SPHERA FUNDS MANAGEMENT LTD.

CIK

1496201

Location

TEL AVIV, L3

Portfolio Value

Small $725,146,283

Diversification

Diversified

Reports for

Sphera Global Healthcare Management LP Sphera Global Healthcare GP Ltd.

Filing Date

Global Rank

#2,340 / 8,700 ▲ 828

Top Industry

Biotechnology 64.0%

Period ended 2 months ago

Filed Aug 14, 2026 · 29d

26 quarters · since Mar 2020

Portfolio Concentration

97 tracked positions · as of Jun 30, 2026 · Δ vs Mar 31, 2026

Top Position

7.0%

+0.9 pts

Top 5

26.0%

+1.8 pts

Top 10

39.3%

+0.2 pts

HHI

237

Diversified+6

Portfolio Trend

26 quarters · across all stocks

Sector Breakdown

As of Jun 30, 2026

Sector	% Portfolio	Value	Positions
Healthcare	90.0%	$652,445,388	89
Technology	8.0%	$57,868,970	4
Utilities	2.0%	$14,831,925	4

Last Quarter's Activity

Export CSV

Jun 30, 2026 vs Mar 31, 2026

Added To

Positions the filer increased

25 positions

Ticker	Company	Δ Shares	Shares	Value
CTMX	CytomX Therapeutics, Inc.	+659,000	879,000	$3,296,250
HELP	Cybin Inc.	+633,663	1,620,753	$10,713,177
PALI	Palisade Bio, Inc.	+523,635	2,257,106	$4,717,351
PRLD	Prelude Therapeutics Inc	+461,493	1,019,832	$5,435,704
TEVA	Teva Pharmaceutical Industries Ltd	+363,107	1,500,082	$50,822,778
ORIC	Oric Pharmaceuticals, Inc.	+315,355	852,983	$9,237,805
SNDX	Syndax Pharmaceuticals Inc	+290,043	1,014,606	$22,179,287
VSTM	Verastem, Inc.	+288,954	632,632	$2,416,654
MAZE	Maze Therapeutics, Inc.	+190,221	417,564	$12,460,109
BMRN	Biomarin Pharmaceutical Inc	+188,650	328,550	$18,799,631
MSLE	Satellos Bioscience Inc.	+163,383	652,590	$5,073,887
MLYS	Mineralys Therapeutics, Inc.	+130,000	1,469,971	$39,659,817
BIOA	BioAge Labs, Inc.	+127,153	213,671	$5,237,076
TENX	Tenax Therapeutics, Inc.	+111,785	247,800	$3,605,490
BIIB	Biogen Inc.	+104,100	196,626	$42,483,013
ACAD	Acadia Pharmaceuticals Inc	+100,332	356,534	$9,020,310
PFE	Pfizer Inc	+100,000	286,000	$6,886,880
VOR	Vor Biopharma Inc.	+94,500	416,417	$7,666,236
WVE	Wave Life Sciences, Inc.	+90,000	638,272	$3,708,360
—		+64,709	249,693	$5,305,976
CLYM	Climb Bio, Inc.	+64,500	483,747	$6,308,060
GENB	Generate Biomedicines, Inc.	+60,000	245,000	$4,133,150
COGT	Cogent Biosciences, Inc.	+43,000	459,340	$17,776,458
DYN	Dyne Therapeutics, Inc.	+39,000	199,594	$4,432,982
IMTX	Immatics N.V.	+23,952	720,057	$7,294,177
No positions match the current search.

Trimmed

Positions the filer reduced

25 positions

Ticker	Company	Δ Shares	Shares	Value
CRIS	Curis Inc	−1,895,941	98,996	$51,477
ELDN	Eledon Pharmaceuticals, Inc.	−580,944	1,191,187	$4,693,276
BCRX	Biocryst Pharmaceuticals Inc	−444,413	422,051	$4,220,510
BHVN	Biohaven Ltd.	−429,563	164,437	$2,446,822
OVID	Ovid Therapeutics Inc.	−269,828	1,353,000	$3,639,570
RARE	Ultragenyx Pharmaceutical Inc.	−220,839	588,494	$19,649,814
STTK	Shattuck Labs, Inc.	−194,325	86,461	$600,039
RLAY	Relay Therapeutics, Inc.	−174,600	233,836	$4,375,071
UPB	Upstream Bio, Inc.	−138,300	219,700	$1,520,324
TNGX	Tango Therapeutics, Inc.	−89,313	254,250	$7,947,855
TRVI	Trevi Therapeutics, Inc.	−75,000	499,029	$9,306,890
EVMN	Evommune, Inc.	−55,602	22,632	$300,779
VYGR	Voyager Therapeutics, Inc.	−42,207	427,554	$1,496,439
ELVN	Enliven Therapeutics, Inc.	−40,500	112,765	$5,722,823
ORA	Ormat Technologies, Inc.	−40,235	28,015	$3,050,833
TSEM	Tower Semiconductor Ltd	−37,470	108,265	$28,218,189
KOD	Kodiak Sciences Inc.	−33,000	81,796	$3,186,772
RVMD	Revolution Medicines, Inc.	−32,710	22,400	$4,195,072
NVMI	Nova Ltd.	−28,197	25,169	$13,665,256
GPCR	Structure Therapeutics Inc.	−22,200	28,600	$1,534,962
XENE	Xenon Pharmaceuticals Inc.	−22,000	105,000	$6,337,800
ACOG	Alpha Cognition Inc.	−21,800	545,816	$3,940,791
GSK	GSK plc	−20,000	102,000	$5,346,840
CRVS	Corvus Pharmaceuticals, Inc.	−3,000	244,961	$3,659,717
CLDX	Celldex Therapeutics, Inc.	−2,707	240,868	$8,962,698
No positions match the current search.

New Positions

Positions the filer opened this quarter

23 positions

Ticker	Company	Shares	Value
INSM	INSMED Inc	118,800	$12,666,456
RYTM	Rhythm Pharmaceuticals, Inc.	80,400	$8,926,812
LRCX	Lam Research Corp	18,470	$8,003,605
AMAT	Applied Materials Inc /De	11,040	$7,981,920
IDYA	IDEAYA Biosciences, Inc.	196,408	$7,320,126
NVCT	Nuvectis Pharma, Inc.	382,945	$7,042,358
HRMY	Harmony Biosciences Holdings, Inc.	176,663	$6,432,299
VST	Vistra Corp.	29,450	$4,671,653
TLN	Talen Energy Corp	12,135	$4,662,995
AVTX	Avalo Therapeutics, Inc.	232,294	$4,292,793
PRAX	Praxis Precision Medicines, Inc.	12,500	$4,184,875
CABA	Cabaletta Bio, Inc.	1,329,012	$4,133,227
BBOT	BridgeBio Oncology Therapeutics, Inc.	460,985	$3,512,705
PRQR	ProQR Therapeutics N.V.	1,757,458	$3,268,871
ALNY	Alnylam Pharmaceuticals, Inc.	10,800	$3,251,124
LRMR	Larimar Therapeutics, Inc.	926,004	$2,824,312
IMMX	Immix Biopharma, Inc.	270,000	$2,783,700
ABVX	Abivax S.A.	20,000	$2,665,200
CEG	Constellation Energy Corp	9,850	$2,446,444
TSHA	Taysha Gene Therapies, Inc.	250,000	$1,702,500
IKT	Inhibikase Therapeutics, Inc.	649,309	$1,318,097
TRAX	First Tracks Biotherapeutics, Inc.	27,876	$560,865
TRAW	Traws Pharma, Inc.	398,486	$334,728
No positions match the current search.

Sold Out

Positions the filer fully exited

20 positions

Ticker	Company	Shares	Value
BWX	State Street SPDR Bloomberg International Treasury Bond ETF	200,000	$25,546,000
CLBT	Cellebrite DI Ltd.	631,521	$8,702,359
PANW	Palo Alto Networks Inc	52,800	$8,464,896
CAMT	Camtek Ltd	53,020	$8,038,362
AMZN	Amazon Com Inc	31,940	$6,652,143
AAOI	Applied Optoelectronics, Inc.	73,400	$6,208,906
ENPH	Enphase Energy, Inc.	142,419	$5,384,862
AAXJ	iShares MSCI All Country Asia ex Japan ETF	47,000	$4,074,430
ZIM	ZIM Integrated Shipping Services Ltd.	105,950	$2,791,782
SEDG	Solaredge Technologies, Inc.	52,836	$2,697,277
IBIT	iShares Bitcoin Trust ETF	59,505	$2,286,182
ASND	Ascendis Pharma A/S	8,000	$1,829,840
OLMA	Olema Pharmaceuticals, Inc.	100,000	$1,491,000
BMY	Bristol Myers Squibb Co	17,500	$1,061,375
NICE	NICE Ltd.	5,611	$618,668
DTIL	Precision Biosciences Inc	40,000	$220,000
FHTX	Foghorn Therapeutics Inc.	12,224	$58,430
—		214,914	$0
—		216,281	$0
—		603,377	$0
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

97 tracked positions · $725,146,283 total · filing declares 106 positions · $766,539,858 · as of Jun 30, 2026

All sectors Healthcare Technology Utilities

Showing 1–50 of 97 positions by value · page 1 of 2

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
TEVA	Teva Pharmaceutical Industries Ltd Healthcare	Added	1,500,082	+363,107	$50,822,778	+48.4%	7.01%
BIIB	Biogen Inc. CALL + SHARES Healthcare	Added	196,626	+104,100	$42,483,013	+150.4%	5.86%
MLYS	Mineralys Therapeutics, Inc. Healthcare	Added	1,469,971	+130,000	$39,659,817	+9.3%	5.47%
TSEM	Tower Semiconductor Ltd Technology	Reduced	108,265	-37,470	$28,218,189	+10.3%	3.89%
CYTK	Cytokinetics Inc CALL + SHARES Healthcare	Added	319,987	+20,870	$27,259,692	+38.3%	3.76%
SNDX	Syndax Pharmaceuticals Inc Healthcare	Added	1,014,606	+290,043	$22,179,287	+31.0%	3.06%
RARE	Ultragenyx Pharmaceutical Inc. Healthcare	Reduced	588,494	-220,839	$19,649,814	+15.9%	2.71%
BMRN	Biomarin Pharmaceutical Inc Healthcare	Added	328,550	+188,650	$18,799,631	+137.9%	2.59%
BBIO	BridgeBio Pharma, Inc. Healthcare	Added	245,346	+100	$18,273,370	+0.3%	2.52%
COGT	Cogent Biosciences, Inc. Healthcare	Added	459,340	+43,000	$17,776,458	+10.9%	2.45%
NVMI	Nova Ltd. Technology	Reduced	25,169	-28,197	$13,665,256	−41.0%	1.88%
INSM	INSMED Inc Healthcare	NEW	118,800	NEW	$12,666,456	NEW	1.75%
MAZE	Maze Therapeutics, Inc. Healthcare	Added	417,564	+190,221	$12,460,109	+83.6%	1.72%
AZN	Astrazeneca PLC Healthcare	Held	62,530	0	$11,856,938	−3.9%	1.64%
SNY	Sanofi Healthcare	Held	269,515	0	$11,497,509	−11.5%	1.59%
HELP	Cybin Inc. Healthcare	Added	1,620,753	+633,663	$10,713,177	+126.1%	1.48%
LLY	ELI LILLY & Co Healthcare	Reduced	8,040	-1,000	$9,643,418	+16.0%	1.33%
MDGL	Madrigal Pharmaceuticals, Inc. Healthcare	Added	17,419	+8,379	$9,353,132	+97.7%	1.29%
TRVI	Trevi Therapeutics, Inc. Healthcare	Reduced	499,029	-75,000	$9,306,890	+35.9%	1.28%
ORIC	Oric Pharmaceuticals, Inc. CALL + SHARES Healthcare	Added	852,983	+315,355	$9,237,805	+35.6%	1.27%
ACAD	Acadia Pharmaceuticals Inc Healthcare	Added	356,534	+100,332	$9,020,310	+58.2%	1.24%
CLDX	Celldex Therapeutics, Inc. Healthcare	Reduced	240,868	-2,707	$8,962,698	+16.0%	1.24%
RYTM	Rhythm Pharmaceuticals, Inc. Healthcare	NEW	80,400	NEW	$8,926,812	NEW	1.23%
LRCX	Lam Research Corp Technology	NEW	18,470	NEW	$8,003,605	NEW	1.10%
AMAT	Applied Materials Inc /De Technology	NEW	11,040	NEW	$7,981,920	NEW	1.10%
TNGX	Tango Therapeutics, Inc. Healthcare	Reduced	254,250	-89,313	$7,947,855	+10.6%	1.10%
NVS	Novartis AG Healthcare	Added	50,000	+13,000	$7,836,000	+38.6%	1.08%
VOR	Vor Biopharma Inc. Healthcare	Added	416,417	+94,500	$7,666,236	+33.5%	1.06%
ABBV	AbbVie Inc. Healthcare	Held	30,256	0	$7,613,619	+15.7%	1.05%
MRK	Merck & Co., Inc. Healthcare	Added	58,600	+10,000	$7,530,100	+28.8%	1.04%
JNJ	Johnson & Johnson Healthcare	Held	28,831	0	$7,322,209	+3.9%	1.01%
IDYA	IDEAYA Biosciences, Inc. Healthcare	NEW	196,408	NEW	$7,320,126	NEW	1.01%
IMTX	Immatics N.V. Healthcare	Added	720,057	+23,952	$7,294,177	+6.5%	1.01%
NVCT	Nuvectis Pharma, Inc. Healthcare	NEW	382,945	NEW	$7,042,358	NEW	0.97%
PFE	Pfizer Inc Healthcare	Added	286,000	+100,000	$6,886,880	+31.9%	0.95%
HRMY	Harmony Biosciences Holdings, Inc. Healthcare	NEW	176,663	NEW	$6,432,299	NEW	0.89%
XENE	Xenon Pharmaceuticals Inc. Healthcare	Reduced	105,000	-22,000	$6,337,800	−14.2%	0.87%
CLYM	Climb Bio, Inc. Healthcare	Added	483,747	+64,500	$6,308,060	+119.7%	0.87%
ZBIO	Zenas BioPharma, Inc. Healthcare	Added	230,834	+16,500	$5,858,566	+39.8%	0.81%
NVO	Novo Nordisk A S Healthcare	Held	120,677	0	$5,785,255	+30.4%	0.80%
ELVN	Enliven Therapeutics, Inc. Healthcare	Reduced	112,765	-40,500	$5,722,823	−4.7%	0.79%
PRLD	Prelude Therapeutics Inc Healthcare	Added	1,019,832	+461,493	$5,435,704	+184.7%	0.75%
GSK	GSK plc Healthcare	Reduced	102,000	-20,000	$5,346,840	−20.6%	0.74%
		Added	249,693	+64,709	$5,305,976	+10.7%	0.73%
BIOA	BioAge Labs, Inc. Healthcare	Added	213,671	+127,153	$5,237,076	+246.1%	0.72%
SRRK	Scholar Rock Holding Corp Healthcare	Held	94,265	0	$5,184,575	+11.9%	0.71%
MSLE	Satellos Bioscience Inc. Healthcare	Added	652,590	+163,383	$5,073,887	+84.2%	0.70%
PALI	Palisade Bio, Inc. Healthcare	Added	2,257,106	+523,635	$4,717,351	+55.5%	0.65%
ELDN	Eledon Pharmaceuticals, Inc. Healthcare	Reduced	1,191,187	-580,944	$4,693,276	−14.0%	0.65%
VST	Vistra Corp. Utilities	NEW	29,450	NEW	$4,671,653	NEW	0.64%

Covers the securities this platform tracks: U.S.-listed common stock and the put/call positions reported on it. A 13F can also report security types outside that coverage — preferred shares, bonds, warrants, untracked share classes — so the filing's own declared total can exceed the figures above. The source filing is linked at the top of this table.