RYTM · Rhythm Pharmaceuticals, Inc.

$109.94 +1.02 (+0.94%)

Market Cap

$7.53B

68.85M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Quarter:

Holders: 301

Total Value: $8,591,916,453

Total Shares: 77,383,770

Institutional Ownership Trend

26 quarters

Superinvestors Holding RYTM

All superinvestors →

Stanley Druckenmiller $22,607,706 Joel Greenblatt $612,441

Holder Concentration

Across 301 13F filers · Δ vs Mar 31, 2026

Top Holder

8.6%

−0.4 pts

Top 5

32.0%

−1.9 pts

Top 10

49.3%

−0.2 pts

HHI

344

Broadly held−11

Quarterly Activity

vs Mar 31, 2026

New

Increased

107

Decreased

Sold Out

Unchanged

Holder count: +14

Institutional value: +33.9%

Shares held: +4.9%

Top Buyers

vs Mar 31, 2026

Institution	Added	Now Holds
Mega JPMORGAN CHASE & CO	+1,099,102	2,652,746
Mega PRICE T ROWE ASSOCIATES INC /MD/	+911,295	2,566,171
Large FEDERATED HERMES, INC.	+499,413	1,785,716
Mega Capital Research Global Investors	+416,843	1,532,303
Mid Siren, L.L.C.	+410,764	1,136,275

Top Sellers

vs Mar 31, 2026

Institution	Sold	Now Holds
Mega FMR LLC	−663,831	1,025,840
Large Point72 Asset Management, L.P.	−432,591	414,210
Large ADAGE CAPITAL PARTNERS GP, L.L.C.	−328,744	397,000
Mid Logos Global Management LP	−325,000	125,000
Large Driehaus Capital Management LLC	−307,261	129,285

Top New Positions

vs Mar 31, 2026

Institution	Acquired	Value (USD)
Mega Jupiter Topco LLC	925,490	$102,757,153
Mega NORGES BANK	685,844	$76,149,259
Mid Duquesne Family Office LLC	203,618	$22,607,706
Large Assenagon Asset Management S.A.	186,491	$20,706,095
Small First Turn Management, LLC	154,018	$17,100,618

Top Sold-Out Positions

vs Mar 31, 2026

Institution	Previously Held	Last Value (USD)
Mega JANUS HENDERSON GROUP PLC	918,153	$79,851,765
Large LORD, ABBETT & CO. LLC	348,953	$30,348,442
Large Hood River Capital Management LLC	239,912	$20,865,146
Large M&G PLC	138,567	$12,051,171
Large CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	65,806	$5,723,147

Filter: New 61 Increased 107 Reduced 99 Sold out 47 Unchanged 34

Showing 100 of 307

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

RA CAPITAL MANAGEMENT, L.P.

$740,218,912

8.62%

6,666,837

BlackRock, Inc.

$683,600,820

7.96%

6,156,902

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	131,601	$14,611,659	2.1%	Sole
BlackRock Investment Management (Australia) Ltd	78	$8,660	0.0%	Sole
BlackRock Asset Management Canada Ltd	5,982	$664,181	0.1%	Sole
BlackRock Investment Management, LLC	171,726	$19,066,737	2.8%	Sole
BLACKROCK ADVISORS LLC	621,699	$69,027,239	10.1%	Sole
BlackRock Fund Advisors	2,628,926	$291,889,653	42.7%	Sole
BlackRock Institutional Trust Company, N.A.	1,913,709	$212,479,110	31.1%	Sole
BlackRock Japan Co. Ltd	3,311	$367,620	0.1%	Sole
BlackRock Fund Managers Ltd.	9,827	$1,091,091	0.2%	Sole
BlackRock Investment Management (UK) Ltd.	57,912	$6,429,969	0.9%	Sole
BlackRock (Netherlands) B.V.	2,124	$235,827	0.0%	Sole
BlackRock Asset Management Ireland Ltd	197,143	$21,888,787	3.2%	Sole
BlackRock (Luxembourg) S.A.	347,385	$38,570,156	5.6%	Sole
BlackRock Life Ltd	99	$10,991	0.0%	Sole
BlackRock Asset Management Schweiz AG	9,732	$1,080,543	0.2%	Sole
Aperio Group, LLC	55,648	$6,178,597	0.9%	Sole

BAKER BROS. ADVISORS LP

$622,265,747

7.24%

5,604,483

PRIMECAP MANAGEMENT CO/CA/

$351,837,748

4.09%

3,168,853

VANGUARD PORTFOLIO MANAGEMENT LLC

$348,289,451

4.05%

3,136,895

VANGUARD CAPITAL MANAGEMENT LLC

$333,753,626

3.88%

3,005,977

JPMORGAN CHASE & CO

$294,534,385

3.43%

2,652,746

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
J.P. Morgan Trust Co of Delaware	176	$19,541	0.0%	Other
JPMorgan Chase Bank, N.A.	90,973	$10,100,732	3.4%	Defined
J.P. Morgan Investment Management Inc.	2,357,145	$261,713,809	88.9%	Other
J.P. Morgan Securities LLC	12	$1,332	0.0%	Defined
JPMorgan Asset Management (UK) Ltd	165,152	$18,336,826	6.2%	Defined
JPMorgan Asset Management (Asia Pacific) Ltd	4,098	$455,000	0.2%	Defined
JPMorgan Asset Management (Japan) Ltd	35,190	$3,907,145	1.3%	Defined

PERCEPTIVE ADVISORS LLC

$287,156,333

3.34%

2,586,295

STATE STREET CORP

$285,738,924

3.33%

2,573,529

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STATE STREET GLOBAL ADVISORS EUROPE LIMITED joint	2,573,529	$285,738,924	100.0%	Defined

PRICE T ROWE ASSOCIATES INC /MD/

$284,921,965

3.32%

2,566,171

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T. Rowe Price International Ltd	79,565	$8,834,101	3.1%	Defined
Held directly	2,486,606	$276,087,864	96.9%	Sole

WESTFIELD CAPITAL MANAGEMENT CO LP

$245,220,302

2.85%

2,208,595

GOLDMAN SACHS GROUP INC

$236,105,516

2.75%

2,126,502

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	1,636,344	$181,683,274	77.0%	Defined
GOLDMAN SACHS ASSET MANAGEMENT, L.P.	482,300	$53,549,769	22.7%	Defined
GOLDMAN SACHS INTERNATIONAL	1,943	$215,731	0.1%	Defined
Goldman Sachs Trust Company, N.A. joint	5,915	$656,742	0.3%	Defined

FEDERATED HERMES, INC.

$198,268,046

2.31%

1,785,716

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
FEDERATED EQUITY MANAGEMENT CO OF PENNSYLVANIA	9,893	$1,098,419	0.6%	Defined
FEDERATED GLOBAL INVESTMENT MANAGEMENT CORP	1,658,447	$184,137,370	92.9%	Defined
FEDERATED MDTA LLC	117,376	$13,032,257	6.6%	Defined

Polar Capital Holdings Plc

$184,713,060

2.15%

1,663,632

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Polar Capital LLP	1,663,632	$184,713,060	100.0%	Defined

GEODE CAPITAL MANAGEMENT, LLC

$170,286,488

1.98%

1,533,698

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	219,838	$24,408,613	14.3%	Defined
Held directly	1,313,860	$145,877,875	85.7%	Defined

Capital Research Global Investors

$170,131,602

1.98%

1,532,303

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
CAPITAL GROUP COMPANIES INC joint	1,532,303	$170,131,602	100.0%	Defined

CITADEL ADVISORS LLC

$140,303,281

1.63%

1,263,652

Checkpoint Capital L.P.

$131,681,580

1.53%

1,186,000

Siren, L.L.C.

$126,160,613

1.47%

1,136,275

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invus Group, LLC	1,136,275	$126,160,613	100.0%	Defined

MORGAN STANLEY

$123,492,003

1.44%

1,112,240

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	255	$28,312	0.0%	Defined
MORGAN STANLEY & CO. LLC	22,174	$2,461,979	2.0%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	853,492	$94,763,216	76.7%	Defined
MORGAN STANLEY INVESTMENT MANAGEMENT INC	56	$6,217	0.0%	Defined
MORGAN STANLEY SMITH BARNEY LLC	67,266	$7,468,543	6.0%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	168,997	$18,763,736	15.2%	Defined

FMR LLC

$113,899,013

1.33%

1,025,840

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	808,931	$89,815,608	78.9%	Defined
STRATEGIC ADVISERS LLC	503	$55,848	0.0%	Defined
Fidelity Institutional Asset Management Trust Co	181,660	$20,169,709	17.7%	Defined
FIAM LLC	34,746	$3,857,848	3.4%	Defined

Pictet Asset Management Holding SA

$106,342,868

1.24%

957,785

Jupiter Topco LLC

$102,757,153

1.20%

925,490

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JANUS HENDERSON INVESTORS UK Ltd	29,065	$3,227,086	3.1%	Defined
JANUS HENDERSON INVESTORS US LLC	896,425	$99,530,067	96.9%	Defined

ALLIANCEBERNSTEIN L.P.

$99,341,094

1.16%

894,723

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Equitable Holdings, Inc.	894,723	$99,341,094	100.0%	Defined

Woodline Partners LP

$84,259,667

0.98%

758,891

Clearbridge Investments, LLC

$77,329,397

0.90%

696,473

Rock Springs Capital Management LP

$76,899,155

0.90%

692,598

NORGES BANK

$76,149,259

0.89%

685,844

FRANKLIN RESOURCES INC

$64,067,973

0.75%

577,033

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
FIDUCIARY TRUST INTERNATIONAL LLC	42	$4,663	0.0%	Defined
FRANKLIN ADVISERS INC	53,479	$5,937,773	9.3%	Defined
PUTNAM INVESTMENT MANAGEMENT LLC	359,512	$39,916,617	62.3%	Defined
PUTNAM ADVISORY CO LLC	164,000	$18,208,920	28.4%	Defined

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$61,370,500

0.71%

552,738

Integral Health Asset Management, LLC

$61,066,500

0.71%

550,000

Invesco Ltd.

$60,319,376

0.70%

543,271

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invesco Advisers, Inc. joint	505,604	$56,137,210	93.1%	Defined
Invesco Trust Co joint	21,969	$2,439,218	4.0%	Defined
Invesco Capital Management LLC	15,698	$1,742,948	2.9%	Defined

NORTHERN TRUST CORP

$59,993,060

0.70%

540,332

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	490,718	$54,484,419	90.8%	Defined
NORTHERN TRUST GLOBAL INVESTMENTS LTD	41,048	$4,557,559	7.6%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC joint	8,566	$951,082	1.6%	Other

UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC

$57,163,791

0.67%

514,850

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Group AG	2,157	$239,491	0.4%	Defined
UBS Asset Management Switzerland AG	274,497	$30,477,401	53.3%	Sole
UBS Asset Management (UK) Ltd.	10,651	$1,182,579	2.1%	Other
Held directly	227,545	$25,264,320	44.2%	Other

WELLINGTON MANAGEMENT GROUP LLP

$54,265,576

0.63%

488,747

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Wellington Management Company LLP	316,634	$35,155,873	64.8%	Defined
Wellington Managment Canada LLC	556	$61,732	0.1%	Defined
Wellington Management Singapore Pte. Ltd.	22,660	$2,515,939	4.6%	Defined
Wellington Management International Ltd	8,096	$898,898	1.7%	Defined
Wellington Trust Company, NA joint	137,593	$15,276,950	28.2%	Defined
Wellington Management Australia Pty Ltd	1,935	$214,843	0.4%	Defined
Wellington Management Europe GmbH	1,273	$141,341	0.3%	Defined

VANGUARD FIDUCIARY TRUST CO

$49,488,624

0.58%

445,723

LOOMIS SAYLES & CO L P

$48,198,345

0.56%

434,102

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
LOOMIS SAYLES TRUST COMPANY, LLC	73,101	$8,116,404	16.8%	Defined
Held directly	361,001	$40,081,941	83.2%	Defined

Candriam S.C.A.

$48,078,765

0.56%

433,025

Squarepoint Ops LLC

$46,956,918

0.55%

422,921

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Squarepoint Capital LLP	422,921	$46,956,918	100.0%	Defined

Point72 Asset Management, L.P.

$45,989,736

0.54%

414,210

Sofinnova Investments, Inc.

$45,303,237

0.53%

408,027

AMERIPRISE FINANCIAL INC

$44,593,421

0.52%

401,634

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Columbia Management Investment Advisers, LLC joint	349,748	$38,832,520	87.1%	Defined
Ameriprise Trust Co	7,093	$787,535	1.8%	Defined
Ameriprise Financial Services, LLC	41,150	$4,568,884	10.2%	Defined
Columbia Threadneedle Management Ltd	3,643	$404,482	0.9%	Defined

ADAGE CAPITAL PARTNERS GP, L.L.C.

$44,078,910

0.51%

397,000

Bank of New York Mellon Corp

$43,750,700

0.51%

394,044

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BNY Mellon Trust of Delaware joint	200	$22,205	0.1%	Defined
Mellon Investments Corporation joint	78,550	$8,721,406	19.9%	Defined
BNY Mellon Securities Corporation	2,865	$318,100	0.7%	Defined
The Bank of New York Mellon	101,811	$11,304,075	25.8%	Defined
BNY Mellon, NA joint	9,763	$1,083,985	2.5%	Defined
BNY Mellon Advisors, Inc. joint	1,141	$126,685	0.3%	Other
Newton Investment Management North America, LLC joint	199,713	$22,174,133	50.7%	Defined
Held directly	1	$111	0.0%	Defined

BRAIDWELL LP

$42,316,641

0.49%

381,128

Artisan Partners Limited Partnership

$39,395,220

0.46%

354,816

BANK OF AMERICA CORP /DE/

$36,136,932

0.42%

325,470

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	145,002	$16,099,572	44.6%	Defined
MERRILL LYNCH, PIERCE, FENNER & SMITH INC.	18,737	$2,080,369	5.8%	Defined
BOFA SECURITIES, INC.	134,156	$14,895,340	41.2%	Defined
MERRILL LYNCH INTERNATIONAL	4,620	$512,958	1.4%	Defined
MANAGED ACCOUNT ADVISORS LLC joint	22,955	$2,548,693	7.1%	Defined

ORBIMED ADVISORS LLC

$35,851,587

0.42%

322,900

MILLENNIUM MANAGEMENT LLC

$35,165,310

0.41%

316,719

SILVERARC CAPITAL MANAGEMENT, LLC

$34,581,514

0.40%

311,461

VOYA INVESTMENT MANAGEMENT LLC

$30,308,302

0.35%

272,974

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Voya Investment Management Co. LLC joint	272,974	$30,308,302	100.0%	Defined

Capital World Investors

$24,587,593

0.29%

221,450

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
CAPITAL GROUP COMPANIES INC joint	221,450	$24,587,593	100.0%	Defined

Duquesne Family Office LLC

$22,607,706

0.26%

203,618

Nuveen, LLC

$22,547,748

0.26%

203,078

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Nuveen Asset Management, LLC joint	6,919	$768,216	3.4%	Defined
TIAA CREF INVESTMENT MANAGEMENT LLC joint	77,260	$8,578,177	38.0%	Defined
TEACHERS ADVISORS, LLC joint	118,899	$13,201,355	58.5%	Defined

BNP PARIBAS ARBITRAGE, SA

$21,914,435

0.26%

197,374

KENNEDY CAPITAL MANAGEMENT LLC

$21,452,661

0.25%

193,215

Assenagon Asset Management S.A.

$20,706,095

0.24%

186,491

SCHRODER INVESTMENT MANAGEMENT GROUP

$17,822,312

0.21%

160,518

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Schroder Investment Management Limited	160,094	$17,775,236	99.7%	Sole
Schroder Investment Management North America Inc.	424	$47,076	0.3%	Sole

First Turn Management, LLC

$17,100,618

0.20%

154,018

NEW YORK STATE COMMON RETIREMENT FUND

$16,449,316

0.19%

148,152

UBS Group AG

$16,030,288

0.19%

144,378

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Financial Services Inc	2,834	$314,659	2.0%	Defined
UBS AG	136,129	$15,114,402	94.3%	Defined
UBS Switzerland AG	5,415	$601,227	3.8%	Defined

Nicholas Investment Partners, LP

$15,463,148

0.18%

139,270

ADAR1 Capital Management, LLC

$15,117,622

0.18%

136,158

Connor, Clark & Lunn Investment Management Ltd.

$15,085,313

0.18%

135,867

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Manager 1	135,867	$15,085,313	100.0%	Sole

Qube Research & Technologies Ltd

$14,923,542

0.17%

134,410

NEXTBio Capital Management LP

$14,629,090

0.17%

131,758

Driehaus Capital Management LLC

$14,354,513

0.17%

129,285

SummitTX Capital, L.P.

$14,034,303

0.16%

126,401

Logos Global Management LP

$13,878,750

0.16%

125,000

Opaleye Management Inc.

$13,601,175

0.16%

122,500

SEGALL BRYANT & HAMILL, LLC

$13,530,781

0.16%

121,866

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NEW YORK LIFE INVESTMENT MANAGEMENT LLC	121,866	$13,530,781	100.0%	Sole

DEUTSCHE BANK AG\

$12,794,208

0.15%

115,232

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DWS Investment GmbH	30,410	$3,376,422	26.4%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC	22,339	$2,480,299	19.4%	Defined
DWS Investments UK Ltd	62,483	$6,937,487	54.2%	Defined

Longaeva Partners L.P.

$12,221,516

0.14%

110,074

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Balyasny Asset Management L.P.	110,074	$12,221,516	100.0%	Other

Swiss National Bank

$12,179,991

0.14%

109,700

PFM Health Sciences, LP

$11,275,096

0.13%

101,550

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$10,991,970

0.13%

99,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	99,000	$10,991,970	100.0%	Other

Aberdeen Group plc

$10,541,854

0.12%

94,946

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
abrdn Inc.	94,946	$10,541,854	100.0%	Defined

AXIOM INVESTORS LLC /DE

$9,646,286

0.11%

86,880

Russell Investments Group, Ltd.

$9,627,297

0.11%

86,709

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Russell Investment Management, LLC	61,947	$6,877,974	71.4%	Defined
Russell Investments Capital, LLC	16,053	$1,782,364	18.5%	Defined
Russell Investments France SAS	3,261	$362,068	3.8%	Defined
Russell Investments Trust Company	5,448	$604,891	6.3%	Defined

First Light Asset Management, LLC

$9,522,487

0.11%

85,765

ALGERT GLOBAL LLC

$9,263,343

0.11%

83,431

Granahan Investment Management, LLC

$9,245,468

0.11%

83,270

NEUBERGER BERMAN GROUP LLC

$9,219,376

0.11%

83,035

WCM INVESTMENT MANAGEMENT, LLC

$8,943,688

0.10%

80,552

SPHERA FUNDS MANAGEMENT LTD.

$8,926,812

0.10%

80,400

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Sphera Global Healthcare Management LP joint	80,400	$8,926,812	100.0%	Defined

Atom Investors LP

$8,156,818

0.09%

73,465

SILVERCREST ASSET MANAGEMENT GROUP LLC

$8,153,154

0.09%

73,432

RHUMBLINE ADVISERS

$8,142,162

0.09%

73,333

WELLS FARGO & COMPANY/MN

$8,010,478

0.09%

72,147

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO BANK N A	52,624	$5,842,842	72.9%	Defined
WELLS FARGO ADVISORS FINANCIAL NETWORK, LLC	10,133	$1,125,066	14.0%	Defined
WELLS FARGO CLEARING SERVICES, LLC	9,364	$1,039,684	13.0%	Defined
WELLS FARGO INVESTMENT INSTITUTE, INC.	26	$2,886	0.0%	Defined

PRUDENTIAL FINANCIAL INC

$7,677,169

0.09%

69,145

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
PGIM Quantitative Solutions LLC	58,045	$6,444,736	83.9%	Defined
Prudential Trust Co	11,100	$1,232,433	16.1%	Defined

CAPITAL FUND MANAGEMENT S.A.

$7,610,884

0.09%

68,548

RENAISSANCE TECHNOLOGIES LLC

$7,581,239

0.09%

68,281

PICTON MAHONEY ASSET MANAGEMENT

$7,314,656

0.09%

65,880

Blue Owl Capital Holdings LP

$6,823,348

0.08%

61,455

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Blue Owl GPSC Advisors LLC	61,455	$6,823,348	100.0%	Defined

ExodusPoint Capital Management, LP

$6,789,151

0.08%

61,147

AQR CAPITAL MANAGEMENT LLC

$6,573,862

0.08%

59,208

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RF&L WEALTH MANAGEMENT, LLC	1	$111	0.0%	Other
Compound Planning, Inc.	5	$555	0.0%	Other
Arax Advisory Partners	254	$28,201	0.4%	Other
HALBERT HARGROVE GLOBAL ADVISORS, LLC	492	$54,626	0.8%	Other
Stokes Family Office, LLC	203	$22,539	0.3%	Other
Held directly	58,253	$6,467,830	98.4%	Defined

CITIGROUP INC

$6,478,266

0.08%

58,347

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citigroup Financial Products Inc. joint	58,347	$6,478,266	100.0%	Defined

RAYMOND JAMES FINANCIAL INC

$6,447,398

0.08%

58,069

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RAYMOND JAMES & ASSOCIATES	17,225	$1,912,491	29.7%	Defined
Raymond James Financial Services Advisors, Inc.	896	$99,482	1.5%	Defined
ClariVest Asset Management LLC joint	5,296	$588,014	9.1%	Defined
CHARTWELL INVESTMENT PARTNERS, LLC	34,652	$3,847,411	59.7%	Defined

MANUFACTURERS LIFE INSURANCE COMPANY, THE

$6,347,585

0.07%

57,170

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MANULIFE FINANCIAL CORP joint	57,170	$6,347,585	100.0%	Defined

Trexquant Investment LP

$6,245,215

0.07%

56,248

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
AHL Partners LLP	4,071	$452,003	8.0%	Defined
Numeric Investors LLC	46,717	$5,186,988	92.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Pivotal bioVenture Partners Investment Advisor LLC joint	49,120	$5,453,793	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	48,300	$5,362,749	100.0%	Other

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Legal & General Investment Management America Inc	5,359	$595,009	12.2%	Defined
Legal & General Investment Management Ltd joint	38,549	$4,280,095	87.8%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BNP PARIBAS ASSET MANAGEMENT Europe	794	$88,157	1.9%	Defined
AXA INVESTMENT MANAGERS UK LIMITED	41,135	$4,567,219	98.1%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
EFG Asset Management (North America) Corp.	33,563	$3,726,499	100.0%	Defined
EFG Private Wealth Management (Americas) Corp.	14	$1,554	0.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
METLIFE INC	32,104	$3,564,507	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
D. E. SHAW & CO, L.P.	14,587	$1,619,594	48.4%	Defined
D. E. Shaw Investment Management, L.L.C. joint	15,581	$1,729,958	51.6%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Global X Management CO LLC joint	25,418	$2,822,160	87.2%	Defined
Global X Management (AUS) Ltd joint	3,741	$415,363	12.8%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	28,000	$3,108,840	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	27,100	$3,008,913	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
CREATIVE PLANNING TRUST Co LLC	1,770	$196,523	6.9%	Defined
Held directly	24,065	$2,671,936	93.1%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	24,000	$2,664,720	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SEI INVESTMENTS MANAGEMENT CORP	6,261	$695,158	28.3%	Sole
SEI TRUST CO	15,826	$1,757,160	71.7%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	17,500	$1,943,025	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Capital	16,280	$1,807,568	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Natixis Investment Managers, L.P.	14,483	$1,608,047	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BARCLAYS BANK PLC	10,568	$1,173,365	80.0%	Defined
BARCLAYS CAPITAL INC.	1,960	$217,618	14.8%	Defined
BARCLAYS CAPITAL SECURITIES LTD	122	$13,545	0.9%	Defined
Barclays Investment Solutions Ltd	559	$62,065	4.2%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STIFEL NICOLAUS & CO INC \MO\	12,636	$1,402,975	99.6%	Defined
Held directly	53	$5,884	0.4%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Edward D. Jones & Co., L.P.	12,066	$1,339,687	100.0%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DNB FUND	11,465	$1,272,958	100.0%	Other

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SECURITY INVESTORS LLC	10,984	$1,219,553	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Universal-Investment-Gesellschaft mbH	9,393	$1,042,904	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Marshall Wace North America L.P. joint	8,174	$907,559	100.0%	Other

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Roundhill Financial Inc.	7,966	$884,464	100.0%	Other

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
PNC Bank, National Association	7,599	$843,716	99.2%	Other
PNC Wealth Management LLC	58	$6,439	0.8%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
ADVISOR PARTNERS II, LLC	6,607	$733,575	95.6%	Defined
Held directly	304	$33,753	4.4%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
ROCKEFELLER & CO. LLC	159	$17,653	2.7%	Defined
ROCKEFELLER TRUST COMPANY, N.A.	1,716	$190,527	28.9%	Defined
ROCKEFELLER FINANCIAL LLC	4,070	$451,892	68.5%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLINGTON SMALL CAP EQUITY	5,601	$621,879	100.0%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
EATON VANCE MANAGEMENT	5,010	$556,260	100.0%	Other

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
ALLSTATE INVESTMENTS LLC	4,925	$546,822	100.0%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	4,372	$485,423	100.0%	Other

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fifth Third Bank, National Association	4,290	$476,318	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Magnetar Asset Management LLC	2,325	$258,144	59.5%	Sole
Held directly	1,583	$175,760	40.5%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
First Sentier Investors RQI Pty Ltd	3,860	$428,575	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
FREESTONE CAPITAL MANAGEMENT LLC	3,700	$410,811	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Amundi Asset Management	3,422	$379,944	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
CIBC National Trust Co	1	$111	0.0%	Defined
CIBC WORLD MARKETS CORP	3,047	$338,308	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Capstone Investment Advisors (UK), LLP	3,005	$333,645	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Allianz Global Invesstors Taiwan Ltd.	3,000	$333,090	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	67	$7,439	2.5%	Defined
Jane Street Global Trading, LLC	2,643	$293,452	97.5%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Nykredit Bank A/S	2,525	$280,350	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Manufacturers & Traders Trust Company joint	163	$18,097	7.5%	Defined
Wilmington Trust Investment Advisors, Inc. joint	28	$3,108	1.3%	Defined
Wilmington Trust National Association joint	1,845	$204,849	84.7%	Defined
Wilmington Trust Company	142	$15,766	6.5%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Latour Trading LLC (Latour)	2,067	$229,499	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Marex Financial	2,000	$222,060	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
XTX EXECUTION SERVICES LLC joint	1,996	$221,615	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
KBC Bank NV joint	1,707	$189,528	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RBC CMA LTD.	1,660	$184,309	99.9%	Defined
RBC Dominion Securities Inc.	1	$111	0.1%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
US BANK NATIONAL ASSOCIATION	1,020	$113,250	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Bellevue Asset Management AG	1,016	$112,806	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
OSAIC WEALTH, INC.	981	$108,920	99.9%	Defined
Osaic Advisory Services, LLC	1	$111	0.1%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Acadian Inc	609	$67,617	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Optiver VOF	220	$24,426	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BMSS Wesson Wealth Solutions, LLC	1	$111	1.4%	Sole
Held directly	69	$7,660	98.6%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BESSEMER TRUST Co NATIONAL ASSOCIATION	30	$3	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JANUS HENDERSON INVESTORS UK Ltd	29,085	$2,529,522	3.2%	Defined
JANUS HENDERSON INVESTORS US LLC	889,068	$77,322,243	96.8%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
M&G Investment Management Limited	138,567	$12,051,171	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
HSBC Bank USA, N.A.	54	$4,696	0.4%	Defined
HSBC BANK PLC	14,110	$1,227,146	98.6%	Defined
HSBC SECURITIES USA INC	143	$12,436	1.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Hudson Bay Capital UK LLP	9,120	$793,166	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BMO Bank N.A.	746	$64,879	19.6%	Defined
BMO NESBITT BURNS INC.	140	$12,175	3.7%	Defined
Held directly	2,915	$253,517	76.7%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Brevan Howard US Investment Management, LP	3,777	$328,485	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Blackstone Alternative Asset Management L.P.	2,600	$226,122	100.0%	Other

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DRW Investments, LLC joint	2,562	$222,817	100.0%	Other

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Manager 1 joint	1,363	$118,540	100.0%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Institutional Asset Management Trust Co	17	$1,478	46.0%	Sole
SEI INVESTMENTS MANAGEMENT CORP	15	$1,304	40.5%	Sole
Held directly	5	$434	13.5%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
TD SECURITIES INC	6	$521	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DIMENSIONAL FUND ADVISORS LP	1	$86	100.0%	Other

Key facts CIK 1649904 CUSIP 76243J105 13F (30d) 278 filings 275 filers Visit website Investor relations