TWO SIGMA INVESTMENTS, LP
Position in VRTX — Vertex Pharmaceuticals Inc / Ma
CIK 1179392
NEW YORK, NY
Position in VRTX
as of Jun 30, 2026
· filed Aug 14, 2026
Position Value
$141,568,050
-$27,289,264 QoQ
Shares Held
285,000
-24.6% QoQ
Ownership
0.112%
of shares outstanding
% of Portfolio
0.12%
of 13F equity value
Holder Rank
#88
of 1,735 holders
Holding Since
Mar 2020
17 quarters on record
Voting authority
Sole 100%
Shared 0%
None 0%
Common Shares in VRTX Over Time
Shares Held
Position Value (USD)
Derivatives in VRTX
reported options exposure · as of Jun 30, 2026CallValue
$894,114
CallShares
1,800
PutValue
$298,038
PutShares
600
Notional value of option positions as reported on Form 13F. Calls and puts are disclosed separately and do not net against the common-share stake above.
Position in Biotechnology
Healthcare · as of Jun 30, 2026TWO SIGMA INVESTMENTS, LP holds $7,273,664,878 across 342 Biotechnology names. VRTX ranks #12 (1.9% of the industry book) .
| # | Ticker | Company | Shares | Value (USD) | Open |
|---|---|---|---|---|---|
| 1 | ALNY |
Alnylam Pharmaceuticals, Inc.
|
1,875,937 | $564,713,315 | |
| 2 | MRNA |
Moderna, Inc.
|
7,193,530 | $503,762,905 | |
| 3 | IONS |
Ionis Pharmaceuticals Inc
|
6,252,342 | $495,748,197 | |
| 4 | REGN |
Regeneron Pharmaceuticals, Inc.
|
656,124 | $409,119,558 | |
| 5 | BBIO |
BridgeBio Pharma, Inc.
|
4,722,185 | $351,708,338 | |
| 6 | EXEL |
Exelixis, Inc.
|
4,209,861 | $229,058,537 | |
| 7 | INCY |
Incyte Corp
|
2,003,559 | $227,123,448 | |
| 8 | ARGX |
Argenx SE
|
185,638 | $172,229,367 |
All Filings in VRTX
Export CSV
20 filing rows on record
| Report Date | Value (USD) | Shares | Type | Discretion | Filed | |
|---|---|---|---|---|---|---|
| 2026-06-30 | $141,568,050 | 285,000 | Shares | Sole | 2026-08-14 | |
| 2026-06-30 | $894,114 | 1,800 | Call | Sole | 2026-08-14 | |
| 2026-06-30 | $298,038 | 600 | Put | Sole | 2026-08-14 | |
| 2026-03-31 | $446,540 | 1,000 | Put | Sole | 2026-05-15 | |
| 2026-03-31 | $168,857,314 | 378,146 | Shares | Sole | 2026-05-15 | |
| 2025-12-31 | $1,883,710 | 4,155 | Shares | Sole | 2026-02-17 | |
| 2025-03-31 | $1,997,943 | 4,121 | Shares | Sole | 2025-05-15 | |
| 2024-12-31 | $13,353,532 | 33,160 | Shares | Sole | 2025-02-14 | |
| 2024-09-30 | $74,661,617 | 160,535 | Shares | Sole | 2024-11-14 | |
| 2024-06-30 | $155,608,946 | 331,987 | Shares | Sole | 2024-08-14 | |
| 2024-03-31 | $135,614,148 | 324,428 | Shares | Sole | 2024-05-15 | |
| 2023-12-31 | $55,407,838 | 136,174 | Shares | Sole | 2024-02-14 | |
| 2023-09-30 | $90,213,840 | 259,429 | Shares | Sole | 2023-11-14 | |
| 2023-06-30 | $136,851,816 | 388,883 | Shares | Sole | 2023-08-14 | |
| 2023-03-31 | $28,751,712 | 91,255 | Shares | Sole | 2023-05-15 | |
| 2022-12-31 | $8,409,851 | 29,122 | Shares | Sole | 2023-02-14 | |
| 2022-03-31 | $8,780,074 | 33,644 | Shares | Sole | 2022-05-16 | |
| 2021-09-30 | $174,077,080 | 959,684 | Shares | Sole | 2021-11-15 | |
| 2020-06-30 | $29,641,231 | 102,102 | Shares | Sole | 2020-08-14 | |
| 2020-03-31 | $110,681,490 | 465,146 | Shares | Sole | 2020-05-15 | |
| No filing history on record for this holder in this stock. | ||||||