RARE · Ultragenyx Pharmaceutical Inc.

$15.30 +0.45 (+3.03%) At close · Sep 4

Russell 2000 member Rebalance outlook locked

Market Cap

$1.51B

98.59M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Use institutional holdings through the 13F API or MCP →

Quarter:

Holders: 317

Total Value: $3,683,933,302

Total Shares: 110,387,462

Showing 1–100 of 328 holdings by value · page 1 of 4

Institutional Ownership Trend

26 quarters

Holder Concentration

Across 317 13F filers · Δ vs Mar 31, 2026

Top Holder

9.7%

+2.4 pts

Top 5

34.4%

+8.0 pts

Top 10

49.7%

+8.0 pts

HHI

338

Broadly held+87

Quarterly Activity

vs Mar 31, 2026

New

Increased

116

Decreased

101

Sold Out

Unchanged

Holder count: +19

Institutional value: +75.3%

Shares held: +10.1%

Top Buyers

vs Mar 31, 2026

Institution	Added	Now Holds
Large RTW INVESTMENTS, LP	+4,148,100	7,796,895
Mega BlackRock, Inc.	+3,354,678	10,654,276
Mega AQR CAPITAL MANAGEMENT LLC	+1,982,785	6,560,809
Large JACOBS LEVY EQUITY MANAGEMENT, INC	+1,508,648	2,939,719
Mega TWO SIGMA INVESTMENTS, LP	+1,415,380	3,621,200

Top Sellers

vs Mar 31, 2026

Institution	Sold	Now Holds
Large Assenagon Asset Management S.A.	−2,136,807	120,864
Mega CITADEL ADVISORS LLC	−2,023,760	347,631
Mega WELLINGTON MANAGEMENT GROUP LLP	−1,390,348	1,250,464
Mid Sofinnova Investments, Inc.	−1,278,383	2,217,505
Mega MILLENNIUM MANAGEMENT LLC	−1,011,359	760,825

Top New Positions

vs Mar 31, 2026

Institution	Acquired	Value (USD)
Mid MPM BIOIMPACT LLC	1,418,215	$47,354,198
Small GREAT POINT PARTNERS LLC	600,000	$20,034,000
Large PANAGORA ASSET MANAGEMENT INC	586,230	$19,574,219
Small Stonepine Capital Management, LLC	225,000	$7,512,750
Mid Ghisallo Capital Management LLC	150,000	$5,008,500

Top Sold-Out Positions

vs Mar 31, 2026

Institution	Previously Held	Last Value (USD)
Small Jones Hill Capital LP	1,165,557	$24,418,419
Large Point72 Asset Management, L.P.	893,295	$18,714,530
Large HRT FINANCIAL LP	613,229	$12,847,147
Small Newtyn Management, LLC	400,000	$8,380,000
Large Balyasny Asset Management L.P.	384,364	$8,052,425

Filter: New 62 Increased 116 Reduced 101 Sold out 43 Unchanged 38

Showing 100 of 328

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

BlackRock, Inc.

$355,746,266

9.66%

10,654,276

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	554,371	$18,510,447	5.2%	Sole
BlackRock Investment Management (Australia) Ltd	214	$7,145	0.0%	Sole
BlackRock Asset Management Canada Ltd	29,828	$995,956	0.3%	Sole
BlackRock Investment Management, LLC	414,606	$13,843,694	3.9%	Sole
BLACKROCK ADVISORS LLC	898,152	$29,989,295	8.4%	Sole
BlackRock Fund Advisors	4,435,145	$148,089,491	41.6%	Sole
BlackRock Institutional Trust Company, N.A.	3,745,451	$125,060,608	35.2%	Sole
BlackRock Japan Co. Ltd	53,523	$1,787,132	0.5%	Sole
BlackRock Fund Managers Ltd.	30,466	$1,017,259	0.3%	Sole
BlackRock Investment Management (UK) Ltd.	138,054	$4,609,623	1.3%	Sole
BlackRock (Netherlands) B.V.	1,693	$56,529	0.0%	Sole
BlackRock Asset Management Ireland Ltd	223,994	$7,479,159	2.1%	Sole
BlackRock (Luxembourg) S.A.	5,423	$181,073	0.1%	Sole
BlackRock Life Ltd	224	$7,479	0.0%	Sole
BlackRock Asset Management Schweiz AG	15,034	$501,985	0.1%	Sole
Aperio Group, LLC	107,535	$3,590,593	1.0%	Sole
SpiderRock Advisors, LLC	563	$18,798	0.0%	Sole

RTW INVESTMENTS, LP

$260,338,324

7.07%

7,796,895

VANGUARD PORTFOLIO MANAGEMENT LLC

$226,722,607

6.15%

6,790,135

AQR CAPITAL MANAGEMENT LLC

$219,065,409

5.95%

6,560,809

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Petros Family Wealth, LLC	104	$3,472	0.0%	Other
KEB ASSET MANAGEMENT, LLC	410	$13,689	0.0%	Other
Arax Advisory Partners	18,427	$615,277	0.3%	Other
HALBERT HARGROVE GLOBAL ADVISORS, LLC	6,434	$214,831	0.1%	Other
Stokes Family Office, LLC	1,481	$49,450	0.0%	Other
Held directly	6,533,953	$218,168,690	99.6%	Defined

STATE STREET CORP

$205,641,196

5.58%

6,158,766

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STATE STREET GLOBAL ADVISORS EUROPE LIMITED joint	6,158,766	$205,641,196	100.0%	Defined

VANGUARD CAPITAL MANAGEMENT LLC

$143,459,834

3.89%

4,296,491

TWO SIGMA INVESTMENTS, LP

$120,911,868

3.28%

3,621,200

SANDS CAPITAL MANAGEMENT, LLC

$105,457,907

2.86%

3,158,368

JACOBS LEVY EQUITY MANAGEMENT, INC

$98,157,217

2.66%

2,939,719

FRONTIER CAPITAL MANAGEMENT CO LLC

$95,092,583

2.58%

2,847,936

GEODE CAPITAL MANAGEMENT, LLC

$86,107,066

2.34%

2,578,828

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	367,000	$12,254,130	14.2%	Defined
Held directly	2,211,828	$73,852,936	85.8%	Defined

Bellevue Group AG

$66,204,857

1.80%

1,982,775

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BB Biotech AG joint	1,982,775	$66,204,857	100.0%	Defined

D. E. Shaw & Co., Inc.

$57,771,143

1.57%

1,730,193

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
D. E. SHAW & CO, L.P.	1,638,717	$54,716,760	94.7%	Defined
D. E. Shaw Investment Management, L.L.C. joint	91,476	$3,054,383	5.3%	Defined

Sofinnova Investments, Inc.

$57,347,491

1.56%

1,717,505

ADAGE CAPITAL PARTNERS GP, L.L.C.

$52,756,200

1.43%

1,580,000

GW&K Investment Management, LLC

$49,456,532

1.34%

1,481,178

MPM BIOIMPACT LLC

$47,354,198

1.29%

1,418,215

PRICE T ROWE ASSOCIATES INC /MD/

$45,293,568

1.23%

1,356,501

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T. Rowe Price International Ltd	156,877	$5,238,123	11.6%	Defined
Held directly	1,199,624	$40,055,445	88.4%	Sole

MORGAN STANLEY

$44,235,235

1.20%

1,324,805

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	6,121	$204,380	0.5%	Defined
MORGAN STANLEY & CO. LLC	164,041	$5,477,328	12.4%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	710,074	$23,709,370	53.6%	Defined
MORGAN STANLEY INVESTMENT MANAGEMENT INC	1,439	$48,048	0.1%	Defined
MORGAN STANLEY SMITH BARNEY LLC	90,750	$3,030,142	6.9%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	301,155	$10,055,565	22.7%	Defined
EATON VANCE MANAGEMENT	51,225	$1,710,402	3.9%	Defined

WELLINGTON MANAGEMENT GROUP LLP

$41,752,990

1.13%

1,250,464

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Wellington Management Company LLP	836,374	$27,926,527	66.9%	Defined
Wellington Management Singapore Pte. Ltd.	43,575	$1,454,969	3.5%	Defined
Wellington Management International Ltd	15,070	$503,187	1.2%	Defined
Wellington Trust Company, NA joint	352,389	$11,766,268	28.2%	Defined
Wellington Management Australia Pty Ltd	3,056	$102,039	0.2%	Defined

VOLORIDGE INVESTMENT MANAGEMENT, LLC

$41,455,554

1.13%

1,241,556

BANK OF AMERICA CORP /DE/

$38,346,877

1.04%

1,148,454

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	703,980	$23,505,892	61.3%	Defined
MERRILL LYNCH, PIERCE, FENNER & SMITH INC.	51,459	$1,718,216	4.5%	Defined
BOFA SECURITIES, INC.	156,037	$5,210,075	13.6%	Defined
MANAGED ACCOUNT ADVISORS LLC joint	236,978	$7,912,694	20.6%	Defined

Candriam S.C.A.

$33,451,470

0.91%

1,001,841

Rock Springs Capital Management LP

$32,316,678

0.88%

967,855

Jefferies Financial Group Inc.

$31,040,212

0.84%

929,626

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jefferies Financial Services, Inc.	929,626	$31,040,212	100.0%	Defined

NORTHERN TRUST CORP

$30,729,282

0.83%

920,314

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	843,976	$28,180,357	91.7%	Defined
NORTHERN TRUST GLOBAL INVESTMENTS LTD	61,344	$2,048,276	6.7%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC joint	14,994	$500,649	1.6%	Other

Eagle Health Investments LP

$29,520,800

0.80%

884,121

Qube Research & Technologies Ltd

$29,457,292

0.80%

882,219

Russell Investments Group, Ltd.

$26,181,059

0.71%

784,099

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Russell Investment Management, LLC joint	214,812	$7,172,571	27.4%	Defined
Russell Investments Canada Limited	10,951	$365,653	1.4%	Defined
Russell Investments Capital, LLC joint	298,814	$9,977,399	38.1%	Other
Russell Investments France SAS	7,138	$238,337	0.9%	Defined
Russell Investments Implementation Services, LLC	20,686	$690,705	2.6%	Defined
Russell Investments Japan Co., LTD. joint	19,911	$664,828	2.5%	Other
Russell Investments Limited joint	171,964	$5,741,877	21.9%	Other
Russell Investments Trust Company joint	39,823	$1,329,689	5.1%	Other

MILLENNIUM MANAGEMENT LLC

$25,403,946

0.69%

760,825

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$25,377,702

0.69%

760,039

Pictet Asset Management Holding SA

$25,165,876

0.68%

753,695

Caption Management, LLC

$24,000,732

0.65%

718,800

Nuveen, LLC

$23,171,290

0.63%

693,959

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Nuveen Asset Management, LLC joint	48,739	$1,627,395	7.0%	Defined
TIAA CREF INVESTMENT MANAGEMENT LLC joint	201,100	$6,714,729	29.0%	Defined
TEACHERS ADVISORS, LLC joint	444,120	$14,829,166	64.0%	Defined

VANGUARD FIDUCIARY TRUST CO

$22,418,413

0.61%

671,411

UBS Group AG

$21,960,568

0.60%

657,699

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Financial Services Inc	5,493	$183,411	0.8%	Defined
UBS AG	645,561	$21,555,281	98.2%	Defined
UBS Switzerland AG	3,478	$116,130	0.5%	Defined
UBS Securities LLC	3,167	$105,746	0.5%	Defined

GREAT POINT PARTNERS LLC

$20,034,000

0.54%

600,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JAY JEFFREY R joint	600,000	$20,034,000	100.0%	Defined

Palo Alto Investors LP

$19,916,968

0.54%

596,495

SPHERA FUNDS MANAGEMENT LTD.

$19,649,814

0.53%

588,494

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Sphera Global Healthcare Management LP joint	588,494	$19,649,814	100.0%	Defined

Legal & General Group Plc

$19,583,902

0.53%

586,520

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Legal & General Investment Management America Inc	9,385	$313,365	1.6%	Defined
Legal & General Investment Management Ltd joint	577,135	$19,270,537	98.4%	Defined

PANAGORA ASSET MANAGEMENT INC

$19,574,219

0.53%

586,230

FMR LLC

$19,260,986

0.52%

576,849

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	257,494	$8,597,724	44.6%	Defined
STRATEGIC ADVISERS LLC	3,495	$116,698	0.6%	Defined
Fidelity Institutional Asset Management Trust Co	2,107	$70,352	0.4%	Defined
FIAM LLC	308,200	$10,290,798	53.4%	Defined
Fidelity Diversifying Solutions LLC	5,553	$185,414	1.0%	Defined

GOLDMAN SACHS GROUP INC

$19,210,535

0.52%

575,338

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	371,201	$12,394,401	64.5%	Defined
GOLDMAN SACHS ASSET MANAGEMENT, L.P.	198,044	$6,612,689	34.4%	Defined
Goldman Sachs Trust Company, N.A.	6,093	$203,445	1.1%	Defined

Trexquant Investment LP

$18,577,695

0.50%

556,385

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$16,995,510

0.46%

509,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	509,000	$16,995,510	100.0%	Other

Sofinnova Investments, Inc.

$16,695,000

0.45%

500,000

BNP PARIBAS ARBITRAGE, SA

$16,633,796

0.45%

498,167

JPMORGAN CHASE & CO

$16,465,475

0.45%

493,126

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JPMorgan Chase Bank, N.A.	56,896	$1,899,757	11.5%	Defined
J.P. Morgan Investment Management Inc.	232,755	$7,771,689	47.2%	Defined
J.P. Morgan Securities LLC	63,207	$2,110,481	12.8%	Defined
J.P. Morgan Securities plc	2,680	$89,485	0.5%	Defined
JPMorgan Asset Management (UK) Ltd	137,588	$4,594,063	27.9%	Defined

Bank of New York Mellon Corp

$15,716,569

0.43%

470,697

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BNY Mellon Trust of Delaware joint	6,180	$206,350	1.3%	Defined
Mellon Investments Corporation joint	113,029	$3,774,037	24.0%	Defined
The Bank of New York Mellon	176,598	$5,896,607	37.5%	Defined
BNY Mellon, NA joint	174,069	$5,812,163	37.0%	Defined
BNY Mellon Advisors, Inc.	819	$27,346	0.2%	Defined
Held directly	2	$66	0.0%	Defined

TORONTO DOMINION BANK

$13,856,850

0.38%

415,000

RENAISSANCE TECHNOLOGIES LLC

$13,813,443

0.37%

413,700

Caption Management, LLC

$13,753,341

0.37%

411,900

BNP PARIBAS ASSET MANAGEMENT Holding S.A.

$13,665,023

0.37%

409,255

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BNP PARIBAS ASSET MANAGEMENT Europe	1,214	$40,535	0.3%	Defined
AXA INVESTMENT MANAGERS UK LIMITED	408,041	$13,624,488	99.7%	Defined

Krensavage Asset Management, LLC

$13,051,449

0.35%

390,879

ALGERT GLOBAL LLC

$13,020,897

0.35%

389,964

MANUFACTURERS LIFE INSURANCE COMPANY, THE

$12,735,613

0.35%

381,420

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MANULIFE FINANCIAL CORP joint	381,420	$12,735,613	100.0%	Defined

SummitTX Capital, L.P.

$12,496,875

0.34%

374,270

Privium Fund Management B.V.

$11,312,532

0.31%

338,800

Squarepoint Ops LLC

$11,298,107

0.31%

338,368

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Squarepoint Capital LLP	338,368	$11,298,107	100.0%	Defined

Walleye Capital LLC

$11,180,775

0.30%

334,854

Catalio Capital Management, LP

$10,559,654

0.29%

316,252

FRANKLIN RESOURCES INC

$10,543,426

0.29%

315,766

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
FIDUCIARY TRUST INTERNATIONAL LLC	5,544	$185,114	1.8%	Defined
FRANKLIN ADVISERS INC	310,222	$10,358,312	98.2%	Defined

CITIGROUP INC

$9,976,430

0.27%

298,785

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citibank, N.A. joint	77	$2,571	0.0%	Defined
Citigroup Financial Products Inc. joint	298,708	$9,973,859	100.0%	Defined

NOMURA ASSET MANAGEMENT INTERNATIONAL INC.

$9,944,176

0.27%

297,819

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NOMURA HOLDINGS INC joint	297,819	$9,944,176	100.0%	Defined

Ensign Peak Advisors, Inc

$9,710,413

0.26%

290,818

GordonMD Global Investments LP

$9,653,082

0.26%

289,101

Jump Financial, LLC

$9,581,327

0.26%

286,952

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jump Trading Holdings, LLC	7,052	$235,466	2.5%	Defined
Leap GP LLC joint	279,900	$9,345,861	97.5%	Defined

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$9,215,640

0.25%

276,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	276,000	$9,215,640	100.0%	Other

MASSACHUSETTS FINANCIAL SERVICES CO /MA/

$9,111,529

0.25%

272,882

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MFS Heritage Trust CO	5,453	$182,075	2.0%	Defined
Held directly	267,429	$8,929,454	98.0%	Sole

Invesco Ltd.

$8,365,294

0.23%

250,533

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invesco Advisers, Inc. joint	13,860	$462,784	5.5%	Defined
Invesco Trust Co joint	38,512	$1,285,915	15.4%	Defined
Invesco Capital Management LLC	198,161	$6,616,595	79.1%	Defined

Quantinno Capital Management LP

$8,363,059

0.23%

250,466

KENNEDY CAPITAL MANAGEMENT LLC

$7,212,139

0.20%

215,997

WORLDQUANT MILLENNIUM ADVISORS LLC

$7,157,947

0.19%

214,374

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MILLENNIUM MANAGEMENT LLC	214,374	$7,157,947	100.0%	Defined

SEI INVESTMENTS CO

$7,073,102

0.19%

211,833

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SEI INVESTMENTS MANAGEMENT CORP	123	$4,106	0.1%	Sole
SEI TRUST CO	211,710	$7,068,996	99.9%	Sole

CITADEL ADVISORS LLC

$7,029,630

0.19%

210,531

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	210,531	$7,029,630	100.0%	Defined

Ishara Investments LP

$6,844,950

0.19%

205,000

Stonepine Capital Management, LLC

$6,678,000

0.18%

200,000

Man Group plc

$6,514,722

0.18%

195,110

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
AHL Partners LLP	194	$6,477	0.1%	Defined
Numeric Investors LLC	194,916	$6,508,245	99.9%	Defined

FIFTH THIRD BANCORP

$6,452,150

0.18%

193,236

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fifth Third Bank, National Association	193,236	$6,452,150	100.0%	Defined

Connor, Clark & Lunn Investment Management Ltd.

$6,396,789

0.17%

191,578

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Manager 1	191,578	$6,396,789	100.0%	Sole

Blue Owl Capital Holdings LP

$6,098,282

0.17%

182,638

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Blue Owl Healthcare Opportunities Advisors LLC	182,638	$6,098,282	100.0%	Defined

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$6,039,282

0.16%

180,871

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	180,871	$6,039,282	100.0%	Other

SCHRODER INVESTMENT MANAGEMENT GROUP

$5,745,950

0.16%

172,086

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Schroder Investment Management Limited	171,456	$5,724,915	99.6%	Sole
Schroder Investment Management North America Inc.	630	$21,035	0.4%	Sole

Woodline Partners LP

$5,736,568

0.16%

171,805

Atom Investors LP

$5,735,433

0.16%

171,771

Swiss National Bank

$5,597,900

0.15%

167,652

UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC

$5,583,673

0.15%

167,226

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Group AG	1,552	$51,821	0.9%	Defined
UBS Asset Management Switzerland AG	103,981	$3,471,924	62.2%	Defined
UBS Asset Management (UK) Ltd.	23,881	$797,386	14.3%	Defined
Held directly	37,812	$1,262,542	22.6%	Defined

Ikarian Capital, LLC

$5,529,951

0.15%

165,617

DEUTSCHE BANK AG\

$5,503,105

0.15%

164,813

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DWS Investment GmbH	65,135	$2,174,857	39.5%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC	821	$27,413	0.5%	Defined
DWS Investments UK Ltd	98,857	$3,300,835	60.0%	Defined

MARSHALL WACE, LLP

$5,338,693

0.14%

159,889

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Marshall Wace North America L.P. joint	159,889	$5,338,693	100.0%	Other

WELLS FARGO & COMPANY/MN

$5,263,697

0.14%

157,643

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO BANK N A	87,379	$2,917,584	55.4%	Defined
WELLS FARGO ADVISORS FINANCIAL NETWORK, LLC	6,865	$229,222	4.4%	Defined
WELLS FARGO CLEARING SERVICES, LLC	63,353	$2,115,356	40.2%	Defined
WELLS FARGO INVESTMENT INSTITUTE, INC.	46	$1,535	0.0%	Defined

MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.

$5,235,852

0.14%

156,809

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Global X Management CO LLC joint	145,000	$4,841,550	92.5%	Defined
Global X Management (AUS) Ltd joint	11,809	$394,302	7.5%	Defined

BOOTHBAY FUND MANAGEMENT, LLC

$5,229,274

0.14%

156,612

BARCLAYS PLC

$5,171,307

0.14%

154,876

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BARCLAYS BANK PLC	112,097	$3,742,918	72.4%	Defined
BARCLAYS CAPITAL INC.	40,489	$1,351,927	26.1%	Defined
BARCLAYS CAPITAL SECURITIES LTD	1,230	$41,069	0.8%	Defined
Barclays Investment Solutions Ltd	1,060	$35,393	0.7%	Defined

Eversept Partners, LP

$5,146,400

0.14%

154,130

Ghisallo Capital Management LLC

$5,008,500

0.14%

150,000

Corient Private Wealth LLC

$4,891,401

0.13%

146,493

Mariner, LLC

$4,888,296

0.13%

146,400

FRED ALGER MANAGEMENT, LLC

$4,779,945

0.13%

143,155

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Weatherbie Capital, LLC	143,155	$4,779,945	100.0%	Sole

SR One Capital Management, LP

$4,599,572

0.12%

137,753

Key facts CIK 1515673 CUSIP 90400D108 13F (30d) 220 filings 219 filers Visit website Investor relations