Mid
Bain Capital Investors LLC
$578,410,449
22.63%
26,255,581
20.252%
—
Shares
2026-08-14
Mid
Bain Capital Life Sciences Investors, LLC
$497,509,394
19.47%
22,583,268
17.419%
—
Shares
2026-08-14
Large
RTW INVESTMENTS, LP
$237,413,344
9.29%
10,776,820
8.313%
—
Shares
2026-08-14
Mega
CANADA PENSION PLAN INVESTMENT BOARD
Pension
$160,922,276
6.30%
7,304,688
5.634%
—
Shares
2026-08-14
Small
Atlas Venture Life Science Advisors, LLC
$113,923,342
4.46%
5,171,282
3.989%
—
Shares
2026-08-13
Mega
FMR LLC
4
$87,478,155
3.42%
3,970,865
3.063%
—
Shares
2026-08-13
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Fidelity Management & Research Co LLC
2,720,523
$59,933,121
68.5%
Defined
FIDELITY MANAGEMENT TRUST CO
1,166,442
$25,696,717
29.4%
Defined
Fidelity Institutional Asset Management Trust Co
70,000
$1,542,100
1.8%
Defined
FIAM LLC
13,900
$306,217
0.4%
Defined
Mega
BlackRock, Inc.
7
$86,547,143
3.39%
3,928,604
3.030%
—
Shares
2026-08-07
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE
20,335
$447,980
0.5%
Sole
BlackRock Asset Management Canada Ltd
363
$7,996
0.0%
Sole
BlackRock Investment Management, LLC
181,333
$3,994,765
4.6%
Sole
BLACKROCK ADVISORS LLC
662,036
$14,584,653
16.9%
Sole
BlackRock Fund Advisors
1,672,084
$36,836,010
42.6%
Sole
BlackRock Institutional Trust Company, N.A.
1,288,716
$28,390,413
32.8%
Sole
BlackRock Investment Management (UK) Ltd.
103,737
$2,285,326
2.6%
Sole
Mega
PRICE T ROWE ASSOCIATES INC /MD/
2
$77,863,052
3.05%
3,534,410
2.726%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
T. Rowe Price International Ltd
52,542
$1,157,500
1.5%
Defined
Held directly
3,481,868
$76,705,552
98.5%
Sole
Mega
CITADEL ADVISORS LLC
$71,394,537
2.79%
3,240,787
2.500%
—
Shares
2026-09-02
Large
ADAGE CAPITAL PARTNERS GP, L.L.C.
$70,678,540
2.77%
3,208,286
2.475%
—
Shares
2026-08-14
Mega
WELLINGTON MANAGEMENT GROUP LLP
4
$64,307,992
2.52%
2,919,110
2.252%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Wellington Management Company LLP
2,804,492
$61,782,958
96.1%
Defined
Wellington Management Singapore Pte. Ltd.
13,800
$304,014
0.5%
Defined
Wellington Management International Ltd
22,951
$505,610
0.8%
Defined
Wellington Trust Company, NA
joint
77,867
$1,715,410
2.7%
Defined
Small
Royalty Pharma Sub-Manager, LLC
1
$54,091,514
2.12%
2,455,357
1.894%
—
Shares
2026-08-21
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Royalty Pharma Manager, LLC
joint
2,455,357
$54,091,514
100.0%
Defined
Mid
Siren, L.L.C.
1
$48,780,720
1.91%
2,214,286
1.708%
—
Shares
2026-08-13
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Invus Group, LLC
2,214,286
$48,780,720
100.0%
Defined
Mega
VANGUARD CAPITAL MANAGEMENT LLC
$37,317,894
1.46%
1,693,958
1.307%
—
Shares
2026-08-13
Mega
VANGUARD PORTFOLIO MANAGEMENT LLC
$36,404,729
1.42%
1,652,507
1.275%
—
Shares
2026-08-13
Mega
GEODE CAPITAL MANAGEMENT, LLC
2
$24,962,523
0.98%
1,133,115
0.874%
—
Shares
2026-08-12
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC
160,448
$3,534,669
14.2%
Defined
Held directly
972,667
$21,427,854
85.8%
Defined
Mid
Frazier Life Sciences Management, L.P.
$24,233,000
0.95%
1,100,000
0.848%
—
Shares
2026-08-14
Large
FARALLON CAPITAL MANAGEMENT LLC
$24,233,000
0.95%
1,100,000
0.848%
—
Shares
2026-08-14
Small
Trails Edge Capital Partners, LP
$21,694,835
0.85%
984,786
0.760%
—
Shares
2026-08-14
Mega
UBS Group AG
1
$21,428,206
0.84%
972,683
0.750%
—
Shares
2026-08-13
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
UBS AG
972,683
$21,428,206
100.0%
Defined
Mega
Jupiter Topco LLC
1
$21,387,979
0.84%
970,857
0.749%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Mega
AMERIPRISE FINANCIAL INC
3
$18,093,920
0.71%
821,331
0.634%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Columbia Management Investment Advisers, LLC
756,793
$16,672,149
92.1%
Defined
Ameriprise Trust Co
46,820
$1,031,444
5.7%
Defined
Columbia Threadneedle Management Ltd
17,718
$390,327
2.2%
Defined
Mid
Deep Track Capital, LP
$15,421,000
0.60%
700,000
0.540%
—
Shares
2026-08-14
Mid
EVENTIDE ASSET MANAGEMENT, LLC
$13,586,341
0.53%
616,720
0.476%
—
Shares
2026-08-14
Mid
Vestal Point Capital, LP
$12,667,250
0.50%
575,000
0.444%
—
Shares
2026-08-14
Mid
Cormorant Asset Management, LP
1
$12,116,500
0.47%
550,000
0.424%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Chen Bihua
550,000
$12,116,500
100.0%
Defined
Small
Catalio Capital Management, LP
$10,326,562
0.40%
468,750
0.362%
—
Shares
2026-08-14
Large
FEDERATED HERMES, INC.
1
$9,562,540
0.37%
434,069
0.335%
—
Shares
2026-08-12
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
FEDERATED GLOBAL INVESTMENT MANAGEMENT CORP
434,069
$9,562,540
100.0%
Defined
Mega
GOLDMAN SACHS GROUP INC
1
$9,275,379
0.36%
421,034
0.325%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
GOLDMAN SACHS & CO. LLC
421,034
$9,275,379
100.0%
Defined
Mega
FRANKLIN RESOURCES INC
1
$8,812,506
0.34%
400,023
0.309%
—
Shares
2026-08-13
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
FRANKLIN ADVISERS INC
400,023
$8,812,506
100.0%
Defined
Mega
CHARLES SCHWAB INVESTMENT MANAGEMENT INC
$7,994,907
0.31%
362,910
0.280%
—
Shares
2026-08-14
Mega
NORTHERN TRUST CORP
Bank
2
$7,808,114
0.31%
354,431
0.273%
—
Shares
2026-08-13
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
NORTHERN TRUST CO
joint
347,173
$7,648,221
98.0%
Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC
joint
7,258
$159,893
2.0%
Other
Mega
VANGUARD FIDUCIARY TRUST CO
Bank
$6,391,519
0.25%
290,128
0.224%
—
Shares
2026-08-13
Mid
SEVEN GRAND MANAGERS, LLC
$3,855,250
0.15%
175,000
0.135%
—
Shares
2026-08-14
Large
Balyasny Asset Management L.P.
$3,411,081
0.13%
154,838
0.119%
—
Shares
2026-08-14
Large
EXCHANGE TRADED CONCEPTS, LLC
1
$3,359,597
0.13%
152,501
0.118%
—
Shares
2026-08-11
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Roundhill Financial Inc.
152,501
$3,359,597
100.0%
Other
Mega
MANUFACTURERS LIFE INSURANCE COMPANY, THE
Insurance
1
$3,300,468
0.13%
149,817
0.116%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
MANULIFE FINANCIAL CORP
joint
149,817
$3,300,468
100.0%
Defined
Mega
TD Asset Management Inc
$3,253,786
0.13%
147,698
0.114%
—
Shares
2026-08-04
Large
a16z Capital Management, L.L.C.
$3,084,200
0.12%
140,000
0.108%
—
Shares
2026-08-14
Large
Aberdeen Group plc
1
$3,084,200
0.12%
140,000
0.108%
—
Shares
2026-07-31
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
abrdn Inc.
140,000
$3,084,200
100.0%
Defined
Mid
Nantahala Capital Management, LLC
$3,084,200
0.12%
140,000
0.108%
—
Shares
2026-08-19
Mega
Bank of New York Mellon Corp
Bank
2
$3,048,929
0.12%
138,399
0.107%
—
Shares
2026-08-06
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Mellon Investments Corporation
53,169
$1,171,313
38.4%
Defined
The Bank of New York Mellon
85,230
$1,877,616
61.6%
Defined
Large
ALPS ADVISORS INC
$2,885,930
0.11%
131,000
0.101%
—
Shares
2026-07-29
Mega
Nuveen, LLC
2
$1,956,175
0.08%
88,796
0.068%
—
Shares
2026-08-11
This filing is a combination report: the position is filed across the managers below.
Small
Avidity Partners Management LP
$1,762,400
0.07%
80,000
0.062%
—
Shares
2026-08-14
Mid
Ghisallo Capital Management LLC
$1,652,250
0.06%
75,000
0.058%
—
Shares
2026-08-14
Mid
Rock Springs Capital Management LP
$1,431,950
0.06%
65,000
0.050%
—
Shares
2026-08-14
Mega
ALLIANCEBERNSTEIN L.P.
1
$1,345,812
0.05%
61,090
0.047%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Mega
RHUMBLINE ADVISERS
$1,286,265
0.05%
58,387
0.045%
—
Shares
2026-08-12
Mega
MORGAN STANLEY
4
$1,273,023
0.05%
57,786
0.045%
—
Shares
2026-08-13
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC
532
$11,719
0.9%
Defined
MORGAN STANLEY & CO. LLC
12,454
$274,361
21.6%
Defined
MORGAN STANLEY CAPITAL SERVICES, LLC
23,819
$524,732
41.2%
Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC
20,981
$462,211
36.3%
Defined
Mega
BANK OF AMERICA CORP /DE/
Bank
2
$1,244,915
0.05%
56,510
0.044%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
BANK OF AMERICA NA
26,642
$586,923
47.1%
Defined
BOFA SECURITIES, INC.
29,868
$657,992
52.9%
Defined
Mega
Russell Investments Group, Ltd.
4
$1,174,572
0.05%
53,317
0.041%
—
Shares
2026-08-06
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Russell Investment Management, LLC
34,087
$750,936
63.9%
Defined
Russell Investments Capital, LLC
10,109
$222,701
19.0%
Defined
Russell Investments France SAS
2,367
$52,145
4.4%
Defined
Russell Investments Trust Company
6,754
$148,790
12.7%
Defined
Mid
XTX Topco Ltd
1
$1,084,404
0.04%
49,224
0.038%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
XTX EXECUTION SERVICES LLC
joint
49,224
$1,084,404
100.0%
Defined
Large
LAZARD ASSET MANAGEMENT LLC
$1,066,053
0.04%
48,391
0.037%
—
Shares
2026-08-14
Large
TUDOR INVESTMENT CORP ET AL
$1,058,541
0.04%
48,050
0.037%
—
Shares
2026-08-14
Mega
DEUTSCHE BANK AG\
Bank
2
$1,005,624
0.04%
45,648
0.035%
—
Shares
2026-08-07
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
DWS INVESTMENT MANAGEMENT AMERICAS, INC
597
$13,151
1.3%
Defined
DWS Investments UK Ltd
45,051
$992,473
98.7%
Defined
Large
Squarepoint Ops LLC
1
$992,715
0.04%
45,062
0.035%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Squarepoint Capital LLP
45,062
$992,715
100.0%
Defined
Mega
WELLS FARGO & COMPANY/MN
2
$949,933
0.04%
43,120
0.033%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
WELLS FARGO BANK N A
42,270
$931,208
98.0%
Defined
WELLS FARGO CLEARING SERVICES, LLC
850
$18,725
2.0%
Defined
Small
Foresite Capital Management VI LLC
$826,125
0.03%
37,500
0.029%
—
Shares
2026-08-14
Large
CIBC WORLD MARKET INC.
$781,536
0.03%
35,476
0.027%
—
Shares
2026-08-13
Mega
SUSQUEHANNA INTERNATIONAL GROUP, LLP
1
$718,376
0.03%
32,609
0.025%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Mega
JPMORGAN CHASE & CO
2
$689,714
0.03%
31,308
0.024%
—
Shares
2026-08-12
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
JPMorgan Chase Bank, N.A.
19,142
$421,698
61.1%
Defined
J.P. Morgan Investment Management Inc.
12,166
$268,016
38.9%
Defined
Mega
Invesco Ltd.
3
$625,408
0.02%
28,389
0.022%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Invesco Advisers, Inc.
joint
6,326
$139,361
22.3%
Defined
Invesco Trust Co
joint
18,412
$405,616
64.9%
Defined
Invesco Capital Management LLC
3,651
$80,431
12.9%
Defined
Large
MetLife Investment Management, LLC
1
$601,991
0.02%
27,326
0.021%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
METLIFE INC
27,326
$601,991
100.0%
Defined
Large
Universal- Beteiligungs- und Servicegesellschaft mbH
1
$505,610
0.02%
22,951
0.018%
—
Shares
2026-08-06
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Universal-Investment-Gesellschaft mbH
22,951
$505,610
100.0%
Defined
Mega
CITIGROUP INC
1
$474,679
0.02%
21,547
0.017%
—
Shares
2026-08-03
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Citigroup Financial Products Inc.
joint
21,547
$474,679
100.0%
Defined
Large
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.
Mutual Fund
1
$466,397
0.02%
21,171
0.016%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Mid
SOROS FUND MANAGEMENT LLC
$440,600
0.02%
20,000
0.015%
—
Shares
2026-08-14
Large
Quadrature Capital Ltd
1
$422,976
0.02%
19,200
0.015%
—
Shares
2026-08-07
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Quadrature US Inc.
19,200
$422,976
100.0%
Other
Mega
D. E. Shaw & Co., Inc.
1
$385,525
0.02%
17,500
0.013%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Mega
Vanguard Global Advisers, LLC
$383,938
0.02%
17,428
0.013%
—
Shares
2026-08-13
Small
Harbour Capital Advisors, LLC
$365,037
0.01%
16,570
0.013%
—
Shares
2026-07-15
Large
NEW YORK STATE COMMON RETIREMENT FUND
Pension
$356,886
0.01%
16,200
0.012%
—
Shares
2026-07-29
Mid
Tema ETFs LLC
Mutual Fund
$309,279
0.01%
14,039
0.011%
—
Shares
2026-07-10
Large
Tidal Investments LLC
$309,279
0.01%
14,039
0.011%
—
Shares
2026-08-13
Large
Police & Firemen's Retirement System of New Jersey
Pension
1
$300,004
0.01%
13,618
0.011%
—
Shares
2026-07-23
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Mellon Capital
13,618
$300,004
100.0%
Defined
Mega
BARCLAYS PLC
2
$227,591
0.01%
10,331
0.008%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
BARCLAYS BANK PLC
6,176
$136,057
59.8%
Defined
BARCLAYS CAPITAL INC.
4,155
$91,534
40.2%
Defined
Mega
VICTORY CAPITAL MANAGEMENT INC
$227,041
0.01%
10,306
0.008%
—
Shares
2026-08-07
Large
Hudson Bay Capital Management LP
$221,401
0.01%
10,050
0.008%
—
Shares
2026-08-14
Large
GABELLI FUNDS LLC
$220,300
0.01%
10,000
0.008%
—
Shares
2026-08-12
Mega
Legal & General Group Plc
2
$199,326
0.01%
9,048
0.007%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Legal & General Investment Management America Inc
4,485
$98,804
49.6%
Defined
Legal & General Investment Management Ltd
4,563
$100,522
50.4%
Defined
Large
STRS OHIO
$198,270
0.01%
9,000
0.007%
—
Shares
2026-07-30
Mega
BNP PARIBAS ARBITRAGE, SA
$154,210
0.01%
7,000
0.005%
—
Shares
2026-08-13
Large
US BANCORP \DE\
Bank
1
$110,436
0.00%
5,013
0.004%
—
Shares
2026-08-12
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
US BANK NATIONAL ASSOCIATION
5,013
$110,436
100.0%
Defined
Large
Penserra Capital Management LLC
$107,153
0.00%
4,864
0.004%
—
Shares
2026-08-13
Mid
Ameritas Investment Partners, Inc.
1
$92,305
0.00%
4,190
0.003%
—
Shares
2026-08-13
This filing is a combination report: the position is filed across the managers below.
Small
DIADEMA PARTNERS LP
$79,770
0.00%
3,621
0.003%
—
Shares
2026-08-14
Mid
Tower Research Capital LLC (TRC)
1
$72,456
0.00%
3,289
0.003%
—
Shares
2026-08-11
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Latour Trading LLC (Latour)
3,289
$72,456
100.0%
Defined
Mega
ROYAL BANK OF CANADA
Bank
3
$64,415
0.00%
2,924
0.002%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
RBC CMA LTD.
1,571
$34,609
53.7%
Defined
RBC Capital Markets, LLC
1,352
$29,784
46.2%
Defined
Held directly
1
$22
0.0%
Sole
Mega
PNC FINANCIAL SERVICES GROUP, INC.
1
$58,203
0.00%
2,642
0.002%
—
Shares
2026-08-07
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
PNC Bank, National Association
2,642
$58,203
100.0%
Defined
Small
Persistent Asset Partners Ltd
$38,882
0.00%
1,765
0.001%
—
Shares
2026-08-07
Large
Federation des caisses Desjardins du Quebec
1
$25,334
0.00%
1,150
0.001%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Desjardins Securities inc.
1,150
$25,334
100.0%
Defined
Large
NISA INVESTMENT ADVISORS, LLC
$19,188
0.00%
871
0.001%
—
Shares
2026-08-10
Mega
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM
Pension
$14,011
0.00%
636
0.000%
—
Shares
2026-08-24
Mid
Sterling Capital Management LLC
$8,856
0.00%
402
0.000%
—
Shares
2026-07-28
Small
Fortitude Family Office, LLC
Family Office
$704
0.00%
32
0.000%
—
Shares
2026-07-20
Small
Caitong International Asset Management Co., Ltd
$440
0.00%
20
0.000%
—
Shares
2026-08-05
Large
JONES FINANCIAL COMPANIES LLLP
1
$330
0.00%
15
0.000%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Edward D. Jones & Co., L.P.
15
$330
100.0%
Sole
Mid
SBI Securities Co., Ltd.
Broker-Dealer
$22
0.00%
1
0.000%
—
Shares
2026-07-23
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