TWO SIGMA INVESTMENTS, LP

Position in REGN — Regeneron Pharmaceuticals, Inc.

CIK 1179392 NEW YORK, NY

Back to REGN Full portfolio

Position in REGN

as of Mar 31, 2026 · filed May 15, 2026 Compact

Position Value

$627,566,023

+$410,554,001 QoQ

Shares Held

812,236

+188.9% QoQ

Ownership

0.775%

of shares outstanding

% of Portfolio

0.58%

of 13F equity value

Holder Rank

—

not a current holder

Holding Since

Mar 2020

22 quarters on record

Voting authority Sole 96.07010770268741.ToString("F0")% Shared 0.ToString("F0")% None 3.9298922973126036.ToString("F0")%

Common Shares in REGN Over Time

Shares Held

Position Value (USD)

Derivatives in REGN

reported options exposure · as of Dec 31, 2021

CallValue

$9,725,408

CallShares

15,400

PutValue

$11,556,816

PutShares

18,300

Notional value of option positions as reported on Form 13F. Calls and puts are disclosed separately and do not net against the common-share stake above.

Position in Biotechnology

Healthcare · as of Mar 31, 2026

TWO SIGMA INVESTMENTS, LP holds $5,502,861,072 across 315 Biotechnology names. REGN ranks #2 (11.4% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	ALNY	Alnylam Pharmaceuticals, Inc.	1,992,577	$659,283,951
2	REGN	Regeneron Pharmaceuticals, Inc. This page	812,236	$627,566,023
3	MRNA	Moderna, Inc.	9,086,404	$461,589,323
4	IONS	Ionis Pharmaceuticals Inc	5,857,629	$439,849,361
5	BBIO	BridgeBio Pharma, Inc.	3,120,631	$231,738,058
6	VRTX	Vertex Pharmaceuticals Inc / Ma	378,146	$168,857,314
7	RVMD	Revolution Medicines, Inc.	1,558,807	$151,593,980
8	VKTX	Viking Therapeutics, Inc.	4,432,142	$144,221,900

All Filings in REGN

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33 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-03-31	$627,566,023	812,236	+188.9%	Shares	Sole	2026-05-15
2025-12-31	$217,012,022	281,151	-40.2%	Shares	Sole	2026-02-17
2025-09-30	$264,212,359	469,903	-6.0%	Shares	Sole	2025-11-14
2025-06-30	$262,409,700	499,828	+34.3%	Shares	Sole	2025-08-14
2025-03-31	$235,978,590	372,071	+977.1%	Shares	Sole	2025-05-15
2024-12-31	$24,606,015	34,543	+54.3%	Shares	Sole	2025-02-14
2024-09-30	$23,536,212	22,389	+368.3%	Shares	Sole	2024-11-14
2024-03-31	$4,601,664	4,781	-92.7%	Shares	Sole	2024-05-15
2023-12-31	$57,280,317	65,218	-26.5%	Shares	Sole	2024-02-14
2023-09-30	$73,008,896	88,715	-28.2%	Shares	Sole	2023-11-14
2023-06-30	$88,830,226	123,626	-34.7%	Shares	Sole	2023-08-14
2023-03-31	$155,538,022	189,295	+488.6%	Shares	Sole	2023-05-15
2022-12-31	$23,201,675	32,158	-84.5%	Shares	Sole	2023-02-14
2022-03-31	$144,873,260	207,430	+1246.9%	Shares	Sole	2022-05-16
2021-12-31	$9,725,408	15,400	-95.2%	Call	Sole	2022-02-14
2021-12-31	$204,244,303	323,417	+1667.3%	Shares	Sole	2022-02-14
2021-12-31	$11,556,816	18,300	-16.4%	Put	Sole	2022-02-14
2021-09-30	$13,253,442	21,900	+173.8%	Put	Sole	2021-11-15
2021-09-30	$4,841,440	8,000	+57.9%	Call	Sole	2021-11-15
2021-09-30	$3,067,052	5,068	-70.7%	Shares	Sole	2021-11-15
2021-06-30	$9,662,742	17,300	-36.6%	Call	Sole	2021-08-16
2021-06-30	$15,248,142	27,300	+40.7%	Put	Sole	2021-08-16
2021-03-31	$9,178,916	19,400	+5.4%	Put	Sole	2021-05-17
2021-03-31	$8,705,776	18,400	-18.9%	Call	Sole	2021-05-17
2020-12-31	$10,966,597	22,700	+12.4%	Put	Sole	2021-02-16
2020-12-31	$9,758,822	20,200	+211.2%	Call	Sole	2021-02-16
2020-12-31	$3,136,350	6,492	-22.7%	Shares	Sole	2021-02-16
2020-09-30	$4,702,152	8,400	+27.3%	Put	Sole	2020-11-16
2020-09-30	$3,694,548	6,600	+500.0%	Call	Sole	2020-11-16
2020-06-30	$686,015	1,100	-97.9%	Call	Sole	2020-08-14
2020-03-31	$25,371,060	51,959	+583.7%	Shares	Sole	2020-05-15
2020-03-31	$3,711,004	7,600	-27.6%	Call	Sole	2020-05-15
2020-03-31	$5,127,045	10,500	—	Put	Sole	2020-05-15
No filing history on record for this holder in this stock.