TWO SIGMA INVESTMENTS, LP

Position in ARGX — Argenx SE

CIK 1179392 NEW YORK, NY

Back to ARGX Full portfolio

Position in ARGX

as of Jun 30, 2026 · filed Aug 14, 2026 Compact

Position Value

$172,229,367

+$92,543,757 QoQ

Shares Held

185,638

+70.1% QoQ

Ownership

0.299%

of shares outstanding

% of Portfolio

0.14%

of 13F equity value

Holder Rank

#24

of 504 holders

Holding Since

Mar 2025

6 quarters on record

Voting authority Sole 99% Shared 0% None 1%

Common Shares in ARGX Over Time

Shares Held

Position Value (USD)

Derivatives in ARGX

reported options exposure · as of Jun 30, 2026

CallValue

CallShares

PutValue

$556,662

PutShares

600

Notional value of option positions as reported on Form 13F. Calls and puts are disclosed separately and do not net against the common-share stake above.

Position in Biotechnology

Healthcare · as of Jun 30, 2026

TWO SIGMA INVESTMENTS, LP holds $7,273,657,992 across 342 Biotechnology names. ARGX ranks #8 (2.4% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	ALNY	Alnylam Pharmaceuticals, Inc.	1,875,937	$564,713,315
2	MRNA	Moderna, Inc.	7,193,530	$503,762,905
3	IONS	Ionis Pharmaceuticals Inc	6,252,342	$495,748,197
4	REGN	Regeneron Pharmaceuticals, Inc.	656,124	$409,119,558
5	BBIO	BridgeBio Pharma, Inc.	4,722,185	$351,708,338
6	EXEL	Exelixis, Inc.	4,209,861	$229,058,537
7	INCY	Incyte Corp	2,003,559	$227,123,448
8	ARGX	Argenx SE This page	185,638	$172,229,367

All Filings in ARGX

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7 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-06-30	$172,229,367	185,638	+70.1%	Shares	Sole	2026-08-14
2026-06-30	$556,662	600	—	Put	Sole	2026-08-14
2026-03-31	$79,685,610	109,121	-57.8%	Shares	Sole	2026-05-15
2025-12-31	$217,432,668	258,556	-12.1%	Shares	Sole	2026-02-17
2025-09-30	$216,960,649	294,160	+570.3%	Shares	Sole	2025-11-14
2025-06-30	$24,188,636	43,882	-40.7%	Shares	Sole	2025-08-14
2025-03-31	$43,767,233	73,948	—	Shares	Sole	2025-05-15
No filing history on record for this holder in this stock.