TWO SIGMA INVESTMENTS, LP
Position in RARE — Ultragenyx Pharmaceutical Inc.
CIK 1179392
NEW YORK, NY
Position in RARE
as of Mar 31, 2026
· filed May 15, 2026
Position Value
$46,211,929
+$36,458,802 QoQ
Shares Held
2,205,820
+420.2% QoQ
Ownership
2.24%
of shares outstanding
% of Portfolio
0.04%
of 13F equity value
Holder Rank
—
not a current holder
Holding Since
Jun 2020
23 quarters on record
Voting authority
Sole 97.82847195147383.ToString("F0")%
Shared 0.ToString("F0")%
None 2.1715280485261714.ToString("F0")%
Common Shares in RARE Over Time
Shares Held
Position Value (USD)
Position in Biotechnology
Healthcare · as of Mar 31, 2026TWO SIGMA INVESTMENTS, LP holds $5,502,861,072 across 315 Biotechnology names. RARE ranks #24 (0.8% of the industry book) .
| # | Ticker | Company | Shares | Value (USD) | Open |
|---|---|---|---|---|---|
| 1 | ALNY |
Alnylam Pharmaceuticals, Inc.
|
1,992,577 | $659,283,951 | |
| 2 | REGN |
Regeneron Pharmaceuticals, Inc.
|
812,236 | $627,566,023 | |
| 3 | MRNA |
Moderna, Inc.
|
9,086,404 | $461,589,323 | |
| 4 | IONS |
Ionis Pharmaceuticals Inc
|
5,857,629 | $439,849,361 | |
| 5 | BBIO |
BridgeBio Pharma, Inc.
|
3,120,631 | $231,738,058 | |
| 6 | VRTX |
Vertex Pharmaceuticals Inc / Ma
|
378,146 | $168,857,314 | |
| 7 | RVMD |
Revolution Medicines, Inc.
|
1,558,807 | $151,593,980 | |
| 8 | VKTX |
Viking Therapeutics, Inc.
|
4,432,142 | $144,221,900 |
All Filings in RARE
Export CSV
23 filing rows on record
| Report Date | Value (USD) | Shares | Type | Discretion | Filed | |
|---|---|---|---|---|---|---|
| 2026-03-31 | $46,211,929 | 2,205,820 | Shares | Sole | 2026-05-15 | |
| 2025-12-31 | $9,753,127 | 424,049 | Shares | Sole | 2026-02-17 | |
| 2025-09-30 | $9,811,494 | 326,180 | Shares | Sole | 2025-11-14 | |
| 2025-06-30 | $20,976,120 | 576,901 | Shares | Sole | 2025-08-14 | |
| 2025-03-31 | $22,926,433 | 633,152 | Shares | Sole | 2025-05-15 | |
| 2024-12-31 | $25,870,862 | 614,948 | Shares | Sole | 2025-02-14 | |
| 2024-09-30 | $41,978,190 | 755,683 | Shares | Sole | 2024-11-14 | |
| 2024-06-30 | $23,357,499 | 568,309 | Shares | Sole | 2024-08-14 | |
| 2024-03-31 | $19,391,010 | 415,314 | Shares | Sole | 2024-05-15 | |
| 2023-12-31 | $6,054,490 | 126,610 | Shares | Sole | 2024-02-14 | |
| 2023-09-30 | $1,397,480 | 39,200 | Shares | Sole | 2023-11-14 | |
| 2023-06-30 | $18,626,094 | 403,774 | Shares | Sole | 2023-08-14 | |
| 2023-03-31 | $19,583,075 | 488,356 | Shares | Sole | 2023-05-15 | |
| 2022-12-31 | $20,474,894 | 441,936 | Shares | Sole | 2023-02-14 | |
| 2022-09-30 | $10,575,658 | 255,389 | Shares | Sole | 2022-11-14 | |
| 2022-06-30 | $3,370,790 | 56,500 | Shares | Sole | 2022-08-15 | |
| 2022-03-31 | $2,824,918 | 38,900 | Shares | Sole | 2022-05-16 | |
| 2021-09-30 | $2,335,921 | 25,900 | Shares | Sole | 2021-11-15 | |
| 2021-06-30 | $27,676,672 | 290,264 | Shares | Sole | 2021-08-16 | |
| 2021-03-31 | $16,432,275 | 144,320 | Shares | Sole | 2021-05-17 | |
| 2020-12-31 | $8,348,990 | 60,312 | Shares | Sole | 2021-02-16 | |
| 2020-09-30 | $469,880 | 5,717 | Shares | Sole | 2020-11-16 | |
| 2020-06-30 | $3,093,913 | 39,554 | Shares | Sole | 2020-08-14 | |
| No filing history on record for this holder in this stock. | ||||||