CNTA · Centessa Pharmaceuticals plc

Market Cap

$6.27B

154.73M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Quarter:

Holders: 162

Total Value: $5,084

Total Shares: 149,814,637

Showing 1–100 of 175 holdings by value · page 1 of 2

Institutional Ownership Trend

20 quarters

Holder Concentration

Across 162 13F filers · Δ vs Dec 31, 2025

Top Holder

100.0%

0.0 pts

Top 5

100.0%

0.0 pts

Top 10

100.0%

0.0 pts

HHI

10,000

Highly concentrated0

Quarterly Activity

vs Dec 31, 2025

New

Increased

Decreased

Sold Out

Unchanged

Holder count: +14

Institutional value: +58.8%

Shares held: +3.7%

Top Buyers

vs Dec 31, 2025

Institution	Added	Now Holds
Mega Capital World Investors	+3,673,849	4,832,548
Mid EcoR1 Capital, LLC	+3,295,800	6,410,800
Mega MORGAN STANLEY	+3,159,255	4,268,353
Mid PERCEPTIVE ADVISORS LLC	+2,341,269	5,258,903
Mid Logos Global Management LP	+1,925,000	2,125,000

Top Sellers

vs Dec 31, 2025

Institution	Sold	Now Holds
Mid GENERAL ATLANTIC, L.P.	−4,762,885	1,354,830
Large Avoro Capital Advisors LLC	−3,125,100	11,430,455
Mid Siren, L.L.C.	−2,974,053	1,053,464
Large ADAGE CAPITAL PARTNERS GP, L.L.C.	−2,356,731	8,925,010
Mega FMR LLC	−2,109,892	6,852,047

Top New Positions

vs Dec 31, 2025

Institution	Acquired	Value (USD)
Mid Brooklyn Investment Group	7,443	$0
Large ProShare Advisors LLC	5,351	$0
Small Greenland Capital Management LP	15,000	$0
Large BNP PARIBAS ASSET MANAGEMENT Holding S.A.	702,254	$0
Large TORONTO DOMINION BANK	654,850	$0

Top Sold-Out Positions

vs Dec 31, 2025

Institution	Previously Held	Last Value (USD)
Small DIADEMA PARTNERS LP	111,100	$0
Mid GSA CAPITAL PARTNERS LLP	33,104	$0
Small Saturn V Capital Management LP	282,692	$0
Large TUDOR INVESTMENT CORP ET AL	121,810	$0
Small Blue Owl Capital Holdings LP	139,450	$0

Filter: New 48 Increased 51 Reduced 45 Sold out 34 Unchanged 18

Showing 100 of 175

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

Basecamp Wealth Advisors LLC

$5,084

100.00%

128

ROYAL BANK OF CANADA

—

1,164

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RBC Capital Markets, LLC	1,164	$0	—	Defined

GAMMA Investing LLC

—

3,980

EverSource Wealth Advisors, LLC

—

Empirical Asset Management, LLC

—

5,083

GOLDMAN SACHS GROUP INC

—

28,200

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	28,200	$0	—	Defined

Steward Partners Investment Advisory, LLC

—

Siren, L.L.C.

—

1,053,464

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invus Group, LLC	1,053,464	$0	—	Defined

TD Waterhouse Canada Inc.

—

15,595

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
TORONTO DOMINION BANK	15,595	$0	—	Defined

First Light Asset Management, LLC

—

1,560,991

Voleon Capital Management LP

—

24,174

UBS Group AG

—

359,939

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Financial Services Inc	2,973	$0	—	Defined
UBS AG	331,215	$0	—	Defined
UBS Securities LLC	25,751	$0	—	Defined

Squarepoint Ops LLC

—

50,606

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Squarepoint Capital LLP	50,606	$0	—	Defined

JANUS HENDERSON GROUP PLC

—

3,492,977

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JANUS HENDERSON INVESTORS UK Ltd	140,834	$0	—	Defined
JANUS HENDERSON INVESTORS US LLC joint	3,352,143	$0	—	Defined

Alyeska Investment Group, L.P.

—

320,430

Ikarian Capital, LLC

—

18,113

Rock Springs Capital Management LP

—

351,828

Deep Track Capital, LP

—

3,158,041

JANE STREET GROUP, LLC

—

114,100

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	114,100	$0	—	Defined

ROYCE & ASSOCIATES LP

—

278,064

BlackRock, Inc.

—

625,420

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BlackRock Fund Advisors	535,926	$0	—	Sole
BlackRock Asset Management Ireland Ltd	89,494	$0	—	Sole

CSS LLC/IL

—

17,000

Caitong International Asset Management Co., Ltd

—

93,685

Brooklyn Investment Group

—

7,443

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Dynasty Wealth Management, LLC joint	7,443	$0	—	Defined

FRED ALGER MANAGEMENT, LLC

—

168,170

Point72 Asset Management, L.P.

—

307,355

WATER ISLAND CAPITAL LLC

—

41,000

Virtus Investment Advisers, LLC

—

10,286

Pentwater Capital Management LP

—

8,170,000

Virtu Financial LLC

—

67,775

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Virtu Americas LLC	67,775	$0	—	Defined

T. Rowe Price Investment Management, Inc.

—

170,016

DEUTSCHE BANK AG\

—

189,961

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DWS Investments UK Ltd	189,961	$0	—	Defined

Legal & General Group Plc

—

110,207

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Legal & General Investment Management Ltd	110,207	$0	—	Defined

SUSQUEHANNA INTERNATIONAL GROUP, LLP

—

173,400

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	173,400	$0	—	Other

SUSQUEHANNA INTERNATIONAL GROUP, LLP

—

17,737

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	17,737	$0	—	Other

Holocene Advisors, LP

—

160,942

Bayforest Capital Ltd

—

1,947

CSS LLC/IL

—

9,900

SILVERARC CAPITAL MANAGEMENT, LLC

—

466,345

GF FUND MANAGEMENT CO. LTD.

—

2,166

Cormorant Asset Management, LP

—

1,050,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Chen Bihua	1,050,000	$0	—	Defined

Caption Management, LLC

—

8,000

LMR Partners LLP

—

125,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
LMR Partners LLC	125,000	$0	—	Sole

FOX RUN MANAGEMENT, L.L.C.

—

14,913

Point72 Asset Management, L.P.

—

5,900

WELLS FARGO & COMPANY/MN

—

6,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO CLEARING SERVICES, LLC	6,000	$0	—	Defined

Burkehill Global Management, LP

—

150,000

EcoR1 Capital, LLC

—

410,800

Allianz Asset Management GmbH

—

6,900

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Allianz Global Invesstors Taiwan Ltd.	6,900	$0	—	Defined

Foresite Capital Management VI LLC

—

1,364,019

China Universal Asset Management Co., Ltd.

—

21,225

GABELLI FUNDS LLC

—

17,600

FEDERATED HERMES, INC.

—

2,049,439

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
FEDERATED GLOBAL INVESTMENT MANAGEMENT CORP	2,049,439	$0	—	Defined

BAKER BROS. ADVISORS LP

—

670,751

RENAISSANCE TECHNOLOGIES LLC

—

185,000

PERCEPTIVE ADVISORS LLC

—

5,258,903

JANE STREET GROUP, LLC

—

19,400

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	19,100	$0	—	Defined
Jane Street Options, LLC	300	$0	—	Defined

Greenland Capital Management LP

—

15,000

ADAGE CAPITAL PARTNERS GP, L.L.C.

—

8,925,010

PFM Health Sciences, LP

—

528,224

TCG Crossover Management, LLC

—

4,286,480

AMERIPRISE FINANCIAL INC

—

16,893

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Columbia Management Investment Advisers, LLC	16,865	$0	—	Defined
Ameriprise Financial Services, LLC	28	$0	—	Defined

Private Advisor Group, LLC

—

6,000

Medicxi Ventures Management (Jersey) Ltd

—

19,963,157

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
De Rubertis Francesco	19,963,157	$0	—	Sole

FRANKLIN RESOURCES INC

—

684,482

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
FIDUCIARY TRUST CO INTERNATIONAL	21,212	$0	—	Defined
FRANKLIN ADVISERS INC	663,270	$0	—	Defined

Crossmark Global Holdings, Inc.

—

19,436

Bellevue Group AG

—

9,030

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Bellevue Asset Management AG	9,030	$0	—	Defined

FMR LLC

—

6,852,047

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	5,340,090	$0	—	Defined
FIDELITY MANAGEMENT TRUST CO	485,786	$0	—	Defined
FIAM LLC	1,026,171	$0	—	Defined

Mirae Asset Global Investments Co., Ltd.

—

6,238

FARALLON CAPITAL MANAGEMENT LLC

—

4,809,000

AMERICAN CENTURY COMPANIES INC

—

687,427

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
AMERICAN CENTURY INVESTMENT MANAGEMENT INC	687,427	$0	—	Defined

HighMark Wealth Management LLC

—

236,785

MILLENNIUM MANAGEMENT LLC

—

69,000

AQR Arbitrage LLC

—

98,028

Bain Capital Life Sciences Investors, LLC

—

635,000

Capital World Investors

—

4,832,548

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
CAPITAL GROUP COMPANIES INC joint	4,832,548	$0	—	Defined

TORNO CAPITAL, LLC

—

20,000

Logos Global Management LP

—

2,125,000

DNB Asset Management AS

—

10,394

BNP PARIBAS ASSET MANAGEMENT Holding S.A.

—

702,254

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BNP PARIBAS ASSET MANAGEMENT Europe	69,686	$0	—	Defined
BNP Paribas Asset Management USA, Inc.	632,568	$0	—	Defined

JBF Capital, Inc.

—

20,887

MILLENNIUM MANAGEMENT LLC

—

722,121

ProShare Advisors LLC

—

5,351

Russell Investments Group, Ltd.

—

38,812

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Russell Investment Management, LLC	38,812	$0	—	Defined

Farther Finance Advisors, LLC

—

MANUFACTURERS LIFE INSURANCE COMPANY, THE

—

13,965

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MANULIFE FINANCIAL CORP joint	13,965	$0	—	Defined

J. Goldman & Co LP

—

40,500

Schonfeld Strategic Advisors LLC

—

171,933

CITADEL ADVISORS LLC

—

598,197

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	27,311	$0	—	Defined
Held directly	570,886	$0	—	Defined

TD Asset Management Inc

—

242,044

Aspect Partners, LLC

—

GABELLI & Co INVESTMENT ADVISERS, INC.

—

9,400

BRAIDWELL LP

—

1,986,768

Tower Research Capital LLC (TRC)

—

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Latour Trading LLC (Latour)	41	$0	—	Defined

NATIONAL BANK OF CANADA /FI/

—

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
National Bank Financial Inc.	25	$0	—	Defined

VOYA INVESTMENT MANAGEMENT LLC

—

29,670

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Voya Investment Management Co. LLC joint	29,670	$0	—	Defined

Atom Investors LP

—

158,509

Qube Research & Technologies Ltd

—

628,049

Index Venture Life Associates VI Ltd

—

9,961,789

Weiss Asset Management LP

—

510,407

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WEISS ANDREW M joint	510,407	$0	—	Defined

Key facts CIK 1847903 CUSIP 152309100 13F (30d) 4 filings 4 filers Visit website Investor relations