RARE · Ultragenyx Pharmaceutical Inc. · Holdings

$16.08 +0.43 (+2.75%) At close · Oct 26

Russell 2000 member Rebalance outlook locked

Market Cap

$1.54B

98.59M

Volume · Oct 26 3.02M Avg daily vol (3M) 4.12M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Use institutional holdings through the 13F API or MCP → See every holder of RARE: 13F, 13D and 13G, insiders and funds →

The Sep 30, 2026 filing window is still open — showing the latest known positions. Funds that have not filed yet carry their prior-quarter positions; a fund that filed without this stock counts as sold out. Each fund's Change is measured against its own previous reported quarter, shown in the Reported column. Pick a completed quarter in the Quarter selector below to put every fund on one quarter and see the stock-wide activity breakdown.

Quarter:

Holders: 309

Total Value: $3,671,366,094

Total Shares: 110,519,757

Showing 1–100 of 320 holdings by value · page 1 of 4

Institutional Ownership Trend

27 quarters

Holder Concentration

Across 317 13F filers

Top Holder

9.7%

of institutional value

Top 5

34.4%

of institutional value

Top 10

49.7%

of institutional value

HHI

338

Broadly held

Who Holds RARE

Last 8 quarters through Sep 30, 2026 (filing window open)

Each kind of 13F filer's share of the common shares 13F filers report. Holder type comes from regulatory records, never the filer's name; style, turnover and horizon are measured from each filer's own 13F book. The quarter selector does not change this card.

Jun 30, 2026, the newest closed quarter: 311 filers, like-for-like change +8.7%; actively managed books +4.2%; index-like books +23.3%.

Holder type	Share	Filers	Change	New	Exited
Registered adviser	57.1%	157	+12.7%	36	21
Exempt adviser	1.7%	6	-21.8%	1	2
Adviser	2.4%	9	+112.7%	3	0
Bank	10.4%	18	+26.1%	0	0
Insurer	0.0%	2	+56.0%	1	0
Broker-dealer	0.0%	1	-87.4%	0	0
Benefit plan	0.2%	4	-36.1%	0	2
Non-US	3.5%	12	-10.3%	0	2
Holding company	14.6%	9	+26.4%	0	3
Unknown	10.1%	93	-27.6%	14	14

Style	Share	Filers	Change	New	Exited
Index-like	28.2%	33	+23.3%	0	4
Systematic-like	9.5%	29	-22.7%	4	4
Concentrated	3.2%	41	-33.2%	7	10
Diversified active	59.2%	208	+13.9%	44	25
Unknown	0.0%	0	-100.0%	0	1
Not measured	0.0%	0	—	0	0

Turnover	Share	Filers	Change	New	Exited
Low turnover	38.1%	156	+25.0%	27	14
Medium turnover	36.4%	72	+19.5%	13	11
High turnover	13.2%	51	-32.0%	6	16
Unknown	12.4%	32	+5.1%	9	3
Not measured	0.0%	0	—	0	0

Holding horizon	Share	Filers	Change	New	Exited
Short horizon	13.8%	54	-3.1%	15	9
Medium horizon	16.9%	53	+44.7%	8	7
Long horizon	59.7%	182	+12.0%	30	19
Unknown	9.5%	22	-25.4%	2	9
Not measured	0.0%	0	—	0	0

13F book size	Share	Filers	Change	New	Exited
Under $1B	4.4%	57	-42.6%	18	19
$1B to $10B	9.2%	89	-7.6%	20	6
$10B to $100B	29.4%	101	+16.4%	15	14
$100B or more	57.1%	64	+15.9%	2	5
Not measured	0.0%	0	—	0	0

Client base	Share	Filers	Change	New	Exited
Individuals and high net worth	3.0%	70	+22.4%	20	4
Pooled investment vehicles	21.4%	45	-4.9%	8	11
Registered funds and BDCs	15.6%	16	+20.5%	2	2
Pension and profit sharing plans	0.0%	2	+65.6%	0	0
Insurance companies	0.1%	3	+1372.8%	2	0
Governments and sovereign funds	1.6%	4	+79.8%	1	0
Other investment advisers	0.0%	2	+17.7%	0	0
Other	0.1%	1	-27.0%	0	2
Diversified	15.3%	13	+30.5%	2	1
Charitable organizations	0.0%	0	-100.0%	0	1
Corporations	0.0%	0	—	0	0
Unknown	42.9%	155	+3.8%	20	23

Private funds	Share	Filers	Change	New	Exited
Hedge funds	33.7%	59	+8.3%	9	12
Private equity funds	0.4%	12	+62.3%	4	1
Venture capital funds	0.3%	2	-62.3%	0	0
Real estate funds	0.0%	3	+207.3%	0	0
Securitized asset funds	0.2%	1	-25.0%	0	0
Other private funds	8.8%	18	+16.5%	6	0
Mixed private funds	0.1%	2	+199.5%	0	1
Private funds, type not stated	0.5%	5	-14.2%	2	3
No private funds	14.7%	61	+20.2%	16	6
Unknown	41.2%	148	+5.2%	18	21

Location	Share	Filers	Change	New	Exited
United States	90.0%	248	+14.1%	49	33
Outside the US	10.0%	63	-24.2%	6	11

The Sep 30, 2026 filing window is still open, so its bar carries the Jun 30, 2026 positions of filers that have not filed yet.

How the mix is measured

Shares are 13F common shares restated to today's split basis; options and principal amounts are left out. The change compares only filers with a 13F in both quarters and keeps each filer in its bucket of the later quarter on both sides; a filer that continues under a new CIK is compared through its successor. Holder type comes from each filer's current regulatory profile; client base and private funds come from the Form ADV roster current at each quarter end (rosters from December 2019, so an earlier quarter reads Unknown). Style, turnover, horizon and book size are measured from each filer's 13F book in the newest measured quarter, and Not measured means none was. Actively managed books are those measured systematic-like, concentrated or diversified active.

Excluded 3 holders with no observed 2026-03-31 13F and 1 holder with no observed 2026-06-30 13F. Compared across CIK changes: JANUS HENDERSON GROUP PLC continues as Jupiter Topco LLC.

Conviction and Crowding

311 13F filers, quarter ended Jun 30, 2026

Measured across every 13F filer's common-share book once the quarter's filing window closed. Crowding counts filers with high turnover or that advise private funds on Form ADV.

Conviction holders

2.57% of filers hold it in their top 10

Mar 31, 2026: 7

Holders above 5%

median weight 0.005%

Mar 31, 2026: 1

Crowding

—

holders exceed shares outstanding: 13F filers report more shares than the cover-page count, which predates an issuance, is misstated, or misses shares lent and reported twice

Private-fund advisers

—

of shares outstanding

Institutional ownership

—

holders exceed shares outstanding: 13F filers report more shares than the cover-page count, which predates an issuance, is misstated, or misses shares lent and reported twice

Top 10 holders

51.4%

of 13F shares, Herfindahl 0.036

Active holders

+4.2%

like-for-like share change of active filers

5% stakes on record

0 13D, 7 13G (7 institutional, 0 passive, 0 exempt)

How long holders have held it value-weighted 12.8 quarters

Under 1 year 24.5% 1 to 3 years 29.5% 3 years or more 46.0% Since coverage start 0.000%

Managers in the top fifth by current three-year FundScore alpha were net sellers of $999,622 (0 buying, 2 selling).

Estimated Holder Cost Basis

Quarter ended Jun 30, 2026, on that quarter's share basis

Estimated, never filed: each 13F buy is costed at its quarter's average traded price and each sale keeps the average cost, so this is what holders paid on average if they traded evenly through each quarter.

Estimated avg cost

$28.85

estimated per share

Mar 31, 2026: $29.87

Quarter-end price

$33.37

implied by 13F values

Estimated gain or loss

+15.7%

price against the estimated cost

Estimated at a loss

14.7%

of costed 13F value

Estimated cost covers 54.1% of the 13F shares; positions already held when a filer's 13F history starts, or bought in a quarter without a trusted average price, have no estimate.

Shared Holders

Companies RARE's active holders also own, quarter ended Jun 30, 2026

#	Company	Shared holders	Similarity
1	TARS Tarsus Pharmaceuticals, Inc.	9	0.300
2	IMTX Immatics N.V.	7	0.283
3	CLDX Celldex Therapeutics, Inc.	11	0.270
4	BBIO BridgeBio Pharma, Inc.	13	0.267
5	INSM INSMED Inc	16	0.263
6	SNDX Syndax Pharmaceuticals Inc	10	0.260
7	ACAD Acadia Pharmaceuticals Inc	8	0.257
8	HELP Helus Pharma Inc.	7	0.249
9	MLYS Mineralys Therapeutics, Inc.	10	0.248
10	RCUS Arcus Biosciences, Inc.	7	0.243

Shareholder Targets

13F filers that own its peers but not RARE, quarter ended Jun 30, 2026

Found through its holder-overlap peers: TARS, IMTX, CLDX, BBIO, INSM, SNDX, ACAD, HELP, MLYS, RCUS, CMPS, VERA, KLRS, VSTM, ANNX, PRQR, WVE, PTGX, BMRN, TENX. 939 filers in all.

#	Filer	In peers	Of book	Largest peers
1	BAKER BROS. ADVISORS LP Registered adviser, Concentrated	$2,204,237,217 7 held	11.1%	ACAD, INSM, IMTX
2	FARALLON CAPITAL MANAGEMENT LLC Registered adviser, Diversified active	$1,578,392,229 2 held	9.32%	BBIO, PTGX
3	VIKING GLOBAL INVESTORS LP Registered adviser, Diversified active	$1,176,837,565 2 held	3.42%	BBIO, BMRN
4	Kohlberg Kravis Roberts & Co. L.P. Registered adviser, Concentrated	$987,677,120 1 held	18.3%	BBIO
5	GILEAD SCIENCES, INC. Unknown, Concentrated	$968,825,350 1 held	58.7%	RCUS
6	PRIMECAP MANAGEMENT CO/CA/ Registered adviser, Diversified active	$918,742,814 3 held	0.540%	BMRN, BBIO, WVE
7	Deep Track Capital, LP Adviser, Diversified active	$895,061,462 6 held	13.6%	TARS, BMRN, CMPS
8	Capital International Investors Adviser, Diversified active	$878,348,780 1 held	0.180%	INSM
9	Dodge & Cox Registered adviser, Diversified active	$849,426,894 1 held	0.440%	BMRN
10	Darwin Global Management, Ltd. Exempt adviser, Concentrated	$685,690,599 1 held	17.7%	INSM

Fund Ownership of RARE by Fund Type

Registered funds' Form N-PORT reports for the quarter ended Jun 30, 2026

Index funds and index ETFs hold 20.40% of shares outstanding.

Fund type	Of shares outstanding	Change	Shares	Funds
Index funds	2.73%	+0.88 pp	2,686,982	65
Index ETFs	17.67%	+2.99 pp	17,423,766	47
Active ETFs	0.34%	+0.11 pp	338,689	15
Active funds	11.45%	+4.72 pp	11,287,557	127
Unclassified	0.12%	+0.12 pp	122,268	6
All registered funds	32.32%	+8.82 pp	31,859,262	260

How fund types are measured

Each fund series counts once, with its latest Form N-PORT report dated inside the quarter; only long share positions count, restated to today's split basis. The fund type is the series' latest Form N-CEN answer on or before the quarter end (the index-fund box and the exchange-traded flag), never its name. Unclassified funds have no usable N-CEN; unit investment trusts are among them, so index ownership is a floor. Funds sit inside their advisers' 13F reports, so these shares overlap the 13F figures and are never added to them.

Holder type: Registered adviser 156 Exempt adviser 5 Adviser 9 Bank 18 Insurer 2 Broker-dealer 1 Benefit plan 4 Non-US 12 Holding company 9 Unknown 93

Showing 100 of 320

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

BlackRock, Inc.

$355,746,266

9.69%

10,654,276

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	554,371	$18,510,447	5.2%	Sole
BlackRock Investment Management (Australia) Ltd	214	$7,145	0.0%	Sole
BlackRock Asset Management Canada Ltd	29,828	$995,956	0.3%	Sole
BlackRock Investment Management, LLC	414,606	$13,843,694	3.9%	Sole
BLACKROCK ADVISORS LLC	898,152	$29,989,295	8.4%	Sole
BlackRock Fund Advisors	4,435,145	$148,089,491	41.6%	Sole
BlackRock Institutional Trust Company, N.A.	3,745,451	$125,060,608	35.2%	Sole
BlackRock Japan Co. Ltd	53,523	$1,787,132	0.5%	Sole
BlackRock Fund Managers Ltd.	30,466	$1,017,259	0.3%	Sole
BlackRock Investment Management (UK) Ltd.	138,054	$4,609,623	1.3%	Sole
BlackRock (Netherlands) B.V.	1,693	$56,529	0.0%	Sole
BlackRock Asset Management Ireland Ltd	223,994	$7,479,159	2.1%	Sole
BlackRock (Luxembourg) S.A.	5,423	$181,073	0.1%	Sole
BlackRock Life Ltd	224	$7,479	0.0%	Sole
BlackRock Asset Management Schweiz AG	15,034	$501,985	0.1%	Sole
Aperio Group, LLC	107,535	$3,590,593	1.0%	Sole
SpiderRock Advisors, LLC	563	$18,798	0.0%	Sole

RTW INVESTMENTS, LP

$260,338,324

7.09%

7,796,895

VANGUARD PORTFOLIO MANAGEMENT LLC

$226,722,607

6.18%

6,790,135

AQR CAPITAL MANAGEMENT LLC

$219,065,409

5.97%

6,560,809

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Petros Family Wealth, LLC	104	$3,472	0.0%	Other
KEB ASSET MANAGEMENT, LLC	410	$13,689	0.0%	Other
Arax Advisory Partners	18,427	$615,277	0.3%	Other
HALBERT HARGROVE GLOBAL ADVISORS, LLC	6,434	$214,831	0.1%	Other
Stokes Family Office, LLC	1,481	$49,450	0.0%	Other
Held directly	6,533,953	$218,168,690	99.6%	Defined

STATE STREET CORP

$205,641,196

5.60%

6,158,766

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STATE STREET GLOBAL ADVISORS EUROPE LIMITED joint	6,158,766	$205,641,196	100.0%	Defined

VANGUARD CAPITAL MANAGEMENT LLC

$143,459,834

3.91%

4,296,491

TWO SIGMA INVESTMENTS, LP

$120,911,868

3.29%

3,621,200

SANDS CAPITAL MANAGEMENT, LLC

$105,457,907

2.87%

3,158,368

JACOBS LEVY EQUITY MANAGEMENT, INC

$98,157,217

2.67%

2,939,719

FRONTIER CAPITAL MANAGEMENT CO LLC

$95,092,583

2.59%

2,847,936

GEODE CAPITAL MANAGEMENT, LLC

$86,107,066

2.35%

2,578,828

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	367,000	$12,254,130	14.2%	Defined
Held directly	2,211,828	$73,852,936	85.8%	Defined

Bellevue Group AG

$66,204,857

1.80%

1,982,775

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BB Biotech AG joint	1,982,775	$66,204,857	100.0%	Defined

D. E. Shaw & Co., Inc.

$57,771,143

1.57%

1,730,193

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
D. E. SHAW & CO, L.P.	1,638,717	$54,716,760	94.7%	Defined
D. E. Shaw Investment Management, L.L.C. joint	91,476	$3,054,383	5.3%	Defined

Sofinnova Investments, Inc.

$57,347,491

1.56%

1,717,505

ADAGE CAPITAL PARTNERS GP, L.L.C.

$52,756,200

1.44%

1,580,000

GW&K Investment Management, LLC

$49,456,532

1.35%

1,481,178

MPM BIOIMPACT LLC

$47,354,198

1.29%

1,418,215

PRICE T ROWE ASSOCIATES INC /MD/

$45,293,568

1.23%

1,356,501

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T. Rowe Price International Ltd	156,877	$5,238,123	11.6%	Defined
Held directly	1,199,624	$40,055,445	88.4%	Sole

MORGAN STANLEY

$44,235,235

1.20%

1,324,805

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	6,121	$204,380	0.5%	Defined
MORGAN STANLEY & CO. LLC	164,041	$5,477,328	12.4%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	710,074	$23,709,370	53.6%	Defined
MORGAN STANLEY INVESTMENT MANAGEMENT INC	1,439	$48,048	0.1%	Defined
MORGAN STANLEY SMITH BARNEY LLC	90,750	$3,030,142	6.9%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	301,155	$10,055,565	22.7%	Defined
EATON VANCE MANAGEMENT	51,225	$1,710,402	3.9%	Defined

WELLINGTON MANAGEMENT GROUP LLP

$41,752,990

1.14%

1,250,464

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Wellington Management Company LLP	836,374	$27,926,527	66.9%	Defined
Wellington Management Singapore Pte. Ltd.	43,575	$1,454,969	3.5%	Defined
Wellington Management International Ltd	15,070	$503,187	1.2%	Defined
Wellington Trust Company, NA joint	352,389	$11,766,268	28.2%	Defined
Wellington Management Australia Pty Ltd	3,056	$102,039	0.2%	Defined

VOLORIDGE INVESTMENT MANAGEMENT, LLC

$41,455,554

1.13%

1,241,556

BANK OF AMERICA CORP /DE/

$38,346,877

1.04%

1,148,454

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	703,980	$23,505,892	61.3%	Defined
MERRILL LYNCH, PIERCE, FENNER & SMITH INC.	51,459	$1,718,216	4.5%	Defined
BOFA SECURITIES, INC.	156,037	$5,210,075	13.6%	Defined
MANAGED ACCOUNT ADVISORS LLC joint	236,978	$7,912,694	20.6%	Defined

Candriam S.C.A.

$33,451,470

0.91%

1,001,841

Rock Springs Capital Management LP

$32,316,678

0.88%

967,855

Jefferies Financial Group Inc.

$31,040,212

0.85%

929,626

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jefferies Financial Services, Inc.	929,626	$31,040,212	100.0%	Defined

NORTHERN TRUST CORP

$30,729,282

0.84%

920,314

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	843,976	$28,180,357	91.7%	Defined
NORTHERN TRUST GLOBAL INVESTMENTS LTD	61,344	$2,048,276	6.7%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC joint	14,994	$500,649	1.6%	Other

Eagle Health Investments LP

$29,520,800

0.80%

884,121

Qube Research & Technologies Ltd

$29,457,292

0.80%

882,219

Russell Investments Group, Ltd.

$26,181,059

0.71%

784,099

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Russell Investment Management, LLC joint	214,812	$7,172,571	27.4%	Defined
Russell Investments Canada Limited	10,951	$365,653	1.4%	Defined
Russell Investments Capital, LLC joint	298,814	$9,977,399	38.1%	Other
Russell Investments France SAS	7,138	$238,337	0.9%	Defined
Russell Investments Implementation Services, LLC	20,686	$690,705	2.6%	Defined
Russell Investments Japan Co., LTD. joint	19,911	$664,828	2.5%	Other
Russell Investments Limited joint	171,964	$5,741,877	21.9%	Other
Russell Investments Trust Company joint	39,823	$1,329,689	5.1%	Other

MILLENNIUM MANAGEMENT LLC

$25,403,946

0.69%

760,825

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$25,377,702

0.69%

760,039

Pictet Asset Management Holding SA

$25,165,876

0.69%

753,695

Caption Management, LLC

$24,000,732

0.65%

718,800

Nuveen, LLC

$23,171,290

0.63%

693,959

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Nuveen Asset Management, LLC joint	48,739	$1,627,395	7.0%	Defined
TIAA CREF INVESTMENT MANAGEMENT LLC joint	201,100	$6,714,729	29.0%	Defined
TEACHERS ADVISORS, LLC joint	444,120	$14,829,166	64.0%	Defined

VANGUARD FIDUCIARY TRUST CO

$22,418,413

0.61%

671,411

UBS Group AG

$21,960,568

0.60%

657,699

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Financial Services Inc	5,493	$183,411	0.8%	Defined
UBS AG	645,561	$21,555,281	98.2%	Defined
UBS Switzerland AG	3,478	$116,130	0.5%	Defined
UBS Securities LLC	3,167	$105,746	0.5%	Defined

GREAT POINT PARTNERS LLC

$20,034,000

0.55%

600,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JAY JEFFREY R joint	600,000	$20,034,000	100.0%	Defined

Palo Alto Investors LP

$19,916,968

0.54%

596,495

SPHERA FUNDS MANAGEMENT LTD.

$19,649,814

0.54%

588,494

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Sphera Global Healthcare Management LP joint	588,494	$19,649,814	100.0%	Defined

Legal & General Group Plc

$19,583,902

0.53%

586,520

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Legal & General Investment Management America Inc	9,385	$313,365	1.6%	Defined
Legal & General Investment Management Ltd joint	577,135	$19,270,537	98.4%	Defined

PANAGORA ASSET MANAGEMENT INC

$19,574,219

0.53%

586,230

FMR LLC

$19,260,986

0.52%

576,849

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	257,494	$8,597,724	44.6%	Defined
STRATEGIC ADVISERS LLC	3,495	$116,698	0.6%	Defined
Fidelity Institutional Asset Management Trust Co	2,107	$70,352	0.4%	Defined
FIAM LLC	308,200	$10,290,798	53.4%	Defined
Fidelity Diversifying Solutions LLC	5,553	$185,414	1.0%	Defined

GOLDMAN SACHS GROUP INC

$19,210,535

0.52%

575,338

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	371,201	$12,394,401	64.5%	Defined
GOLDMAN SACHS ASSET MANAGEMENT, L.P.	198,044	$6,612,689	34.4%	Defined
Goldman Sachs Trust Company, N.A.	6,093	$203,445	1.1%	Defined

Trexquant Investment LP

$18,577,695

0.51%

556,385

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$16,995,510

0.46%

509,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	509,000	$16,995,510	100.0%	Other

Sofinnova Investments, Inc.

$16,695,000

0.45%

500,000

BNP PARIBAS ARBITRAGE, SA

$16,633,796

0.45%

498,167

JPMORGAN CHASE & CO

$16,465,475

0.45%

493,126

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JPMorgan Chase Bank, N.A.	56,896	$1,899,757	11.5%	Defined
J.P. Morgan Investment Management Inc.	232,755	$7,771,689	47.2%	Defined
J.P. Morgan Securities LLC	63,207	$2,110,481	12.8%	Defined
J.P. Morgan Securities plc	2,680	$89,485	0.5%	Defined
JPMorgan Asset Management (UK) Ltd	137,588	$4,594,063	27.9%	Defined

Bank of New York Mellon Corp

$15,716,569

0.43%

470,697

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BNY Mellon Trust of Delaware joint	6,180	$206,350	1.3%	Defined
Mellon Investments Corporation joint	113,029	$3,774,037	24.0%	Defined
The Bank of New York Mellon	176,598	$5,896,607	37.5%	Defined
BNY Mellon, NA joint	174,069	$5,812,163	37.0%	Defined
BNY Mellon Advisors, Inc.	819	$27,346	0.2%	Defined
Held directly	2	$66	0.0%	Defined

TORONTO DOMINION BANK

$13,856,850

0.38%

415,000

RENAISSANCE TECHNOLOGIES LLC

$13,813,443

0.38%

413,700

Caption Management, LLC

$13,753,341

0.37%

411,900

BNP PARIBAS ASSET MANAGEMENT Holding S.A.

$13,665,023

0.37%

409,255

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BNP PARIBAS ASSET MANAGEMENT Europe	1,214	$40,535	0.3%	Defined
AXA INVESTMENT MANAGERS UK LIMITED	408,041	$13,624,488	99.7%	Defined

Krensavage Asset Management, LLC

$13,051,449

0.36%

390,879

ALGERT GLOBAL LLC

$13,020,897

0.35%

389,964

MANUFACTURERS LIFE INSURANCE COMPANY, THE

$12,735,613

0.35%

381,420

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MANULIFE FINANCIAL CORP joint	381,420	$12,735,613	100.0%	Defined

SummitTX Capital, L.P.

$12,496,875

0.34%

374,270

Privium Fund Management B.V.

$11,312,532

0.31%

338,800

Squarepoint Ops LLC

$11,298,107

0.31%

338,368

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Squarepoint Capital LLP	338,368	$11,298,107	100.0%	Defined

Walleye Capital LLC

$11,180,775

0.30%

334,854

Catalio Capital Management, LP

$10,559,654

0.29%

316,252

FRANKLIN RESOURCES INC

$10,543,426

0.29%

315,766

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
FIDUCIARY TRUST INTERNATIONAL LLC	5,544	$185,114	1.8%	Defined
FRANKLIN ADVISERS INC	310,222	$10,358,312	98.2%	Defined

CITIGROUP INC

$9,976,430

0.27%

298,785

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citibank, N.A. joint	77	$2,571	0.0%	Defined
Citigroup Financial Products Inc. joint	298,708	$9,973,859	100.0%	Defined

NOMURA ASSET MANAGEMENT INTERNATIONAL INC.

$9,944,176

0.27%

297,819

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NOMURA HOLDINGS INC joint	297,819	$9,944,176	100.0%	Defined

Ensign Peak Advisors, Inc

$9,710,413

0.26%

290,818

GordonMD Global Investments LP

$9,653,082

0.26%

289,101

Jump Financial, LLC

$9,581,327

0.26%

286,952

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jump Trading Holdings, LLC	7,052	$235,466	2.5%	Defined
Leap GP LLC joint	279,900	$9,345,861	97.5%	Defined

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$9,215,640

0.25%

276,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	276,000	$9,215,640	100.0%	Other

MASSACHUSETTS FINANCIAL SERVICES CO /MA/

$9,111,529

0.25%

272,882

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MFS Heritage Trust CO	5,453	$182,075	2.0%	Defined
Held directly	267,429	$8,929,454	98.0%	Sole

Invesco Ltd.

$8,365,294

0.23%

250,533

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invesco Advisers, Inc. joint	13,860	$462,784	5.5%	Defined
Invesco Trust Co joint	38,512	$1,285,915	15.4%	Defined
Invesco Capital Management LLC	198,161	$6,616,595	79.1%	Defined

Quantinno Capital Management LP

$8,363,059

0.23%

250,466

KENNEDY CAPITAL MANAGEMENT LLC

$7,212,139

0.20%

215,997

Assenagon Asset Management S.A.

$7,182,371

0.20%

477,869

WORLDQUANT MILLENNIUM ADVISORS LLC

$7,157,947

0.19%

214,374

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MILLENNIUM MANAGEMENT LLC	214,374	$7,157,947	100.0%	Defined

SEI INVESTMENTS CO

$7,073,102

0.19%

211,833

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SEI INVESTMENTS MANAGEMENT CORP	123	$4,106	0.1%	Sole
SEI TRUST CO	211,710	$7,068,996	99.9%	Sole

CITADEL ADVISORS LLC

$7,029,630

0.19%

210,531

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	210,531	$7,029,630	100.0%	Defined

Ishara Investments LP

$6,844,950

0.19%

205,000

Stonepine Capital Management, LLC

$6,678,000

0.18%

200,000

Man Group plc

$6,514,722

0.18%

195,110

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
AHL Partners LLP	194	$6,477	0.1%	Defined
Numeric Investors LLC	194,916	$6,508,245	99.9%	Defined

FIFTH THIRD BANCORP

$6,452,150

0.18%

193,236

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fifth Third Bank, National Association	193,236	$6,452,150	100.0%	Defined

Connor, Clark & Lunn Investment Management Ltd.

$6,396,789

0.17%

191,578

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Manager 1	191,578	$6,396,789	100.0%	Sole

Blue Owl Capital Holdings LP

$6,098,282

0.17%

182,638

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Blue Owl Healthcare Opportunities Advisors LLC	182,638	$6,098,282	100.0%	Defined

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$6,039,282

0.16%

180,871

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	180,871	$6,039,282	100.0%	Other

SCHRODER INVESTMENT MANAGEMENT GROUP

$5,745,950

0.16%

172,086

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Schroder Investment Management Limited	171,456	$5,724,915	99.6%	Sole
Schroder Investment Management North America Inc.	630	$21,035	0.4%	Sole

Woodline Partners LP

$5,736,568

0.16%

171,805

Atom Investors LP

$5,735,433

0.16%

171,771

Swiss National Bank

$5,597,900

0.15%

167,652

UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC

$5,583,673

0.15%

167,226

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Group AG	1,552	$51,821	0.9%	Defined
UBS Asset Management Switzerland AG	103,981	$3,471,924	62.2%	Defined
UBS Asset Management (UK) Ltd.	23,881	$797,386	14.3%	Defined
Held directly	37,812	$1,262,542	22.6%	Defined

Ikarian Capital, LLC

$5,529,951

0.15%

165,617

DEUTSCHE BANK AG\

$5,503,105

0.15%

164,813

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DWS Investment GmbH	65,135	$2,174,857	39.5%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC	821	$27,413	0.5%	Defined
DWS Investments UK Ltd	98,857	$3,300,835	60.0%	Defined

MARSHALL WACE, LLP

$5,338,693

0.15%

159,889

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Marshall Wace North America L.P. joint	159,889	$5,338,693	100.0%	Other

WELLS FARGO & COMPANY/MN

$5,263,697

0.14%

157,643

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO BANK N A	87,379	$2,917,584	55.4%	Defined
WELLS FARGO ADVISORS FINANCIAL NETWORK, LLC	6,865	$229,222	4.4%	Defined
WELLS FARGO CLEARING SERVICES, LLC	63,353	$2,115,356	40.2%	Defined
WELLS FARGO INVESTMENT INSTITUTE, INC.	46	$1,535	0.0%	Defined

MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.

$5,235,852

0.14%

156,809

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Global X Management CO LLC joint	145,000	$4,841,550	92.5%	Defined
Global X Management (AUS) Ltd joint	11,809	$394,302	7.5%	Defined

BOOTHBAY FUND MANAGEMENT, LLC

$5,229,274

0.14%

156,612

BARCLAYS PLC

$5,171,307

0.14%

154,876

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BARCLAYS BANK PLC	112,097	$3,742,918	72.4%	Defined
BARCLAYS CAPITAL INC.	40,489	$1,351,927	26.1%	Defined
BARCLAYS CAPITAL SECURITIES LTD	1,230	$41,069	0.8%	Defined
Barclays Investment Solutions Ltd	1,060	$35,393	0.7%	Defined

Eversept Partners, LP

$5,146,400

0.14%

154,130

Ghisallo Capital Management LLC

$5,008,500

0.14%

150,000

Corient Private Wealth LLC

$4,891,401

0.13%

146,493

Mariner, LLC

$4,888,296

0.13%

146,400

FRED ALGER MANAGEMENT, LLC

$4,779,945

0.13%

143,155

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Weatherbie Capital, LLC	143,155	$4,779,945	100.0%	Sole

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Key facts CIK 1515673 CUSIP 90400D108 13F (30d) 26 filings 26 filers Visit website Investor relations