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CTMX · CytomX Therapeutics, Inc.

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$2.04 +0.00 (+0.00%) At close · Nov 13
Market Cap
$444.73M
Shares
218.00M
Volume · Nov 13 2.72M Avg daily vol (3M) 4.16M

Price & Indicators

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20d MA 50d MA 200d MA Earnings Filing Insider Congress Investor day
Close$2.04 Open$2.02 Day$1.96–2.13 52W close$1.98–6.75 Avg vol 30d4.6M Short int45.2M · 20.8% of shares · 12.0d Short vol67% Last earningsNov 5, 2026 DataJan 2020–Nov 2026 Filing10-Q · Nov 5

Up next

Mar 15, 2027 Est · unconfirmed · in 17 wks

Latest documents

2026
Nov 9
Investor event
Varseta M update to include first survival data

Cytomics said its January Varseta M update will disclose first overall survival data, plus safety, ORR and PFS from 40 dose-optimization patients; 113 patients are enrolled in the phase one study.

5 source passages
Very importantly, this next update from Cytomics will include the first disclosure of an overall survival number for Varseta-M. We've now got 113 patients enrolled into the phase one study, 73 in escalation and expansion, 40 in dose optimization. We'll also share from the optimization cohorts safety and ORR and PFS. It'll be too early to share OS from the optimization cohorts, but we will have ORR and PFS. So maybe just to underline the upcoming update, which I think you recently refined to January of next year. Open the document at this passage
Nov 5
Earnings call
Varsetta M registrational study targeted for first half of 2027

Cytomex Therapeutics plans an integrated Varsetta M update in January, including a first look at overall survival, and aims to begin its first potential registrational study in the first half of 2027.

4 source passages
Welcome to Cytomex Therapeutics' third quarter 2026 financial results call. We expect this next update to provide the first look at overall survival for Varsetta M, which we anticipate will be the primary endpoint in our initial registrational study. And we are looking forward to the update in January. We're very pleased to be here today to provide an update on our third quarter developments and what continues to be a highly productive year for cytomics as we advance our lead program, Varsetta M, towards its first potential registrational study in the first half of 2027. Open the document at this passage
Nov 5
Current report 8-K
Varseta-M earns FDA Fast Track, cash runway into 2028

CytomX Therapeutics said Varseta-M received FDA Fast Track designation for relapsed/refractory metastatic colorectal cancer and ended Q3 2026 with $348.0 million in cash, cash equivalents and investments, providing cash runway into the second half of 2028.

Financial results
2 source passages
Announced FDA Fast Track Designation for Varseta-M for relapsed/refractory metastatic colorectal cancer in August. CytomX ended Q3 2026 with $348.0 million of cash, cash equivalents and investments with expected cash runway into the second half of 2028. Open the document at this passage
Nov 5
Quarterly report 10-Q FY2026 Q3, ended Sep 30
Varseta-M earns fast track designation after positive expansion data

CytomX reports Varseta-M received FDA fast track designation for relapsed/refractory metastatic colorectal cancer; expansion data showed confirmed response rates of 20% at 8.6 mg/kg and 32% at 10 mg/kg, and additional dose-selection data are expected in January of 2027.

Revenue $1.69M ▼ 71.7% Net loss $20M
Read from the MD&A section
4 source passages
In May 2026, we and Regeneron amended the Regeneron Agreement to expand our collaboration, building upon the research momentum in developing next-generation bispecific immunotherapies using CytomX’s PROBODY and Regeneron's Veloci-Bi platforms. Also, on August 27, 2026, we announced that the FDA granted Varseta-M fast track designation for the treatment of patients with relapsed/refractory metastatic colorectal cancer. At the 8.6 mg/kg dose, the confirmed response rate was 20% with an estimated median PFS of 6.8 months and at the 10 mg/kg dose, the confirmed response rate was 32% with an estimated median PFS of 7.1 months. Additional Phase 1 Varseta-M monotherapy data, including dose selection and potential registrational strategy is expected in January of 2027, with the potential to initiate the first Varseta-M registrational study in first half of 2027. Open the document at this passage
All documents

Metrics snapshot

Useful current figures from the complete screener profile.

Revenue (TTM)
$14.03M
Trailing 12 months
Net income (TTM)
−$85.42M
Trailing 12 months
Revenue growth YoY
-71.7%
Year over year
Operating margin
-676.5%
Trailing 12 months
P / E (TTM)
—
Trailing earnings
FCF yield
—
TTM · current market cap
Return on invested capital
—
Trailing 12 months
Net cash
$33.96M
Latest balance sheet
Dividend yield
—
Trailing 12 months
Shares change YoY
+32.8%
Year over year · more shares
Price change (1Y)
-47.2%
Trailing year
Short interest
20.8%
Latest settlement · 12.0 days to cover
View all 125 metrics

AI Brief

Q3 FY26 earnings call · Nov 5, 2026
Q3 FY26

TL;DR. Varseta-M received Fast Track designation and advanced toward a January 2027 update, a potential 1H 2027 registrational study, combination development and expansion into additional gastrointestinal tumors, while CX-801 enrollment progressed. CytomX ended Q3 with $348.0 million, including the $37 million Regeneron payment, and expects runway into the second half of 2028, but revenue declined, operating expenses increased, the net loss widened and grade 3 diarrhea remained a key safety risk.

Bullish
  • + Varseta-M received FDA Fast Track designation for relapsed/refractory metastatic colorectal cancer. new
  • + Varseta-M expansion enrollment began in gastric, gastroesophageal junction, EpCAM-selected pancreatic ductal adenocarcinoma and EpCAM-selected biliary tract cancer. new
Bearish
  • − Q3 revenue fell to $1.7 million from $6.0 million in Q3 2025, primarily because the Astellas collaboration concluded in Q2 2026. new
  • − Total quarterly operating expenses increased to $25.2 million from $21.7 million in Q3 2025. new
  • − Research and development expense increased to $16.5 million from $15.3 million in Q3 2025. new
  • − General and administrative expense increased to $8.7 million from $6.4 million in Q3 2025. new
  • − Quarterly net loss attributable to common stockholders widened from $(14,229) thousand to $(19,998) thousand. new

AI-generated from the earnings call and 8-K · may contain errors · not investment advice

Equibles Rating

blended score · not investment advice
Overall
Strong Sell
SellHoldBuy
Technical Strong Sell Momentum Very Weak Sentiment Neutral Fundamentals Weak Quant / Vol Very High
Market backdrop VIX 19.3 · elevated Equity put/call 0.63
Technical
price trend
Strong Sell
50 / 200-day cross No cross
Price vs 200-day avg −45%
below
Price vs 50-day avg −20%
below
RSI (14) 39
neutral
MACD trend Negative
52-week position 1%
near low
Volume (OBV) Confirms
volume backs price
Momentum
relative strength
Very Weak
1-month return −11%
trailing
6-month return −45%
trailing
YTD return −52%
this year
Relative strength −45%
vs S&P · 6-mo
Sentiment
smart money
Neutral
Trend (MA cross) No cross
50d $3 › 200d $4 — 200d above 50d
Institutional flow Accumulating
143 of 179 funds reported for Sep 30 · net +8.5M sh shares · +30 new
Insider flow Flat
No net insider activity over 90 days
Short interest Rising
20.76% of shares out · ▲ +5.7% MoM · 12.0 days cover
Volume signal Normal
Volume near normal
Institution breadth Multi-yr high
179 holders — near 3-yr high, broad support
Squeeze score 66
elevated · 0–100
Fundamentals
Weak
Revenue growth −45%
Y/Y
Free cash flow $-75.8M
Balance sheet $12.7M
net cash
Quant / Vol
risk profile
Very High
Volatility 85%
annualized · 1-yr
Max drawdown −71%
past year
ATR 8.7%
of price · 14-day

Blended from price, momentum, positioning, fundamentals & volatility · daily-close · not investment advice. Market backdrop is context, not part of the score.

Technicals

trend & momentum for long-term holders Strong Sell
4 · 3 · 0
50 / 200-day cross
No cross Neutral
Price vs 200-day avg
−45% Bearish
Price vs 50-day avg
−20% Bearish
RSI (14)
39 Neutral
MACD trend
Negative Bearish
52-week position
1% Bearish
Volume (OBV)
Confirms Neutral
Market signals — smart money & positioning
Bullish · 2 of 6
Trend (MA cross) No cross
50d $3 › 200d $4 — 200d above 50d
Institutional flow Accumulating
143 of 179 funds reported for Sep 30 · net +8.5M sh shares · +30 new
Insider flow Flat
No net insider activity over 90 days
Short interest Rising
20.76% of shares out · ▲ +5.7% MoM · 12.0 days cover
Volume signal Normal
Volume near normal
Institution breadth Multi-yr high
179 holders — near 3-yr high, broad support
Price context
position in its 52-week range
Range low $2 Now $2 · 1% Range high $7
vs 200-day avg -45% vs 50-day avg -20%

Illustrative technical + ownership context — a signal mix, not investment advice.

Key metrics

Earlier KPI extraction records exist, but do not meet the current evidence-completeness requirements. No current verified series is available. Earlier figures remain withheld until revalidated; this is not evidence that the company reports no KPIs.

Versus peers

Biotechnology — same industry group
Open screener →
Company Mkt cap YTD Rev growth Y/Y P/E Short % shares
CTMX
CytomX Therapeutics, Inc.
this stock
$444.73M -52.1% -44.8% — 20.8%
VRTX
Vertex Pharmaceuticals Inc
$136.56B +18.8% +46.2% 34.7 1.9%
REGN
Regeneron Pharmaceuticals, Inc.
$98.84B +23.8% +20.8% 21.1 2.1%
MRNA
Moderna, Inc.
$90.38B +657.4% +4.3% — 8.2%
CSLLY
Csl Ltd
$66.05B — — — 0.0%

Peers by industry group · P/E from as-reported trailing EPS · short % is of shares outstanding

At a glance

key data from every section
Ownership
Institutional Holders Accumulating
Holders
195
% held
102.5%
Reported
143 of 179
Top holder
FMR LLC
Held Float
View
Held by Funds
Fund positions
165
View
Short & Settlement
Short Interest Rising
Shares short
45.2M
Days to cover
12.0d
Change
+2.5M sh
View
Short Volume
Short vol %
67%
As of
Nov 13, 2026
Short Total
View
Fails to Deliver
FTD shares
10.3K
Value
$28.1K
As of
Oct 1, 2026
View
Off-Exchange
Off-exchange %
38.4%
Week of
Oct 5, 2026
Off-exch Lit
View
Financials
Financials
Revenue (FY)
$76.2M
Net income (FY)
$-17.4M
View
Filings
SEC Filings
Latest
Investor Event Transcript
Filed
Nov 9, 2026
This year
22

Cytomics said its January Varseta M update will disclose first overall survival data, plus safety, ORR and PFS from 40 dose-optimization patients; 113 patients are enrolled in the phase one study.

View
Proposed Sales
Value
$461.9K
Shares
101.8K
Filed
Nov 6, 2025
View
Exempt Offerings
Offering
$30.0M
Filed
Aug 17, 2023
View
Earnings & Events
Webcasts Upcoming
Next webcast
Nov 18, 2026
Last webcast
Nov 9, 2026
View
Investor Relations
Latest news
CytomX Therapeutics Announces Q3…
Published
Nov 5, 2026
Upcoming events
1
View

Performance

5D 20D 120D MTD YTD
CTMX -6.9% -10.5% -44.7% -12.8% -52.1%
SPY +2.6% -1.2% +0.5% -0.2% +10.6%
vs SPY -9.4% -9.4% -45.2% -12.6% -62.7%
Key facts CIK 1501989 CUSIP 23284F105 13F (30d) 139 filings 124 filers Visit website Investor relations