CMPX · Compass Therapeutics, Inc.

$2.53 +0.13 (+5.42%) At close · Aug 25

Market Cap

$455.62M

180.09M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Quarter:

Holders: 213

Total Value: $363,373,894

Total Shares: 165,924,212

Institutional Ownership Trend

19 quarters

Holder Concentration

Across 213 13F filers · Δ vs Mar 31, 2026

Top Holder

10.8%

+1.3 pts

Top 5

41.3%

+4.3 pts

Top 10

60.7%

+2.9 pts

HHI

483

Broadly held+62

Quarterly Activity

vs Mar 31, 2026

New

Increased

Decreased

Sold Out

Unchanged

Holder count: +9

Institutional value: -61.1%

Shares held: -6.1%

Top Buyers

vs Mar 31, 2026

Institution	Added	Now Holds
Small Palo Alto Investors LP	+4,317,309	5,831,813
Mega MILLENNIUM MANAGEMENT LLC	+3,867,027	4,713,247
Mega AQR CAPITAL MANAGEMENT LLC	+3,308,709	3,509,137
Mega STATE STREET CORP	+3,258,677	9,953,653
Mega CITADEL ADVISORS LLC	+2,818,864	3,709,974

Top Sellers

vs Mar 31, 2026

Institution	Sold	Now Holds
Large ADAGE CAPITAL PARTNERS GP, L.L.C.	−7,300,000	1,186,500
Mid Vivo Capital, LLC	−1,788,406	7,757,060
Mega UBS Group AG	−1,678,570	712,763
Large Caption Management, LLC	−1,096,123	263,577
Large Schonfeld Strategic Advisors LLC	−983,777	92,227

Top New Positions

vs Mar 31, 2026

Institution	Acquired	Value (USD)
Small KINGDON CAPITAL MANAGEMENT, L.L.C.	1,400,000	$3,066,000
Large ACADIAN ASSET MANAGEMENT LLC	1,161,231	$2,543,095
Mega FIRST TRUST ADVISORS LP	807,004	$1,767,338
Large Point72 Asset Management, L.P.	686,577	$1,503,603
Small CM Management, LLC	550,000	$1,204,500

Top Sold-Out Positions

vs Mar 31, 2026

Institution	Previously Held	Last Value (USD)
Mid BVF INC/IL	7,764,842	$41,076,014
Large RTW INVESTMENTS, LP	4,186,599	$22,147,108
Mid DEERFIELD MANAGEMENT COMPANY, L.P.	3,606,000	$19,075,740
Mid Logos Global Management LP	3,150,000	$16,663,500
Mid Sofinnova Investments, Inc.	2,556,161	$13,522,091

Filter: New 63 Increased 86 Reduced 43 Sold out 54 Unchanged 21

Showing 100 of 218

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

TANG CAPITAL MANAGEMENT LLC

$39,399,812

10.84%

17,990,782

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
TANG KEVIN	17,990,782	$39,399,812	100.0%	Other

ORBIMED ADVISORS LLC

$33,331,786

9.17%

15,219,994

SUVRETTA CAPITAL MANAGEMENT, LLC

$30,881,538

8.50%

14,101,159

BlackRock, Inc.

$24,707,097

6.80%

11,281,781

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	81,376	$178,213	0.7%	Sole
BlackRock Asset Management Canada Ltd	100	$219	0.0%	Sole
BlackRock Investment Management, LLC	369,487	$809,176	3.3%	Sole
BLACKROCK ADVISORS LLC	266,607	$583,869	2.4%	Sole
BlackRock Fund Advisors	5,445,410	$11,925,447	48.3%	Sole
BlackRock Institutional Trust Company, N.A.	4,789,632	$10,489,294	42.5%	Sole
BlackRock Asset Management Ireland Ltd	95,233	$208,560	0.8%	Sole
Aperio Group, LLC	233,936	$512,319	2.1%	Sole

STATE STREET CORP

$21,798,500

6.00%

9,953,653

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STATE STREET GLOBAL ADVISORS EUROPE LIMITED joint	9,953,653	$21,798,500	100.0%	Defined

ENAVATE SCIENCES GP, LLC

$17,056,048

4.69%

7,788,150

Vivo Capital, LLC

$16,987,961

4.68%

7,757,060

VANGUARD CAPITAL MANAGEMENT LLC

$13,400,132

3.69%

6,118,782

Palo Alto Investors LP

$12,771,670

3.51%

5,831,813

MILLENNIUM MANAGEMENT LLC

$10,322,010

2.84%

4,713,247

GEODE CAPITAL MANAGEMENT, LLC

$8,355,263

2.30%

3,815,189

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	543,199	$1,189,605	14.2%	Defined
Held directly	3,271,990	$7,165,658	85.8%	Defined

VANGUARD PORTFOLIO MANAGEMENT LLC

$8,258,560

2.27%

3,771,032

Qube Research & Technologies Ltd

$8,075,600

2.22%

3,687,489

Blue Owl Capital Holdings LP

$7,936,726

2.18%

3,624,076

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Blue Owl Healthcare Opportunities Advisors LLC	3,624,076	$7,936,726	100.0%	Defined

CITADEL ADVISORS LLC

$7,819,776

2.15%

3,570,674

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	3,489,674	$7,642,386	97.7%	Defined
Held directly	81,000	$177,390	2.3%	Defined

GOLDMAN SACHS GROUP INC

$7,732,888

2.13%

3,531,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	2,685,743	$5,881,777	76.1%	Defined
GOLDMAN SACHS ASSET MANAGEMENT, L.P.	821,447	$1,798,968	23.3%	Defined
Goldman Sachs Trust Company, N.A. joint	23,810	$52,143	0.7%	Other

Rock Springs Capital Management LP

$7,719,594

2.12%

3,524,929

AQR CAPITAL MANAGEMENT LLC

$7,685,007

2.11%

3,509,137

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Petros Family Wealth, LLC	637	$1,395	0.0%	Other
RF&L WEALTH MANAGEMENT, LLC	8	$17	0.0%	Other
Compound Planning, Inc.	14	$30	0.0%	Other
Arax Advisory Partners	4,912	$10,757	0.1%	Other
HALBERT HARGROVE GLOBAL ADVISORS, LLC	4,594	$10,060	0.1%	Other
Stokes Family Office, LLC	514	$1,125	0.0%	Other
Held directly	3,498,458	$7,661,623	99.7%	Defined

Birchview Capital, LP

$3,668,250

1.01%

1,675,000

KINGDON CAPITAL MANAGEMENT, L.L.C.

$3,066,000

0.84%

1,400,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Manager 1 joint	1,400,000	$3,066,000	100.0%	Defined

Fisher Asset Management, LLC

$3,048,239

0.84%

1,391,890

ROYCE & ASSOCIATES LP

$2,927,548

0.81%

1,336,780

FMR LLC

$2,654,709

0.73%

1,212,196

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	1,212,196	$2,654,709	100.0%	Defined

ADAGE CAPITAL PARTNERS GP, L.L.C.

$2,598,435

0.72%

1,186,500

ACADIAN ASSET MANAGEMENT LLC

$2,543,095

0.70%

1,161,231

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Acadian Inc	1,161,231	$2,543,095	100.0%	Defined

NORTHERN TRUST CORP

$2,498,599

0.69%

1,140,914

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	1,101,308	$2,411,863	96.5%	Defined
NORTHERN TRUST GLOBAL INVESTMENTS LTD	19,029	$41,673	1.7%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC joint	20,577	$45,063	1.8%	Other

Atle Fund Management AB

$2,296,418

0.63%

1,048,593

Nuveen, LLC

$2,213,130

0.61%

1,010,562

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Nuveen Asset Management, LLC joint	6,886	$15,080	0.7%	Defined
TIAA CREF INVESTMENT MANAGEMENT LLC joint	719,590	$1,575,902	71.2%	Defined
TEACHERS ADVISORS, LLC joint	284,086	$622,148	28.1%	Defined

Squarepoint Ops LLC

$2,206,440

0.61%

1,007,507

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Squarepoint Capital LLP	1,007,507	$2,206,440	100.0%	Defined

VANGUARD FIDUCIARY TRUST CO

$2,192,054

0.60%

1,000,938

Blackstone Inc.

$1,970,859

0.54%

899,936

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Blackstone Alternative Asset Management L.P.	899,936	$1,970,859	100.0%	Other

FIRST TRUST ADVISORS LP

$1,767,338

0.49%

807,004

JPMORGAN CHASE & CO

$1,728,782

0.48%

789,399

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JPMorgan Chase Bank, N.A.	92,424	$202,408	11.7%	Defined
J.P. Morgan Investment Management Inc.	696,934	$1,526,285	88.3%	Defined
J.P. Morgan Securities LLC	41	$89	0.0%	Defined

KVP Capital Advisors, LP

$1,688,490

0.46%

771,000

MORGAN STANLEY

$1,610,053

0.44%

735,186

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	2,341	$5,126	0.3%	Defined
MORGAN STANLEY & CO. LLC	173,310	$379,548	23.6%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	497,005	$1,088,440	67.6%	Defined
MORGAN STANLEY SMITH BARNEY LLC	17,788	$38,955	2.4%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	44,742	$97,984	6.1%	Defined

CITIGROUP INC

$1,563,455

0.43%

713,907

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citigroup Financial Products Inc. joint	713,907	$1,563,455	100.0%	Defined

UBS Group AG

$1,560,950

0.43%

712,763

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS AG	712,763	$1,560,950	100.0%	Defined

Burkehill Global Management, LP

$1,533,000

0.42%

700,000

Point72 Asset Management, L.P.

$1,503,603

0.41%

686,577

ACUTA CAPITAL PARTNERS, LLC

$1,303,516

0.36%

595,213

BANK OF AMERICA CORP /DE/

$1,241,551

0.34%

566,919

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	453,922	$994,089	80.1%	Defined
BOFA SECURITIES, INC.	93,914	$205,671	16.6%	Defined
BofA Securities Europe SA	19,083	$41,791	3.4%	Defined

CM Management, LLC

$1,204,500

0.33%

550,000

DIMENSIONAL FUND ADVISORS LP

$1,185,178

0.33%

541,178

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Dimensional Fund Advisors Ltd.	13,608	$29,801	2.5%	Defined
DFA Australia Ltd.	18,003	$39,426	3.3%	Defined
Dimensional Ireland Ltd	32,356	$70,859	6.0%	Defined
Held directly	477,211	$1,045,092	88.2%	Sole

Connor, Clark & Lunn Investment Management Ltd.

$1,147,071

0.32%

523,777

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Manager 1	523,777	$1,147,071	100.0%	Sole

Artia Global Partners LP

$839,208

0.23%

383,200

WELLINGTON MANAGEMENT GROUP LLP

$829,323

0.23%

378,687

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Wellington Management Company LLP	113,774	$249,165	30.0%	Defined
Wellington Trust Company, NA joint	247,821	$542,727	65.4%	Defined
Wellington Management Australia Pty Ltd	17,092	$37,431	4.5%	Defined

ArrowMark Colorado Holdings LLC

$798,784

0.22%

364,742

Bank of New York Mellon Corp

$768,759

0.21%

351,032

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Investments Corporation	110,903	$242,877	31.6%	Defined
The Bank of New York Mellon	240,127	$525,878	68.4%	Defined
Held directly	2	$4	0.0%	Defined

MARSHALL WACE, LLP

$733,362

0.20%

334,869

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Marshall Wace North America L.P. joint	334,869	$733,362	100.0%	Other

TWO SIGMA INVESTMENTS, LP

$701,483

0.19%

320,312

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$675,166

0.19%

308,295

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	308,295	$675,166	100.0%	Other

ALGERT GLOBAL LLC

$674,760

0.19%

308,110

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$663,874

0.18%

303,139

NATIXIS

$651,995

0.18%

297,715

Exome Asset Management LLC

$604,801

0.17%

276,165

Caption Management, LLC

$577,233

0.16%

263,577

Seven Fleet Capital Management LP

$510,414

0.14%

233,066

DV EQUITIES, LLC

$510,414

0.14%

233,066

PANAGORA ASSET MANAGEMENT INC

$486,572

0.13%

222,179

XTX Topco Ltd

$476,292

0.13%

217,485

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
XTX EXECUTION SERVICES LLC joint	217,485	$476,292	100.0%	Defined

Orion Porfolio Solutions, LLC

$468,359

0.13%

213,863

D. E. Shaw & Co., Inc.

$447,825

0.12%

204,487

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
D. E. SHAW & CO, L.P.	64,663	$141,611	31.6%	Defined
D. E. Shaw Investment Management, L.L.C. joint	139,824	$306,214	68.4%	Defined

Rafferty Asset Management, LLC

$416,375

0.11%

190,126

Creative Planning

$400,421

0.11%

182,841

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
CREATIVE PLANNING TRUST Co LLC	471	$1,031	0.3%	Defined
Held directly	182,370	$399,390	99.7%	Sole

ALPS ADVISORS INC

$400,281

0.11%

182,777

UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC

$389,411

0.11%

177,814

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Group AG	794	$1,738	0.4%	Defined
UBS Asset Management Switzerland AG	177,020	$387,673	99.6%	Sole

Mariner, LLC

$378,477

0.10%

172,821

Swiss National Bank

$376,023

0.10%

171,700

HRT FINANCIAL LP

$372,523

0.10%

170,102

JANE STREET GROUP, LLC

$372,300

0.10%

170,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	170,000	$372,300	100.0%	Defined

ALLIANCEBERNSTEIN L.P.

$354,517

0.10%

161,880

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Equitable Holdings, Inc.	161,880	$354,517	100.0%	Defined

Virtus Investment Advisers, LLC

$352,986

0.10%

161,181

CANADA PENSION PLAN INVESTMENT BOARD

$352,371

0.10%

160,900

RHUMBLINE ADVISERS

$346,992

0.10%

158,444

DEUTSCHE BANK AG\

$294,226

0.08%

134,350

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DWS INVESTMENT MANAGEMENT AMERICAS, INC	14,554	$31,873	10.8%	Defined
DWS Investments UK Ltd	119,796	$262,353	89.2%	Defined

IEQ CAPITAL, LLC

$269,256

0.07%

122,948

ADAR1 Capital Management, LLC

$267,469

0.07%

122,132

WELLS FARGO & COMPANY/MN

$240,446

0.07%

109,793

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO BANK N A	109,793	$240,446	100.0%	Defined

Quadrature Capital Ltd

$237,067

0.07%

108,250

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Quadrature US Inc.	108,250	$237,067	100.0%	Other

MERCER GLOBAL ADVISORS INC /ADV

$233,388

0.06%

106,570

LOS ANGELES CAPITAL MANAGEMENT LLC

$230,197

0.06%

105,113

PRICE T ROWE ASSOCIATES INC /MD/

$228,309

0.06%

104,251

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T. Rowe Price International Ltd	104,251	$228,309	100.0%	Defined

PROFUND ADVISORS LLC

$208,507

0.06%

95,209

Schonfeld Strategic Advisors LLC

$201,977

0.06%

92,227

TUDOR INVESTMENT CORP ET AL

$197,196

0.05%

90,044

Jain Global LLC

$193,381

0.05%

88,302

SmartHarvest Portfolios, LLC

$189,452

0.05%

86,508

WEALTH ENHANCEMENT ADVISORY SERVICES, LLC

$183,011

0.05%

83,567

MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.

$180,584

0.05%

82,459

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Global X Management CO LLC joint	60,373	$132,216	73.2%	Defined
Global X Management (AUS) Ltd joint	22,086	$48,368	26.8%	Defined

GROUP ONE TRADING LLC

$178,609

0.05%

81,557

Cerity Partners LLC

$177,329

0.05%

80,973

Sound Capital Solutions LLC

$175,550

0.05%

80,160

SG Americas Securities, LLC

$167,217

0.05%

76,355

Legal & General Group Plc

$164,474

0.05%

75,103

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Legal & General Investment Management America Inc	11,671	$25,559	15.5%	Defined
Legal & General Investment Management Ltd joint	63,432	$138,915	84.5%	Defined

VANGUARD ASSET MANAGEMENT, Ltd

$163,568

0.05%

74,689

CITADEL ADVISORS LLC

$161,622

0.04%

73,800

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	73,800	$161,622	100.0%	Defined

MetLife Investment Management, LLC

$156,411

0.04%

71,421

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
METLIFE INC	71,421	$156,411	100.0%	Defined

GSA CAPITAL PARTNERS LLP

$153,692

0.04%

70,179

Invesco Ltd.

$152,900

0.04%

69,818

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invesco Advisers, Inc. joint	17,443	$38,199	25.0%	Defined
Invesco Trust Co joint	52,375	$114,701	75.0%	Defined

MANUFACTURERS LIFE INSURANCE COMPANY, THE

$149,395

0.04%

68,217

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MANULIFE FINANCIAL CORP joint	68,217	$149,395	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	65,500	$143,445	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Manager 1	60,826	$133,208	100.0%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	59,955	$131,301	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	56,200	$123,078	100.0%	Other

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JANUS HENDERSON INVESTORS UK Ltd	55,600	$121,764	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Russell Investment Management, LLC	50,505	$110,605	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BARCLAYS BANK PLC	16,938	$37,094	33.6%	Defined
BARCLAYS CAPITAL INC.	33,459	$73,275	66.4%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
OSAIC WEALTH, INC.	20,656	$45,236	49.2%	Defined
CW Advisors, LLC	14,585	$31,941	34.8%	Sole
Osaic Advisory Services, LLC	6,724	$14,725	16.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Capital	35,503	$77,751	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	32,600	$71,394	100.0%	Other

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Voya Investment Management Co. LLC joint	27,069	$59,281	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Orion Custom Indexing	7,343	$16,081	31.0%	Other
AQR Capital Management	5,979	$13,094	25.3%	Other
Held directly	10,352	$22,670	43.7%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
PGIM Quantitative Solutions LLC	21,720	$47,566	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SEI INVESTMENTS MANAGEMENT CORP	707	$1,548	3.3%	Sole
SEI TRUST CO	20,845	$45,650	96.7%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Manufacturers & Traders Trust Company	302	$661	1.7%	Defined
Wilmington Trust National Association joint	17,896	$39,191	98.3%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Virtu Americas LLC	16,394	$35,902	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STONEX FINANCIAL INC.	15,000	$32,850	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STIFEL NICOLAUS & CO INC \MO\	13,972	$30,598	98.3%	Defined
Held directly	239	$523	1.7%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
EVOKE WEALTH, LLC	4,174	$9,141	29.4%	Defined
Held directly	10,015	$21,932	70.6%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
PNC Bank, National Association	10,939	$23,956	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
EATON VANCE MANAGEMENT	10,621	$23,259	100.0%	Other

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Brevan Howard US Investment Management, LP	10,202	$22,342	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
FEDERATED MDTA LLC	7,522	$16,473	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Latour Trading LLC (Latour)	7,474	$16,368	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
ROCKEFELLER & CO. LLC	2,042	$4,471	42.4%	Defined
ROCKEFELLER TRUST COMPANY, N.A.	2,772	$6,070	57.6%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RBC CMA LTD.	3,966	$8,685	98.0%	Defined
RBC Dominion Securities Inc.	81	$177	2.0%	Defined
Held directly	1	$2	0.0%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Desjardins Securities inc.	4,000	$8,760	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BMSS Wesson Wealth Solutions, LLC	86	$188	7.7%	Sole
Held directly	1,028	$2,249	92.3%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Optiver VOF	568	$1,243	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
National Bank Financial Inc.	300	$657	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BVF PARTNERS L P/IL	7,764,842	$41,076,014	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Deerfield UGP, LLC	3,606,000	$19,075,740	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Columbia Management Investment Advisers, LLC	1,596,815	$8,447,151	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JAY JEFFREY R joint	1,350,000	$7,141,500	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Leap GP LLC joint	371,400	$1,964,706	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RAYMOND JAMES & ASSOCIATES	116,645	$617,052	95.7%	Defined
Raymond James Financial Services Advisors, Inc.	5,244	$27,740	4.3%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
AMERICAN CENTURY INVESTMENT MANAGEMENT INC	78,328	$414,355	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DRW Investments, LLC joint	76,493	$404,647	100.0%	Other

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
FRANKLIN ADVISERS INC	66,607	$352,351	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JANUS HENDERSON INVESTORS UK Ltd	55,600	$294,124	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Landscape High Leverage Fund, LP	6,758	$35,749	18.8%	Defined
LANDSCAPE OFFSHORE HL FUND LTD.	18,648	$98,647	51.9%	Defined
Held directly	10,517	$55,634	29.3%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Wabon Partners, L.P.	30,000	$158,700	100.0%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
US BANK NATIONAL ASSOCIATION	77	$407	100.0%	Defined

Key facts CIK 1738021 CUSIP 20454B104 13F (30d) 194 filings 193 filers Visit website