Allogene Therapeutics reported ALPHA3 interim results showing MRD negativity in 58.3% (7/12) of cema-cel patients versus 16.7% (2/12) under observation, with no treatment-related serious adverse events reported in the cema-cel arm.
ALLO · Allogene Therapeutics, Inc.
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Allogene Therapeutics reported $388.9 million in cash, cash equivalents and investments as of September 30, 2026. It anticipates a clinical update in mid-2027, enrollment completion by year-end 2027, and a cash runway into 2029.
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Quarterly results
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AI Brief
Q2 FY26 earnings call · Aug 12, 2026TL;DR. Allogene's Q2 2026 was highlighted by FDA RMAT and Fast Track designations for cema-cel in 1L LBCL consolidation, accelerated ALPHA3 site activation to ~100 by year-end (six months ahead of plan), and brisk ALLO-329 enrollment with a Q4 2026 clinical update planned; cash runway extends into 2029, though the company posted a $42.7M net loss.
- + FDA granted RMAT and Fast Track designations for cema-cel as 1L consolidation therapy in July 2026 following review of the interim futility analysis.
- + ALPHA3 interim futility analysis showed a 41.6% absolute MRD clearance advantage for cema-cel vs observation with a favorable outpatient safety profile and no treatment-related serious adverse events.
- + ALPHA3 site activation target accelerated by six months; ~100 sites now expected active by year-end 2026 versus prior 80-site goal.
- + ALLO-329 RESOLUTION trial enrollment is brisk across dose escalation and lymphodepletion cohorts, with a clinical and translational update on track for Q4 2026.
- + Cash runway projected into 2029 supported by $423.6M in cash, cash equivalents and investments as of June 30, 2026.
- − Company reported a Q2 2026 net loss of $42.7M ($0.13 per share).
- − ALLO-316 TRAVERSE program has faced real safety challenges despite notable 31% confirmed ORR in CD70-high RCC.
AI-generated from the earnings call and 8-K · may contain errors · not investment advice
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Key metrics
the company's own KPIs, from written earnings releases and filings| Metric | Latest | Period | YoY |
|---|---|---|---|
| All other development costs | 3.07M | Three Months Ended September 30, 2026 filing | — |
| Cema-cel | 13.95M | Three Months Ended September 30, 2026 filing | — |
| Clinical trial milestones recorded as research and development expenses | $1.6M | three months ended September 30, 2026 filing | — |
| Collaboration costs recorded as research and development expenses | $0.2M | three months ended September 30, 2026 filing | — |
| Facilities & IT-related spend | 6.99M | Three Months Ended September 30, 2026 filing | — |
| Other operating expenses | 9.65M | Three Months Ended September 30, 2026 filing | — |
| Payroll | 15.41M | Three Months Ended September 30, 2026 filing | — |
| Supporting external spend | 5.73M | Three Months Ended September 30, 2026 filing | — |
| Workforce Reduction | 28% | the second quarter of 2025 filing | — |
Figures exactly as the company stated them in writing · click a metric with a to chart its history · period links open the stating document · "filing" marks figures stated in the 10-K/10-Q · YoY needs an exactly comparable prior-year period
Versus peers
Biotechnology — same industry group| Company | Mkt cap | YTD | Rev growth Y/Y | P/E | Short % shares |
|---|---|---|---|---|---|
|
ALLO
this stock
Allogene Therapeutics, Inc.
|
$290.58M | -38.8% | -100.0% | — | 14.8% |
|
VRTX
Vertex Pharmaceuticals Inc
|
$136.56B | +18.8% | +46.2% | 34.7 | 1.9% |
|
REGN
Regeneron Pharmaceuticals, Inc.
|
$98.84B | +23.8% | +20.8% | 21.1 | 2.1% |
|
MRNA
Moderna, Inc.
|
$90.38B | +657.4% | +4.3% | — | 8.2% |
|
CSLLY
Csl Ltd
|
$66.05B | — | — | — | 0.0% |
Peers by industry group · P/E from as-reported trailing EPS · short % is of shares outstanding
At a glance
key data from every section- Filed
- Nov 6, 2026
- This year
- 24
Allogene Therapeutics reported ALPHA3 interim results showing MRD negativity in 58.3% (7/12) of cema-cel patients versus 16.7% (2/12) under observation, with no treatment-related serious adverse events reported in the cema-cel arm.
ViewPerformance
| 5D | 20D | 120D | MTD | YTD | |
|---|---|---|---|---|---|
| ALLO | -19.4% | -36.0% | -60.4% | -28.9% | -38.8% |
| SPY | +2.6% | -1.2% | +0.5% | -0.2% | +10.6% |
| vs SPY | -22.0% | -34.8% | -60.9% | -28.7% | -49.4% |