TWO SIGMA INVESTMENTS, LP
Position in VRTX — Vertex Pharmaceuticals Inc / Ma
CIK 1179392
NEW YORK, NY
Position in VRTX
as of Mar 31, 2026
· filed May 15, 2026
Position Value
$168,857,314
+$166,973,604 QoQ
Shares Held
378,146
+9001.0% QoQ
Ownership
0.149%
of shares outstanding
% of Portfolio
0.16%
of 13F equity value
Holder Rank
—
not a current holder
Holding Since
Mar 2020
16 quarters on record
Voting authority
Sole 99.10087638108033.ToString("F0")%
Shared 0.ToString("F0")%
None 0.8991236189196765.ToString("F0")%
Common Shares in VRTX Over Time
Shares Held
Position Value (USD)
Derivatives in VRTX
reported options exposure · as of Mar 31, 2026CallValue
$0
CallShares
0
PutValue
$446,540
PutShares
1,000
Notional value of option positions as reported on Form 13F. Calls and puts are disclosed separately and do not net against the common-share stake above.
Position in Biotechnology
Healthcare · as of Mar 31, 2026TWO SIGMA INVESTMENTS, LP holds $5,509,413,147 across 314 Biotechnology names. VRTX ranks #6 (3.1% of the industry book) .
| # | Ticker | Company | Shares | Value (USD) | Open |
|---|---|---|---|---|---|
| 1 | ALNY |
Alnylam Pharmaceuticals, Inc.
|
1,992,577 | $659,283,951 | |
| 2 | REGN |
Regeneron Pharmaceuticals, Inc.
|
812,236 | $627,566,023 | |
| 3 | MRNA |
Moderna, Inc.
|
9,086,404 | $461,589,323 | |
| 4 | IONS |
Ionis Pharmaceuticals Inc
|
5,857,629 | $439,849,361 | |
| 5 | BBIO |
BridgeBio Pharma, Inc.
|
3,120,631 | $231,738,058 | |
| 6 | VRTX |
Vertex Pharmaceuticals Inc / Ma
This page
|
378,146 | $168,857,314 | |
| 7 | RVMD |
Revolution Medicines, Inc.
|
1,558,807 | $151,593,980 | |
| 8 | VKTX |
Viking Therapeutics, Inc.
|
4,432,142 | $144,221,900 |
All Filings in VRTX
Export CSV
17 filing rows on record
| Report Date | Value (USD) | Shares | Type | Discretion | Filed | |
|---|---|---|---|---|---|---|
| 2026-03-31 | $446,540 | 1,000 | Put | Sole | 2026-05-15 | |
| 2026-03-31 | $168,857,314 | 378,146 | Shares | Sole | 2026-05-15 | |
| 2025-12-31 | $1,883,710 | 4,155 | Shares | Sole | 2026-02-17 | |
| 2025-03-31 | $1,997,943 | 4,121 | Shares | Sole | 2025-05-15 | |
| 2024-12-31 | $13,353,532 | 33,160 | Shares | Sole | 2025-02-14 | |
| 2024-09-30 | $74,661,617 | 160,535 | Shares | Sole | 2024-11-14 | |
| 2024-06-30 | $155,608,946 | 331,987 | Shares | Sole | 2024-08-14 | |
| 2024-03-31 | $135,614,148 | 324,428 | Shares | Sole | 2024-05-15 | |
| 2023-12-31 | $55,407,838 | 136,174 | Shares | Sole | 2024-02-14 | |
| 2023-09-30 | $90,213,840 | 259,429 | Shares | Sole | 2023-11-14 | |
| 2023-06-30 | $136,851,816 | 388,883 | Shares | Sole | 2023-08-14 | |
| 2023-03-31 | $28,751,712 | 91,255 | Shares | Sole | 2023-05-15 | |
| 2022-12-31 | $8,409,851 | 29,122 | Shares | Sole | 2023-02-14 | |
| 2022-03-31 | $8,780,074 | 33,644 | Shares | Sole | 2022-05-16 | |
| 2021-09-30 | $174,077,080 | 959,684 | Shares | Sole | 2021-11-15 | |
| 2020-06-30 | $29,641,231 | 102,102 | Shares | Sole | 2020-08-14 | |
| 2020-03-31 | $110,681,490 | 465,146 | Shares | Sole | 2020-05-15 | |
| No filing history on record for this holder in this stock. | ||||||