TNGX · Tango Therapeutics, Inc.

$23.34 -1.94 (-7.67%) At close · Aug 28

Russell 2000 member Rebalance outlook locked

Market Cap

$3.94B

168.61M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Quarter:

Holders: 248

Total Value: $6,701,652,185

Total Shares: 214,478,710

Showing 1–100 of 256 holdings by value · page 1 of 3

Institutional Ownership Trend

24 quarters

Holder Concentration

Across 248 13F filers · Δ vs Mar 31, 2026

Top Holder

6.5%

−0.9 pts

Top 5

28.8%

−3.0 pts

Top 10

46.6%

−7.1 pts

HHI

304

Broadly held−70

Quarterly Activity

vs Mar 31, 2026

New

Increased

103

Decreased

Sold Out

Unchanged

Holder count: +53

Institutional value: +77.5%

Shares held: +18.9%

Top Buyers

vs Mar 31, 2026

Institution	Added	Now Holds
Mega PRICE T ROWE ASSOCIATES INC /MD/	+5,459,427	6,348,827
Mega GOLDMAN SACHS GROUP INC	+4,904,228	9,980,620
Mega BlackRock, Inc.	+3,690,399	12,438,444
Large FARALLON CAPITAL MANAGEMENT LLC	+3,179,589	12,277,000
Small Seven Fleet Capital Management LP	+2,726,132	3,228,144

Top Sellers

vs Mar 31, 2026

Institution	Sold	Now Holds
Large ADAGE CAPITAL PARTNERS GP, L.L.C.	−7,209,485	5,600,000
Large Woodline Partners LP	−3,999,446	4,000,567
Large Balyasny Asset Management L.P.	−1,710,280	2,116,379
Mid Bellevue Group AG	−1,705,818	694,182
Large Holocene Advisors, LP	−1,521,664	2,410,939

Top New Positions

vs Mar 31, 2026

Institution	Acquired	Value (USD)
Mega Jupiter Topco LLC	5,056,352	$158,061,562
Mid Commodore Capital LP	2,250,000	$70,335,000
Large Jefferies Financial Group Inc.	2,010,534	$62,849,292
Large Polar Capital Holdings Plc	1,480,740	$46,287,932
Small DV EQUITIES, LLC	1,318,551	$41,217,904

Top Sold-Out Positions

vs Mar 31, 2026

Institution	Previously Held	Last Value (USD)
Mid Nextech Invest, Ltd.	7,266,081	$152,006,414
Mega JANUS HENDERSON GROUP PLC	2,394,972	$50,102,814
Mid Sofinnova Investments, Inc.	395,081	$8,265,094
Mid DV Trading LLC	300,648	$6,289,556
Small Parkman Healthcare Partners LLC	266,127	$5,567,376

Filter: New 78 Increased 103 Reduced 55 Sold out 25 Unchanged 12

Showing 100 of 256

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

RTW INVESTMENTS, LP

$434,533,381

6.48%

13,900,620

BlackRock, Inc.

$388,825,752

5.80%

12,438,444

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	218,968	$6,844,939	1.8%	Sole
BlackRock Investment Management (Australia) Ltd	333	$10,409	0.0%	Sole
BlackRock Asset Management Canada Ltd	22,242	$695,284	0.2%	Sole
BlackRock Investment Management, LLC	414,314	$12,951,455	3.3%	Sole
BLACKROCK ADVISORS LLC	893,782	$27,939,625	7.2%	Sole
BlackRock Fund Advisors	6,144,385	$192,073,475	49.4%	Sole
BlackRock Institutional Trust Company, N.A.	4,094,549	$127,995,601	32.9%	Sole
BlackRock Japan Co. Ltd	3,121	$97,562	0.0%	Sole
BlackRock Fund Managers Ltd.	17,563	$549,019	0.1%	Sole
BlackRock Investment Management (UK) Ltd.	51,342	$1,604,950	0.4%	Sole
BlackRock Asset Management Ireland Ltd	218,487	$6,829,903	1.8%	Sole
BlackRock (Luxembourg) S.A.	224,601	$7,021,027	1.8%	Sole
BlackRock Asset Management Schweiz AG	14,752	$461,147	0.1%	Sole
Aperio Group, LLC	120,005	$3,751,356	1.0%	Sole

FMR LLC

$385,540,174

5.75%

12,333,339

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	8,074,546	$252,410,307	65.5%	Defined
FIDELITY MANAGEMENT TRUST CO	3,578,244	$111,855,907	29.0%	Defined
STRATEGIC ADVISERS LLC	2	$62	0.0%	Defined
Fidelity Institutional Asset Management Trust Co	565,830	$17,687,845	4.6%	Defined
FIAM LLC	114,717	$3,586,053	0.9%	Defined

FARALLON CAPITAL MANAGEMENT LLC

$383,779,020

5.73%

12,277,000

Boxer Capital Management, LLC

$339,990,605

5.07%

10,876,219

GOLDMAN SACHS GROUP INC

$311,994,180

4.66%

9,980,620

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	9,648,092	$301,599,355	96.7%	Defined
GOLDMAN SACHS ASSET MANAGEMENT, L.P.	332,528	$10,394,825	3.3%	Defined

TCG Crossover Management, LLC

$283,878,343

4.24%

9,081,201

TRV GP IV, LLC

$199,269,183

2.97%

6,374,574

Paradigm Biocapital Advisors LP

$198,736,168

2.97%

6,357,523

PRICE T ROWE ASSOCIATES INC /MD/

$198,464,331

2.96%

6,348,827

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T. Rowe Price International Ltd	169,015	$5,283,408	2.7%	Defined
Held directly	6,179,812	$193,180,923	97.3%	Sole

Siren, L.L.C.

$193,166,918

2.88%

6,179,364

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invus Group, LLC	6,179,364	$193,166,918	100.0%	Defined

STATE STREET CORP

$186,928,735

2.79%

5,979,806

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STATE STREET GLOBAL ADVISORS EUROPE LIMITED joint	5,979,806	$186,928,735	100.0%	Defined

VANGUARD CAPITAL MANAGEMENT LLC

$186,226,698

2.78%

5,957,348

ADAGE CAPITAL PARTNERS GP, L.L.C.

$175,056,000

2.61%

5,600,000

Jupiter Topco LLC

$158,061,562

2.36%

5,056,352

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JANUS HENDERSON INVESTORS UK Ltd	49,769	$1,555,778	1.0%	Defined
JANUS HENDERSON INVESTORS US LLC	5,006,583	$156,505,784	99.0%	Defined

Deep Track Capital, LP

$131,292,000

1.96%

4,200,000

DEERFIELD MANAGEMENT COMPANY, L.P.

$130,998,499

1.95%

4,190,611

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Deerfield UGP, LLC	4,190,611	$130,998,499	100.0%	Defined

Woodline Partners LP

$125,057,724

1.87%

4,000,567

GEODE CAPITAL MANAGEMENT, LLC

$116,999,645

1.75%

3,742,791

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	481,211	$15,042,655	12.9%	Defined
Held directly	3,261,580	$101,956,990	87.1%	Defined

PERCEPTIVE ADVISORS LLC

$105,565,020

1.58%

3,377,000

Seven Fleet Capital Management LP

$100,911,781

1.51%

3,228,144

Logos Global Management LP

$89,091,000

1.33%

2,850,000

Caligan Partners LP

$78,153,219

1.17%

2,500,103

Holocene Advisors, LP

$75,365,953

1.12%

2,410,939

Commodore Capital LP

$70,335,000

1.05%

2,250,000

Balyasny Asset Management L.P.

$63,032,007

0.94%

2,016,379

Jefferies Financial Group Inc.

$62,849,292

0.94%

2,010,534

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jefferies Financial Services, Inc.	2,010,534	$62,849,292	100.0%	Defined

FRANKLIN RESOURCES INC

$58,994,215

0.88%

1,887,211

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
FIDUCIARY TRUST INTERNATIONAL LLC	951	$29,728	0.1%	Defined
FRANKLIN ADVISERS INC	1,883,125	$58,866,487	99.8%	Defined
PUTNAM ADVISORY CO LLC	3,135	$98,000	0.2%	Defined

Candriam S.C.A.

$50,971,086

0.76%

1,630,553

VANGUARD PORTFOLIO MANAGEMENT LLC

$49,550,569

0.74%

1,585,111

Polar Capital Holdings Plc

$46,287,932

0.69%

1,480,740

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Polar Capital LLP	1,480,740	$46,287,932	100.0%	Defined

JPMORGAN CHASE & CO

$44,332,711

0.66%

1,418,193

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
J.P. Morgan Trust Co of Delaware	628	$19,631	0.0%	Other
JPMorgan Chase Bank, N.A.	82,138	$2,567,633	5.8%	Defined
J.P. Morgan Investment Management Inc.	1,022,985	$31,978,511	72.1%	Defined
J.P. Morgan Securities plc	10,778	$336,920	0.8%	Defined
JPMorgan Asset Management (UK) Ltd	301,664	$9,430,016	21.3%	Defined

Vivo Capital, LLC

$43,131,578

0.64%

1,379,769

DV EQUITIES, LLC

$41,217,904

0.62%

1,318,551

Cormorant Asset Management, LP

$40,638,000

0.61%

1,300,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Chen Bihua	1,300,000	$40,638,000	100.0%	Defined

NORTHERN TRUST CORP

$38,510,223

0.57%

1,231,933

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	1,155,842	$36,131,620	93.8%	Defined
NORTHERN TRUST GLOBAL INVESTMENTS LTD	54,238	$1,695,479	4.4%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC joint	21,853	$683,124	1.8%	Other

STEMPOINT CAPITAL LP

$38,231,573

0.57%

1,223,019

FEDERATED HERMES, INC.

$37,968,802

0.57%

1,214,613

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
FEDERATED GLOBAL INVESTMENT MANAGEMENT CORP	862,328	$26,956,373	71.0%	Defined
FEDERATED MDTA LLC	352,285	$11,012,429	29.0%	Defined

VOYA INVESTMENT MANAGEMENT LLC

$34,480,716

0.51%

1,103,030

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Voya Investment Management Co. LLC joint	1,103,030	$34,480,716	100.0%	Defined

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$33,512,564

0.50%

1,072,059

AMERICAN CENTURY COMPANIES INC

$31,691,200

0.47%

1,013,794

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
AMERICAN CENTURY INVESTMENT MANAGEMENT INC	1,013,794	$31,691,200	100.0%	Defined

Integral Health Asset Management, LLC

$31,260,000

0.47%

1,000,000

VANGUARD FIDUCIARY TRUST CO

$28,620,561

0.43%

915,565

Nuveen, LLC

$27,826,713

0.42%

890,170

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Nuveen Asset Management, LLC joint	36,694	$1,147,054	4.1%	Defined
TIAA CREF INVESTMENT MANAGEMENT LLC joint	335,583	$10,490,324	37.7%	Defined
TEACHERS ADVISORS, LLC joint	517,893	$16,189,335	58.2%	Defined

SAMLYN CAPITAL, LLC

$23,959,944

0.36%

766,473

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SAMLYN ONSHORE FUND, LP joint	123,600	$3,863,736	16.1%	Defined
Samlyn Offshore Master Fund, Ltd.	292,563	$9,145,519	38.2%	Defined
Samlyn Net Neutral Master Fund, Ltd.	272,315	$8,512,566	35.5%	Defined
Samlyn Long Alpha Master Fund, Ltd.	77,995	$2,438,123	10.2%	Defined

RENAISSANCE TECHNOLOGIES LLC

$23,391,858

0.35%

748,300

Soleus Capital Management, L.P.

$22,163,340

0.33%

709,000

ArrowMark Colorado Holdings LLC

$22,144,115

0.33%

708,385

Bellevue Group AG

$21,700,129

0.32%

694,182

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BB Biotech AG joint	694,182	$21,700,129	100.0%	Defined

Alyeska Investment Group, L.P.

$21,604,067

0.32%

691,109

Connor, Clark & Lunn Investment Management Ltd.

$19,883,547

0.30%

636,070

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Manager 1	635,687	$19,871,575	99.9%	Sole
Held directly	383	$11,972	0.1%	Sole

BANK OF AMERICA CORP /DE/

$18,782,069

0.28%

600,834

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	403,214	$12,604,469	67.1%	Defined
BOFA SECURITIES, INC.	77,878	$2,434,466	13.0%	Defined
MANAGED ACCOUNT ADVISORS LLC joint	119,742	$3,743,134	19.9%	Defined

Pictet Asset Management Holding SA

$18,201,510

0.27%

582,262

Fisher Asset Management, LLC

$18,073,219

0.27%

578,158

LORD, ABBETT & CO. LLC

$16,633,727

0.25%

532,109

JANE STREET GROUP, LLC

$16,075,923

0.24%

514,265

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	299,264	$9,354,992	58.2%	Defined
Jane Street Global Trading, LLC	215,001	$6,720,931	41.8%	Defined

MORGAN STANLEY

$15,966,918

0.24%

510,778

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	2,698	$84,339	0.5%	Defined
MORGAN STANLEY & CO. LLC	360,781	$11,278,014	70.6%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	99,975	$3,125,218	19.6%	Defined
MORGAN STANLEY SMITH BARNEY LLC	5,277	$164,959	1.0%	Defined
Morgan Stanley Strategic Investments, Inc	1	$31	0.0%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	42,046	$1,314,357	8.2%	Defined

FIRST TRUST ADVISORS LP

$15,920,999

0.24%

509,309

Nantahala Capital Management, LLC

$15,650,600

0.23%

500,659

BOOTHBAY FUND MANAGEMENT, LLC

$15,645,536

0.23%

500,497

MILLENNIUM MANAGEMENT LLC

$15,506,085

0.23%

496,036

DIMENSIONAL FUND ADVISORS LP

$15,264,256

0.23%

488,300

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DFA Australia Ltd.	6,919	$216,287	1.4%	Defined
Dimensional Ireland Ltd	16,357	$511,319	3.3%	Defined
Held directly	465,024	$14,536,650	95.2%	Sole

Invesco Ltd.

$14,464,656

0.22%

462,721

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invesco Advisers, Inc. joint	21,411	$669,307	4.6%	Defined
Invesco Trust Co joint	55,591	$1,737,774	12.0%	Defined
Invesco Capital Management LLC	385,719	$12,057,575	83.4%	Defined

Rock Springs Capital Management LP

$14,271,784

0.21%

456,551

BOONE CAPITAL MANAGEMENT LLC

$14,242,212

0.21%

455,605

Longaeva Partners L.P.

$12,969,836

0.19%

414,902

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Balyasny Asset Management L.P.	414,902	$12,969,836	100.0%	Other

EVENTIDE ASSET MANAGEMENT, LLC

$12,504,000

0.19%

400,000

ACUTA CAPITAL PARTNERS, LLC

$12,221,065

0.18%

390,949

Bank of New York Mellon Corp

$12,220,155

0.18%

390,920

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BNY Mellon Trust of Delaware joint	65	$2,031	0.0%	Defined
Mellon Investments Corporation joint	135,662	$4,240,793	34.7%	Defined
The Bank of New York Mellon	250,414	$7,827,941	64.1%	Defined
BNY Mellon, NA joint	1,060	$33,135	0.3%	Defined
BNY Mellon Advisors, Inc. joint	3,718	$116,224	1.0%	Other
Held directly	1	$31	0.0%	Defined

UBS Group AG

$11,994,272

0.18%

383,694

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Financial Services Inc	2,718	$84,964	0.7%	Defined
UBS AG	378,153	$11,821,062	98.6%	Defined
UBS Switzerland AG	2,823	$88,246	0.7%	Defined

CONGRESS ASSET MANAGEMENT CO

$11,902,119

0.18%

380,746

BESSEMER GROUP INC

$11,072,479

0.17%

354,206

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BESSEMER TRUST Co NATIONAL ASSOCIATION	354,206	$11,072,479	100.0%	Defined

Mass General Brigham, Inc

$11,072,041

0.17%

354,192

LMR Partners LLP

$10,850,533

0.16%

347,106

Assenagon Asset Management S.A.

$10,789,576

0.16%

345,156

BAKER BROS. ADVISORS LP

$10,419,989

0.16%

333,333

PFM Health Sciences, LP

$10,192,229

0.15%

326,047

AMERIPRISE FINANCIAL INC

$9,576,344

0.14%

306,345

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Columbia Management Investment Advisers, LLC	306,345	$9,576,344	100.0%	Defined

Point72 Asset Management, L.P.

$9,326,077

0.14%

298,339

WELLINGTON MANAGEMENT GROUP LLP

$9,287,531

0.14%

297,106

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Wellington Management Company LLP	101,121	$3,161,042	34.0%	Defined
Wellington Managment Canada LLC	1,172	$36,636	0.4%	Defined
Wellington Trust Company, NA joint	177,280	$5,541,772	59.7%	Defined
Wellington Management Australia Pty Ltd	14,850	$464,211	5.0%	Defined
Wellington Management Europe GmbH	2,683	$83,870	0.9%	Defined

Handelsbanken Fonder AB

$8,999,754

0.13%

287,900

Russell Investments Group, Ltd.

$8,803,845

0.13%

281,633

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Russell Investment Management, LLC	136,239	$4,258,830	48.4%	Defined
Russell Investments Capital, LLC	86,734	$2,711,304	30.8%	Defined
Russell Investments France SAS	20,443	$639,048	7.3%	Defined
Russell Investments Trust Company	38,217	$1,194,663	13.6%	Defined

SCHRODER INVESTMENT MANAGEMENT GROUP

$8,706,253

0.13%

278,511

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Schroder Investment Management Limited	278,511	$8,706,253	100.0%	Sole

ALGERT GLOBAL LLC

$8,489,278

0.13%

271,570

HighVista Strategies LLC

$8,129,788

0.12%

260,070

SPHERA FUNDS MANAGEMENT LTD.

$7,947,855

0.12%

254,250

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Sphera Global Healthcare Management LP joint	254,250	$7,947,855	100.0%	Defined

T. Rowe Price Investment Management, Inc.

$7,880,927

0.12%

252,109

TWO SIGMA INVESTMENTS, LP

$7,558,136

0.11%

241,783

KVP Capital Advisors, LP

$7,198,052

0.11%

230,264

TD Asset Management Inc

$6,938,719

0.10%

221,968

Sio Capital Management, LLC

$6,517,710

0.10%

208,500

Atle Fund Management AB

$6,206,891

0.09%

198,557

TRV GP VI, LLC

$6,069,879

0.09%

194,174

Walleye Capital LLC

$6,010,360

0.09%

192,270

Swiss National Bank

$5,858,124

0.09%

187,400

MANUFACTURERS LIFE INSURANCE COMPANY, THE

$5,664,687

0.08%

181,212

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MANULIFE FINANCIAL CORP joint	181,212	$5,664,687	100.0%	Defined

CITADEL ADVISORS LLC

$5,659,904

0.08%

181,059

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	126,300	$3,948,138	69.8%	Defined
Held directly	54,759	$1,711,766	30.2%	Defined

VICTORY CAPITAL MANAGEMENT INC

$5,525,142

0.08%

176,748

RHUMBLINE ADVISERS

$5,474,657

0.08%

175,133

MARSHALL WACE, LLP

$5,467,654

0.08%

174,909

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Marshall Wace North America L.P. joint	174,909	$5,467,654	100.0%	Other

Key facts CIK 1819133 CUSIP 87583X109 13F (30d) 228 filings 225 filers Visit website Investor relations