Position in IONS
as of Mar 31, 2026
· filed May 15, 2026
Position Value
$439,849,361
+$229,523,876 QoQ
Shares Held
5,857,629
+120.3% QoQ
Ownership
3.54%
of shares outstanding
% of Portfolio
0.40%
of 13F equity value
Holder Rank
—
not a current holder
Holding Since
Mar 2020
25 quarters on record
Voting authority
Sole 98.08454922631665.ToString("F0")%
Shared 0.ToString("F0")%
None 1.9154507736833453.ToString("F0")%
Common Shares in IONS Over Time
Shares Held
Position Value (USD)
Position in Biotechnology
Healthcare · as of Mar 31, 2026TWO SIGMA INVESTMENTS, LP holds $5,502,861,072 across 315 Biotechnology names. IONS ranks #4 (8.0% of the industry book) .
| # | Ticker | Company | Shares | Value (USD) | Open |
|---|---|---|---|---|---|
| 1 | ALNY |
Alnylam Pharmaceuticals, Inc.
|
1,992,577 | $659,283,951 | |
| 2 | REGN |
Regeneron Pharmaceuticals, Inc.
|
812,236 | $627,566,023 | |
| 3 | MRNA |
Moderna, Inc.
|
9,086,404 | $461,589,323 | |
| 4 | IONS |
Ionis Pharmaceuticals Inc
This page
|
5,857,629 | $439,849,361 | |
| 5 | BBIO |
BridgeBio Pharma, Inc.
|
3,120,631 | $231,738,058 | |
| 6 | VRTX |
Vertex Pharmaceuticals Inc / Ma
|
378,146 | $168,857,314 | |
| 7 | RVMD |
Revolution Medicines, Inc.
|
1,558,807 | $151,593,980 | |
| 8 | VKTX |
Viking Therapeutics, Inc.
|
4,432,142 | $144,221,900 |
All Filings in IONS
Export CSV
25 filing rows on record
| Report Date | Value (USD) | Shares | Type | Discretion | Filed | |
|---|---|---|---|---|---|---|
| 2026-03-31 | $439,849,361 | 5,857,629 | Shares | Sole | 2026-05-15 | |
| 2025-12-31 | $210,325,485 | 2,658,646 | Shares | Sole | 2026-02-17 | |
| 2025-09-30 | $103,098,191 | 1,575,943 | Shares | Sole | 2025-11-14 | |
| 2025-06-30 | $70,658,380 | 1,788,367 | Shares | Sole | 2025-08-14 | |
| 2025-03-31 | $50,862,185 | 1,685,853 | Shares | Sole | 2025-05-15 | |
| 2024-12-31 | $32,213,507 | 921,439 | Shares | Sole | 2025-02-14 | |
| 2024-09-30 | $36,818,224 | 919,077 | Shares | Sole | 2024-11-14 | |
| 2024-06-30 | $49,001,247 | 1,028,142 | Shares | Sole | 2024-08-14 | |
| 2024-03-31 | $46,986,154 | 1,083,879 | Shares | Sole | 2024-05-15 | |
| 2023-12-31 | $40,545,254 | 801,448 | Shares | Sole | 2024-02-14 | |
| 2023-09-30 | $21,593,945 | 476,057 | Shares | Sole | 2023-11-14 | |
| 2023-06-30 | $8,754,653 | 213,372 | Shares | Sole | 2023-08-14 | |
| 2023-03-31 | $824,879 | 23,080 | Shares | Sole | 2023-05-15 | |
| 2022-12-31 | $7,601,854 | 201,267 | Shares | Sole | 2023-02-14 | |
| 2022-09-30 | $12,959,124 | 292,994 | Shares | Sole | 2022-11-14 | |
| 2022-06-30 | $20,732,347 | 560,031 | Shares | Sole | 2022-08-15 | |
| 2022-03-31 | $28,900,682 | 780,256 | Shares | Sole | 2022-05-16 | |
| 2021-12-31 | $18,102,350 | 594,885 | Shares | Sole | 2022-02-14 | |
| 2021-09-30 | $10,536,054 | 314,134 | Shares | Sole | 2021-11-15 | |
| 2021-06-30 | $12,225,806 | 306,488 | Shares | Sole | 2021-08-16 | |
| 2021-03-31 | $8,349,971 | 185,720 | Shares | Sole | 2021-05-17 | |
| 2020-12-31 | $9,453,770 | 167,205 | Shares | Sole | 2021-02-16 | |
| 2020-09-30 | $45,178,853 | 952,136 | Shares | Sole | 2020-11-16 | |
| 2020-06-30 | $35,983,936 | 610,311 | Shares | Sole | 2020-08-14 | |
| 2020-03-31 | $25,909,298 | 547,997 | Shares | Sole | 2020-05-15 | |
| No filing history on record for this holder in this stock. | ||||||