Sofinnova Investments, Inc.

CIK

1631134

Location

Menlo Park, CA

Portfolio Value

Mid $2,262,888,163

Diversification

Diversified

Filing Date

Global Rank

#1,114 / 8,603 ▲ 72 · as of Mar 2026

Top Industry

Biotechnology 56.8%

3Y Alpha vs SPY

+8.7%

Period ended 3 months ago

Filed May 15, 2026 · 55d

25 quarters · since Mar 2020

Clone Performance

Jul 2023–Jul 2026 · vs SPY

Hypothetical growth of cloning every reported 13F position and rebalancing on each filing, indexed to the same start.

Cloned portfolio

+122.8%

SPY

+76.5%

Annualised alpha

+9.7%

Max drawdown

−37.1%

Estimate. 13F holdings are quarter-lagged and long-only, so the clone rebalances about 45 days after each period end — when the filing becomes public — and excludes options and short positions. Past performance does not predict future results.

Portfolio Concentration

65 positions · as of Mar 31, 2026 · Δ vs Dec 31, 2025

Top Position

13.7%

−3.5 pts

Top 5

35.3%

−4.2 pts

Top 10

53.3%

−3.4 pts

HHI

446

Diversified−114

Portfolio Trend

25 quarters · across all stocks

Sector Breakdown

As of Mar 31, 2026

Sector	% Portfolio	Value	Positions
Healthcare	96.2%	$2,176,311,163	64
Unclassified	3.8%	$86,577,000	1

Last Quarter's Activity

Export CSV

Mar 31, 2026 vs Dec 31, 2025

Added To

Positions the filer increased

24 positions

Ticker	Company	Δ Shares	Shares	Value
RARE	Ultragenyx Pharmaceutical Inc.	+3,412,588	3,495,888	$73,238,853
BMY	Bristol Myers Squibb Co	+475,727	1,988,721	$120,615,928
SUPN	Supernus Pharmaceuticals, Inc.	+401,214	954,309	$49,328,232
AXSM	Axsome Therapeutics, Inc.	+400,481	412,747	$69,762,497
ALC	Alcon Inc	+397,452	729,972	$55,003,390
CELC	Celcuity Inc.	+366,758	666,175	$76,037,214
IDYA	IDEAYA Biosciences, Inc.	+246,665	1,131,786	$37,711,109
XENE	Xenon Pharmaceuticals Inc.	+245,316	305,216	$17,748,310
IMTX	Immatics N.V.	+194,912	3,630,454	$35,723,667
INSM	INSMED Inc	+189,274	346,075	$56,590,184
RYTM	Rhythm Pharmaceuticals, Inc.	+178,702	450,096	$39,144,849
COGT	Cogent Biosciences, Inc.	+139,926	2,113,551	$81,350,577
BMRN	Biomarin Pharmaceutical Inc	+84,849	781,982	$44,174,163
IMNM	Immunome Inc.	+83,427	1,701,904	$37,220,640
UTHR	UNITED THERAPEUTICS Corp	+82,729	240,370	$142,534,602
PHVS	Pharvaris N.V.	+73,159	818,328	$23,117,766
NKTR	Nektar Therapeutics	+70,916	509,546	$36,661,834
SVRA	Savara Inc	+59,993	364,763	$1,991,605
WVE	Wave Life Sciences Ltd.	+31,071	189,253	$1,372,084
DXCM	Dexcom Inc	+15,357	393,576	$24,716,572
ACAD	Acadia Pharmaceuticals Inc	+12,984	78,551	$1,748,545
ESTA	Establishment Labs Holdings Inc.	+5,564	33,930	$1,926,545
MIRM	Mirum Pharmaceuticals, Inc.	+4,491	27,591	$2,548,856
SLNO	Soleno Therapeutics Inc	+2,275	14,689	$491,787
No positions match the current search.

Trimmed

Positions the filer reduced

11 positions

Ticker	Company	Δ Shares	Shares	Value
CMPX	Compass Therapeutics, Inc.	−809,285	2,556,161	$13,522,091
DYN	Dyne Therapeutics, Inc.	−620,264	1,633,897	$29,622,552
JAZZ	Jazz Pharmaceuticals plc	−361,533	598,327	$113,113,719
BBIO	BridgeBio Pharma, Inc.	−311,265	409,183	$30,385,929
ROIV	Roivant Sciences Ltd.	−256,587	477,995	$13,240,461
RCUS	Arcus Biosciences, Inc.	−173,619	923,086	$19,938,657
PRAX	Praxis Precision Medicines, Inc.	−62,042	63,680	$20,517,059
EWTX	Edgewise Therapeutics, Inc.	−51,321	386,498	$12,174,687
INBX	Inhibrx Biosciences, Inc.	−48,628	406,029	$27,297,329
ANAB	Anaptysbio, Inc	−39,437	248,253	$9,178,732
IRON	Disc Medicine, Inc.	−32,690	78,320	$5,007,780
No positions match the current search.

New Positions

Positions the filer opened this quarter

22 positions

Ticker	Company	Shares	Value
AZN	Astrazeneca PLC	456,031	$89,938,433
QQQ	Invesco Qqq Trust, Series 1	150,000	$86,577,000
BIIB	Biogen Inc.	229,521	$42,078,084
PFE	Pfizer Inc	800,000	$22,464,000
GMAB	Genmab A/S	752,261	$20,183,162
LQDA	Liquidia Corp	500,000	$18,870,000
SYK	Stryker Corp	44,480	$14,615,683
EXEL	Exelixis, Inc.	251,500	$10,786,835
ORIC	Oric Pharmaceuticals, Inc.	679,578	$8,610,253
TNGX	Tango Therapeutics, Inc.	395,081	$8,265,094
TYRA	Tyra Biosciences, Inc.	204,015	$7,813,774
REPL	Replimune Group, Inc.	1,015,400	$7,767,810
AXGN	Axogen, Inc.	210,665	$6,979,331
DFTX	Definium Therapeutics, Inc.	344,166	$6,504,737
CYTK	Cytokinetics Inc	91,791	$6,049,944
MANE	Veradermics, Inc	73,315	$4,629,842
HRMY	Harmony Biosciences Holdings, Inc.	152,695	$4,276,986
PCVX	Vaxcyte, Inc.	50,600	$2,940,366
TENX	Tenax Therapeutics, Inc.	104,400	$1,669,356
SEPN	Septerna, Inc.	47,506	$1,141,569
OKUR	OnKure Therapeutics, Inc.	141,700	$586,638
ZYME	Zymeworks Inc.	1,610	$40,314
No positions match the current search.

Sold Out

Positions the filer fully exited

13 positions

Ticker	Company	Shares	Value
VRTX	Vertex Pharmaceuticals Inc / Ma	164,594	$74,620,335
ABBV	AbbVie Inc.	317,783	$72,610,237
ISRG	Intuitive Surgical Inc	126,968	$71,909,596
LLY	ELI LILLY & Co	61,652	$66,256,177
APGE	Apogee Therapeutics, Inc.	534,845	$40,370,100
GKOS	GLAUKOS Corp	288,128	$32,532,532
CNTA	Centessa Pharmaceuticals plc	1,104,274	$27,617,892
GEHC	GE HealthCare Technologies Inc.	160,876	$13,195,049
EXAS	EXACT SCIENCES CORP	101,443	$10,302,551
AMLX	Amylyx Pharmaceuticals, Inc.	527,099	$6,367,355
MASI	Masimo Corp	46,201	$6,008,902
QURE	uniQure N.V.	176,513	$4,223,956
EVMN	Evommune, Inc.	153,320	$2,624,838
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

65 positions · $2,262,888,163 total · as of Mar 31, 2026

All sectors Healthcare

Showing 1–50 of 65 positions by value · page 1 of 2

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
NTRA	Natera, Inc. Healthcare	Held	1,550,280	0	$310,040,497	−12.7%	13.70%
UTHR	UNITED THERAPEUTICS Corp Healthcare	Added	240,370	+82,729	$142,534,602	+85.6%	6.30%
BMY	Bristol Myers Squibb Co Healthcare	Added	1,988,721	+475,727	$120,615,928	+47.8%	5.33%
JAZZ	Jazz Pharmaceuticals plc Healthcare	Reduced	598,327	-361,533	$113,113,719	−30.7%	5.00%
VERA	Vera Therapeutics, Inc. Healthcare	Held	2,793,987	0	$112,402,097	−20.6%	4.97%
AZN	Astrazeneca PLC Healthcare	NEW	456,031	NEW	$89,938,433	NEW	3.97%
QQQ	Invesco Qqq Trust, Series 1	NEW	150,000	NEW	$86,577,000	NEW	3.83%
COGT	Cogent Biosciences, Inc. Healthcare	Added	2,113,551	+139,926	$81,350,577	+16.0%	3.59%
CELC	Celcuity Inc. Healthcare	Added	666,175	+366,758	$76,037,214	+154.6%	3.36%
RARE	Ultragenyx Pharmaceutical Inc. Healthcare	Added	3,495,888	+3,412,588	$73,238,853	+3722.7%	3.24%
AXSM	Axsome Therapeutics, Inc. Healthcare	Added	412,747	+400,481	$69,762,497	+3014.0%	3.08%
RAPP	Rapport Therapeutics, Inc. Healthcare	Held	1,904,408	0	$59,588,926	+3.1%	2.63%
INSM	INSMED Inc Healthcare	Added	346,075	+189,274	$56,590,184	+107.4%	2.50%
ALC	Alcon Inc Healthcare	Added	729,972	+397,452	$55,003,390	+109.9%	2.43%
SUPN	Supernus Pharmaceuticals, Inc. Healthcare	Added	954,309	+401,214	$49,328,232	+79.4%	2.18%
BMRN	Biomarin Pharmaceutical Inc Healthcare	Added	781,982	+84,849	$44,174,163	+6.6%	1.95%
BIIB	Biogen Inc. Healthcare	NEW	229,521	NEW	$42,078,084	NEW	1.86%
BIOA	BioAge Labs, Inc. Healthcare	Held	2,293,788	0	$40,118,352	+32.2%	1.77%
RYTM	Rhythm Pharmaceuticals, Inc. Healthcare	Added	450,096	+178,702	$39,144,849	+34.7%	1.73%
AVBP	ArriVent BioPharma, Inc. Healthcare	Held	1,696,752	0	$39,144,068	+14.7%	1.73%
IDYA	IDEAYA Biosciences, Inc. Healthcare	Added	1,131,786	+246,665	$37,711,109	+23.2%	1.67%
IMNM	Immunome Inc. Healthcare	Added	1,701,904	+83,427	$37,220,640	+7.1%	1.64%
NKTR	Nektar Therapeutics Healthcare	Added	509,546	+70,916	$36,661,834	+97.7%	1.62%
IMTX	Immatics N.V. Healthcare	Added	3,630,454	+194,912	$35,723,667	−1.0%	1.58%
BBIO	BridgeBio Pharma, Inc. Healthcare	Reduced	409,183	-311,265	$30,385,929	−44.9%	1.34%
DYN	Dyne Therapeutics, Inc. Healthcare	Reduced	1,633,897	-620,264	$29,622,552	−32.8%	1.31%
INBX	Inhibrx Biosciences, Inc. Healthcare	Reduced	406,029	-48,628	$27,297,329	−24.0%	1.21%
DXCM	Dexcom Inc Healthcare	Added	393,576	+15,357	$24,716,572	−1.5%	1.09%
PHVS	Pharvaris N.V. Healthcare	Added	818,328	+73,159	$23,117,766	+11.8%	1.02%
PFE	Pfizer Inc Healthcare	NEW	800,000	NEW	$22,464,000	NEW	0.99%
PRAX	Praxis Precision Medicines, Inc. Healthcare	Reduced	63,680	-62,042	$20,517,059	−44.6%	0.91%
GMAB	Genmab A/S Healthcare	NEW	752,261	NEW	$20,183,162	NEW	0.89%
RCUS	Arcus Biosciences, Inc. Healthcare	Reduced	923,086	-173,619	$19,938,657	−23.7%	0.88%
LQDA	Liquidia Corp Healthcare	NEW	500,000	NEW	$18,870,000	NEW	0.83%
XENE	Xenon Pharmaceuticals Inc. Healthcare	Added	305,216	+245,316	$17,748,310	+561.1%	0.78%
SYK	Stryker Corp Healthcare	NEW	44,480	NEW	$14,615,683	NEW	0.65%
CMPX	Compass Therapeutics, Inc. Healthcare	Reduced	2,556,161	-809,285	$13,522,091	−25.2%	0.60%
ROIV	Roivant Sciences Ltd. Healthcare	Reduced	477,995	-256,587	$13,240,461	−16.9%	0.59%
EWTX	Edgewise Therapeutics, Inc. Healthcare	Reduced	386,498	-51,321	$12,174,687	+12.1%	0.54%
EXEL	Exelixis, Inc. Healthcare	NEW	251,500	NEW	$10,786,835	NEW	0.48%
ANAB	Anaptysbio, Inc Healthcare	Reduced	248,253	-39,437	$9,178,732	−1.3%	0.41%
ORIC	Oric Pharmaceuticals, Inc. Healthcare	NEW	679,578	NEW	$8,610,253	NEW	0.38%
TNGX	Tango Therapeutics, Inc. Healthcare	NEW	395,081	NEW	$8,265,094	NEW	0.37%
TYRA	Tyra Biosciences, Inc. Healthcare	NEW	204,015	NEW	$7,813,774	NEW	0.35%
REPL	Replimune Group, Inc. Healthcare	NEW	1,015,400	NEW	$7,767,810	NEW	0.34%
AXGN	Axogen, Inc. Healthcare	NEW	210,665	NEW	$6,979,331	NEW	0.31%
DFTX	Definium Therapeutics, Inc. Healthcare	NEW	344,166	NEW	$6,504,737	NEW	0.29%
CYTK	Cytokinetics Inc Healthcare	NEW	91,791	NEW	$6,049,944	NEW	0.27%
IRON	Disc Medicine, Inc. Healthcare	Reduced	78,320	-32,690	$5,007,780	−43.2%	0.22%
MANE	Veradermics, Inc Healthcare	NEW	73,315	NEW	$4,629,842	NEW	0.20%