Sofinnova Investments, Inc.

CIK

1631134

Location

Menlo Park, CA

Portfolio Value

Mid $1,934,262,112

Diversification

Diversified

Filing Date

Global Rank

#1,639 / 8,819 ▼ 387

Top Industry

Biotechnology 62.7%

Period ended 4 months ago

Filed Aug 14, 2026 · 3mo

26 quarters · since Mar 2020

Regulatory profile

From Form ADV, the SEC filer profile, 13D/13G type codes and N-CEN, never from the name.

Holder type

Unknown

Portfolio style

Measured from the filed 13F common-share book for Jun 30, 2026, never from the firm's own description.

Style

Diversified active

Top 10 weight 59.8%, 13.5 effective positions, active share 97.6% against the Russell 2000 as of 2026-06-30; it meets none of the index-like, systematic-like or concentrated tests

Turnover

Medium turnover

84.5% over the last four quarters (30% to under 100%)

Horizon

Horizon unknown

The value-weighted holding period is at least 11.9 quarters, but 22.5% of the book was already held when coverage starts

Closest benchmark: the Russell 2000 as of 2026-06-30, active share 97.6%; sector active share 90.9% against the combined 13F book's sector weights.

Over time 26 measured quarters

How the bands are measured

Style bands measure the filed 13F common-share book each closed quarter, tested in this order. Unknown: under $10,000,000 of valued equity or 5 stocks. Index-like (100+ stocks): active share of 20% or less against the closest benchmark, which is the S&P 500, S&P MidCap 400, S&P SmallCap 600, Russell 1000, Russell 2000, Nasdaq-100 or Dow Jones Industrial Average (weighted by an index-tracking fund's reported holdings or the index's constituents nearest the quarter end, over the names resolved to companies, and only when those are 90%+ of its weight) or every 13F filer's combined book, or index series holding 80%+ of the registered fund assets it advises (N-CEN) and equal to 50%+ of its book. Systematic-like: 500+ stocks, 100%+ annual turnover and a top 10 weight of 25% or less. Concentrated: a top 10 weight of 60%+ or 12 or fewer effective positions. Diversified active: none of these. Turnover is the smaller of buys and sells over average equity value, summed over four quarters: low under 30%, high 100%+. Horizon is the value-weighted number of quarters each position has been held: short under 4, long 12+.

Clone Performance

Build a hypothetical price-return history from this filer's public 13F holdings.

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Portfolio Concentration

56 tracked positions · as of Jun 30, 2026 · Δ vs Mar 31, 2026

Top Position

21.8%

+10.0 pts

Top 5

42.4%

+9.8 pts

Top 10

58.8%

+7.8 pts

HHI

703

Diversified+306

Portfolio Trend

26 quarters · across all stocks

Sector Breakdown

As of Jun 30, 2026

Sector	% Portfolio	Value	Positions
Healthcare	100.0%	$1,934,262,112	56

Last Quarter's Activity

Export CSV

Jun 30, 2026 vs Mar 31, 2026

Added To

Positions the filer increased

12 positions

Ticker	Company	Δ Shares	Shares	Value
GMAB	Genmab A/S	+3,292,954	4,045,215	$111,122,056
TENX	Tenax Therapeutics, Inc.	+395,639	500,039	$7,275,567
ANAB	Anaptysbio, Inc	+245,283	493,536	$33,313,680
OKUR	OnKure Therapeutics, Inc.	+179,992	321,692	$1,466,915
SUPN	Supernus Pharmaceuticals, Inc.	+82,019	1,036,328	$48,199,615
MANE	Veradermics, Inc	+75,678	148,993	$18,317,199
IRON	Disc Medicine, Inc.	+67,919	146,239	$10,695,920
PHVS	Pharvaris N.V.	+62,971	881,299	$30,475,319
IMTX	Immatics N.V.	+38,892	3,669,346	$37,170,474
DYN	Dyne Therapeutics, Inc.	+24,487	1,658,384	$36,832,708
RCUS	Arcus Biosciences, Inc.	+22,604	945,690	$29,155,622
IMNM	Immunome Inc.	+18,412	1,720,316	$36,453,496
No positions match the current search.

Trimmed

Positions the filer reduced

17 positions

Ticker	Company	Δ Shares	Shares	Value
RARE	Ultragenyx Pharmaceutical Inc.	−1,428,383	1,717,505	$57,347,491
BMY	Bristol Myers Squibb Co	−1,111,751	876,970	$50,531,011
COGT	Cogent Biosciences, Inc.	−1,078,403	1,035,148	$40,060,227
ALC	Alcon Inc	−474,148	255,824	$17,165,790
BMRN	Biomarin Pharmaceutical Inc	−423,414	358,568	$20,517,260
JAZZ	Jazz Pharmaceuticals plc	−232,986	365,341	$88,036,220
IDYA	IDEAYA Biosciences, Inc.	−206,667	925,119	$34,479,185
INSM	INSMED Inc	−187,677	158,398	$16,888,394
TYRA	Tyra Biosciences, Inc.	−171,748	32,267	$1,030,607
INBX	Inhibrx Biosciences, Inc.	−102,926	303,103	$28,719,009
DFTX	Definium Therapeutics, Inc.	−88,263	255,903	$12,037,677
UTHR	UNITED THERAPEUTICS Corp	−83,581	76,489	$41,444,034
PRAX	Praxis Precision Medicines, Inc.	−57,240	6,440	$2,156,047
AXSM	Axsome Therapeutics, Inc.	−52,318	160,429	$39,268,206
RYTM	Rhythm Pharmaceuticals, Inc.	−42,069	408,027	$45,303,237
NKTR	Nektar Therapeutics	−37,783	471,763	$32,933,775
EWTX	Edgewise Therapeutics, Inc.	−5,575	380,923	$15,476,901
No positions match the current search.

New Positions

Positions the filer opened this quarter

11 positions

Ticker	Company	Shares	Value
SPTX	Seaport Therapeutics, Inc.	3,564,871	$77,428,998
GILD	Gilead Sciences, Inc.	343,100	$43,347,254
NRIX	Nurix Therapeutics, Inc.	524,098	$12,714,617
DSGN	Design Therapeutics, Inc.	865,135	$12,518,503
TRAX	First Tracks Biotherapeutics, Inc.	565,199	$11,371,803
ABT	Abbott Laboratories	122,998	$11,160,838
SION	Sionna Therapeutics, Inc.	144,432	$6,353,563
ABSI	Absci Corp	337,400	$3,910,466
SGMT	Sagimet Biosciences Inc.	166,667	$1,288,335
AKTS	Aktis Oncology, Inc.	32,436	$1,045,412
HTFL	Heartflow, Inc.	5,079	$149,017
No positions match the current search.

Sold Out

Positions the filer fully exited

19 positions

Ticker	Company	Shares	Value
AZN	Astrazeneca PLC	456,031	$89,938,433
BIIB	Biogen Inc.	229,521	$42,078,084
CELC	Celcuity Inc.	366,175	$41,795,214
BBIO	BridgeBio Pharma, Inc.	409,183	$30,385,929
DXCM	Dexcom Inc	393,576	$24,716,572
XENE	Xenon Pharmaceuticals Inc.	305,216	$17,748,310
SYK	Stryker Corp	44,480	$14,615,683
ROIV	Roivant Sciences Ltd.	477,995	$13,240,461
CMPX	Compass Therapeutics, Inc.	2,056,161	$10,877,091
ORIC	Oric Pharmaceuticals, Inc.	679,578	$8,610,253
TNGX	Tango Therapeutics, Inc.	395,081	$8,265,094
AXGN	Axogen, Inc.	210,665	$6,979,331
CYTK	Cytokinetics Inc	91,791	$6,049,944
HRMY	Harmony Biosciences Holdings, Inc.	152,695	$4,276,986
PCVX	Vaxcyte, Inc.	50,600	$2,940,366
ESTA	Establishment Labs Holdings Inc.	33,930	$1,926,545
ACAD	Acadia Pharmaceuticals Inc	78,551	$1,748,545
—		14,689	$491,788
ZYME	Zymeworks Inc.	1,610	$40,314
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

56 tracked positions · $1,934,262,112 total · filing declares 57 positions · $1,934,262,135 · as of Jun 30, 2026

All sectors Healthcare

Showing 1–50 of 56 positions by value · page 1 of 2

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	Held (qtrs)	Est. cost/share	% of Portfolio
NTRA	Natera, Inc. Healthcare	Held	1,550,280	0	$420,823,506	+35.7%	26+	before history	21.76%
VERA	Vera Therapeutics, Inc. Healthcare	Held	2,793,987	0	$119,889,982	+6.7%	21	$15.35	6.20%
GMAB	Genmab A/S Healthcare	Added	4,045,215	+3,292,954	$111,122,056	+450.6%	2	$27.21	5.74%
JAZZ	Jazz Pharmaceuticals plc Healthcare	Reduced	365,341	-232,986	$88,036,220	−22.2%	8	$128.75	4.55%
RAPP	Rapport Therapeutics, Inc. Healthcare	Held	1,904,408	0	$79,356,681	+33.2%	9	unpriced	4.10%
SPTX	Seaport Therapeutics, Inc. Healthcare	NEW	3,564,871	NEW	$77,428,998	NEW	1	$17.59	4.00%
RARE	Ultragenyx Pharmaceutical Inc. CALL + SHARES Healthcare	Reduced	2,217,505	-1,278,383	$74,042,491	+1.1%	3	$22.79	3.83%
AVBP	ArriVent BioPharma, Inc. Healthcare	Held	1,696,752	0	$58,945,164	+50.6%	10	$20.17	3.05%
BIOA	BioAge Labs, Inc. Healthcare	Held	2,293,788	0	$56,220,743	+40.1%	8	unpriced	2.91%
BMY	Bristol Myers Squibb Co Healthcare	Reduced	876,970	-1,111,751	$50,531,011	−58.1%	3	$50.54	2.61%
SUPN	Supernus Pharmaceuticals, Inc. Healthcare	Added	1,036,328	+82,019	$48,199,615	−2.3%	6	$44.24	2.49%
RYTM	Rhythm Pharmaceuticals, Inc. Healthcare	Reduced	408,027	-42,069	$45,303,237	+15.7%	8	$73.57	2.34%
GILD	Gilead Sciences, Inc. Healthcare	NEW	343,100	NEW	$43,347,254	NEW	1	$131.76	2.24%
UTHR	UNITED THERAPEUTICS Corp Healthcare	Reduced	76,489	-163,881	$41,444,034	−70.9%	5	$315.83	2.14%
COGT	Cogent Biosciences, Inc. Healthcare	Reduced	1,035,148	-1,078,403	$40,060,227	−50.8%	10	$9.13	2.07%
AXSM	Axsome Therapeutics, Inc. Healthcare	Reduced	160,429	-252,318	$39,268,206	−43.7%	9	$168.82	2.03%
IMTX	Immatics N.V. Healthcare	Added	3,669,346	+38,892	$37,170,474	+4.0%	24	$7.51	1.92%
DYN	Dyne Therapeutics, Inc. Healthcare	Added	1,658,384	+24,487	$36,832,708	+24.3%	13	$18.03	1.90%
IMNM	Immunome Inc. Healthcare	Added	1,720,316	+18,412	$36,453,496	−2.1%	10	$18.05	1.88%
IDYA	IDEAYA Biosciences, Inc. Healthcare	Reduced	925,119	-206,667	$34,479,185	−8.6%	16	$27.13	1.78%
ANAB	Anaptysbio, Inc Healthcare	Added	493,536	+245,283	$33,313,680	+142.0%	7	unpriced	1.72%
NKTR	Nektar Therapeutics Healthcare	Reduced	471,763	-37,783	$32,933,775	−10.2%	4	$50.79	1.70%
PHVS	Pharvaris N.V. Healthcare	Added	881,299	+62,971	$30,475,319	+31.8%	11	$22.22	1.58%
RCUS	Arcus Biosciences, Inc. Healthcare	Added	945,690	+22,604	$29,155,622	+46.2%	6	$11.47	1.51%
INBX	Inhibrx Biosciences, Inc. Healthcare	Reduced	303,103	-102,926	$28,719,009	+5.2%	9	$16.63	1.48%
BMRN	Biomarin Pharmaceutical Inc Healthcare	Reduced	358,568	-423,414	$20,517,260	−53.6%	3	$54.86	1.06%
MANE	Veradermics, Inc Healthcare	Added	148,993	+75,678	$18,317,199	+295.6%	2	$72.40	0.95%
ALC	Alcon Inc Healthcare	Reduced	255,824	-474,148	$17,165,790	−68.8%	3	$78.52	0.89%
INSM	INSMED Inc Healthcare	Reduced	158,398	-187,677	$16,888,394	−70.2%	9	$127.29	0.87%
ISRG	Intuitive Surgical Inc CALL Healthcare	NEW	40,000	NEW	$15,907,200	NEW	—	—	0.82%
GMED	Globus Medical Inc CALL Healthcare	NEW	200,000	NEW	$15,802,000	NEW	—	—	0.82%
EWTX	Edgewise Therapeutics, Inc. Healthcare	Reduced	380,923	-5,575	$15,476,901	+27.1%	9	$16.17	0.80%
EXEL	Exelixis, Inc. PUT Healthcare	Added	254,200	+2,700	$13,831,022	+28.2%	—	—	0.72%
NRIX	Nurix Therapeutics, Inc. Healthcare	NEW	524,098	NEW	$12,714,617	NEW	1	$17.03	0.66%
DSGN	Design Therapeutics, Inc. Healthcare	NEW	865,135	NEW	$12,518,503	NEW	1	$12.47	0.65%
DFTX	Definium Therapeutics, Inc. Healthcare	Reduced	255,903	-88,263	$12,037,677	+85.1%	2	$16.97	0.62%
TRAX	First Tracks Biotherapeutics, Inc. Healthcare	NEW	565,199	NEW	$11,371,803	NEW	1	$18.70	0.59%
ABT	Abbott Laboratories Healthcare	NEW	122,998	NEW	$11,160,838	NEW	1	$91.27	0.58%
IRON	Disc Medicine, Inc. Healthcare	Added	146,239	+67,919	$10,695,920	+113.6%	10	$74.93	0.55%
TENX	Tenax Therapeutics, Inc. Healthcare	Added	500,039	+395,639	$7,275,567	+335.8%	2	$12.93	0.38%
SION	Sionna Therapeutics, Inc. Healthcare	NEW	144,432	NEW	$6,353,563	NEW	1	$40.00	0.33%
ABSI	Absci Corp Healthcare	NEW	337,400	NEW	$3,910,466	NEW	1	$5.63	0.20%
MIRM	Mirum Pharmaceuticals, Inc. Healthcare	Held	27,591	0	$3,230,078	+26.7%	3	$75.41	0.17%
JBIO	Jade Biosciences, Inc. Healthcare	Held	107,391	0	$2,386,228	+58.1%	5	unpriced	0.12%
SVRA	Savara Inc Healthcare	Held	364,763	0	$2,246,940	+12.8%	13	$4.39	0.12%
PRAX	Praxis Precision Medicines, Inc. Healthcare	Reduced	6,440	-57,240	$2,156,047	−89.5%	6	$49.76	0.11%
SEPN	Septerna, Inc. Healthcare	Held	47,506	0	$1,590,975	+39.4%	2	$26.29	0.08%
OKUR	OnKure Therapeutics, Inc. Healthcare	Added	321,692	+179,992	$1,466,915	+150.1%	2	$3.76	0.08%
SGMT	Sagimet Biosciences Inc. Healthcare	NEW	166,667	NEW	$1,288,335	NEW	1	$6.80	0.07%
WVE	Wave Life Sciences, Inc. Healthcare	Held	189,253	0	$1,099,559	−19.9%	5	$8.04	0.06%

Showing the top 50 of 56 positions. Create a free account to see every position, past quarters, search, filters and CSV export.

Covers the securities this platform tracks: U.S.-listed common stock and the put/call positions reported on it. A 13F can also report security types outside that coverage — preferred shares, bonds, warrants, untracked share classes — so the filing's own declared total can exceed the figures above. The source filing is linked at the top of this table.