$49,281,682	1
Unclassified	0.4%	$3,060,613	1

Last Quarter's Activity

Export CSV

Mar 31, 2026 vs Dec 31, 2025

Added To

Positions the filer increased

24 positions

Ticker	Company	Δ Shares	Shares	Value
AVR	Anteris Technologies Global Corp.	+3,508,324	5,382,965	$29,875,455
WAY	Waystar Holding Corp.	+1,028,511	1,642,236	$39,594,309
VIR	Vir Biotechnology, Inc.	+1,020,277	1,498,620	$13,427,635
AQST	Aquestive Therapeutics, Inc.	+929,792	1,922,887	$7,979,981
PMVP	PMV Pharmaceuticals, Inc.	+440,032	3,076,580	$3,814,959
MMS	Maximus, Inc.	+268,521	768,825	$49,281,682
TARA	Protara Therapeutics, Inc.	+254,445	1,969,839	$10,262,861
RAPP	Rapport Therapeutics, Inc.	+181,544	366,809	$11,477,453
ICLR	Icon PLC	+179,156	306,358	$33,901,576
ANIP	Ani Pharmaceuticals Inc	+178,271	265,543	$20,420,256
IBIO	iBio, Inc.	+164,268	904,268	$1,718,109
HAE	Haemonetics Corp	+128,041	220,672	$12,437,073
CRNX	Crinetics Pharmaceuticals, Inc.	+125,046	249,887	$9,075,895
LIVN	LivaNova PLC	+99,233	421,615	$26,797,849
ABVX	Abivax S.A.	+92,676	135,800	$15,121,330
COR	Cencora, Inc.	+84,994	100,894	$31,694,841
TYRA	Tyra Biosciences, Inc.	+79,437	605,439	$23,188,313
EWTX	Edgewise Therapeutics, Inc.	+31,505	268,986	$8,473,059
CCRN	Cross Country Healthcare Inc	+29,572	1,098,393	$10,324,894
ORKA	Oruka Therapeutics, Inc.	+14,370	132,496	$6,498,928
TFX	Teleflex Inc	+7,924	94,800	$11,339,028
IRON	Disc Medicine, Inc.	+7,617	65,203	$4,169,079
GPCR	Structure Therapeutics Inc.	+7,593	209,093	$10,078,282
DRUG	Bright Minds Biosciences Inc.	+4,200	86,083	$6,281,476
No positions match the current search.

Trimmed

Positions the filer reduced

16 positions

Ticker	Company	Δ Shares	Shares	Value
OGN	Organon & Co.	−2,555,857	865,908	$5,186,788
HYPR	Hyperfine, Inc.	−1,000,000	1,000,000	$1,080,000
SNY	Sanofi	−732,015	239,671	$11,547,348
NMTC	NEUROONE MEDICAL TECHNOLOGIES Corp	−643,426	496,614	$2,315,214
CNTX	Context Therapeutics Inc.	−423,714	917,922	$2,404,955
ZBH	Zimmer Biomet Holdings, Inc.	−323,029	62,613	$5,661,467
ELTX	Elicio Therapeutics, Inc.	−285,200	11,700	$125,073
CELC	Celcuity Inc.	−283,224	193,843	$22,125,240
PRQR	ProQR Therapeutics N.V.	−209,466	1,954,715	$3,166,638
OVID	Ovid Therapeutics Inc.	−175,114	1,252,381	$2,780,285
CNC	Centene Corp	−174,350	100,000	$3,274,000
DNTH	Dianthus Therapeutics, Inc. /DE/	−104,458	370,045	$31,054,176
BHVN	Biohaven Ltd.	−80,838	1,163,926	$9,846,813
BMRN	Biomarin Pharmaceutical Inc	−38,462	194,226	$10,971,826
SI	Shoulder Innovations, Inc.	−17,330	210,641	$3,060,613
ALGS	Aligos Therapeutics, Inc.	−8,700	327,237	$2,431,370
No positions match the current search.

New Positions

Positions the filer opened this quarter

21 positions

Ticker	Company	Shares	Value
CORT	Corcept Therapeutics Inc	674,759	$27,199,535
GSK	GSK plc	385,879	$21,296,662
ABT	Abbott Laboratories	186,574	$19,155,552
EMBC	Embecta Corp.	1,847,850	$16,334,994
SION	Sionna Therapeutics, Inc.	294,340	$11,800,090
MNPR	Monopar Therapeutics	173,506	$9,506,393
EYPT	EyePoint, Inc.	721,785	$9,303,808
CMPS	COMPASS Pathways plc	1,506,525	$8,331,083
OCUL	Ocular Therapeutix, Inc	968,597	$8,204,016
RLMD	Relmada Therapeutics, Inc.	965,000	$6,716,400
ZBIO	Zenas BioPharma, Inc.	331,730	$6,485,321
QDEL	QuidelOrtho Corp	359,011	$5,898,550
REPL	Replimune Group, Inc.	720,036	$5,508,275
OKUR	OnKure Therapeutics, Inc.	1,078,965	$4,466,915
IMNM	Immunome Inc.	165,110	$3,610,955
IART	Integra Lifesciences Holdings Corp	383,140	$3,609,178
ANTX	AN2 Therapeutics, Inc.	657,200	$2,247,624
SER	Serina Therapeutics, Inc.	1,000,000	$1,940,000
ERAS	Erasca, Inc.	5,000	$80,900
OSCR	Oscar Health, Inc.	3,000	$34,410
SLP	Simulations Plus, Inc.	200	$2,364
No positions match the current search.

Sold Out

Positions the filer fully exited

14 positions

Ticker	Company	Shares	Value
CI	Cigna Group	172,203	$47,395,431
RYTM	Rhythm Pharmaceuticals, Inc.	265,700	$28,440,528
KVUE	Kenvue Inc.	1,465,442	$25,278,874
XLO	Xilio Therapeutics, Inc.	2,134,537	$19,125,451
BTSG	BrightSpring Health Services, Inc.	308,010	$11,534,974
CRL	Charles River Laboratories International, Inc.	54,985	$10,968,407
MODD	Modular Medical, Inc.	785,824	$8,581,198
MCK	Mckesson Corp	6,400	$5,249,856
FULC	Fulcrum Therapeutics, Inc.	382,000	$4,320,420
ALKS	Alkermes plc.	95,353	$2,667,976
IDYA	IDEAYA Biosciences, Inc.	75,730	$2,617,986
OTLK	Outlook Therapeutics, Inc.	1,125,400	$1,778,132
AVTX	Avalo Therapeutics, Inc.	72,173	$1,310,661
NXTC	NextCure, Inc.	10,940	$155,238
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

72 positions · $697,805,888 total · as of Mar 31, 2026

All sectors Healthcare Industrials

Showing 1–50 of 72 positions by value · page 1 of 2

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
MMS	Maximus, Inc. Industrials	Added	768,825	+268,521	$49,281,682	+14.1%	7.06%
WAY	Waystar Holding Corp. Healthcare	Added	1,642,236	+1,028,511	$39,594,309	+97.0%	5.67%
ICLR	Icon PLC Healthcare	Added	306,358	+179,156	$33,901,576	+46.3%	4.86%
COR	Cencora, Inc. Healthcare	Added	100,894	+84,994	$31,694,841	+490.2%	4.54%
DNTH	Dianthus Therapeutics, Inc. /DE/ Healthcare	Reduced	370,045	-104,458	$31,054,176	+58.8%	4.45%
AVR	Anteris Technologies Global Corp. Healthcare	Added	5,382,965	+3,508,324	$29,875,455	+219.4%	4.28%
CORT	Corcept Therapeutics Inc Healthcare	NEW	674,759	NEW	$27,199,535	NEW	3.90%
LIVN	LivaNova PLC Healthcare	Added	421,615	+99,233	$26,797,849	+35.1%	3.84%
TYRA	Tyra Biosciences, Inc. Healthcare	Added	605,439	+79,437	$23,188,313	+67.7%	3.32%
CELC	Celcuity Inc. Healthcare	Reduced	193,843	-283,224	$22,125,240	−53.5%	3.17%
GSK	GSK plc Healthcare	NEW	385,879	NEW	$21,296,662	NEW	3.05%
ANIP	Ani Pharmaceuticals Inc Healthcare	Added	265,543	+178,271	$20,420,256	+196.4%	2.93%
ABT	Abbott Laboratories Healthcare	NEW	186,574	NEW	$19,155,552	NEW	2.75%
EMBC	Embecta Corp. Healthcare	NEW	1,847,850	NEW	$16,334,994	NEW	2.34%
ABVX	Abivax S.A. Healthcare	Added	135,800	+92,676	$15,121,330	+160.0%	2.17%
VIR	Vir Biotechnology, Inc. Healthcare	Added	1,498,620	+1,020,277	$13,427,635	+365.5%	1.92%
HAE	Haemonetics Corp Healthcare	Added	220,672	+128,041	$12,437,073	+67.5%	1.78%
SION	Sionna Therapeutics, Inc. Healthcare	NEW	294,340	NEW	$11,800,090	NEW	1.69%
SNY	Sanofi Healthcare	Reduced	239,671	-732,015	$11,547,348	−75.5%	1.65%
RAPP	Rapport Therapeutics, Inc. Healthcare	Added	366,809	+181,544	$11,477,453	+104.2%	1.64%
TFX	Teleflex Inc Healthcare	Added	94,800	+7,924	$11,339,028	+6.9%	1.62%
BMRN	Biomarin Pharmaceutical Inc Healthcare	Reduced	194,226	-38,462	$10,971,826	−20.7%	1.57%
CCRN	Cross Country Healthcare Inc Healthcare	Added	1,098,393	+29,572	$10,324,894	+19.3%	1.48%
TARA	Protara Therapeutics, Inc. Healthcare	Added	1,969,839	+254,445	$10,262,861	+12.2%	1.47%
GPCR	Structure Therapeutics Inc. Healthcare	Added	209,093	+7,593	$10,078,282	−28.1%	1.44%
BHVN	Biohaven Ltd. Healthcare	Reduced	1,163,926	-80,838	$9,846,813	−29.9%	1.41%
MNPR	Monopar Therapeutics Healthcare	NEW	173,506	NEW	$9,506,393	NEW	1.36%
EYPT	EyePoint, Inc. Healthcare	NEW	721,785	NEW	$9,303,808	NEW	1.33%
CRNX	Crinetics Pharmaceuticals, Inc. Healthcare	Added	249,887	+125,046	$9,075,895	+56.2%	1.30%
EWTX	Edgewise Therapeutics, Inc. Healthcare	Added	268,986	+31,505	$8,473,059	+43.8%	1.21%
CMPS	COMPASS Pathways plc Healthcare	NEW	1,506,525	NEW	$8,331,083	NEW	1.19%
OCUL	Ocular Therapeutix, Inc Healthcare	NEW	968,597	NEW	$8,204,016	NEW	1.18%
AQST	Aquestive Therapeutics, Inc. Healthcare	Added	1,922,887	+929,792	$7,979,981	+24.4%	1.14%
RLMD	Relmada Therapeutics, Inc. Healthcare	NEW	965,000	NEW	$6,716,400	NEW	0.96%
ORKA	Oruka Therapeutics, Inc. Healthcare	Added	132,496	+14,370	$6,498,928	+81.5%	0.93%
ZBIO	Zenas BioPharma, Inc. Healthcare	NEW	331,730	NEW	$6,485,321	NEW	0.93%
DRUG	Bright Minds Biosciences Inc. Healthcare	Added	86,083	+4,200	$6,281,476	−1.7%	0.90%
QDEL	QuidelOrtho Corp Healthcare	NEW	359,011	NEW	$5,898,550	NEW	0.85%
ZBH	Zimmer Biomet Holdings, Inc. Healthcare	Reduced	62,613	-323,029	$5,661,467	−83.7%	0.81%
REPL	Replimune Group, Inc. Healthcare	NEW	720,036	NEW	$5,508,275	NEW	0.79%
OGN	Organon & Co. Healthcare	Reduced	865,908	-2,555,857	$5,186,788	−78.9%	0.74%
OKUR	OnKure Therapeutics, Inc. Healthcare	NEW	1,078,965	NEW	$4,466,915	NEW	0.64%
IRON	Disc Medicine, Inc. Healthcare	Added	65,203	+7,617	$4,169,079	−8.8%	0.60%
PMVP	PMV Pharmaceuticals, Inc. Healthcare	Added	3,076,580	+440,032	$3,814,959	+15.8%	0.55%
IMNM	Immunome Inc. Healthcare	NEW	165,110	NEW	$3,610,955	NEW	0.52%
IART	Integra Lifesciences Holdings Corp Healthcare	NEW	383,140	NEW	$3,609,178	NEW	0.52%
SVRA	Savara Inc Healthcare	Held	613,888	0	$3,351,828	−9.5%	0.48%
CNC	Centene Corp Healthcare	Reduced	100,000	-174,350	$3,274,000	−71.0%	0.47%
PRQR	ProQR Therapeutics N.V. Healthcare	Reduced	1,954,715	-209,466	$3,166,638	−27.6%	0.45%
SI	Shoulder Innovations, Inc.	Reduced	210,641	-17,330	$3,060,613	−6.1%	0.44%