IRON · Disc Medicine, Inc. · Holdings

$79.48 +0.55 (+0.70%) At close · Oct 20

Russell 2000 member Rebalance outlook locked

Market Cap

$3.05B

38.39M

Volume · Oct 20 2.21M Avg daily vol (3M) 646.26K

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Use institutional holdings through the 13F API or MCP → See every holder of IRON: 13F, 13D and 13G, insiders and funds →

Institutional holdings are being reconciled with SEC filings. Holder totals and changes may be incomplete until reconciliation finishes.

The Sep 30, 2026 filing window is still open — showing the latest known positions. Funds that have not filed yet carry their prior-quarter positions; a fund that filed without this stock counts as sold out. Each fund's Change is measured against its own previous reported quarter, shown in the Reported column. Pick a completed quarter in the Quarter selector below to put every fund on one quarter and see the stock-wide activity breakdown.

Quarter:

Holders: 220

Total Value: $3,203,990,066

Total Shares: 43,927,653

Showing 1–100 of 229 holdings by value · page 1 of 3

Institutional Ownership Trend

25 quarters

Holder Concentration

Across 222 13F filers

Top Holder

11.3%

of institutional value

Top 5

31.4%

of institutional value

Top 10

49.5%

of institutional value

HHI

366

Broadly held

Who Holds IRON

Last 8 quarters through Sep 30, 2026 (filing window open)

Each kind of 13F filer's share of the common shares 13F filers report. Holder type comes from regulatory records, never the filer's name; style, turnover and horizon are measured from each filer's own 13F book. The quarter selector does not change this card.

Jun 30, 2026, the newest closed quarter: 216 filers, like-for-like change +2.1%; actively managed books +3.4%; index-like books -3.4%.

Holder type	Share	Filers	Change	New	Exited
Registered adviser	46.2%	100	+7.9%	19	17
Exempt adviser	0.4%	5	+118.3%	3	0
Adviser	0.5%	5	-29.4%	0	1
Bank	10.2%	16	+12.4%	1	0
Insurer	0.0%	1	+8.6%	0	0
Broker-dealer	0.0%	0	-100.0%	0	1
Benefit plan	0.2%	5	+10.3%	0	0
Non-US	1.9%	7	+26.6%	1	0
Holding company	22.8%	7	-9.1%	0	0
Unknown	17.8%	70	-3.8%	11	4

Style	Share	Filers	Change	New	Exited
Index-like	18.9%	30	-3.4%	0	0
Systematic-like	4.9%	26	+25.2%	11	8
Concentrated	23.1%	31	+3.7%	3	5
Diversified active	53.1%	129	+1.7%	21	10
Not measured	0.0%	0	—	0	0
Unknown	0.0%	0	—	0	0

Turnover	Share	Filers	Change	New	Exited
Low turnover	60.2%	97	-0.1%	7	5
Medium turnover	22.4%	55	-6.7%	8	4
High turnover	12.6%	43	+40.5%	17	13
Unknown	4.8%	21	+1.4%	3	1
Not measured	0.0%	0	—	0	0

Holding horizon	Share	Filers	Change	New	Exited
Short horizon	6.0%	38	+4.0%	13	9
Medium horizon	22.3%	41	+14.9%	5	2
Long horizon	61.9%	119	-1.0%	12	4
Unknown	9.8%	18	-4.4%	5	8
Not measured	0.0%	0	—	0	0

13F book size	Share	Filers	Change	New	Exited
Under $1B	8.4%	36	-4.1%	10	10
$1B to $10B	27.5%	61	+5.4%	9	10
$10B to $100B	14.3%	61	+2.6%	13	3
$100B or more	49.8%	58	+1.3%	3	0
Not measured	0.0%	0	—	0	0

Client base	Share	Filers	Change	New	Exited
Individuals and high net worth	0.2%	25	+16.1%	8	5
Pooled investment vehicles	29.5%	40	+6.9%	8	11
Registered funds and BDCs	14.3%	15	+6.7%	0	0
Pension and profit sharing plans	0.0%	1	+135.8%	0	0
Insurance companies	0.1%	3	+13.1%	0	0
Governments and sovereign funds	0.5%	3	+250.6%	1	0
Other investment advisers	0.0%	2	+6.7%	0	0
Diversified	1.6%	10	+18.6%	2	0
Other	0.0%	0	—	0	0
Unknown	53.9%	117	-2.5%	16	7

Private funds	Share	Filers	Change	New	Exited
Hedge funds	17.4%	43	+23.5%	14	9
Private equity funds	0.8%	5	+1.2%	1	0
Venture capital funds	9.1%	5	+10.0%	0	0
Real estate funds	0.0%	3	+40.5%	2	1
Securitized asset funds	0.3%	1	+2.9%	0	0
Other private funds	8.7%	8	-7.1%	0	0
Mixed private funds	3.5%	5	+1.5%	1	0
Private funds, type not stated	0.3%	2	+4.2%	1	0
No private funds	6.7%	33	+1.5%	3	6
Unknown	53.4%	111	-2.9%	13	7

Location	Share	Filers	Change	New	Exited
United States	93.5%	170	+2.0%	28	20
Outside the US	6.5%	46	+3.6%	7	3

The Sep 30, 2026 filing window is still open, so its bar carries the Jun 30, 2026 positions of filers that have not filed yet.

How the mix is measured

Shares are 13F common shares restated to today's split basis; options and principal amounts are left out. The change compares only filers with a 13F in both quarters and keeps each filer in its bucket of the later quarter on both sides; a filer that continues under a new CIK is compared through its successor. Holder type comes from each filer's current regulatory profile; client base and private funds come from the Form ADV roster current at each quarter end (rosters from December 2019, so an earlier quarter reads Unknown). Style, turnover, horizon and book size are measured from each filer's 13F book in the newest measured quarter, and Not measured means none was. Actively managed books are those measured systematic-like, concentrated or diversified active.

Excluded 2 holders with no observed 2026-03-31 13F and 1 holder with no observed 2026-06-30 13F. Compared across CIK changes: JANUS HENDERSON GROUP PLC continues as Jupiter Topco LLC.

Conviction and Crowding

216 13F filers, quarter ended Jun 30, 2026

Measured across every 13F filer's common-share book once the quarter's filing window closed. Crowding counts filers with high turnover or that advise private funds on Form ADV.

Conviction holders

3.24% of filers hold it in their top 10

Mar 31, 2026: 6

Holders above 5%

median weight 0.003%

Mar 31, 2026: 4

Crowding

—

holders exceed shares outstanding: 13F filers report more shares than the cover-page count, which predates an issuance, is misstated, or misses shares lent and reported twice

Private-fund advisers

—

of shares outstanding

Institutional ownership

—

holders exceed shares outstanding: 13F filers report more shares than the cover-page count, which predates an issuance, is misstated, or misses shares lent and reported twice

Top 10 holders

50.0%

of 13F shares, Herfindahl 0.037

Active holders

+3.4%

like-for-like share change of active filers

5% stakes on record

1 13D, 3 13G (2 institutional, 1 passive, 0 exempt)

How long holders have held it value-weighted 9.2 quarters

Under 1 year 18.3% 1 to 3 years 37.4% 3 years or more 44.3% Since coverage start 0.000%

Managers in the top fifth by current three-year FundScore alpha were net buyers of $66,653 (1 buying, 0 selling).

Estimated Holder Cost Basis

Quarter ended Jun 30, 2026, on that quarter's share basis

Estimated, never filed: each 13F buy is costed at its quarter's average traded price and each sale keeps the average cost, so this is what holders paid on average if they traded evenly through each quarter.

Estimated avg cost

$62.80

estimated per share

Mar 31, 2026: $62.20

Quarter-end price

$73.14

implied by 13F values

Estimated gain or loss

+16.5%

price against the estimated cost

Estimated at a loss

14.6%

of costed 13F value

Estimated cost covers 65.8% of the 13F shares; positions already held when a filer's 13F history starts, or bought in a quarter without a trusted average price, have no estimate.

Shared Holders

Companies IRON's active holders also own, quarter ended Jun 30, 2026

#	Company	Shared holders	Similarity
1	DYN Dyne Therapeutics, Inc.	16	0.433
2	TRVI Trevi Therapeutics, Inc.	15	0.352
3	PBLS Parabilis Medicines, Inc.	10	0.345
4	SVRA Savara Inc	11	0.324
5	VSTM Verastem, Inc.	8	0.319
6	KLRA Kailera Therapeutics, Inc.	8	0.319
7	TSHA Taysha Gene Therapies, Inc.	11	0.310
8	IMMX Immix Biopharma, Inc.	7	0.306
9	MNPR Monopar Therapeutics	7	0.306
10	TNGX Tango Therapeutics, Inc.	12	0.299

Shareholder Targets

13F filers that own its peers but not IRON, quarter ended Jun 30, 2026

Found through its holder-overlap peers: DYN, TRVI, PBLS, SVRA, VSTM, KLRA, TSHA, IMMX, MNPR, TNGX, RYTM, GLUE, IMCR, SION, CGON, XENE, GPCR, IDYA, CBIO, JBIO. 577 filers in all.

#	Filer	In peers	Of book	Largest peers
1	T. Rowe Price Investment Management, Inc. Adviser, Diversified active	$1,295,469,043 4 held	0.850%	DYN, CGON, XENE
2	Avoro Capital Advisors LLC Registered adviser, Concentrated	$863,266,582 3 held	7.75%	GPCR, XENE, TSHA
3	Polar Capital Holdings Plc Registered adviser, Diversified active	$693,071,991 9 held	1.96%	XENE, RYTM, SVRA
4	ADAGE CAPITAL PARTNERS GP, L.L.C. Registered adviser, Diversified active	$591,090,399 13 held	0.830%	TNGX, IDYA, KLRA
5	NEA Management Company, LLC Registered adviser, Concentrated	$583,491,149 3 held	36.8%	TRVI, GLUE, SVRA
6	Bain Capital Investors LLC Unknown, Concentrated	$578,410,449 1 held	12.0%	KLRA
7	FRANKLIN RESOURCES INC Adviser, Diversified active	$502,367,424 16 held	0.110%	CGON, XENE, RYTM
8	PERCEPTIVE ADVISORS LLC Registered adviser, Diversified active	$495,985,168 5 held	8.00%	RYTM, TNGX, DYN
9	Deep Track Capital, LP Adviser, Diversified active	$494,849,132 7 held	7.53%	GPCR, TNGX, DYN
10	FARALLON CAPITAL MANAGEMENT LLC Registered adviser, Diversified active	$488,152,154 4 held	2.88%	TNGX, PBLS, KLRA

Fund Ownership of IRON by Fund Type

Registered funds' Form N-PORT reports for the quarter ended Jun 30, 2026

Index funds and index ETFs hold 13.47% of shares outstanding.

Fund type	Of shares outstanding	Change	Shares	Funds
Index funds	2.65%	+0.45 pp	1,016,613	59
Index ETFs	10.82%	+0.21 pp	4,155,527	36
Active ETFs	0.79%	+0.35 pp	302,842	16
Active funds	25.26%	+3.16 pp	9,697,621	105
Unclassified	0.11%	+0.11 pp	43,613	3
All registered funds	39.63%	+4.29 pp	15,216,216	219

How fund types are measured

Each fund series counts once, with its latest Form N-PORT report dated inside the quarter; only long share positions count, restated to today's split basis. The fund type is the series' latest Form N-CEN answer on or before the quarter end (the index-fund box and the exchange-traded flag), never its name. Unclassified funds have no usable N-CEN; unit investment trusts are among them, so index ownership is a floor. Funds sit inside their advisers' 13F reports, so these shares overlap the 13F figures and are never added to them.

Holder type: Registered adviser 105 Exempt adviser 4 Adviser 5 Bank 16 Insurer 1 Broker-dealer 1 Benefit plan 5 Non-US 7 Holding company 7 Unknown 69

Showing 100 of 229

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

FMR LLC

$357,981,753

11.17%

4,894,473

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	2,829,550	$206,953,287	57.8%	Defined
FIDELITY MANAGEMENT TRUST CO	40,521	$2,963,705	0.8%	Defined
STRATEGIC ADVISERS LLC	111	$8,118	0.0%	Defined
Fidelity Institutional Asset Management Trust Co	67,001	$4,900,453	1.4%	Defined
FIAM LLC	1,957,290	$143,156,190	40.0%	Defined

BlackRock, Inc.

$180,502,128

5.63%

2,467,899

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	22,115	$1,617,491	0.9%	Sole
BlackRock Investment Management (Australia) Ltd	33	$2,413	0.0%	Sole
BlackRock Asset Management Canada Ltd	7,081	$517,904	0.3%	Sole
BlackRock Investment Management, LLC	76,988	$5,630,902	3.1%	Sole
BLACKROCK ADVISORS LLC	68,499	$5,010,016	2.8%	Sole
BlackRock Fund Advisors	1,307,850	$95,656,149	53.0%	Sole
BlackRock Institutional Trust Company, N.A.	901,939	$65,967,818	36.5%	Sole
BlackRock Fund Managers Ltd.	4,101	$299,947	0.2%	Sole
BlackRock Investment Management (UK) Ltd.	5,711	$417,702	0.2%	Sole
BlackRock Asset Management Ireland Ltd	52,642	$3,850,235	2.1%	Sole
BlackRock Asset Management Schweiz AG	4,454	$325,765	0.2%	Sole
Aperio Group, LLC	16,486	$1,205,786	0.7%	Sole

RA CAPITAL MANAGEMENT, L.P.

$179,209,163

5.59%

2,450,221

JPMORGAN CHASE & CO

$137,195,645

4.28%

1,875,795

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JPMorgan Chase Bank, N.A.	37,500	$2,742,750	2.0%	Defined
J.P. Morgan Investment Management Inc.	1,471,102	$107,596,400	78.4%	Defined
J.P. Morgan Securities LLC	1	$73	0.0%	Defined
J.P. Morgan Securities plc	2,893	$211,594	0.2%	Defined
JPMorgan Asset Management (UK) Ltd	364,299	$26,644,828	19.4%	Defined

PRICE T ROWE ASSOCIATES INC /MD/

$137,166,682

4.28%

1,875,399

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T. Rowe Price International Ltd	44,888	$3,283,108	2.4%	Defined
Held directly	1,830,511	$133,883,574	97.6%	Sole

WELLINGTON MANAGEMENT GROUP LLP

$127,362,408

3.98%

1,741,351

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Wellington Management Company LLP	1,243,136	$90,922,967	71.4%	Defined
Wellington Managment Canada LLC	48,591	$3,553,945	2.8%	Defined
Wellington Management Singapore Pte. Ltd.	19,462	$1,423,450	1.1%	Defined
Wellington Management International Ltd	99,417	$7,271,359	5.7%	Defined
Wellington Trust Company, NA joint	303,220	$22,177,510	17.4%	Defined
Wellington Management Australia Pty Ltd	2,005	$146,645	0.1%	Defined
Wellington Management Europe GmbH	25,520	$1,866,532	1.5%	Defined

STATE STREET CORP

$120,595,865

3.76%

1,648,836

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STATE STREET GLOBAL ADVISORS EUROPE LIMITED joint	1,648,836	$120,595,865	100.0%	Defined

Vestal Point Capital, LP

$113,367,000

3.54%

1,550,000

Atlas Venture Life Science Advisors, LLC

$110,724,817

3.46%

1,513,875

VANGUARD CAPITAL MANAGEMENT LLC

$100,130,634

3.13%

1,369,027

Frazier Life Sciences Management, L.P.

$99,093,875

3.09%

1,354,852

TCG Crossover Management, LLC

$98,143,786

3.06%

1,341,862

BVF INC/IL

$84,375,181

2.63%

1,153,612

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BVF PARTNERS L P/IL	1,153,612	$84,375,181	100.0%	Defined

Assenagon Asset Management S.A.

$73,279,720

2.29%

1,119,458

Woodline Partners LP

$70,088,672

2.19%

958,281

Siren, L.L.C.

$64,977,649

2.03%

888,401

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invus Group, LLC	888,401	$64,977,649	100.0%	Defined

Logos Global Management LP

$63,997,500

2.00%

875,000

Opaleye Management Inc.

$62,534,700

1.95%

855,000

GEODE CAPITAL MANAGEMENT, LLC

$57,760,413

1.80%

789,724

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	114,316	$8,361,072	14.5%	Defined
Held directly	675,408	$49,399,341	85.5%	Defined

DEERFIELD MANAGEMENT COMPANY, L.P.

$48,052,980

1.50%

657,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Deerfield UGP, LLC	657,000	$48,052,980	100.0%	Defined

DIMENSIONAL FUND ADVISORS LP

$41,617,974

1.30%

569,018

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Dimensional Fund Advisors Ltd.	3,774	$276,030	0.7%	Defined
DFA Australia Ltd.	8,782	$642,315	1.5%	Defined
Dimensional Fund Advisors Pte. Ltd.	174	$12,726	0.0%	Defined
Dimensional Ireland Ltd	19,749	$1,444,441	3.5%	Defined
Held directly	536,539	$39,242,462	94.3%	Sole

Bellevue Group AG

$40,958,400

1.28%

560,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BB Biotech AG joint	560,000	$40,958,400	100.0%	Defined

Saturn V Capital Management LP

$38,378,752

1.20%

524,730

ARMISTICE CAPITAL, LLC

$33,644,400

1.05%

460,000

JENNISON ASSOCIATES LLC

$32,146,492

1.00%

439,520

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Prudential Financial Inc	439,520	$32,146,492	100.0%	Defined

Aberdeen Group plc

$32,048,046

1.00%

438,174

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
abrdn Inc.	438,174	$32,048,046	100.0%	Defined

Palo Alto Investors LP

$30,473,488

0.95%

416,646

EVENTIDE ASSET MANAGEMENT, LLC

$28,937,914

0.90%

395,651

Pictet Asset Management Holding SA

$28,186,327

0.88%

385,375

LOOMIS SAYLES & CO L P

$27,929,532

0.87%

381,864

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
LOOMIS SAYLES TRUST COMPANY, LLC	64,296	$4,702,609	16.8%	Defined
Held directly	317,568	$23,226,923	83.2%	Defined

Foresite Capital Management V, LLC

$27,359,406

0.85%

374,069

ORBIMED ADVISORS LLC

$26,150,109

0.82%

357,535

BAKER BROS. ADVISORS LP

$25,573,912

0.80%

349,657

VANGUARD PORTFOLIO MANAGEMENT LLC

$20,620,872

0.64%

281,937

Octagon Capital Advisors LP

$19,747,800

0.62%

270,000

NORTHERN TRUST CORP

$19,381,367

0.60%

264,990

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	244,560	$17,887,118	92.3%	Defined
NORTHERN TRUST GLOBAL INVESTMENTS LTD	16,055	$1,174,262	6.1%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC joint	4,375	$319,987	1.7%	Other

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$18,824,919

0.59%

257,382

Checkpoint Capital L.P.

$17,562,742

0.55%

240,125

VANGUARD FIDUCIARY TRUST CO

$16,470,981

0.51%

225,198

CITADEL ADVISORS LLC

$15,308,786

0.48%

209,308

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	192,912	$14,109,583	92.2%	Defined
Held directly	16,396	$1,199,203	7.8%	Defined

Bank of New York Mellon Corp

$14,973,727

0.47%

204,727

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BNY Mellon Trust of Delaware joint	120	$8,776	0.1%	Defined
Mellon Investments Corporation joint	29,971	$2,192,078	14.6%	Defined
BNY Mellon Securities Corporation	3,275	$239,533	1.6%	Defined
The Bank of New York Mellon	52,019	$3,804,669	25.4%	Defined
BNY Mellon, NA joint	830	$60,705	0.4%	Defined
Newton Investment Management North America, LLC joint	118,511	$8,667,893	57.9%	Defined
Held directly	1	$73	0.0%	Defined

BNP PARIBAS ARBITRAGE, SA

$13,508,592

0.42%

184,695

Catalio Capital Management, LP

$11,657,345

0.36%

159,384

Caption Management, LLC

$10,971,000

0.34%

150,000

Sofinnova Investments, Inc.

$10,695,920

0.33%

146,239

Bain Capital Life Sciences Investors, LLC

$10,329,854

0.32%

141,234

TWO SIGMA INVESTMENTS, LP

$10,001,895

0.31%

136,750

BANK OF AMERICA CORP /DE/

$9,882,017

0.31%

135,111

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	94,132	$6,884,814	69.7%	Defined
MERRILL LYNCH, PIERCE, FENNER & SMITH INC.	5,800	$424,212	4.3%	Defined
BOFA SECURITIES, INC.	24,815	$1,814,969	18.4%	Defined
MANAGED ACCOUNT ADVISORS LLC	10,364	$758,022	7.7%	Defined

Alyeska Investment Group, L.P.

$9,142,500

0.29%

125,000

Ensign Peak Advisors, Inc

$8,931,198

0.28%

122,111

UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC

$8,345,930

0.26%

114,109

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Group AG	467	$34,156	0.4%	Defined
UBS Asset Management Switzerland AG	109,650	$8,019,800	96.1%	Defined
Held directly	3,992	$291,974	3.5%	Defined

UBS Group AG

$8,116,418

0.25%

110,971

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Financial Services Inc	84	$6,143	0.1%	Defined
UBS AG	103,887	$7,598,295	93.6%	Defined
UBS Switzerland AG	7,000	$511,980	6.3%	Defined

Trexquant Investment LP

$7,877,104

0.25%

107,699

KENNEDY CAPITAL MANAGEMENT LLC

$7,809,084

0.24%

106,769

MILLENNIUM MANAGEMENT LLC

$7,770,978

0.24%

106,248

GOLDMAN SACHS GROUP INC

$7,122,592

0.22%

97,383

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	67,825	$4,960,720	69.6%	Defined
GOLDMAN SACHS ASSET MANAGEMENT, L.P.	29,558	$2,161,872	30.4%	Defined

MORGAN STANLEY

$6,699,255

0.21%

91,595

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	10	$731	0.0%	Defined
MORGAN STANLEY & CO. LLC	19,735	$1,443,417	21.5%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	57,743	$4,223,323	63.0%	Defined
MORGAN STANLEY SMITH BARNEY LLC	2,919	$213,495	3.2%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	11,188	$818,289	12.2%	Defined

HRT FINANCIAL LP

$6,642,721

0.21%

90,822

SILVERARC CAPITAL MANAGEMENT, LLC

$6,055,992

0.19%

82,800

RAYMOND JAMES FINANCIAL INC

$5,703,455

0.18%

77,980

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RAYMOND JAMES & ASSOCIATES	4,816	$352,242	6.2%	Defined
Raymond James Financial Services Advisors, Inc.	1,184	$86,597	1.5%	Defined
EAGLE ASSET MANAGEMENT INC joint	71,980	$5,264,616	92.3%	Defined

Squarepoint Ops LLC

$5,549,278

0.17%

75,872

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Squarepoint Capital LLP	75,872	$5,549,278	100.0%	Defined

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$5,383,104

0.17%

73,600

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	73,600	$5,383,104	100.0%	Other

DNB Asset Management AS

$5,348,508

0.17%

73,127

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DNB FUND	73,127	$5,348,508	100.0%	Other

iA Global Asset Management Inc.

$4,828,922

0.15%

66,023

Casdin Capital, LLC

$4,754,100

0.15%

65,000

SPHERA FUNDS MANAGEMENT LTD.

$4,647,169

0.15%

63,538

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Sphera Global Healthcare Management LP joint	63,538	$4,647,169	100.0%	Defined

Nuveen, LLC

$4,414,510

0.14%

60,357

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Nuveen Asset Management, LLC joint	6,471	$473,288	10.7%	Defined
TEACHERS ADVISORS, LLC joint	53,886	$3,941,222	89.3%	Defined

PEAK6 LLC

$4,388,400

0.14%

60,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
PEAK6 Investments LLC joint	60,000	$4,388,400	100.0%	Defined

KVP Capital Advisors, LP

$4,260,405

0.13%

58,250

MOORE CAPITAL MANAGEMENT, LP

$4,227,199

0.13%

57,796

XTX Topco Ltd

$4,147,769

0.13%

56,710

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
XTX EXECUTION SERVICES LLC joint	56,710	$4,147,769	100.0%	Defined

NEXTBio Capital Management LP

$3,851,186

0.12%

52,655

ALGERT GLOBAL LLC

$3,792,309

0.12%

51,850

ExodusPoint Capital Management, LP

$3,775,706

0.12%

51,623

Burkehill Global Management, LP

$3,657,000

0.11%

50,000

SCHRODER INVESTMENT MANAGEMENT GROUP

$3,656,999

0.11%

50,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Schroder Investment Management Limited	49,674	$3,633,156	99.3%	Sole
Schroder Investment Management North America Inc.	326	$23,843	0.7%	Sole

Brevan Howard Capital Management LP

$3,656,707

0.11%

49,996

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Brevan Howard Investment Products Ltd	41,886	$3,063,542	83.8%	Defined
Brevan Howard US Investment Management, LP	8,110	$593,165	16.2%	Defined

Swiss National Bank

$3,642,372

0.11%

49,800

AMERIPRISE FINANCIAL INC

$3,355,224

0.10%

45,874

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Columbia Management Investment Advisers, LLC	45,874	$3,355,224	100.0%	Defined

Atle Fund Management AB

$3,194,901

0.10%

43,682

Quadrature Capital Ltd

$3,102,525

0.10%

42,419

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Quadrature US Inc.	42,419	$3,102,525	100.0%	Other

Invesco Ltd.

$3,076,047

0.10%

42,057

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invesco Advisers, Inc. joint	4,394	$321,376	10.4%	Defined
Invesco Trust Co joint	11,316	$827,652	26.9%	Defined
Invesco Capital Management LLC	26,347	$1,927,019	62.6%	Defined

CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM

$2,878,790

0.09%

39,360

ALPS ADVISORS INC

$2,820,644

0.09%

38,565

CITIGROUP INC

$2,802,504

0.09%

38,317

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citigroup Financial Products Inc. joint	38,317	$2,802,504	100.0%	Defined

BNP PARIBAS ASSET MANAGEMENT Holding S.A.

$2,798,481

0.09%

38,262

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BNP PARIBAS ASSET MANAGEMENT Europe	414	$30,279	1.1%	Defined
AXA INVESTMENT MANAGERS UK LIMITED	37,848	$2,768,202	98.9%	Defined

Universal- Beteiligungs- und Servicegesellschaft mbH

$2,679,410

0.08%

36,634

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Universal-Investment-Gesellschaft mbH	36,634	$2,679,410	100.0%	Defined

RHUMBLINE ADVISERS

$2,621,630

0.08%

35,844

LAZARD ASSET MANAGEMENT LLC

$2,562,386

0.08%

35,034

SEVEN GRAND MANAGERS, LLC

$2,559,900

0.08%

35,000

ALLIANCEBERNSTEIN L.P.

$2,535,763

0.08%

34,670

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Equitable Holdings, Inc.	34,670	$2,535,763	100.0%	Defined

MARSHALL WACE, LLP

$2,515,577

0.08%

34,394

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Marshall Wace North America L.P. joint	34,394	$2,515,577	100.0%	Other

Jump Financial, LLC

$2,380,633

0.07%

32,549

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jump Trading Holdings, LLC	1	$73	0.0%	Defined
Leap GP LLC joint	32,548	$2,380,560	100.0%	Defined

BANK OF MONTREAL /CAN/

$2,363,007

0.07%

32,308

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BMO NESBITT BURNS INC.	32,258	$2,359,350	99.8%	Defined
BMO NESBITT BURNS SECURITIES LTD.	50	$3,657	0.2%	Defined

PINNACLE ASSOCIATES LTD

$2,310,148

0.07%

35,291

DEUTSCHE BANK AG\

$2,241,228

0.07%

30,643

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DWS INVESTMENT MANAGEMENT AMERICAS, INC	797	$58,292	2.6%	Defined
DWS Investments UK Ltd	29,846	$2,182,936	97.4%	Defined

Squadron Capital Management LLC

$2,194,200

0.07%

30,000

RTW INVESTMENTS, LP

$2,194,200

0.07%

30,000

VICTORY CAPITAL MANAGEMENT INC

$2,129,617

0.07%

29,117

WELLS FARGO & COMPANY/MN

$2,115,499

0.07%

28,924

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO BANK N A	25,810	$1,887,743	89.2%	Defined
WELLS FARGO ADVISORS FINANCIAL NETWORK, LLC	472	$34,522	1.6%	Defined
WELLS FARGO CLEARING SERVICES, LLC	2,621	$191,699	9.1%	Defined
WELLS FARGO INVESTMENT INSTITUTE, INC.	21	$1,535	0.1%	Defined

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Key facts CIK 1816736 CUSIP 254604101 13F (30d) 12 filings 12 filers Visit website Investor relations