ANNX · Annexon, Inc. · Holdings

$3.91 +0.08 (+2.05%)

Russell 2000 member Rebalance outlook locked

Market Cap

$798.36M

204.44M

Volume · Oct 21 4.95M Avg daily vol (3M) 3.05M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Use institutional holdings through the 13F API or MCP → See every holder of ANNX: 13F, 13D and 13G, insiders and funds →

Institutional holdings are being reconciled with SEC filings. Holder totals and changes may be incomplete until reconciliation finishes.

The Sep 30, 2026 filing window is still open — showing the latest known positions. Funds that have not filed yet carry their prior-quarter positions; a fund that filed without this stock counts as sold out. Each fund's Change is measured against its own previous reported quarter, shown in the Reported column. Pick a completed quarter in the Quarter selector below to put every fund on one quarter and see the stock-wide activity breakdown.

Quarter:

Holders: 218

Total Value: $1,027,527,213

Total Shares: 180,463,420

Showing 1–100 of 227 holdings by value · page 1 of 3

Institutional Ownership Trend

25 quarters

Holder Concentration

Across 217 13F filers

Top Holder

10.9%

of institutional value

Top 5

35.3%

of institutional value

Top 10

51.9%

of institutional value

HHI

385

Broadly held

Who Holds ANNX

Last 8 quarters through Sep 30, 2026 (filing window open)

Each kind of 13F filer's share of the common shares 13F filers report. Holder type comes from regulatory records, never the filer's name; style, turnover and horizon are measured from each filer's own 13F book. The quarter selector does not change this card.

Jun 30, 2026, the newest closed quarter: 216 filers, like-for-like change +14.4%; actively managed books +10.1%; index-like books +27.0%.

Holder type	Share	Filers	Change	New	Exited
Registered adviser	42.0%	112	+12.8%	16	13
Exempt adviser	2.1%	5	-31.2%	0	1
Adviser	4.2%	4	+73.4%	1	1
Bank	8.5%	13	+1.3%	1	1
Insurer	0.0%	2	+82.0%	1	0
Broker-dealer	0.0%	2	+96.0%	1	0
Benefit plan	0.3%	4	+257.6%	0	0
Non-US	2.8%	7	-20.1%	0	1
Holding company	23.9%	6	+57.8%	0	0
Unknown	16.3%	61	-7.7%	8	11

Style	Share	Filers	Change	New	Exited
Index-like	28.4%	30	+27.0%	1	0
Systematic-like	11.5%	32	+12.5%	6	1
Concentrated	21.0%	22	-8.3%	1	6
Diversified active	39.1%	132	+22.5%	20	21
Not measured	0.0%	0	—	0	0
Unknown	0.0%	0	—	0	0

Turnover	Share	Filers	Change	New	Exited
Low turnover	55.6%	99	+16.0%	7	7
Medium turnover	23.2%	54	+6.9%	11	12
High turnover	14.9%	48	+15.6%	9	8
Unknown	6.4%	15	+28.7%	1	1
Not measured	0.0%	0	—	0	0

Holding horizon	Share	Filers	Change	New	Exited
Short horizon	9.4%	33	+16.2%	7	6
Medium horizon	15.5%	29	+27.9%	5	9
Long horizon	57.8%	128	+12.8%	13	12
Unknown	17.3%	26	+8.4%	3	1
Not measured	0.0%	0	—	0	0

13F book size	Share	Filers	Change	New	Exited
Under $1B	9.7%	40	+12.5%	6	8
$1B to $10B	25.8%	53	-0.4%	10	8
$10B to $100B	14.3%	64	+17.0%	8	9
$100B or more	50.2%	59	+23.4%	4	3
Not measured	0.0%	0	—	0	0

Client base	Share	Filers	Change	New	Exited
Individuals and high net worth	0.3%	34	-12.2%	5	4
Pooled investment vehicles	29.4%	42	+10.9%	9	6
Registered funds and BDCs	10.1%	15	+18.3%	0	0
Pension and profit sharing plans	0.1%	2	+14.0%	0	0
Insurance companies	0.1%	3	+28.9%	0	0
Governments and sovereign funds	0.9%	3	+118.2%	1	1
Corporations	0.0%	1	0.0%	0	0
Other investment advisers	0.0%	3	+250.1%	1	0
Diversified	1.2%	9	-12.4%	0	2
Unknown	58.0%	104	+15.6%	12	15

Private funds	Share	Filers	Change	New	Exited
Hedge funds	25.9%	52	-1.4%	9	6
Private equity funds	2.2%	7	+34.4%	1	0
Venture capital funds	0.8%	2	+343206.4%	1	0
Real estate funds	0.0%	3	+323.4%	0	1
Securitized asset funds	0.1%	1	+38.3%	0	0
Other private funds	1.8%	9	+66.7%	1	1
Mixed private funds	3.4%	2	+22.3%	0	1
Private funds, type not stated	1.1%	3	+4.2%	1	2
No private funds	8.8%	38	+18.7%	3	3
Unknown	55.9%	99	+18.6%	12	14

Location	Share	Filers	Change	New	Exited
United States	92.7%	175	+17.7%	23	21
Outside the US	7.3%	41	-15.7%	5	7

The Sep 30, 2026 filing window is still open, so its bar carries the Jun 30, 2026 positions of filers that have not filed yet.

How the mix is measured

Shares are 13F common shares restated to today's split basis; options and principal amounts are left out. The change compares only filers with a 13F in both quarters and keeps each filer in its bucket of the later quarter on both sides; a filer that continues under a new CIK is compared through its successor. Holder type comes from each filer's current regulatory profile; client base and private funds come from the Form ADV roster current at each quarter end (rosters from December 2019, so an earlier quarter reads Unknown). Style, turnover, horizon and book size are measured from each filer's 13F book in the newest measured quarter, and Not measured means none was. Actively managed books are those measured systematic-like, concentrated or diversified active.

Excluded 1 holder with no observed 2026-03-31 13F and 2 holders with no observed 2026-06-30 13F. Compared across CIK changes: JANUS HENDERSON GROUP PLC continues as Jupiter Topco LLC; Trask Adam Roland continues as Burnham & Co LLC.

Conviction and Crowding

216 13F filers, quarter ended Jun 30, 2026

Measured across every 13F filer's common-share book once the quarter's filing window closed. Crowding counts filers with high turnover or that advise private funds on Form ADV.

Conviction holders

1.85% of filers hold it in their top 10

Mar 31, 2026: 5

Holders above 5%

median weight 0.001%

Mar 31, 2026: 1

Crowding

—

the issuer has more than one class of common stock, so its count is the total across classes

Private-fund advisers

—

of shares outstanding

Institutional ownership

—

the issuer has more than one class of common stock, so its count is the total across classes

Top 10 holders

52.4%

of 13F shares, Herfindahl 0.039

Active holders

+10.1%

like-for-like share change of active filers

5% stakes on record

1 13D, 6 13G (3 institutional, 3 passive, 0 exempt)

How long holders have held it value-weighted 13.1 quarters

Under 1 year 24.7% 1 to 3 years 30.2% 3 years or more 45.1% Since coverage start 0.000%

Managers in the top fifth by current three-year FundScore alpha were net sellers of $582,658 (0 buying, 1 selling).

Estimated Holder Cost Basis

Quarter ended Jun 30, 2026, on that quarter's share basis

Estimated, never filed: each 13F buy is costed at its quarter's average traded price and each sale keeps the average cost, so this is what holders paid on average if they traded evenly through each quarter.

Estimated avg cost

$5.38

estimated per share

Mar 31, 2026: $5.33

Quarter-end price

$5.71

implied by 13F values

Estimated gain or loss

+6.0%

price against the estimated cost

Estimated at a loss

22.4%

of costed 13F value

Estimated cost covers 93.6% of the 13F shares; positions already held when a filer's 13F history starts, or bought in a quarter without a trusted average price, have no estimate.

Shared Holders

Companies ANNX's active holders also own, quarter ended Jun 30, 2026

#	Company	Shared holders	Similarity
1	STOK Stoke Therapeutics, Inc.	9	0.367
2	DBVT DBV Technologies S.A.	7	0.340
3	COAG Hemab Therapeutics Holdings, Inc.	6	0.333
4	FHTX Foghorn Therapeutics Inc.	5	0.302
5	SLN Silence Therapeutics plc	6	0.300
6	IRON Disc Medicine, Inc.	8	0.270
7	MNPR Monopar Therapeutics	5	0.258
8	RCUS Arcus Biosciences, Inc.	6	0.250
9	QTTB Q32 Bio Inc.	5	0.250
10	ENTX Entera Bio Ltd.	3	0.245

Shareholder Targets

13F filers that own its peers but not ANNX, quarter ended Jun 30, 2026

Found through its holder-overlap peers: STOK, DBVT, COAG, FHTX, SLN, IRON, MNPR, RCUS, QTTB, ENTX, XERS, RARE, ACAD, AGIO, VERA, ZURA, DRUG, GLUE, AMLX, LXRX. 578 filers in all.

#	Filer	In peers	Of book	Largest peers
1	BAKER BROS. ADVISORS LP Registered adviser, Concentrated	$1,375,626,966 6 held	6.92%	ACAD, STOK, GLUE
2	GILEAD SCIENCES, INC. Unknown, Concentrated	$968,825,350 1 held	58.7%	RCUS
3	RTW INVESTMENTS, LP Registered adviser, Diversified active	$627,290,719 4 held	5.36%	RARE, STOK, ACAD
4	RA CAPITAL MANAGEMENT, L.P. Registered adviser, Concentrated	$576,115,230 5 held	5.07%	COAG, IRON, MNPR
5	Artal Group S.A. Unknown, Unknown	$420,374,548 1 held	45.2%	LXRX
6	TCG Crossover Management, LLC Unknown, Diversified active	$374,273,237 5 held	9.00%	AMLX, GLUE, IRON
7	Avoro Capital Advisors LLC Registered adviser, Concentrated	$316,322,793 2 held	2.84%	VERA, COAG
8	Deep Track Capital, LP Adviser, Diversified active	$303,944,875 2 held	4.63%	VERA, COAG
9	SUVRETTA CAPITAL MANAGEMENT, LLC Registered adviser, Diversified active	$288,869,669 3 held	6.07%	RCUS, GLUE, ZURA
10	Vestal Point Capital, LP Registered adviser, Diversified active	$276,883,902 5 held	6.47%	IRON, GLUE, DRUG

Fund Ownership of ANNX by Fund Type

Registered funds' Form N-PORT reports for the quarter ended Jun 30, 2026

Index funds and index ETFs hold 13.72% of shares outstanding.

Fund type	Of shares outstanding	Change	Shares	Funds
Index funds	2.35%	+0.58 pp	4,801,952	56
Index ETFs	11.38%	+2.54 pp	23,257,884	32
Active ETFs	0.84%	+0.43 pp	1,723,943	15
Active funds	10.70%	+3.81 pp	21,865,685	84
Unclassified	0.00%	0.00 pp	9,567	1
All registered funds	25.27%	+7.37 pp	51,659,031	188

How fund types are measured

Each fund series counts once, with its latest Form N-PORT report dated inside the quarter; only long share positions count, restated to today's split basis. The fund type is the series' latest Form N-CEN answer on or before the quarter end (the index-fund box and the exchange-traded flag), never its name. Unclassified funds have no usable N-CEN; unit investment trusts are among them, so index ownership is a floor. Funds sit inside their advisers' 13F reports, so these shares overlap the 13F figures and are never added to them.

Holder type: Registered adviser 113 Exempt adviser 5 Adviser 4 Bank 13 Insurer 2 Broker-dealer 2 Benefit plan 4 Non-US 7 Holding company 6 Unknown 62

Showing 100 of 227

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

FMR LLC

$111,450,610

10.85%

19,518,496

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	18,163,391	$103,712,962	93.1%	Defined
STRATEGIC ADVISERS LLC	1,070	$6,109	0.0%	Defined
Fidelity Institutional Asset Management Trust Co	560,926	$3,202,887	2.9%	Defined
FIAM LLC	793,109	$4,528,652	4.1%	Defined

BlackRock, Inc.

$77,311,931

7.52%

13,539,744

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	137,001	$782,275	1.0%	Sole
BlackRock Asset Management Canada Ltd	1,088	$6,212	0.0%	Sole
BlackRock Investment Management, LLC	472,099	$2,695,685	3.5%	Sole
BLACKROCK ADVISORS LLC	582,664	$3,327,011	4.3%	Sole
BlackRock Fund Advisors	7,422,521	$42,382,594	54.8%	Sole
BlackRock Institutional Trust Company, N.A.	4,558,665	$26,029,977	33.7%	Sole
BlackRock Japan Co. Ltd	1,397	$7,976	0.0%	Sole
BlackRock Fund Managers Ltd.	18,769	$107,170	0.1%	Sole
BlackRock Investment Management (UK) Ltd.	12,451	$71,095	0.1%	Sole
BlackRock Asset Management Ireland Ltd	244,677	$1,397,105	1.8%	Sole
BlackRock (Luxembourg) S.A.	1,973	$11,265	0.0%	Sole
BlackRock Asset Management Schweiz AG	19,910	$113,686	0.1%	Sole
Aperio Group, LLC	66,529	$379,880	0.5%	Sole

Redmile Group, LLC

$67,776,997

6.60%

11,869,877

STATE STREET CORP

$56,096,872

5.46%

9,824,321

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STATE STREET GLOBAL ADVISORS EUROPE LIMITED joint	9,824,321	$56,096,872	100.0%	Defined

BVF INC/IL

$49,666,567

4.83%

8,698,173

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BVF PARTNERS L P/IL	8,698,173	$49,666,567	100.0%	Defined

Woodline Partners LP

$39,542,132

3.85%

6,925,067

VANGUARD CAPITAL MANAGEMENT LLC

$39,233,495

3.82%

6,871,015

MAK CAPITAL ONE LLC

$33,473,047

3.26%

5,862,180

GOLDMAN SACHS GROUP INC

$33,264,054

3.24%

5,825,579

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	3,139,169	$17,924,654	53.9%	Defined
GOLDMAN SACHS ASSET MANAGEMENT, L.P.	2,622,712	$14,975,685	45.0%	Defined
Goldman Sachs Trust Company, N.A. joint	63,698	$363,715	1.1%	Other

Siren, L.L.C.

$25,458,868

2.48%

4,458,646

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invus Group, LLC	4,458,646	$25,458,868	100.0%	Defined

Bain Capital Life Sciences Investors, LLC

$25,339,444

2.47%

4,437,731

Bellevue Group AG

$23,411,091

2.28%

4,100,016

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BB Biotech AG joint	4,100,016	$23,411,091	100.0%	Defined

GEODE CAPITAL MANAGEMENT, LLC

$23,052,371

2.24%

4,037,193

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	577,582	$3,297,993	14.3%	Defined
Held directly	3,459,611	$19,754,378	85.7%	Defined

MPM BIOIMPACT LLC

$20,238,261

1.97%

3,544,354

AMERIPRISE FINANCIAL INC

$20,039,945

1.95%

3,509,623

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Columbia Management Investment Advisers, LLC joint	3,433,390	$19,604,656	97.8%	Defined
Ameriprise Financial Services, LLC	160	$913	0.0%	Defined
Columbia Threadneedle Management Ltd	76,073	$434,376	2.2%	Defined

GREAT POINT PARTNERS LLC

$19,985,000

1.94%

3,500,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JAY JEFFREY R joint	3,500,000	$19,985,000	100.0%	Defined

ADAGE CAPITAL PARTNERS GP, L.L.C.

$19,985,000

1.94%

3,500,000

MORGAN STANLEY

$17,954,823

1.75%

3,144,453

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	119	$679	0.0%	Defined
MORGAN STANLEY & CO. LLC	2,127,397	$12,147,436	67.7%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	285,881	$1,632,380	9.1%	Defined
MORGAN STANLEY INVESTMENT MANAGEMENT INC	11,380	$64,979	0.4%	Defined
MORGAN STANLEY SMITH BARNEY LLC	428,753	$2,448,179	13.6%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	290,923	$1,661,170	9.3%	Defined

Palo Alto Investors LP

$16,833,593

1.64%

2,948,090

Balyasny Asset Management L.P.

$16,164,872

1.57%

2,830,976

Nuveen, LLC

$15,788,605

1.54%

2,765,080

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Nuveen Asset Management, LLC joint	98,863	$564,507	3.6%	Defined
TIAA CREF INVESTMENT MANAGEMENT LLC joint	840,499	$4,799,249	30.4%	Defined
TEACHERS ADVISORS, LLC joint	1,825,718	$10,424,849	66.0%	Defined

Qube Research & Technologies Ltd

$15,702,277

1.53%

2,749,961

VANGUARD PORTFOLIO MANAGEMENT LLC

$12,829,228

1.25%

2,246,800

Opaleye Management Inc.

$9,789,515

0.95%

1,714,451

Logos Global Management LP

$8,565,000

0.83%

1,500,000

DIMENSIONAL FUND ADVISORS LP

$8,552,184

0.83%

1,497,756

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Dimensional Fund Advisors Ltd.	11,443	$65,339	0.8%	Defined
DFA Australia Ltd.	12,369	$70,626	0.8%	Defined
Dimensional Ireland Ltd	48,414	$276,443	3.2%	Defined
Held directly	1,425,530	$8,139,776	95.2%	Sole

Point72 Asset Management, L.P.

$7,895,211

0.77%

1,382,699

NORTHERN TRUST CORP

$7,720,180

0.75%

1,352,046

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	1,255,593	$7,169,435	92.9%	Defined
NORTHERN TRUST GLOBAL INVESTMENTS LTD	72,058	$411,450	5.3%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC joint	24,395	$139,295	1.8%	Other

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$7,182,032

0.70%

1,257,799

Tetragon Partners GP Ltd

$7,094,418

0.69%

1,242,455

Candriam S.C.A.

$6,824,260

0.66%

1,195,142

MILLENNIUM MANAGEMENT LLC

$6,765,956

0.66%

1,184,931

VANGUARD FIDUCIARY TRUST CO

$6,312,119

0.61%

1,105,450

MASSACHUSETTS FINANCIAL SERVICES CO /MA/

$5,923,359

0.58%

1,037,366

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MFS Heritage Trust CO	21,785	$124,392	2.1%	Defined
Held directly	1,015,581	$5,798,967	97.9%	Sole

JPMORGAN CHASE & CO

$5,734,597

0.56%

1,004,308

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JPMorgan Chase Bank, N.A.	128,323	$732,724	12.8%	Defined
J.P. Morgan Investment Management Inc.	856,471	$4,890,449	85.3%	Defined
J.P. Morgan Securities LLC	7,250	$41,397	0.7%	Defined
J.P. Morgan Securities plc	12,264	$70,027	1.2%	Defined

WELLS FARGO & COMPANY/MN

$5,584,692

0.54%

978,055

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO BANK N A	141,697	$809,089	14.5%	Defined
WELLS FARGO ADVISORS FINANCIAL NETWORK, LLC	276,606	$1,579,420	28.3%	Defined
WELLS FARGO CLEARING SERVICES, LLC	559,752	$3,196,183	57.2%	Defined

PANAGORA ASSET MANAGEMENT INC

$5,526,857

0.54%

967,926

Y-Intercept (Hong Kong) Ltd

$5,487,304

0.53%

1,297,235

KENNEDY CAPITAL MANAGEMENT LLC

$5,129,829

0.50%

898,394

Ishara Investments LP

$4,682,200

0.46%

820,000

Ensign Peak Advisors, Inc

$4,570,946

0.44%

800,516

ARROWSTREET CAPITAL, LIMITED PARTNERSHIP

$4,213,608

0.41%

737,935

Russell Investments Group, Ltd.

$4,027,209

0.39%

705,291

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Russell Investment Management, LLC	415,237	$2,371,003	58.9%	Defined
Russell Investments Capital, LLC	140,897	$804,521	20.0%	Defined
Russell Investments France SAS	49,908	$284,974	7.1%	Defined
Russell Investments Trust Company	99,249	$566,711	14.1%	Defined

AQR CAPITAL MANAGEMENT LLC

$3,950,243

0.38%

691,812

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RF&L WEALTH MANAGEMENT, LLC	58	$331	0.0%	Other
Prism Planning Partners LLC	394	$2,249	0.1%	Other
Compound Planning, Inc.	57	$325	0.0%	Other
Arax Advisory Partners	7,519	$42,933	1.1%	Other
HALBERT HARGROVE GLOBAL ADVISORS, LLC	2,614	$14,925	0.4%	Other
Stokes Family Office, LLC	4,688	$26,768	0.7%	Other
Held directly	676,482	$3,862,712	97.8%	Defined

Parkman Healthcare Partners LLC

$3,660,275

0.36%

641,029

ACADIAN ASSET MANAGEMENT LLC

$3,592,315

0.35%

629,127

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Acadian Inc	629,127	$3,592,315	100.0%	Defined

UBS Group AG

$3,557,866

0.35%

623,094

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Financial Services Inc	247,575	$1,413,653	39.7%	Defined
UBS AG	302,719	$1,728,525	48.6%	Defined
UBS Switzerland AG	72,800	$415,688	11.7%	Defined

DEUTSCHE BANK AG\

$3,520,150

0.34%

616,489

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DWS Investment GmbH	441,584	$2,521,444	71.6%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC	13,535	$77,284	2.2%	Defined
DWS Investments UK Ltd	161,370	$921,422	26.2%	Defined

BANK OF AMERICA CORP /DE/

$3,507,001

0.34%

614,186

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	435,553	$2,487,007	70.9%	Defined
MERRILL LYNCH, PIERCE, FENNER & SMITH INC.	57,972	$331,020	9.4%	Defined
BOFA SECURITIES, INC.	120,661	$688,974	19.6%	Defined

CITADEL ADVISORS LLC

$3,406,482

0.33%

596,582

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	536,892	$3,065,653	90.0%	Defined
Held directly	59,690	$340,829	10.0%	Defined

DEERFIELD MANAGEMENT COMPANY, L.P.

$3,334,143

0.32%

583,913

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Deerfield UGP, LLC	583,913	$3,334,143	100.0%	Defined

SIRIOS CAPITAL MANAGEMENT L P

$3,250,565

0.32%

569,276

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Manager 1	569,276	$3,250,565	100.0%	Other

Schonfeld Strategic Advisors LLC

$3,046,667

0.30%

533,567

TWO SIGMA INVESTMENTS, LP

$2,928,065

0.28%

512,796

Bank of New York Mellon Corp

$2,863,232

0.28%

501,442

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Investments Corporation	175,554	$1,002,413	35.0%	Defined
The Bank of New York Mellon	269,127	$1,536,715	53.7%	Defined
BNY Mellon, NA joint	56,760	$324,099	11.3%	Defined
Held directly	1	$5	0.0%	Defined

Board of Trustees of The Leland Stanford Junior University

$2,755,360

0.27%

482,550

Hennion & Walsh Asset Management, Inc.

$2,622,705

0.26%

620,025

RENAISSANCE TECHNOLOGIES LLC

$2,620,890

0.26%

459,000

Ikarian Capital, LLC

$2,456,693

0.24%

430,244

MOORE CAPITAL MANAGEMENT, LP

$2,428,645

0.24%

425,332

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$2,352,520

0.23%

412,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	412,000	$2,352,520	100.0%	Other

Trexquant Investment LP

$2,339,198

0.23%

409,667

WELLINGTON MANAGEMENT GROUP LLP

$2,322,798

0.23%

406,795

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Wellington Management Company LLP	129,288	$738,234	31.8%	Defined
Wellington Trust Company, NA joint	259,853	$1,483,760	63.9%	Defined
Wellington Management Australia Pty Ltd	17,654	$100,804	4.3%	Defined

Susquehanna Portfolio Strategies, LLC

$2,256,763

0.22%

395,230

MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC

$2,253,166

0.22%

394,600

DIADEMA PARTNERS LP

$2,016,772

0.20%

353,200

Invesco Ltd.

$1,888,461

0.18%

330,729

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invesco Advisers, Inc. joint	23,737	$135,537	7.2%	Defined
Invesco Trust Co joint	61,593	$351,696	18.6%	Defined
Invesco Capital Management LLC	245,399	$1,401,228	74.2%	Defined

Engineers Gate Manager LP

$1,821,815

0.18%

319,057

DAFNA Capital Management LLC

$1,700,506

0.17%

297,812

Jump Financial, LLC

$1,700,438

0.17%

297,800

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Leap GP LLC joint	297,800	$1,700,438	100.0%	Defined

STATE OF WISCONSIN INVESTMENT BOARD

$1,635,201

0.16%

286,375

D. E. Shaw & Co., Inc.

$1,514,771

0.15%

265,284

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
D. E. SHAW & CO, L.P.	234,284	$1,337,761	88.3%	Defined
D. E. Shaw Investment Management, L.L.C. joint	31,000	$177,010	11.7%	Defined

VOLORIDGE INVESTMENT MANAGEMENT, LLC

$1,427,642

0.14%

250,025

Swiss National Bank

$1,396,666

0.14%

244,600

CITIGROUP INC

$1,347,502

0.13%

235,990

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citigroup Financial Products Inc. joint	235,990	$1,347,502	100.0%	Defined

CITADEL ADVISORS LLC

$1,340,137

0.13%

234,700

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	234,700	$1,340,137	100.0%	Defined

Cinctive Capital Management LP

$1,231,921

0.12%

215,748

MARSHALL WACE, LLP

$1,202,565

0.12%

210,607

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Marshall Wace North America L.P. joint	210,607	$1,202,565	100.0%	Other

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$1,086,042

0.11%

190,200

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	190,200	$1,086,042	100.0%	Other

RHUMBLINE ADVISERS

$1,082,490

0.11%

189,578

SEI INVESTMENTS CO

$1,049,594

0.10%

183,817

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SEI INVESTMENTS MANAGEMENT CORP	29,275	$167,160	15.9%	Sole
SEI TRUST CO	154,542	$882,434	84.1%	Sole

UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC

$1,031,492

0.10%

180,647

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Group AG	961	$5,487	0.5%	Defined
UBS Asset Management Switzerland AG	164,953	$941,881	91.3%	Defined
Held directly	14,733	$84,124	8.2%	Defined

Squarepoint Ops LLC

$989,457

0.10%

173,285

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Squarepoint Capital LLP	173,285	$989,457	100.0%	Defined

Rafferty Asset Management, LLC

$989,423

0.10%

173,279

OSAIC HOLDINGS, INC.

$842,932

0.08%

147,624

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
OSAIC WEALTH, INC.	147,595	$842,767	100.0%	Defined
Osaic Advisory Services, LLC	29	$165	0.0%	Defined

ALLIANCEBERNSTEIN L.P.

$840,740

0.08%

147,240

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Equitable Holdings, Inc.	147,240	$840,740	100.0%	Defined

CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM

$766,618

0.07%

134,259

PRICE T ROWE ASSOCIATES INC /MD/

$737,977

0.07%

129,243

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T. Rowe Price International Ltd	129,243	$737,977	100.0%	Defined

VICTORY CAPITAL MANAGEMENT INC

$727,099

0.07%

127,338

BOOTHBAY FUND MANAGEMENT, LLC

$685,936

0.07%

120,129

IEQ CAPITAL, LLC

$685,257

0.07%

120,010

J. Goldman & Co LP

$662,622

0.06%

116,046

XTX Topco Ltd

$640,359

0.06%

112,147

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
XTX EXECUTION SERVICES LLC joint	112,147	$640,359	100.0%	Defined

GSA CAPITAL PARTNERS LLP

$595,998

0.06%

104,378

Vanguard Global Advisers, LLC

$582,802

0.06%

102,067

Quarry LP

$571,000

0.06%

100,000

SCS Capital Management LLC

$565,290

0.06%

99,000

Legal & General Group Plc

$560,252

0.05%

98,118

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Legal & General Investment Management America Inc	15,074	$86,072	15.4%	Defined
Legal & General Investment Management Ltd joint	83,044	$474,180	84.6%	Defined

MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.

$523,383

0.05%

91,661

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Global X Management CO LLC joint	71,532	$408,447	78.0%	Defined
Global X Management (AUS) Ltd joint	20,129	$114,936	22.0%	Defined

MetLife Investment Management, LLC

$519,638

0.05%

91,005

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
METLIFE INC	91,005	$519,638	100.0%	Defined

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Key facts CIK 1528115 CUSIP 03589W102 13F (30d) 15 filings 15 filers Visit website Investor relations