5AM Venture Management, LLC

CIK

1799883

Location

SAN FRANCISCO, CA

Portfolio Value

Small $360,212,474

Diversification

Diversified

Filing Date

Global Rank

#3,108 / 8,603 ▲ 294 · as of Mar 2026

Top Industry

Biotechnology 100.0%

3Y Alpha vs SPY

+0.8%

Period ended 3 months ago

Filed May 15, 2026 · 55d

25 quarters · since Mar 2020

Clone Performance

Jul 2023–Jul 2026 · vs SPY

Hypothetical growth of cloning every reported 13F position and rebalancing on each filing, indexed to the same start.

Cloned portfolio

+75.6%

SPY

+76.5%

Annualised alpha

-0.2%

Max drawdown

−59.7%

Estimate. 13F holdings are quarter-lagged and long-only, so the clone rebalances about 45 days after each period end — when the filing becomes public — and excludes options and short positions. Past performance does not predict future results.

Portfolio Concentration

20 positions · as of Mar 31, 2026 · Δ vs Dec 31, 2025

Top Position

15.7%

+2.4 pts

Top 5

54.4%

+6.9 pts

Top 10

79.8%

+5.7 pts

HHI

841

Diversified+141

Portfolio Trend

25 quarters · across all stocks

Sector Breakdown

As of Mar 31, 2026

Sector	% Portfolio	Value	Positions
Healthcare	100.0%	$360,212,474	20

Last Quarter's Activity

Export CSV

Mar 31, 2026 vs Dec 31, 2025

Added To

Positions the filer increased

No qualifying positions this quarter.

Trimmed

Positions the filer reduced

1 positions

Ticker	Company	Δ Shares	Shares	Value	Open
ERAS	Erasca, Inc.	−1,919,433	3,485,971	$56,403,010
No positions match the current search.

New Positions

Positions the filer opened this quarter

2 positions

Ticker	Company	Shares	Value
ALXO	Alx Oncology Holdings Inc	3,057,325	$6,129,936
RLYB	Rallybio Corp	291,788	$2,617,338
No positions match the current search.

Sold Out

Positions the filer fully exited

2 positions

Ticker	Company	Shares	Value
VRDN	Viridian Therapeutics, Inc.\DE	736,595	$22,922,836
ELVN	Enliven Therapeutics, Inc.	772,477	$11,896,145
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

20 positions · $360,212,474 total · as of Mar 31, 2026

All sectors Healthcare

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
ERAS	Erasca, Inc. Healthcare	Reduced	3,485,971	-1,919,433	$56,403,010	+180.5%	15.66%
TRDA	Entrada Therapeutics, Inc. Healthcare	Held	4,056,379	0	$51,191,502	+22.8%	14.21%
TYRA	Tyra Biosciences, Inc. Healthcare	Held	1,029,298	0	$39,422,113	+45.7%	10.94%
CAMP	Camp4 Therapeutics Corp Healthcare	Held	5,869,091	0	$25,882,691	−28.1%	7.19%
CNTA	Centessa Pharmaceuticals plc Healthcare	Held	580,945	0	$23,075,135	+58.8%	6.41%
PHVS	Pharvaris N.V. Healthcare	Held	797,600	0	$22,532,200	+1.8%	6.26%
MPLT	MapLight Therapeutics, Inc. Healthcare	Held	950,011	0	$19,313,723	+15.7%	5.36%
TECX	Tectonic Therapeutic, Inc. Healthcare	Held	606,660	0	$18,751,860	+48.2%	5.21%
CLDX	Celldex Therapeutics, Inc. Healthcare	Held	497,270	0	$15,773,404	+16.8%	4.38%
ARTV	Artiva Biotherapeutics, Inc. Healthcare	Held	2,353,304	0	$15,155,277	+50.1%	4.21%
EYPT	EyePoint, Inc. Healthcare	Held	1,050,000	0	$13,534,500	−29.4%	3.76%
SRZN	Surrozen, Inc./DE Healthcare	Held	387,500	0	$11,287,875	+28.9%	3.13%
ZNTL	Zentalis Pharmaceuticals, Inc. Healthcare	Held	3,947,913	0	$9,238,116	+73.3%	2.56%
GHRS	GH Research PLC Healthcare	Held	572,665	0	$8,051,669	+10.7%	2.24%
TARA	Protara Therapeutics, Inc. Healthcare	Held	1,369,782	0	$7,136,564	−2.3%	1.98%
BHVN	Biohaven Ltd. Healthcare	Held	738,972	0	$6,251,703	−25.1%	1.74%
ALXO	Alx Oncology Holdings Inc Healthcare	NEW	3,057,325	NEW	$6,129,936	NEW	1.70%
SKYE	Skye Bioscience, Inc. Healthcare	Held	9,681,763	0	$5,954,284	−18.0%	1.65%
RLYB	Rallybio Corp Healthcare	NEW	291,788	NEW	$2,617,338	NEW	0.73%
SLN	Silence Therapeutics plc Healthcare	Held	476,200	0	$2,509,574	−13.3%	0.70%