Mega
FMR LLC
5
$192,096,724
13.26%
5,835,259
13.162%
—
Shares
2026-08-13
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Fidelity Management & Research Co LLC
3,107,439
$102,296,891
53.3%
Defined
FIDELITY MANAGEMENT TRUST CO
400,808
$13,194,599
6.9%
Defined
Impresa Management LLC
2,284,535
$75,206,892
39.2%
Defined
Fidelity Institutional Asset Management Trust Co
33,400
$1,099,528
0.6%
Defined
FIAM LLC
9,077
$298,814
0.2%
Defined
Mid
NOVO HOLDINGS A/S
$127,837,873
8.82%
3,883,289
8.759%
—
Shares
2026-08-14
Mid
SR One Capital Management, LP
$108,920,725
7.52%
3,308,649
7.463%
—
Shares
2026-08-12
Mid
PERCEPTIVE ADVISORS LLC
$88,070,744
6.08%
2,675,296
6.035%
—
Shares
2026-08-14
Mid
SUVRETTA CAPITAL MANAGEMENT, LLC
$82,402,348
5.69%
2,503,109
5.646%
—
Shares
2026-08-14
Small
NVP ASSOCIATES, LLC
$74,675,859
5.15%
2,268,404
5.117%
—
Shares
2026-08-07
Mega
WELLINGTON MANAGEMENT GROUP LLP
5
$72,489,377
5.00%
2,201,986
4.967%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Wellington Management Company LLP
1,893,722
$62,341,328
86.0%
Defined
Wellington Management Hong Kong Ltd
480
$15,801
0.0%
Defined
Wellington Management Singapore Pte. Ltd.
23,932
$787,841
1.1%
Defined
Wellington Management International Ltd
15,628
$514,473
0.7%
Defined
Wellington Trust Company, NA
joint
268,224
$8,829,934
12.2%
Defined
Mega
PRICE T ROWE ASSOCIATES INC /MD/
2
$57,123,803
3.94%
1,735,231
3.914%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
T. Rowe Price International Ltd
22,265
$732,963
1.3%
Defined
Held directly
1,712,966
$56,390,840
98.7%
Sole
Small
Catalio Capital Management, LP
$55,168,323
3.81%
1,675,830
3.780%
—
Shares
2026-08-14
Mega
T. Rowe Price Investment Management, Inc.
$52,762,365
3.64%
1,602,745
3.615%
—
Shares
2026-08-14
Mid
EVENTIDE ASSET MANAGEMENT, LLC
$45,280,999
3.13%
1,375,486
3.103%
—
Shares
2026-08-14
Mid
Bellevue Group AG
1
$44,442,000
3.07%
1,350,000
3.045%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
BB Biotech AG
joint
1,350,000
$44,442,000
100.0%
Defined
Mega
BlackRock, Inc.
5
$32,171,529
2.22%
977,264
2.204%
—
Shares
2026-08-07
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE
4,505
$148,304
0.5%
Sole
BlackRock Investment Management, LLC
38,268
$1,259,782
3.9%
Sole
BLACKROCK ADVISORS LLC
29,857
$982,892
3.1%
Sole
BlackRock Fund Advisors
466,997
$15,373,541
47.8%
Sole
BlackRock Institutional Trust Company, N.A.
437,637
$14,407,010
44.8%
Sole
Small
Pivotal bioVenture Partners Investment Advisor LLC
Venture Capital
1
$31,826,792
2.20%
966,792
2.181%
—
Shares
2026-08-13
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Pivotal bioVenture Partners Fund I U.G.P. Ltd
966,792
$31,826,792
100.0%
Defined
Mega
CITADEL ADVISORS LLC
$31,573,506
2.18%
959,098
2.163%
—
Shares
2026-09-02
Small
ANDERA PARTNERS
$30,609,806
2.11%
929,824
2.097%
—
Shares
2026-07-22
Mega
JENNISON ASSOCIATES LLC
1
$26,755,697
1.85%
812,749
1.833%
—
Shares
2026-08-03
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Prudential Financial Inc
812,749
$26,755,697
100.0%
Defined
Mid
BRAIDWELL LP
$26,381,923
1.82%
801,395
1.808%
—
Shares
2026-08-14
Mid
TPG GP A, LLC
$25,449,431
1.76%
773,069
1.744%
—
Shares
2026-08-14
Mega
VANGUARD CAPITAL MANAGEMENT LLC
$24,353,228
1.68%
739,770
1.669%
—
Shares
2026-08-13
Mid
DEERFIELD MANAGEMENT COMPANY, L.P.
1
$24,064,520
1.66%
731,000
1.649%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Deerfield UGP, LLC
731,000
$24,064,520
100.0%
Defined
Mid
Rock Springs Capital Management LP
$21,823,260
1.51%
662,918
1.495%
—
Shares
2026-08-14
Mega
GEODE CAPITAL MANAGEMENT, LLC
2
$14,308,677
0.99%
434,650
0.980%
—
Shares
2026-08-12
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC
63,282
$2,083,243
14.6%
Defined
Held directly
371,368
$12,225,434
85.4%
Defined
Mid
Soleus Capital Management, L.P.
$13,793,480
0.95%
419,000
0.945%
—
Shares
2026-08-11
Small
INFINITUM ASSET MANAGEMENT, LLC
$13,542,563
0.93%
411,378
0.928%
—
Shares
2026-08-14
Large
BAKER BROS. ADVISORS LP
$11,522,000
0.80%
350,000
0.789%
—
Shares
2026-08-14
Mega
FRANKLIN RESOURCES INC
1
$10,919,037
0.75%
331,684
0.748%
—
Shares
2026-08-13
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
FRANKLIN ADVISERS INC
331,684
$10,919,037
100.0%
Defined
Small
SILVERARC CAPITAL MANAGEMENT, LLC
$10,879,632
0.75%
330,487
0.745%
—
Shares
2026-08-13
Mega
GOLDMAN SACHS GROUP INC
1
$9,344,473
0.65%
283,854
0.640%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
GOLDMAN SACHS & CO. LLC
283,854
$9,344,473
100.0%
Defined
Large
FEDERATED HERMES, INC.
1
$5,267,200
0.36%
160,000
0.361%
—
Shares
2026-08-12
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
FEDERATED GLOBAL INVESTMENT MANAGEMENT CORP
160,000
$5,267,200
100.0%
Defined
Large
Woodline Partners LP
$4,970,887
0.34%
150,999
0.341%
—
Shares
2026-08-14
Mega
CHARLES SCHWAB INVESTMENT MANAGEMENT INC
$4,838,976
0.33%
146,992
0.332%
—
Shares
2026-08-14
Mid
ADAR1 Capital Management, LLC
$4,821,035
0.33%
146,447
0.330%
—
Shares
2026-08-14
Mega
NORTHERN TRUST CORP
Bank
2
$4,490,089
0.31%
136,394
0.308%
—
Shares
2026-08-13
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
NORTHERN TRUST CO
joint
133,704
$4,401,535
98.0%
Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC
joint
2,690
$88,554
2.0%
Other
Small
STEMPOINT CAPITAL LP
$3,884,560
0.27%
118,000
0.266%
—
Shares
2026-08-14
Mega
VANGUARD PORTFOLIO MANAGEMENT LLC
$3,862,766
0.27%
117,338
0.265%
—
Shares
2026-08-13
Mega
VANGUARD FIDUCIARY TRUST CO
Bank
$3,843,837
0.27%
116,763
0.263%
—
Shares
2026-08-13
Mid
Burkehill Global Management, LP
$3,785,800
0.26%
115,000
0.259%
—
Shares
2026-08-14
Small
ACUTA CAPITAL PARTNERS, LLC
$3,785,800
0.26%
115,000
0.259%
—
Shares
2026-08-14
Mid
MOORE CAPITAL MANAGEMENT, LP
$3,636,046
0.25%
110,451
0.249%
—
Shares
2026-08-14
Large
Blackstone Inc.
1
$3,225,666
0.22%
97,985
0.221%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Blackstone Alternative Asset Management L.P.
97,985
$3,225,666
100.0%
Other
Mega
TD Asset Management Inc
$3,115,417
0.22%
94,636
0.213%
—
Shares
2026-08-04
Mid
SEVEN GRAND MANAGERS, LLC
$2,469,000
0.17%
75,000
0.169%
—
Shares
2026-08-14
Mid
Ghisallo Capital Management LLC
$2,304,400
0.16%
70,000
0.158%
—
Shares
2026-08-14
Mid
Atom Investors LP
$2,246,921
0.16%
68,254
0.154%
—
Shares
2026-08-14
Large
Aberdeen Group plc
1
$2,211,368
0.15%
67,174
0.152%
—
Shares
2026-07-31
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
abrdn Inc.
67,174
$2,211,368
100.0%
Defined
Mid
Zimmer Partners, LP
$2,057,500
0.14%
62,500
0.141%
—
Shares
2026-08-14
Small
Avidity Partners Management LP
$1,975,200
0.14%
60,000
0.135%
—
Shares
2026-08-14
Large
LMR Partners LLP
1
$1,788,313
0.12%
54,323
0.123%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
LMR Partners LLC
54,323
$1,788,313
100.0%
Sole
Mega
AMERIPRISE FINANCIAL INC
1
$1,647,481
0.11%
50,045
0.113%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Columbia Management Investment Advisers, LLC
50,045
$1,647,481
100.0%
Defined
Large
Freestone Grove Partners LP
$1,646,000
0.11%
50,000
0.113%
—
Shares
2026-08-14
Mid
Brevan Howard Capital Management LP
1
$1,415,592
0.10%
43,001
0.097%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Brevan Howard Investment Products Ltd
43,001
$1,415,592
100.0%
Defined
Mega
Bank of New York Mellon Corp
Bank
2
$1,321,408
0.09%
40,140
0.091%
—
Shares
2026-08-06
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Mellon Investments Corporation
11,431
$376,308
28.5%
Defined
The Bank of New York Mellon
28,709
$945,100
71.5%
Defined
Mid
Shay Capital LLC
$1,316,800
0.09%
40,000
0.090%
—
Shares
2026-08-14
Large
Balyasny Asset Management L.P.
$1,118,457
0.08%
33,975
0.077%
—
Shares
2026-08-14
Mega
Nuveen, LLC
2
$976,735
0.07%
29,670
0.067%
—
Shares
2026-08-11
This filing is a combination report: the position is filed across the managers below.
Mid
Davidson Kempner Capital Management LP
$757,160
0.05%
23,000
0.052%
—
Shares
2026-08-14
Mega
D. E. Shaw & Co., Inc.
1
$757,160
0.05%
23,000
0.052%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Mega
RHUMBLINE ADVISERS
$674,925
0.05%
20,502
0.046%
—
Shares
2026-08-12
Mega
DEUTSCHE BANK AG\
Bank
2
$557,434
0.04%
16,933
0.038%
—
Shares
2026-08-07
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
DWS INVESTMENT MANAGEMENT AMERICAS, INC
225
$7,407
1.3%
Defined
DWS Investments UK Ltd
16,708
$550,027
98.7%
Defined
Mega
MORGAN STANLEY
5
$556,543
0.04%
16,906
0.038%
—
Shares
2026-08-13
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC
116
$3,818
0.7%
Defined
MORGAN STANLEY & CO. LLC
4,572
$150,510
27.0%
Defined
MORGAN STANLEY CAPITAL SERVICES, LLC
1,287
$42,368
7.6%
Defined
MORGAN STANLEY SMITH BARNEY LLC
2,637
$86,810
15.6%
Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC
8,294
$273,037
49.1%
Defined
Mega
WELLS FARGO & COMPANY/MN
2
$501,304
0.03%
15,228
0.034%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
WELLS FARGO BANK N A
15,227
$501,272
100.0%
Defined
Wells Fargo Securities, LLC
1
$32
0.0%
Defined
Large
Hudson Bay Capital Management LP
2
$466,805
0.03%
14,180
0.032%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Hudson Bay Capital UK LLP
1,880
$61,889
13.3%
Defined
Held directly
12,300
$404,916
86.7%
Sole
Mid
Longaeva Partners L.P.
1
$411,500
0.03%
12,500
0.028%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Balyasny Asset Management L.P.
12,500
$411,500
100.0%
Other
Mega
UBS Group AG
2
$404,784
0.03%
12,296
0.028%
—
Shares
2026-08-13
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
UBS AG
4,848
$159,596
39.4%
Defined
UBS Securities LLC
7,448
$245,188
60.6%
Defined
Mega
BANK OF AMERICA CORP /DE/
Bank
1
$384,110
0.03%
11,668
0.026%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
BANK OF AMERICA NA
11,668
$384,110
100.0%
Defined
Mega
Invesco Ltd.
3
$382,101
0.03%
11,607
0.026%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Invesco Advisers, Inc.
joint
2,353
$77,460
20.3%
Defined
Invesco Trust Co
joint
6,831
$224,876
58.9%
Defined
Invesco Capital Management LLC
2,423
$79,765
20.9%
Defined
Mega
RAYMOND JAMES FINANCIAL INC
2
$378,020
0.03%
11,483
0.026%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Mid
XTX Topco Ltd
1
$350,268
0.02%
10,640
0.024%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
XTX EXECUTION SERVICES LLC
joint
10,640
$350,268
100.0%
Defined
Large
MetLife Investment Management, LLC
1
$339,339
0.02%
10,308
0.023%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
METLIFE INC
10,308
$339,339
100.0%
Defined
Mid
SOROS FUND MANAGEMENT LLC
$329,200
0.02%
10,000
0.023%
—
Shares
2026-08-14
Mid
Virtu Financial LLC
1
$289,432
0.02%
8,792
0.020%
—
Shares
2026-08-13
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Virtu Americas LLC
8,792
$289,432
100.0%
Defined
Mega
CITIGROUP INC
1
$264,511
0.02%
8,035
0.018%
—
Shares
2026-08-03
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Citigroup Financial Products Inc.
joint
8,035
$264,511
100.0%
Defined
Large
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.
Mutual Fund
1
$258,553
0.02%
7,854
0.018%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Mega
Vanguard Global Advisers, LLC
$246,406
0.02%
7,485
0.017%
—
Shares
2026-08-13
Mega
JPMORGAN CHASE & CO
1
$233,797
0.02%
7,102
0.016%
—
Shares
2026-08-12
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
JPMorgan Chase Bank, N.A.
7,102
$233,797
100.0%
Defined
Mega
TWO SIGMA INVESTMENTS, LP
$219,741
0.02%
6,675
0.015%
—
Shares
2026-08-14
Large
SEI INVESTMENTS CO
1
$217,008
0.01%
6,592
0.015%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
SEI TRUST CO
6,592
$217,008
100.0%
Sole
Large
NEW YORK STATE COMMON RETIREMENT FUND
Pension
$197,520
0.01%
6,000
0.014%
—
Shares
2026-07-29
Large
Police & Firemen's Retirement System of New Jersey
Pension
1
$166,311
0.01%
5,052
0.011%
—
Shares
2026-07-23
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Mellon Capital
5,052
$166,311
100.0%
Defined
Mega
BARCLAYS PLC
2
$144,517
0.01%
4,390
0.010%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
BARCLAYS BANK PLC
2,814
$92,636
64.1%
Defined
BARCLAYS CAPITAL INC.
1,576
$51,881
35.9%
Defined
Mega
BNP PARIBAS ARBITRAGE, SA
$130,297
0.01%
3,958
0.009%
—
Shares
2026-08-13
Mega
Legal & General Group Plc
2
$115,350
0.01%
3,504
0.008%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Legal & General Investment Management America Inc
1,665
$54,811
47.5%
Defined
Legal & General Investment Management Ltd
1,839
$60,539
52.5%
Defined
Large
STRS OHIO
$111,928
0.01%
3,400
0.008%
—
Shares
2026-07-30
Small
Persistent Asset Partners Ltd
$67,946
0.00%
2,064
0.005%
—
Shares
2026-08-07
Mid
Ameritas Investment Partners, Inc.
1
$51,190
0.00%
1,555
0.004%
—
Shares
2026-08-13
This filing is a combination report: the position is filed across the managers below.
Mega
Russell Investments Group, Ltd.
1
$45,067
0.00%
1,369
0.003%
—
Shares
2026-08-06
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Russell Investment Management, LLC
1,369
$45,067
100.0%
Defined
Mid
Tower Research Capital LLC (TRC)
1
$34,730
0.00%
1,055
0.002%
—
Shares
2026-08-11
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Latour Trading LLC (Latour)
1,055
$34,730
100.0%
Defined
Mega
ROYAL BANK OF CANADA
Bank
2
$19,356
0.00%
588
0.001%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
RBC CMA LTD.
553
$18,204
94.0%
Defined
RBC Dominion Securities Inc.
35
$1,152
6.0%
Defined
Large
NISA INVESTMENT ADVISORS, LLC
$16,558
0.00%
503
0.001%
—
Shares
2026-08-10
Mega
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM
Pension
$7,769
0.00%
236
0.001%
—
Shares
2026-08-24
Mid
Sterling Capital Management LLC
$4,905
0.00%
149
0.000%
—
Shares
2026-07-28
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