SLN · Silence Therapeutics plc

$13.27 +0.10 (+0.76%) At close · Aug 21

Market Cap

$824.78M

62.15M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Quarter:

Holders: 72

Total Value: $251,473,525

Total Shares: 22,902,874

Institutional Ownership Trend

24 quarters

Holder Concentration

Across 72 13F filers · Δ vs Mar 31, 2026

Top Holder

14.5%

−0.7 pts

Top 5

48.8%

−8.8 pts

Top 10

68.0%

−12.4 pts

HHI

660

Broadly held−183

Quarterly Activity

vs Mar 31, 2026

New

Increased

Decreased

Sold Out

Unchanged

Holder count: +16

Institutional value: +139.1%

Shares held: +14.7%

Top Buyers

vs Mar 31, 2026

Institution	Added	Now Holds
Small Tetragon Partners GP Ltd	+434,095	1,064,256
Mid Siren, L.L.C.	+400,000	3,311,438
Mega MORGAN STANLEY	+337,686	403,172
Mega JANE STREET GROUP, LLC	+286,624	387,551
Mid ADAR1 Capital Management, LLC	+166,216	338,373

Top Sellers

vs Mar 31, 2026

Institution	Sold	Now Holds
Mid Nantahala Capital Management, LLC	−800,000	1,346,731
Small GREAT POINT PARTNERS LLC	−570,489	450,000
Mega SG Americas Securities, LLC	−274,642	12,056
Mega MILLENNIUM MANAGEMENT LLC	−164,912	909,279
Large MARSHALL WACE, LLP	−97,577	72,039

Top New Positions

vs Mar 31, 2026

Institution	Acquired	Value (USD)
Mid Soleus Capital Management, L.P.	630,000	$6,917,400
Large Balyasny Asset Management L.P.	610,980	$6,708,560
Large Caption Management, LLC	460,376	$5,054,928
Mega AMERIPRISE FINANCIAL INC	370,052	$4,063,170
Mid SummitTX Capital, L.P.	326,648	$3,586,595

Top Sold-Out Positions

vs Mar 31, 2026

Institution	Previously Held	Last Value (USD)
Small Jones Hill Capital LP	301,604	$1,589,453
Large Point72 Asset Management, L.P.	119,711	$630,876
Small Dynamic Technology Lab Private Ltd	10,490	$55,282
Mid SIMPLEX TRADING, LLC	612	$3,225

Filter: New 20 Increased 21 Reduced 19 Sold out 4 Unchanged 12

Showing 77 of 77

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

Siren, L.L.C.

$36,359,589

14.46%

3,311,438

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invus Group, LLC	3,311,438	$36,359,589	100.0%	Defined

TCG Crossover Management, LLC

$33,308,488

13.25%

3,033,560

Redmile Group, LLC

$23,769,251

9.45%

2,164,777

Nantahala Capital Management, LLC

$14,787,106

5.88%

1,346,731

CITADEL ADVISORS LLC

$14,599,282

5.81%

1,329,625

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	99,239	$1,089,644	7.5%	Defined
Held directly	1,230,386	$13,509,638	92.5%	Defined

Nextech Invest, Ltd.

$10,457,352

4.16%

952,400

MILLENNIUM MANAGEMENT LLC

$9,983,883

3.97%

909,279

Ikarian Capital, LLC

$9,122,008

3.63%

830,784

Tetragon Partners GP Ltd

$8,391,530

3.34%

764,256

Soleus Capital Management, L.P.

$6,917,400

2.75%

630,000

Balyasny Asset Management L.P.

$6,708,560

2.67%

610,980

5AM Venture Management, LLC

$5,228,676

2.08%

476,200

GREAT POINT PARTNERS LLC

$4,941,000

1.96%

450,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JAY JEFFREY R joint	450,000	$4,941,000	100.0%	Defined

MORGAN STANLEY

$4,426,827

1.76%

403,172

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	377	$4,139	0.1%	Defined
MORGAN STANLEY & CO. LLC	16	$175	0.0%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	202,579	$2,224,317	50.2%	Defined
MORGAN STANLEY SMITH BARNEY LLC	200,200	$2,198,196	49.7%	Defined

AMERIPRISE FINANCIAL INC

$4,063,170

1.62%

370,052

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Columbia Management Investment Advisers, LLC	370,052	$4,063,170	100.0%	Defined

JANE STREET GROUP, LLC

$4,053,277

1.61%

369,151

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	203,538	$2,234,847	55.1%	Defined
Jane Street Global Trading, LLC	165,613	$1,818,430	44.9%	Defined

ADAR1 Capital Management, LLC

$3,715,335

1.48%

338,373

SummitTX Capital, L.P.

$3,586,595

1.43%

326,648

Tetragon Partners GP Ltd

$3,294,000

1.31%

300,000

Caption Management, LLC

$3,270,942

1.30%

297,900

Schonfeld Strategic Advisors LLC

$2,957,441

1.18%

269,348

UBS Group AG

$2,669,808

1.06%

243,152

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Financial Services Inc	1,200	$13,176	0.5%	Defined
UBS AG	241,952	$2,656,632	99.5%	Defined

BlackRock, Inc.

$2,414,688

0.96%

219,917

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BlackRock Fund Advisors	187,717	$2,061,132	85.4%	Sole
BlackRock Asset Management Ireland Ltd	32,200	$353,556	14.6%	Sole

BANK OF MONTREAL /CAN/

$2,215,039

0.88%

201,734

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BMO NESBITT BURNS INC.	196,734	$2,160,139	97.5%	Defined
BMO NESBITT BURNS SECURITIES LTD.	5,000	$54,900	2.5%	Defined

BOOTHBAY FUND MANAGEMENT, LLC

$2,177,850

0.87%

198,347

Propel Bio Management, LLC

$2,105,228

0.84%

191,733

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Simplify Asset Management Inc.	191,733	$2,105,228	100.0%	Defined

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$2,026,018

0.81%

184,519

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	184,519	$2,026,018	100.0%	Other

FRED ALGER MANAGEMENT, LLC

$1,943,460

0.77%

177,000

Qube Research & Technologies Ltd

$1,800,116

0.72%

163,945

Caption Management, LLC

$1,783,986

0.71%

162,476

BNP PARIBAS ARBITRAGE, SA

$1,745,271

0.69%

158,950

GOLDMAN SACHS GROUP INC

$1,712,100

0.68%

155,929

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	155,929	$1,712,100	100.0%	Defined

HSBC HOLDINGS PLC

$1,348,717

0.54%

122,834

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
HSBC BANK PLC	122,834	$1,348,717	100.0%	Defined

TWO SIGMA INVESTMENTS, LP

$1,328,623

0.53%

121,004

Quadrature Capital Ltd

$1,297,056

0.52%

118,129

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Quadrature US Inc.	118,129	$1,297,056	100.0%	Other

Squarepoint Ops LLC

$1,272,779

0.51%

115,918

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Squarepoint Capital LLP	115,918	$1,272,779	100.0%	Defined

XTX Topco Ltd

$1,181,217

0.47%

107,579

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
XTX EXECUTION SERVICES LLC joint	107,579	$1,181,217	100.0%	Defined

M28 Capital Management LP

$1,111,208

0.44%

101,203

MARSHALL WACE, LLP

$790,988

0.31%

72,039

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Marshall Wace North America L.P. joint	72,039	$790,988	100.0%	Other

Birchview Capital, LP

$781,973

0.31%

71,218

Seven Fleet Capital Management LP

$659,974

0.26%

60,107

Ishara Investments LP

$607,743

0.24%

55,350

HRT FINANCIAL LP

$337,613

0.13%

30,748

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$327,204

0.13%

29,800

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	29,800	$327,204	100.0%	Other

GEODE CAPITAL MANAGEMENT, LLC

$324,327

0.13%

29,538

Virtu Financial LLC

$281,538

0.11%

25,641

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Virtu Americas LLC	25,641	$281,538	100.0%	Defined

BANK OF AMERICA CORP /DE/

$277,574

0.11%

25,280

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BOFA SECURITIES, INC.	25,280	$277,574	100.0%	Defined

Trexquant Investment LP

$261,785

0.10%

23,842

Verdad Advisers, LP

$223,992

0.09%

20,400

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$213,012

0.08%

19,400

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	19,400	$213,012	100.0%	Other

Scientech Research LLC

$210,080

0.08%

19,133

JANE STREET GROUP, LLC

$202,032

0.08%

18,400

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	18,400	$202,032	100.0%	Defined

RENAISSANCE TECHNOLOGIES LLC

$185,891

0.07%

16,930

Arrowpoint Investment Partners (Singapore) Pte. Ltd.

$179,347

0.07%

16,334

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Arrowpoint Investment Partners (Hong Kong) Ltd	16,334	$179,347	100.0%	Defined

Persistent Asset Partners Ltd

$166,566

0.07%

15,170

RAYMOND JAMES FINANCIAL INC

$164,700

0.07%

15,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RAYMOND JAMES & ASSOCIATES	15,000	$164,700	100.0%	Defined

RHUMBLINE ADVISERS

$151,688

0.06%

13,815

CITIGROUP INC

$145,122

0.06%

13,217

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citigroup Financial Products Inc. joint	13,217	$145,122	100.0%	Defined

AXQ CAPITAL, LP

$137,974

0.05%

12,566

SG Americas Securities, LLC

$132,374

0.05%

12,056

ACADIAN ASSET MANAGEMENT LLC

$129,959

0.05%

11,836

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Acadian Inc	11,836	$129,959	100.0%	Defined

GAMMA Investing LLC

$121,471

0.05%

11,063

CenterBook Partners LP

$114,367

0.05%

10,416

China Universal Asset Management Co., Ltd.

$82,075

0.03%

7,475

JPMORGAN CHASE & CO

$42,415

0.02%

3,863

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
J.P. Morgan Securities plc	3,863	$42,415	100.0%	Defined

BARCLAYS PLC

$37,529

0.01%

3,418

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BARCLAYS BANK PLC	3,418	$37,529	100.0%	Defined

JONES FINANCIAL COMPANIES LLLP

$27,450

0.01%

2,500

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Edward D. Jones & Co., L.P.	2,500	$27,450	100.0%	Sole

Mirae Asset Global Investments Co., Ltd.

$23,068

0.01%

2,101

Tower Research Capital LLC (TRC)

$17,996

0.01%

1,639

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Latour Trading LLC (Latour)	1,639	$17,996	100.0%	Defined

Parallel Advisors, LLC

$14,274

0.01%

1,300

Rialto Wealth Management, LLC

$11,210

0.00%

1,021

GF FUND MANAGEMENT CO. LTD.

$10,705

0.00%

975

Steward Partners Investment Advisory, LLC

$1,098

0.00%

100

Rockefeller Capital Management L.P.

$494

0.00%

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
ROCKEFELLER FINANCIAL LLC	45	$494	100.0%	Defined

Caitong International Asset Management Co., Ltd

$450

0.00%

SBI Securities Co., Ltd.

$307

0.00%

ROYAL BANK OF CANADA

$284

0.00%

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RBC Capital Markets, LLC	10	$109	38.4%	Defined
RBC Europe Ltd	16	$175	61.6%	Defined

Key facts CIK 1479615 CUSIP 82686Q101 13F (30d) 71 filings 71 filers Visit website Investor relations