Mid
Frazier Life Sciences Management, L.P.
$150,182,183
8.59%
5,032,915
9.060%
+465,641
+10.2%
Shares
2026-08-14
Small
TRV GP IV, LLC
$133,502,906
7.63%
4,473,958
8.054%
0
0.0%
Shares
2026-08-10
Mid
ARCH Venture Management, LLC
$122,942,381
7.03%
4,120,053
7.417%
0
0.0%
Shares
2026-08-14
Mid
Deep Track Capital, LP
$111,379,858
6.37%
3,732,569
6.719%
+255,007
+7.3%
Shares
2026-08-14
Mega
BlackRock, Inc.
10
$104,524,771
5.98%
3,502,841
6.306%
+932,416
+36.3%
Shares
2026-08-07
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE
87,225
$2,602,794
2.5%
Sole
BlackRock Asset Management Canada Ltd
203
$6,057
0.0%
Sole
BlackRock Investment Management, LLC
116,202
$3,467,467
3.3%
Sole
BLACKROCK ADVISORS LLC
323,907
$9,665,384
9.2%
Sole
BlackRock Fund Advisors
1,758,099
$52,461,674
50.2%
Sole
BlackRock Institutional Trust Company, N.A.
952,885
$28,434,088
27.2%
Sole
BlackRock Investment Management (UK) Ltd.
17,792
$530,913
0.5%
Sole
BlackRock Asset Management Ireland Ltd
60,907
$1,817,464
1.7%
Sole
BlackRock (Luxembourg) S.A.
173,705
$5,183,357
5.0%
Sole
Aperio Group, LLC
11,916
$355,573
0.3%
Sole
Mega
Jupiter Topco LLC
2
$101,696,062
5.81%
3,408,045
6.135%
New
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
JANUS HENDERSON INVESTORS UK Ltd
10,600
$316,304
0.3%
Defined
JANUS HENDERSON INVESTORS US LLC
3,397,445
$101,379,758
99.7%
Defined
Mega
T. Rowe Price Investment Management, Inc.
$77,693,870
4.44%
2,603,682
4.687%
New
Shares
2026-08-14
Mid
Logos Global Management LP
$57,740,400
3.30%
1,935,000
3.483%
+700,000
+56.7%
Shares
2026-08-14
Mega
VANGUARD CAPITAL MANAGEMENT LLC
$53,062,144
3.03%
1,778,222
3.201%
+342,566
+23.9%
Shares
2026-08-13
Large
a16z Capital Management, L.L.C.
$50,794,394
2.90%
1,702,225
3.064%
0
0.0%
Shares
2026-08-14
Mid
Venrock Adviser, LLC
$47,804,694
2.73%
1,602,034
2.884%
0
0.0%
Shares
2026-08-14
Large
Alphabet Inc.
1
$41,435,316
2.37%
1,388,583
2.500%
0
0.0%
Shares
2026-08-07
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
GV Management Company, L.L.C.
1,388,583
$41,435,316
100.0%
Defined
Mid
BRAIDWELL LP
$34,018,793
1.94%
1,140,040
2.052%
New
Shares
2026-08-14
Large
FARALLON CAPITAL MANAGEMENT LLC
$33,057,169
1.89%
1,107,814
1.994%
+734,814
+197.0%
Shares
2026-08-14
Mega
FMR LLC
3
$31,539,655
1.80%
1,056,959
1.903%
+192,745
+22.3%
Shares
2026-08-13
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Fidelity Management & Research Co LLC
914,801
$27,297,661
86.6%
Defined
FIDELITY MANAGEMENT TRUST CO
141,150
$4,211,916
13.4%
Defined
STRATEGIC ADVISERS LLC
1,008
$30,078
0.1%
Defined
Small
General Catalyst Group Management, LLC
$30,911,554
1.77%
1,035,910
1.865%
0
0.0%
Shares
2026-08-17
Mega
STATE STREET CORP
1
$29,766,384
1.70%
997,533
1.796%
+360,811
+56.7%
Shares
2026-08-07
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
STATE STREET GLOBAL ADVISORS EUROPE LIMITED
joint
997,533
$29,766,384
100.0%
Defined
Mega
JPMORGAN CHASE & CO
4
$28,766,086
1.64%
964,011
1.735%
+905,565
+1549.4%
Shares
2026-08-12
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
JPMorgan Chase Bank, N.A.
31,458
$938,706
3.3%
Defined
J.P. Morgan Investment Management Inc.
707,191
$21,102,579
73.4%
Defined
J.P. Morgan Securities plc
4,361
$130,132
0.5%
Defined
JPMorgan Asset Management (UK) Ltd
221,001
$6,594,669
22.9%
Defined
Large
Driehaus Capital Management LLC
$28,493,798
1.63%
954,886
1.719%
+318,724
+50.1%
Shares
2026-08-14
Small
TRV GP V, LLC
$28,371,872
1.62%
950,800
1.712%
0
0.0%
Shares
2026-08-10
Large
MARSHALL WACE, LLP
1
$27,290,828
1.56%
914,572
1.646%
+603,933
+194.4%
Shares
2026-08-13
This filing is a combination report: the position is filed across the managers below.
Mega
GEODE CAPITAL MANAGEMENT, LLC
2
$25,604,330
1.46%
858,054
1.545%
+258,087
+43.0%
Shares
2026-08-12
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC
117,428
$3,504,051
13.7%
Defined
Held directly
740,626
$22,100,279
86.3%
Defined
Mega
CITADEL ADVISORS LLC
2
$25,443,851
1.45%
852,676
1.535%
+76,962
+9.9%
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Citadel Securities GP LLC
223,876
$6,680,459
26.3%
Defined
Held directly
628,800
$18,763,392
73.7%
Defined
Mid
Casdin Capital, LLC
$25,180,692
1.44%
843,857
1.519%
+85,000
+11.2%
Shares
2026-08-14
Mid
ArrowMark Colorado Holdings LLC
$22,898,708
1.31%
767,383
1.381%
0
0.0%
Shares
2026-08-13
Large
Woodline Partners LP
$21,968,685
1.26%
736,216
1.325%
+85,987
+13.2%
Shares
2026-08-14
Large
BESSEMER GROUP INC
1
$14,376,613
0.82%
481,790
0.867%
0
0.0%
Shares
2026-08-12
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
BESSEMER TRUST Co NATIONAL ASSOCIATION
481,790
$14,376,613
100.0%
Defined
Small
SPHERA FUNDS MANAGEMENT LTD.
1
$12,460,109
0.71%
417,564
0.752%
+190,221
+83.7%
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Sphera Global Healthcare Management LP
joint
417,564
$12,460,109
100.0%
Defined
Mega
VANGUARD PORTFOLIO MANAGEMENT LLC
$11,730,312
0.67%
393,107
0.708%
+197,565
+101.0%
Shares
2026-08-13
Large
Aberdeen Group plc
1
$11,451,786
0.65%
383,773
0.691%
+157,546
+69.6%
Shares
2026-07-31
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
abrdn Inc.
383,773
$11,451,786
100.0%
Defined
Small
Ikarian Capital, LLC
$11,309,330
0.65%
378,999
0.682%
0
0.0%
Shares
2026-08-14
Small
HHLR ADVISORS, LTD.
1
$10,922,275
0.62%
366,028
0.659%
0
0.0%
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Mid
ADAR1 Capital Management, LLC
$10,123,995
0.58%
339,276
0.611%
+289,181
+577.3%
Shares
2026-08-14
Small
Squadron Capital Management LLC
$9,996,400
0.57%
335,000
0.603%
+77,500
+30.1%
Shares
2026-08-14
Mega
BANK OF AMERICA CORP /DE/
Bank
2
$9,585,413
0.55%
321,227
0.578%
+126,143
+64.7%
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
BANK OF AMERICA NA
311,927
$9,307,901
97.1%
Defined
BOFA SECURITIES, INC.
9,300
$277,512
2.9%
Defined
Mega
NORTHERN TRUST CORP
Bank
2
$8,795,100
0.50%
294,742
0.531%
+83,360
+39.4%
Shares
2026-08-13
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
NORTHERN TRUST CO
joint
289,197
$8,629,638
98.1%
Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC
joint
5,545
$165,462
1.9%
Other
Mega
GOLDMAN SACHS GROUP INC
2
$8,747,416
0.50%
293,144
0.528%
+13,431
+4.8%
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Large
Candriam S.C.A.
$8,174,130
0.47%
273,932
0.493%
-4,235
-1.5%
Shares
2026-08-13
Large
Hudson Bay Capital Management LP
$8,056,800
0.46%
270,000
0.486%
+261,850
+3212.9%
Shares
2026-08-14
Mega
CHARLES SCHWAB INVESTMENT MANAGEMENT INC
$7,775,289
0.44%
260,566
0.469%
+74,133
+39.8%
Shares
2026-08-14
Large
ADAGE CAPITAL PARTNERS GP, L.L.C.
$7,400,320
0.42%
248,000
0.446%
-930,000
-78.9%
Shares
2026-08-14
Small
Mass General Brigham, Inc
$7,161,420
0.41%
239,994
0.432%
0
0.0%
Shares
2026-08-07
Mega
AMERIPRISE FINANCIAL INC
1
$6,786,362
0.39%
227,425
0.409%
+119,939
+111.6%
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Columbia Management Investment Advisers, LLC
227,425
$6,786,362
100.0%
Defined
Mega
VANGUARD FIDUCIARY TRUST CO
Bank
$6,562,949
0.38%
219,938
0.396%
+68,938
+45.7%
Shares
2026-08-13
Large
RTW INVESTMENTS, LP
$6,326,080
0.36%
212,000
0.382%
New
Shares
2026-08-14
Mega
SCHRODER INVESTMENT MANAGEMENT GROUP
1
$5,964,180
0.34%
199,872
0.360%
+162,691
+437.6%
Shares
2026-08-13
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Schroder Investment Management Limited
199,872
$5,964,180
100.0%
Sole
Mega
TWO SIGMA INVESTMENTS, LP
$5,757,687
0.33%
192,952
0.347%
+177,107
+1117.7%
Shares
2026-08-14
Mid
BOOTHBAY FUND MANAGEMENT, LLC
$5,635,492
0.32%
188,857
0.340%
-95,619
-33.6%
Shares
2026-08-14
Large
ExodusPoint Capital Management, LP
$5,468,597
0.31%
183,264
0.330%
New
Shares
2026-08-14
Mid
SummitTX Capital, L.P.
$5,260,523
0.30%
176,291
0.317%
+92,541
+110.5%
Shares
2026-08-14
Small
HighVista Strategies LLC
$4,075,308
0.23%
136,572
0.246%
+36,722
+36.8%
Shares
2026-08-14
Mega
MORGAN STANLEY
4
$4,033,411
0.23%
135,168
0.243%
-69,663
-34.0%
Shares
2026-08-13
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC
58
$1,730
0.0%
Defined
MORGAN STANLEY & CO. LLC
107,904
$3,219,855
79.8%
Defined
MORGAN STANLEY CAPITAL SERVICES, LLC
15,546
$463,892
11.5%
Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC
11,660
$347,934
8.6%
Defined
Mega
PRICE T ROWE ASSOCIATES INC /MD/
2
$3,964,840
0.23%
132,870
0.239%
+10,175
+8.3%
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
T. Rowe Price International Ltd
28,986
$864,942
21.8%
Defined
Held directly
103,884
$3,099,898
78.2%
Sole
Mega
Qube Research & Technologies Ltd
$3,910,323
0.22%
131,043
0.236%
-3,907
-2.9%
Shares
2026-08-14
Large
Walleye Capital LLC
$3,819,699
0.22%
128,006
0.230%
+100,061
+358.1%
Shares
2026-08-03
Small
Exome Asset Management LLC
$3,422,409
0.20%
114,692
0.206%
+26,182
+29.6%
Shares
2026-08-14
Large
Ensign Peak Advisors, Inc
$3,033,056
0.17%
101,644
0.183%
-84,150
-45.3%
Shares
2026-08-14
Large
Alyeska Investment Group, L.P.
$2,984,000
0.17%
100,000
0.180%
0
0.0%
Shares
2026-08-14
Mega
Bank of New York Mellon Corp
Bank
4
$2,912,024
0.17%
97,588
0.176%
+23,320
+31.4%
Shares
2026-08-06
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Mellon Investments Corporation
32,841
$979,975
33.7%
Defined
The Bank of New York Mellon
64,661
$1,929,484
66.3%
Defined
BNY Mellon, NA
joint
85
$2,536
0.1%
Defined
Held directly
1
$29
0.0%
Defined
Mid
ALGERT GLOBAL LLC
$2,785,772
0.16%
93,357
0.168%
New
Shares
2026-08-13
Mega
UBS Group AG
2
$2,526,820
0.14%
84,679
0.152%
-9,219
-9.8%
Shares
2026-08-13
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
UBS AG
84,557
$2,523,180
99.9%
Defined
UBS Securities LLC
122
$3,640
0.1%
Defined
Mega
WELLINGTON MANAGEMENT GROUP LLP
3
$2,468,482
0.14%
82,724
0.149%
+22,137
+36.5%
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Wellington Management Company LLP
26,215
$782,255
31.7%
Defined
Wellington Trust Company, NA
joint
53,033
$1,582,504
64.1%
Defined
Wellington Management Australia Pty Ltd
3,476
$103,723
4.2%
Defined
Large
Trexquant Investment LP
$2,436,973
0.14%
81,668
0.147%
New
Shares
2026-08-14
Mega
FRANKLIN RESOURCES INC
2
$2,393,645
0.14%
80,216
0.144%
+20,579
+34.5%
Shares
2026-08-13
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
FRANKLIN ADVISERS INC
77,785
$2,321,104
97.0%
Defined
PUTNAM ADVISORY CO LLC
2,431
$72,541
3.0%
Defined
Mega
Nuveen, LLC
2
$2,341,485
0.13%
78,468
0.141%
+15,108
+23.8%
Shares
2026-08-11
This filing is a combination report: the position is filed across the managers below.
Large
OSAIC HOLDINGS, INC.
2
$2,323,043
0.13%
77,850
0.140%
+17,907
+29.9%
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
OSAIC WEALTH, INC.
14
$417
0.0%
Defined
CW Advisors, LLC
77,836
$2,322,626
100.0%
Sole
Mega
BNP PARIBAS ARBITRAGE, SA
$2,305,169
0.13%
77,251
0.139%
+70,776
+1093.1%
Shares
2026-08-13
Mid
XTX Topco Ltd
1
$2,247,459
0.13%
75,317
0.136%
+48,463
+180.5%
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
XTX EXECUTION SERVICES LLC
joint
75,317
$2,247,459
100.0%
Defined
Large
LOS ANGELES CAPITAL MANAGEMENT LLC
$2,219,618
0.13%
74,384
0.134%
+64,964
+689.6%
Shares
2026-08-13
Mega
RAYMOND JAMES FINANCIAL INC
3
$1,979,972
0.11%
66,353
0.119%
-3,022
-4.4%
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Large
JACOBS LEVY EQUITY MANAGEMENT, INC
$1,953,565
0.11%
65,468
0.118%
New
Shares
2026-08-14
Small
DAFNA Capital Management LLC
$1,939,600
0.11%
65,000
0.117%
+30,000
+85.7%
Shares
2026-08-14
Large
ALPS ADVISORS INC
$1,670,144
0.10%
55,970
0.101%
+16,799
+42.9%
Shares
2026-07-29
Mid
Jump Financial, LLC
1
$1,406,329
0.08%
47,129
0.085%
New
Shares
2026-08-13
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Leap GP LLC
joint
47,129
$1,406,329
100.0%
Defined
Mega
Swiss National Bank
Bank
$1,405,464
0.08%
47,100
0.085%
New
Shares
2026-08-11
Mega
FIRST TRUST ADVISORS LP
$1,379,413
0.08%
46,227
0.083%
+20,742
+81.4%
Shares
2026-08-11
Small
Propel Bio Management, LLC
1
$1,306,932
0.07%
43,798
0.079%
0
0.0%
Shares
2026-08-13
This filing is a combination report: the position is filed across the managers below.
Mega
RHUMBLINE ADVISERS
$1,279,330
0.07%
42,873
0.077%
+11,360
+36.0%
Shares
2026-08-12
Mega
ALLIANCEBERNSTEIN L.P.
1
$1,127,952
0.06%
37,800
0.068%
-26,962
-41.6%
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Mega
DEUTSCHE BANK AG\
Bank
2
$1,044,190
0.06%
34,993
0.063%
+14,730
+72.7%
Shares
2026-08-07
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
DWS INVESTMENT MANAGEMENT AMERICAS, INC
559
$16,680
1.6%
Defined
DWS Investments UK Ltd
34,434
$1,027,510
98.4%
Defined
Mega
SUSQUEHANNA INTERNATIONAL GROUP, LLP
1
$969,800
0.06%
32,500
0.059%
-9,900
-23.3%
Put
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Mega
WELLS FARGO & COMPANY/MN
2
$956,282
0.05%
32,047
0.058%
+21,678
+209.1%
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
WELLS FARGO BANK N A
31,747
$947,330
99.1%
Defined
WELLS FARGO CLEARING SERVICES, LLC
300
$8,952
0.9%
Defined
Mega
SUSQUEHANNA INTERNATIONAL GROUP, LLP
1
$954,880
0.05%
32,000
0.058%
-28,300
-46.9%
Call
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Mega
CITIGROUP INC
1
$903,107
0.05%
30,265
0.054%
+21,702
+253.4%
Shares
2026-08-03
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Citigroup Financial Products Inc.
joint
30,265
$903,107
100.0%
Defined
Large
Quadrature Capital Ltd
1
$896,602
0.05%
30,047
0.054%
New
Shares
2026-08-07
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Quadrature US Inc.
30,047
$896,602
100.0%
Other
Mega
Invesco Ltd.
3
$846,618
0.05%
28,372
0.051%
-58,047
-67.2%
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Invesco Advisers, Inc.
joint
5,218
$155,704
18.4%
Defined
Invesco Trust Co
joint
14,060
$419,550
49.6%
Defined
Invesco Capital Management LLC
9,094
$271,364
32.1%
Defined
Mega
AQR CAPITAL MANAGEMENT LLC
6
$810,481
0.05%
27,161
0.049%
-784
-2.8%
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Large
STATE OF WISCONSIN INVESTMENT BOARD
$711,385
0.04%
23,840
0.043%
New
Shares
2026-08-14
Mega
BARCLAYS PLC
3
$708,192
0.04%
23,733
0.043%
+14,471
+156.2%
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
BARCLAYS BANK PLC
20,606
$614,883
86.8%
Defined
BARCLAYS CAPITAL INC.
3,047
$90,922
12.8%
Defined
BARCLAYS CAPITAL SECURITIES LTD
80
$2,387
0.3%
Defined
Mega
SUSQUEHANNA INTERNATIONAL GROUP, LLP
1
$706,521
0.04%
23,677
0.043%
-1,624
-6.4%
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Mega
TD Asset Management Inc
$661,672
0.04%
22,174
0.040%
New
Shares
2026-08-04
Large
NOMURA HOLDINGS INC
1
$626,640
0.04%
21,000
0.038%
-8,900
-29.8%
Call
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
NOMURA SECURITIES INTERNATIONAL INC
21,000
$626,640
100.0%
Defined
Large
NOMURA HOLDINGS INC
1
$626,640
0.04%
21,000
0.038%
-8,900
-29.8%
Put
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
NOMURA SECURITIES INTERNATIONAL INC
21,000
$626,640
100.0%
Defined
Large
MetLife Investment Management, LLC
1
$623,626
0.04%
20,899
0.038%
+6,357
+43.7%
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
METLIFE INC
20,899
$623,626
100.0%
Defined
Large
Balyasny Asset Management L.P.
$602,469
0.03%
20,190
0.036%
-440,961
-95.6%
Shares
2026-08-14
Large
Squarepoint Ops LLC
1
$579,910
0.03%
19,434
0.035%
+5,822
+42.8%
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Squarepoint Capital LLP
19,434
$579,910
100.0%
Defined
Large
Verition Fund Management LLC
$543,117
0.03%
18,201
0.033%
-933
-4.9%
Shares
2026-08-14
Mega
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC
2
$529,331
0.03%
17,739
0.032%
+17,312
+4054.3%
Shares
2026-08-13
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
UBS Group AG
427
$12,741
2.4%
Defined
UBS Asset Management Switzerland AG
17,312
$516,590
97.6%
Sole
Mega
VANGUARD ASSET MANAGEMENT, Ltd
$490,450
0.03%
16,436
0.030%
New
Shares
2026-08-13
Mega
MANUFACTURERS LIFE INSURANCE COMPANY, THE
Insurance
1
$489,435
0.03%
16,402
0.030%
+1,832
+12.6%
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Large
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.
Mutual Fund
1
$484,840
0.03%
16,248
0.029%
+3,832
+30.9%
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Mega
Legal & General Group Plc
2
$470,903
0.03%
15,781
0.028%
+9,991
+172.6%
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Legal & General Investment Management America Inc
3,426
$102,231
21.7%
Defined
Legal & General Investment Management Ltd
joint
12,355
$368,672
78.3%
Defined
Small
AXQ CAPITAL, LP
$453,359
0.03%
15,193
0.027%
+8,098
+114.1%
Shares
2026-08-06
Mega
Russell Investments Group, Ltd.
1
$432,918
0.02%
14,508
0.026%
-18,018
-55.4%
Shares
2026-08-06
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Russell Investment Management, LLC
14,508
$432,918
100.0%
Defined
Mid
Y-Intercept (Hong Kong) Ltd
$428,800
0.02%
14,370
0.026%
-7,358
-33.9%
Shares
2026-07-14
Mid
China Universal Asset Management Co., Ltd.
$412,030
0.02%
13,808
0.025%
+1,813
+15.1%
Shares
2026-07-24
Small
Virtus Investment Advisers, LLC
$405,973
0.02%
13,605
0.024%
+6,589
+93.9%
Shares
2026-08-11
Small
Verdad Advisers, LP
$376,521
0.02%
12,618
0.023%
New
Shares
2026-08-14
Mega
CITADEL ADVISORS LLC
1
$375,984
0.02%
12,600
0.023%
+4,000
+46.5%
Call
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Large
NEW YORK STATE COMMON RETIREMENT FUND
Pension
$370,016
0.02%
12,400
0.022%
+4,200
+51.2%
Shares
2026-07-29
Large
Jain Global LLC
$365,181
0.02%
12,238
0.022%
New
Shares
2026-08-14
Mega
D. E. Shaw & Co., Inc.
1
$358,646
0.02%
12,019
0.022%
-33,617
-73.7%
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
D. E. Shaw Investment Management, L.L.C.
joint
12,019
$358,646
100.0%
Defined
Mid
Entropy Technologies, LP
$337,997
0.02%
11,327
0.020%
New
Shares
2026-08-13
Mid
Engineers Gate Manager LP
$332,507
0.02%
11,143
0.020%
-3,967
-26.3%
Shares
2026-08-14
Mega
Vanguard Global Advisers, LLC
$329,881
0.02%
11,055
0.020%
-4,147
-27.3%
Shares
2026-08-13
Mid
PROFUND ADVISORS LLC
$328,986
0.02%
11,025
0.020%
New
Shares
2026-08-11
Large
Police & Firemen's Retirement System of New Jersey
Pension
1
$310,544
0.02%
10,407
0.019%
+3,306
+46.6%
Shares
2026-07-23
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Mellon Capital
10,407
$310,544
100.0%
Defined
Small
EntryPoint Capital, LLC
$292,849
0.02%
9,814
0.018%
New
Shares
2026-08-13
Small
Falcon Wealth Planning
$287,359
0.02%
9,630
0.017%
-9
-0.1%
Shares
2026-07-13
Mega
CITADEL ADVISORS LLC
1
$286,464
0.02%
9,600
0.017%
-15,300
-61.4%
Put
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Mega
CANADA PENSION PLAN INVESTMENT BOARD
Pension
$271,544
0.02%
9,100
0.016%
New
Shares
2026-08-14
Large
INTECH INVESTMENT MANAGEMENT LLC
$256,444
0.01%
8,594
0.015%
-929
-9.8%
Shares
2026-08-10
Large
Rafferty Asset Management, LLC
$241,017
0.01%
8,077
0.015%
New
Shares
2026-08-14
Large
Creative Planning
2
$240,868
0.01%
8,072
0.015%
New
Shares
2026-08-13
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
CREATIVE PLANNING TRUST Co LLC
274
$8,176
3.4%
Defined
Held directly
7,798
$232,692
96.6%
Sole
Large
State of New Jersey Common Pension Fund D
Pension
$226,545
0.01%
7,592
0.014%
New
Shares
2026-08-04
Small
Arrowpoint Investment Partners (Singapore) Pte. Ltd.
1
$222,755
0.01%
7,465
0.013%
New
Shares
2026-08-13
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Arrowpoint Investment Partners (Hong Kong) Ltd
7,465
$222,755
100.0%
Defined
Large
VOYA INVESTMENT MANAGEMENT LLC
1
$208,134
0.01%
6,975
0.013%
New
Shares
2026-08-12
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Voya Investment Management Co. LLC
joint
6,975
$208,134
100.0%
Defined
Small
Persistent Asset Partners Ltd
$200,196
0.01%
6,709
0.012%
-2,059
-23.5%
Shares
2026-08-07
Large
Vanguard Investments Australia, Ltd.
$174,504
0.01%
5,848
0.011%
New
Shares
2026-08-13
Large
KLP KAPITALFORVALTNING AS
$158,152
0.01%
5,300
0.010%
New
Shares
2026-08-12
Mid
Ameritas Investment Partners, Inc.
1
$95,547
0.01%
3,202
0.006%
+1,037
+47.9%
Shares
2026-08-13
This filing is a combination report: the position is filed across the managers below.
Small
Caitong International Asset Management Co., Ltd
$93,429
0.01%
3,131
0.006%
-14,652
-82.4%
Shares
2026-08-05
Mid
Quantbot Technologies LP
1
$79,732
0.00%
2,672
0.005%
New
Shares
2026-08-12
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Manager 1
2,672
$79,732
100.0%
Sole
Large
Mirae Asset Global Investments Co., Ltd.
$73,854
0.00%
2,475
0.004%
-35
-1.4%
Shares
2026-07-22
Mid
GROUP ONE TRADING LLC
$61,231
0.00%
2,052
0.004%
New
Shares
2026-08-14
Mega
Mitsubishi UFJ Asset Management Co., Ltd.
1
$47,744
0.00%
1,600
0.003%
New
Shares
2026-08-07
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
MITSUBISHI UFJ FINANCIAL GROUP INC
1,600
$47,744
100.0%
Defined
Mid
Tower Research Capital LLC (TRC)
1
$40,492
0.00%
1,357
0.002%
-1,421
-51.2%
Shares
2026-08-11
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Latour Trading LLC (Latour)
1,357
$40,492
100.0%
Defined
Mid
SIMPLEX TRADING, LLC
$34,793
0.00%
1,166
0.002%
-44
-3.6%
Shares
2026-08-12
Mega
ROYAL BANK OF CANADA
Bank
1
$31,988
0.00%
1,072
0.002%
-957
-47.2%
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
RBC CMA LTD.
1,072
$31,988
100.0%
Defined
Mid
GF FUND MANAGEMENT CO. LTD.
$30,466
0.00%
1,021
0.002%
-59
-5.5%
Shares
2026-08-07
Small
State of Wyoming
$24,259
0.00%
813
0.001%
New
Shares
2026-08-06
Large
Zurcher Kantonalbank (Zurich Cantonalbank)
Bank
$19,545
0.00%
655
0.001%
+294
+81.4%
Shares
2026-08-12
Mid
IFP Advisors, Inc
$9,787
0.00%
328
0.001%
-8,660
-96.4%
Shares
2026-07-20
Mid
Farther Finance Advisors, LLC
$9,727
0.00%
326
0.001%
-33
-9.2%
Shares
2026-07-17
Large
NISA INVESTMENT ADVISORS, LLC
$8,325
0.00%
279
0.001%
-1,125
-80.1%
Shares
2026-08-10
Mid
Sterling Capital Management LLC
$6,624
0.00%
222
0.000%
-607
-73.2%
Shares
2026-07-28
Small
Aster Capital Management (DIFC) Ltd
$6,594
0.00%
221
0.000%
New
Shares
2026-08-14
Mid
GAMMA Investing LLC
$5,072
0.00%
170
0.000%
-182
-51.7%
Shares
2026-07-07
Mid
Quarry LP
$4,923
0.00%
165
0.000%
New
Shares
2026-08-14
Mid
Arax Advisory Partners
$4,595
0.00%
154
0.000%
New
Shares
2026-08-10
Mid
EverSource Wealth Advisors, LLC
2
$4,445
0.00%
149
0.000%
-54
-26.6%
Shares
2026-07-24
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
BMSS Wesson Wealth Solutions, LLC
53
$1,581
35.6%
Sole
Held directly
96
$2,864
64.4%
Sole
Micro
Torren Management, LLC
$3,342
0.00%
112
0.000%
0
0.0%
Shares
2026-07-10
Mid
Integrated Wealth Concepts LLC
$2,984
0.00%
100
0.000%
New
Shares
2026-08-12
Large
JONES FINANCIAL COMPANIES LLLP
1
$2,685
0.00%
90
0.000%
0
0.0%
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Edward D. Jones & Co., L.P.
90
$2,685
100.0%
Sole
Large
US BANCORP \DE\
Bank
1
$2,387
0.00%
80
0.000%
+71
+788.9%
Shares
2026-08-12
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
US BANK NATIONAL ASSOCIATION
80
$2,387
100.0%
Defined
Large
Steward Partners Investment Advisory, LLC
$1,492
0.00%
50
0.000%
New
Shares
2026-08-13
Mega
PNC FINANCIAL SERVICES GROUP, INC.
1
$954
0.00%
32
0.000%
-26
-44.8%
Shares
2026-08-07
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
PNC Bank, National Association
32
$954
100.0%
Defined
Micro
Cornerstone Financial Management LLC
$835
0.00%
28
0.000%
0
0.0%
Shares
2026-08-12
Mid
SIGNATUREFD, LLC
$507
0.00%
17
0.000%
-152
-89.9%
Shares
2026-07-24
Small
Jackson Creek Investment Advisors LLC
$494
0.00%
18,345
0.033%
New
Shares
2026-08-10
Small
Covestor Ltd
$358
0.00%
12
0.000%
+9
+300.0%
Shares
2026-08-07
Small
Fortitude Family Office, LLC
Family Office
$328
0.00%
11
0.000%
New
Shares
2026-07-20
Small
Essential Partners LLC
$208
0.00%
7
0.000%
0
0.0%
Shares
2026-08-10
Mid
SBI Securities Co., Ltd.
Broker-Dealer
$179
0.00%
6
0.000%
0
0.0%
Shares
2026-07-23
Mid
ROTHSCHILD INVESTMENT LLC
$149
0.00%
5
0.000%
-15
-75.0%
Shares
2026-08-06
Mid
Allworth Financial LP
$59
0.00%
2
0.000%
-12
-85.7%
Shares
2026-08-11
Mid
Global Retirement Partners, LLC
Pension
$29
0.00%
1
0.000%
New
Shares
2026-08-06
Mega
JANUS HENDERSON GROUP PLC
1
$85,337,448
4.88%
2,858,876
5.147%
Sold Out
Shares
2026-05-18
This filing is a combination report: the position is filed across the managers below.
Mid
Paradigm Biocapital Advisors LP
$81,920,310
4.68%
2,744,399
4.940%
Sold Out
Shares
2026-05-15
Mid
Cormorant Asset Management, LP
1
$22,387,500
1.28%
750,000
1.350%
Sold Out
Shares
2026-05-15
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Chen Bihua
750,000
$22,387,500
100.0%
Defined
Mid
Caligan Partners LP
$18,356,615
1.05%
614,962
1.107%
Sold Out
Shares
2026-05-15
Small
WASHINGTON UNIVERSITY
Endowment
$8,381,939
0.48%
280,802
0.506%
Sold Out
Shares
2026-05-06
Large
Freestone Grove Partners LP
$7,013,347
0.40%
234,953
0.423%
Sold Out
Shares
2026-05-15
Small
Spruce Street Capital LP
$5,970,000
0.34%
200,000
0.360%
Sold Out
Shares
2026-05-14
Small
Foresite Capital Management IV, LLC
$4,683,494
0.27%
156,901
0.282%
Sold Out
Shares
2026-05-15
Large
Holocene Advisors, LP
$4,064,614
0.23%
136,168
0.245%
Sold Out
Shares
2026-05-15
Mid
Atika Capital Management LLC
3
$3,328,273
0.19%
111,500
0.201%
Sold Out
Shares
2026-05-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Atika Capital Partners LP
64,990
$1,939,951
58.3%
Defined
Optika Master Portfolio Ltd
28,203
$841,859
25.3%
Other
Held directly
18,307
$546,463
16.4%
Sole
Mid
Integral Health Asset Management, LLC
$2,985,000
0.17%
100,000
0.180%
Sold Out
Shares
2026-05-15
Small
Ally Bridge Group (NY) LLC
$2,985,000
0.17%
100,000
0.180%
Sold Out
Call
2026-05-18
Large
Caption Management, LLC
$2,895,450
0.17%
97,000
0.175%
Sold Out
Call
2026-05-15
Mid
Aquatic Capital Management LLC
$1,044,063
0.06%
34,977
0.063%
Sold Out
Shares
2026-05-15
Small
Parkman Healthcare Partners LLC
$950,543
0.05%
31,844
0.057%
Sold Out
Shares
2026-05-15
Small
TWINBEECH CAPITAL LP
$925,021
0.05%
30,989
0.056%
Sold Out
Shares
2026-05-15
Small
Seven Fleet Capital Management LP
$916,603
0.05%
30,707
0.055%
Sold Out
Shares
2026-05-15
Mega
MILLENNIUM MANAGEMENT LLC
$892,276
0.05%
29,892
0.054%
Sold Out
Shares
2026-05-15
Small
Foresite Capital Management V, LLC
$773,264
0.04%
25,905
0.047%
Sold Out
Shares
2026-05-15
Large
Blackstone Inc.
1
$745,951
0.04%
24,990
0.045%
Sold Out
Shares
2026-05-15
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Blackstone Alternative Asset Management L.P.
24,990
$745,951
100.0%
Other
Mega
JANE STREET GROUP, LLC
1
$582,075
0.03%
19,500
0.035%
Sold Out
Call
2026-05-12
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Jane Street Capital, LLC
19,500
$582,075
100.0%
Defined
Small
ACUTA CAPITAL PARTNERS, LLC
$577,149
0.03%
19,335
0.035%
Sold Out
Shares
2026-05-15
Mid
PRELUDE CAPITAL MANAGEMENT, LLC
$541,090
0.03%
18,127
0.033%
Sold Out
Shares
2026-05-15
Mid
GILDER GAGNON HOWE & CO LLC
$521,986
0.03%
17,487
0.031%
Sold Out
Shares
2026-05-15
Large
RENAISSANCE TECHNOLOGIES LLC
$471,630
0.03%
15,800
0.028%
Sold Out
Shares
2026-05-14
Small
DIADEMA PARTNERS LP
$447,750
0.03%
15,000
0.027%
Sold Out
Shares
2026-05-15
Micro
Ground Swell Capital, LLC
$406,228
0.02%
13,609
0.024%
Sold Out
Shares
2026-04-21
Mega
JANE STREET GROUP, LLC
1
$399,990
0.02%
13,400
0.024%
Sold Out
Put
2026-05-12
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Jane Street Capital, LLC
13,400
$399,990
100.0%
Defined
Mega
AMERICAN CENTURY COMPANIES INC
1
$287,604
0.02%
9,635
0.017%
Sold Out
Shares
2026-05-15
This filing is a combination report: the position is filed across the managers below.
Large
PEAK6 LLC
1
$274,620
0.02%
9,200
0.017%
Sold Out
Call
2026-05-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
PEAK6 Investments LLC
joint
9,200
$274,620
100.0%
Defined
Large
CAPSTONE INVESTMENT ADVISORS, LLC
1
$272,799
0.02%
9,139
0.016%
Sold Out
Shares
2026-05-15
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Capstone Investment Advisors (UK), LLP
9,139
$272,799
100.0%
Defined
Mid
Voleon Capital Management LP
$217,516
0.01%
7,287
0.013%
Sold Out
Shares
2026-05-15
Mid
MANGROVE PARTNERS IM, LLC
$201,427
0.01%
6,748
0.012%
Sold Out
Shares
2026-05-15
Large
STRS OHIO
$188,055
0.01%
6,300
0.011%
Sold Out
Shares
2026-04-24
Large
Caption Management, LLC
$149,250
0.01%
5,000
0.009%
Sold Out
Shares
2026-05-15
Large
CWM, LLC
$63,968
0.00%
2,143
0.004%
Sold Out
Shares
2026-05-14
Large
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM
Pension
$42,834
0.00%
1,435
0.003%
Sold Out
Shares
2026-05-18
Large
FEDERATED HERMES, INC.
1
$32,745
0.00%
1,097
0.002%
Sold Out
Shares
2026-05-11
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
FEDERATED MDTA LLC
1,097
$32,745
100.0%
Defined
Small
Kemnay Advisory Services Inc.
$9,134
0.00%
306
0.001%
Sold Out
Shares
2026-05-15
Small
SMA Capital LLC
$3,999
0.00%
134
0.000%
Sold Out
Shares
2026-05-14
Small
Sunbelt Securities, Inc.
Broker-Dealer
$358
0.00%
12
0.000%
Sold Out
Shares
2026-05-18
Mid
Larson Financial Group LLC
$179
0.00%
6
0.000%
Sold Out
Shares
2026-05-15
Large
MAI Capital Management
$149
0.00%
5
0.000%
Sold Out
Shares
2026-05-15
Micro
True Wealth Design, LLC
$149
0.00%
5
0.000%
Sold Out
Shares
2026-04-13
Mid
QUADRANT CAPITAL GROUP LLC
$119
0.00%
4
0.000%
Sold Out
Shares
2026-05-13
Micro
Rachor Investment Advisory Services, LLC
$89
0.00%
3
0.000%
Sold Out
Shares
2026-05-07
Micro
Stone House Investment Management, LLC
$59
0.00%
2
0.000%
Sold Out
Shares
2026-04-22
Micro
Hughes Financial Services, LLC
$29
0.00%
1
0.000%
Sold Out
Shares
2026-04-29
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