SLN · Silence Therapeutics plc

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

The securities were sold by Cream Capital Limited ("CCL"), Blake Holdings Limited ("BHL"), Ora Ventures Limited ("OVL"), Ora Capital Limited ("OCL), Sarossa Plc ("SAR"), Pinkeys Limited ("PKL") and Mr. Griffiths personally. Mr Griffiths is a director and the controlling shareholder of CCL, BHL, OVL and OCL and the controlling shareholder of SAR and PKL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

The securities were sold by Cream Capital Limited ("CCL"), Blake Holdings Limited ("BHL"), Ora Ventures Limited ("OVL"), Ora Capital Limited ("OCL), Sarossa Plc ("SAR"), Pinkeys Limited ("PKL") and Mr. Griffiths personally. Mr Griffiths is a director and the controlling shareholder of CCL, BHL, OVL and OCL and the controlling shareholder of SAR and PKL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

The securities were sold by Cream Capital Limited ("CCL"), Blake Holdings Limited ("BHL"), Ora Ventures Limited ("OVL"), Ora Capital Limited ("OCL), Sarossa Plc ("SAR"), Pinkeys Limited ("PKL") and Mr. Griffiths personally. Mr Griffiths is a director and the controlling shareholder of CCL, BHL, OVL and OCL and the controlling shareholder of SAR and PKL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

The securities were sold by Cream Capital Limited ("CCL"), Blake Holdings Limited ("BHL"), Ora Ventures Limited ("OVL"), Ora Capital Limited ("OCL), Sarossa Plc ("SAR"), Pinkeys Limited ("PKL") and Mr. Griffiths personally. Mr Griffiths is a director and the controlling shareholder of CCL, BHL, OVL and OCL and the controlling shareholder of SAR and PKL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

The securities were sold by Cream Capital Limited ("CCL"), Blake Holdings Limited ("BHL"), Ora Ventures Limited ("OVL"), Ora Capital Limited ("OCL), Sarossa Plc ("SAR"), Pinkeys Limited ("PKL") and Mr. Griffiths personally. Mr Griffiths is a director and the controlling shareholder of CCL, BHL, OVL and OCL and the controlling shareholder of SAR and PKL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

The securities were sold by Cream Capital Limited ("CCL"), Blake Holdings Limited ("BHL"), Ora Ventures Limited ("OVL"), Ora Capital Limited ("OCL), Sarossa Plc ("SAR"), Pinkeys Limited ("PKL") and Mr. Griffiths personally. Mr Griffiths is a director and the controlling shareholder of CCL, BHL, OVL and OCL and the controlling shareholder of SAR and PKL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

The securities were sold by Cream Capital Limited ("CCL"), Blake Holdings Limited ("BHL"), Ora Ventures Limited ("OVL"), Ora Capital Limited ("OCL), Sarossa Plc ("SAR"), Pinkeys Limited ("PKL") and Mr. Griffiths personally. Mr Griffiths is a director and the controlling shareholder of CCL, BHL, OVL and OCL and the controlling shareholder of SAR and PKL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

The securities were sold by Cream Capital Limited ("CCL"), Blake Holdings Limited ("BHL"), Ora Ventures Limited ("OVL"), Ora Capital Limited ("OCL), Sarossa Plc ("SAR"), Pinkeys Limited ("PKL") and Mr. Griffiths personally. Mr Griffiths is a director and the controlling shareholder of CCL, BHL, OVL and OCL and the controlling shareholder of SAR and PKL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

The securities were sold by Cream Capital Limited ("CCL"), Blake Holdings Limited ("BHL"), Ora Ventures Limited ("OVL"), Ora Capital Limited ("OCL), Sarossa Plc ("SAR"), Pinkeys Limited ("PKL") and Mr. Griffiths personally. Mr Griffiths is a director and the controlling shareholder of CCL, BHL, OVL and OCL and the controlling shareholder of SAR and PKL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

The securities were sold by Cream Capital Limited ("CCL"), Blake Holdings Limited ("BHL"), Ora Ventures Limited ("OVL"), Ora Capital Limited ("OCL), Sarossa Plc ("SAR"), Pinkeys Limited ("PKL") and Mr. Griffiths personally. Mr Griffiths is a director and the controlling shareholder of CCL, BHL, OVL and OCL and the controlling shareholder of SAR and PKL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

The securities were sold by Cream Capital Limited ("CCL"), Blake Holdings Limited ("BHL"), Ora Ventures Limited ("OVL"), Ora Capital Limited ("OCL), Sarossa Plc ("SAR"), Pinkeys Limited ("PKL") and Mr. Griffiths personally. Mr Griffiths is a director and the controlling shareholder of CCL, BHL, OVL and OCL and the controlling shareholder of SAR and PKL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

The securities were sold by Cream Capital Limited ("CCL") and Mr. Griffiths personally. Mr Griffiths is a director and the controlling shareholder of CCL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

The securities were sold by Cream Capital Limited ("CCL") and Mr. Griffiths personally. Mr Griffiths is a director and the controlling shareholder of CCL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

The securities were sold by Cream Capital Limited ("CCL") and Mr. Griffiths personally. Mr Griffiths is a director and the controlling shareholder of CCL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

The securities were sold by Cream Capital Limited ("CCL") and Mr. Griffiths personally. Mr Griffiths is a director and the controlling shareholder of CCL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

The securities were sold by Cream Capital Limited ("CCL") and Mr. Griffiths personally. Mr Griffiths is a director and the controlling shareholder of CCL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

The securities were sold by Cream Capital Limited ("CCL") and Mr. Griffiths personally. Mr Griffiths is a director and the controlling shareholder of CCL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

This option shall vest in equal monthly installments over a one-year period measured from one month following January 2, 2026, subject to the Reporting Person's continuous service as of each applicable vesting date.

This option shall vest in equal monthly installments over a one-year period measured from one month following January 2, 2026, subject to the Reporting Person's continuous service as of each applicable vesting date.

This option shall vest in equal monthly installments over a one-year period measured from one month following January 2, 2026, subject to the Reporting Person's continuous service as of each applicable vesting date.

One fourth (1/4th) of the shares subject to the option shall vest on January 2, 2027 and the remaining shares subject to the option shall vest in thirty-six (36) equal monthly installments thereafter, subject to the Reporting Person's continuous service with the Issuer on each such vesting date.

One fourth (1/4th) of the shares subject to the option shall vest on January 2, 2027 and the remaining shares subject to the option shall vest in thirty-six (36) equal monthly installments thereafter, subject to the Reporting Person's continuous service with the Issuer on each such vesting date.

This option shall vest in equal monthly installments over a one-year period measured from one month following December 22, 2025, subject to the Reporting Person's continuous service as of each applicable vesting date.

This option shall vest in equal monthly installments over a one-year period measured from one month following December 18, 2025, subject to the Reporting Person's continuous service as of each applicable vesting date.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

The securities were sold by Ora Capital Limited ("OCL") and purchased by Mr. Griffiths personally, essentially internal transfers with no change in total beneficial holding. Mr Griffiths is a director and the controlling shareholder of OCL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

The securities were sold by Ora Capital Limited ("OCL") and purchased by Mr. Griffiths personally, essentially internal transfers with no change in total beneficial holding. Mr Griffiths is a director and the controlling shareholder of OCL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

The securities were sold by Ora Capital Limited ("OCL") and purchased by Mr. Griffiths personally, essentially internal transfers with no change in total beneficial holding. Mr Griffiths is a director and the controlling shareholder of OCL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

The securities were sold by Ora Capital Limited ("OCL") and purchased by Mr. Griffiths personally, essentially internal transfers with no change in total beneficial holding. Mr Griffiths is a director and the controlling shareholder of OCL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

The securities are held by Cream Capital Limited ("Cream"). Mr. Griffiths is a director and the controlling shareholder of Cream. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

The securities are held by Cream Capital Limited ("Cream"). Mr. Griffiths is a director and the controlling shareholder of Cream. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

The securities are held by Cream Capital Limited ("Cream"). Mr. Griffiths is a director and the controlling shareholder of Cream. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

The securities are held by Cream Capital Limited ("Cream"). Mr. Griffiths is a director and the controlling shareholder of Cream. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

The securities are held by Cream Capital Limited ("Cream"). Mr. Griffiths is a director and the controlling shareholder of Cream. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

The securities are held by Cream Capital Limited ("Cream"). Mr. Griffiths is a director and the controlling shareholder of Cream. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

The securities are held by Cream Capital Limited ("Cream"). Mr Griffiths is a director and the controlling shareholder of Cream. Mr Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.