TWO SIGMA INVESTMENTS, LP
Position in RARE — Ultragenyx Pharmaceutical Inc.
CIK 1179392
NEW YORK, NY
Position in RARE
as of Jun 30, 2026
· filed Aug 14, 2026
Position Value
$120,911,868
+$74,699,939 QoQ
Shares Held
3,621,200
+64.2% QoQ
Ownership
3.67%
of shares outstanding
% of Portfolio
0.10%
of 13F equity value
Holder Rank
#7
of 311 holders
Holding Since
Jun 2020
24 quarters on record
Voting authority
Sole 98%
Shared 0%
None 2%
Common Shares in RARE Over Time
Shares Held
Position Value (USD)
Position in Biotechnology
Healthcare · as of Jun 30, 2026TWO SIGMA INVESTMENTS, LP holds $7,283,390,440 across 343 Biotechnology names. RARE ranks #17 (1.7% of the industry book) .
| # | Ticker | Company | Shares | Value (USD) | Open |
|---|---|---|---|---|---|
| 1 | ALNY |
Alnylam Pharmaceuticals, Inc.
|
1,875,937 | $564,713,315 | |
| 2 | MRNA |
Moderna, Inc.
|
7,193,530 | $503,762,905 | |
| 3 | IONS |
Ionis Pharmaceuticals Inc
|
6,252,342 | $495,748,197 | |
| 4 | REGN |
Regeneron Pharmaceuticals, Inc.
|
656,124 | $409,119,558 | |
| 5 | BBIO |
BridgeBio Pharma, Inc.
|
4,722,185 | $351,708,338 | |
| 6 | EXEL |
Exelixis, Inc.
|
4,209,861 | $229,058,537 | |
| 7 | INCY |
Incyte Corp
|
2,003,559 | $227,123,448 | |
| 8 | ARGX |
Argenx SE
|
185,638 | $172,229,367 |
All Filings in RARE
Export CSV
24 filing rows on record
| Report Date | Value (USD) | Shares | Type | Discretion | Filed | |
|---|---|---|---|---|---|---|
| 2026-06-30 | $120,911,868 | 3,621,200 | Shares | Sole | 2026-08-14 | |
| 2026-03-31 | $46,211,929 | 2,205,820 | Shares | Sole | 2026-05-15 | |
| 2025-12-31 | $9,753,127 | 424,049 | Shares | Sole | 2026-02-17 | |
| 2025-09-30 | $9,811,494 | 326,180 | Shares | Sole | 2025-11-14 | |
| 2025-06-30 | $20,976,120 | 576,901 | Shares | Sole | 2025-08-14 | |
| 2025-03-31 | $22,926,433 | 633,152 | Shares | Sole | 2025-05-15 | |
| 2024-12-31 | $25,870,862 | 614,948 | Shares | Sole | 2025-02-14 | |
| 2024-09-30 | $41,978,190 | 755,683 | Shares | Sole | 2024-11-14 | |
| 2024-06-30 | $23,357,499 | 568,309 | Shares | Sole | 2024-08-14 | |
| 2024-03-31 | $19,391,010 | 415,314 | Shares | Sole | 2024-05-15 | |
| 2023-12-31 | $6,054,490 | 126,610 | Shares | Sole | 2024-02-14 | |
| 2023-09-30 | $1,397,480 | 39,200 | Shares | Sole | 2023-11-14 | |
| 2023-06-30 | $18,626,094 | 403,774 | Shares | Sole | 2023-08-14 | |
| 2023-03-31 | $19,583,075 | 488,356 | Shares | Sole | 2023-05-15 | |
| 2022-12-31 | $20,474,894 | 441,936 | Shares | Sole | 2023-02-14 | |
| 2022-09-30 | $10,575,658 | 255,389 | Shares | Sole | 2022-11-14 | |
| 2022-06-30 | $3,370,790 | 56,500 | Shares | Sole | 2022-08-15 | |
| 2022-03-31 | $2,824,918 | 38,900 | Shares | Sole | 2022-05-16 | |
| 2021-09-30 | $2,335,921 | 25,900 | Shares | Sole | 2021-11-15 | |
| 2021-06-30 | $27,676,672 | 290,264 | Shares | Sole | 2021-08-16 | |
| 2021-03-31 | $16,432,275 | 144,320 | Shares | Sole | 2021-05-17 | |
| 2020-12-31 | $8,348,990 | 60,312 | Shares | Sole | 2021-02-16 | |
| 2020-09-30 | $469,880 | 5,717 | Shares | Sole | 2020-11-16 | |
| 2020-06-30 | $3,093,913 | 39,554 | Shares | Sole | 2020-08-14 | |
| No filing history on record for this holder in this stock. | ||||||