BCRX · Biocryst Pharmaceuticals Inc · Holdings

$8.21 -0.19 (-2.26%)

Russell 2000 member Rebalance outlook locked

Market Cap

$2.15B

255.54M

Volume · Oct 8 5.1M Avg daily vol (3M) 4.16M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Use institutional holdings through the 13F API or MCP →

Some SEC filings for this period have not finished importing. Holder totals and changes may be incomplete; these filings remain queued for recovery.

The Sep 30, 2026 filing window is still open — showing the latest known positions. Funds that have not filed yet carry their prior-quarter positions; a fund that filed without this stock counts as sold out. Each fund's Change is measured against its own previous reported quarter, shown in the Reported column. Pick a completed quarter in the Quarter selector below to put every fund on one quarter and see the stock-wide activity breakdown.

Quarter:

Holders: 319

Total Value: $2,638,238,995

Total Shares: 263,874,789

Showing 1–100 of 332 holdings by value · page 1 of 4

Institutional Ownership Trend

27 quarters

Superinvestors Holding BCRX

All superinvestors →

Ray Dalio $4,910,570 Joel Greenblatt $1,564,210

Holder Concentration

Across 320 13F filers

Top Holder

9.1%

of institutional value

Top 5

30.8%

of institutional value

Top 10

49.9%

of institutional value

HHI

328

Broadly held

Showing 100 of 332

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

BlackRock, Inc.

$238,930,360

9.06%

23,893,036

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	598,440	$5,984,400	2.5%	Sole
BlackRock Investment Management (Australia) Ltd	697	$6,970	0.0%	Sole
BlackRock Asset Management Canada Ltd	1,600	$16,000	0.0%	Sole
BlackRock Investment Management, LLC	857,447	$8,574,470	3.6%	Sole
BLACKROCK ADVISORS LLC	1,638,693	$16,386,930	6.9%	Sole
BlackRock Fund Advisors	11,179,928	$111,799,280	46.8%	Sole
BlackRock Institutional Trust Company, N.A.	8,232,071	$82,320,710	34.5%	Sole
BlackRock Japan Co. Ltd	13,192	$131,920	0.1%	Sole
BlackRock Fund Managers Ltd.	41,693	$416,930	0.2%	Sole
BlackRock Investment Management (UK) Ltd.	241,141	$2,411,410	1.0%	Sole
BlackRock (Netherlands) B.V.	3,166	$31,660	0.0%	Sole
BlackRock Asset Management Ireland Ltd	792,627	$7,926,270	3.3%	Sole
BlackRock (Luxembourg) S.A.	64,223	$642,230	0.3%	Sole
BlackRock Life Ltd	1,821	$18,210	0.0%	Sole
BlackRock Asset Management Schweiz AG	33,574	$335,740	0.1%	Sole
Aperio Group, LLC	192,723	$1,927,230	0.8%	Sole

RA CAPITAL MANAGEMENT, L.P.

$158,271,860

6.00%

15,827,186

STATE STREET CORP

$151,910,980

5.76%

15,191,098

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STATE STREET GLOBAL ADVISORS EUROPE LIMITED joint	15,191,098	$151,910,980	100.0%	Defined

DEERFIELD MANAGEMENT COMPANY, L.P.

$150,964,030

5.72%

15,096,403

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Deerfield UGP, LLC	15,096,403	$150,964,030	100.0%	Defined

VANGUARD CAPITAL MANAGEMENT LLC

$113,642,360

4.31%

11,364,236

VANGUARD PORTFOLIO MANAGEMENT LLC

$111,391,580

4.22%

11,139,158

TCG Crossover Management, LLC

$110,209,680

4.18%

11,020,968

PERCEPTIVE ADVISORS LLC

$103,088,880

3.91%

10,308,888

Jupiter Topco LLC

$95,407,640

3.62%

9,540,764

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JANUS HENDERSON INVESTORS UK Ltd	93,641	$936,410	1.0%	Defined
JANUS HENDERSON INVESTORS US LLC	9,447,123	$94,471,230	99.0%	Defined

Vestal Point Capital, LP

$83,000,000

3.15%

8,300,000

TWO SIGMA INVESTMENTS, LP

$67,753,490

2.57%

6,775,349

GEODE CAPITAL MANAGEMENT, LLC

$62,480,460

2.37%

6,248,046

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	891,166	$8,911,660	14.3%	Defined
Held directly	5,356,880	$53,568,800	85.7%	Defined

Aberdeen Group plc

$53,108,710

2.01%

5,310,871

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
abrdn Inc.	5,310,871	$53,108,710	100.0%	Defined

UBS Group AG

$50,782,800

1.92%

5,078,280

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Financial Services Inc	12,829	$128,290	0.3%	Defined
UBS AG	5,065,451	$50,654,510	99.7%	Defined

BANK OF AMERICA CORP /DE/

$48,012,840

1.82%

4,801,284

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	775,402	$7,754,020	16.1%	Defined
MERRILL LYNCH, PIERCE, FENNER & SMITH INC.	29,367	$293,670	0.6%	Defined
BOFA SECURITIES, INC.	3,660,067	$36,600,670	76.2%	Defined
MANAGED ACCOUNT ADVISORS LLC joint	336,448	$3,364,480	7.0%	Defined

GOLDMAN SACHS GROUP INC

$44,818,740

1.70%

4,481,874

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	3,539,321	$35,393,210	79.0%	Defined
GOLDMAN SACHS ASSET MANAGEMENT, L.P.	915,743	$9,157,430	20.4%	Defined
Goldman Sachs Trust Company, N.A.	26,810	$268,100	0.6%	Defined

Frazier Life Sciences Management, L.P.

$40,092,400

1.52%

4,009,240

Nuveen, LLC

$40,072,370

1.52%

4,007,237

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Nuveen Asset Management, LLC joint	259,903	$2,599,030	6.5%	Defined
TIAA CREF INVESTMENT MANAGEMENT LLC joint	1,386,232	$13,862,320	34.6%	Defined
TEACHERS ADVISORS, LLC joint	2,361,102	$23,611,020	58.9%	Defined

MILLENNIUM MANAGEMENT LLC

$33,947,290

1.29%

3,394,729

GW&K Investment Management, LLC

$31,711,130

1.20%

3,171,113

JANE STREET GROUP, LLC

$27,626,830

1.05%

2,762,683

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	1,426,768	$14,267,680	51.6%	Defined
Jane Street Global Trading, LLC	1,335,915	$13,359,150	48.4%	Defined

DIMENSIONAL FUND ADVISORS LP

$27,187,810

1.03%

2,718,781

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Dimensional Ireland Ltd	2,670	$26,700	0.1%	Defined
Held directly	2,716,111	$27,161,110	99.9%	Sole

Fisher Asset Management, LLC

$26,040,270

0.99%

2,604,027

RENAISSANCE TECHNOLOGIES LLC

$25,302,900

0.96%

2,530,290

Kynam Capital Management, LP

$25,226,600

0.96%

2,522,660

Candriam S.C.A.

$25,149,490

0.95%

2,514,949

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$23,532,910

0.89%

2,353,291

RICE HALL JAMES & ASSOCIATES, LLC

$23,320,430

0.88%

2,332,043

NORTHERN TRUST CORP

$22,557,310

0.86%

2,255,731

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	2,073,718	$20,737,180	91.9%	Defined
NORTHERN TRUST GLOBAL INVESTMENTS LTD	145,946	$1,459,460	6.5%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC joint	36,067	$360,670	1.6%	Other

AQR CAPITAL MANAGEMENT LLC

$22,143,020

0.84%

2,214,302

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RF&L WEALTH MANAGEMENT, LLC	20	$200	0.0%	Other
Prism Planning Partners LLC	477	$4,770	0.0%	Other
Compound Planning, Inc.	39	$390	0.0%	Other
Arax Advisory Partners	18,271	$182,710	0.8%	Other
HALBERT HARGROVE GLOBAL ADVISORS, LLC	8,646	$86,460	0.4%	Other
Stokes Family Office, LLC	1,838	$18,380	0.1%	Other
Held directly	2,185,011	$21,850,110	98.7%	Defined

MORGAN STANLEY

$19,996,840

0.76%

1,999,684

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	314,771	$3,147,710	15.7%	Defined
MORGAN STANLEY & CO. LLC	852,005	$8,520,050	42.6%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	384,071	$3,840,710	19.2%	Defined
MORGAN STANLEY INVESTMENT MANAGEMENT INC	9,292	$92,920	0.5%	Defined
MORGAN STANLEY SMITH BARNEY LLC	32,743	$327,430	1.6%	Defined
Parametric Sas	3,551	$35,510	0.2%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	403,251	$4,032,510	20.2%	Defined

Nantahala Capital Management, LLC

$19,011,600

0.72%

1,901,160

Eversept Partners, LP

$18,656,530

0.71%

1,865,653

ORBIMED ADVISORS LLC

$18,520,000

0.70%

1,852,000

HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND

$18,449,120

0.70%

1,844,912

STIFEL FINANCIAL CORP

$18,262,340

0.69%

1,826,234

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STIFEL NICOLAUS & CO INC \MO\	21,085	$210,850	1.2%	Defined
1919 Investment Counsel, LLC	1,804,977	$18,049,770	98.8%	Defined
Held directly	172	$1,720	0.0%	Defined

VANGUARD FIDUCIARY TRUST CO

$17,595,730

0.67%

1,759,573

CITADEL ADVISORS LLC

$17,591,600

0.67%

1,759,160

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	1,759,160	$17,591,600	100.0%	Defined

JUPITER ASSET MANAGEMENT LTD

$16,428,740

0.62%

1,642,874

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jupiter Investment Management Limited	222,103	$2,221,030	13.5%	Defined
Held directly	1,420,771	$14,207,710	86.5%	Sole

IMC-Chicago, LLC

$16,343,360

0.62%

1,634,336

Parkman Healthcare Partners LLC

$16,242,790

0.62%

1,624,279

Legal & General Group Plc

$14,555,140

0.55%

1,455,514

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Legal & General Investment Management America Inc	22,603	$226,030	1.6%	Defined
Legal & General Investment Management Ltd joint	1,432,911	$14,329,110	98.4%	Defined

OP Asset Management Ltd

$13,409,900

0.51%

1,340,990

Pictet Asset Management Holding SA

$12,497,710

0.47%

1,249,771

Invesco Ltd.

$12,337,830

0.47%

1,233,783

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invesco Advisers, Inc. joint	36,093	$360,930	2.9%	Defined
Invesco Trust Co joint	92,776	$927,760	7.5%	Defined
Invesco Capital Management LLC	1,104,914	$11,049,140	89.6%	Defined

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$11,956,510

0.45%

1,195,651

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	1,195,651	$11,956,510	100.0%	Other

BNP PARIBAS ARBITRAGE, SA

$11,740,520

0.45%

1,174,052

FIRST TRUST ADVISORS LP

$11,204,690

0.42%

1,120,469

HRT FINANCIAL LP

$10,815,230

0.41%

1,081,523

JANE STREET GROUP, LLC

$9,944,130

0.38%

994,413

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	994,413	$9,944,130	100.0%	Defined

MOORE CAPITAL MANAGEMENT, LP

$8,483,360

0.32%

848,336

FMR LLC

$8,089,030

0.31%

808,903

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	806,233	$8,062,330	99.7%	Defined
STRATEGIC ADVISERS LLC	2,670	$26,700	0.3%	Defined

ExodusPoint Capital Management, LP

$7,449,170

0.28%

744,917

Man Group plc

$7,328,670

0.28%

732,867

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
AHL Partners LLP	387	$3,870	0.1%	Defined
Numeric Investors LLC	732,480	$7,324,800	99.9%	Defined

Rosalind Advisors, Inc.

$7,215,040

0.27%

721,504

Schonfeld Strategic Advisors LLC

$7,108,160

0.27%

710,816

Bank of New York Mellon Corp

$6,804,810

0.26%

680,481

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Investments Corporation	225,167	$2,251,670	33.1%	Defined
The Bank of New York Mellon	453,406	$4,534,060	66.6%	Defined
BNY Mellon, NA joint	1,907	$19,070	0.3%	Defined
Held directly	1	$10	0.0%	Defined

Jump Financial, LLC

$5,699,560

0.22%

569,956

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jump Trading Holdings, LLC	10,556	$105,560	1.9%	Defined
Leap GP LLC joint	559,400	$5,594,000	98.1%	Defined

DEUTSCHE BANK AG\

$5,633,610

0.21%

563,361

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DWS INVESTMENT MANAGEMENT AMERICAS, INC	5,082	$50,820	0.9%	Defined
DWS Investments UK Ltd	558,279	$5,582,790	99.1%	Defined

VOYA INVESTMENT MANAGEMENT LLC

$5,388,130

0.20%

538,813

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Voya Investment Management Co. LLC joint	538,813	$5,388,130	100.0%	Defined

JPMORGAN CHASE & CO

$5,254,490

0.20%

525,449

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JPMorgan Chase Bank, N.A.	121,724	$1,217,240	23.2%	Defined
J.P. Morgan Investment Management Inc.	374,336	$3,743,360	71.2%	Defined
J.P. Morgan Securities LLC	5,839	$58,390	1.1%	Defined
J.P. Morgan Securities plc	1,220	$12,200	0.2%	Defined
J.P. MORGAN MANSART MANAGEMENT Ltd	22,330	$223,300	4.2%	Defined

Elmind Capital, LP

$5,200,000

0.20%

520,000

Bridgewater Associates, LP

$4,910,570

0.19%

491,057

FRANKLIN RESOURCES INC

$4,803,640

0.18%

480,364

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
FIDUCIARY TRUST INTERNATIONAL LLC	11,130	$111,300	2.3%	Defined
FRANKLIN ADVISERS INC	440,618	$4,406,180	91.7%	Defined
FRANKLIN ADVISORY SERVICES LLC	13,335	$133,350	2.8%	Defined
Franklin Templeton International Services S.a r.l	833	$8,330	0.2%	Defined
PUTNAM ADVISORY CO LLC	14,448	$144,480	3.0%	Defined

PRINCIPAL FINANCIAL GROUP INC

$4,687,850

0.18%

468,785

NAN FUNG TRINITY (HK) LTD

$4,500,000

0.17%

450,000

SPHERA FUNDS MANAGEMENT LTD.

$4,220,510

0.16%

422,051

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Sphera Global Healthcare Management LP joint	422,051	$4,220,510	100.0%	Defined

Swiss National Bank

$4,152,680

0.16%

415,268

D. E. Shaw & Co., Inc.

$4,085,290

0.15%

408,529

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
D. E. SHAW & CO, L.P.	183,617	$1,836,170	44.9%	Defined
D. E. Shaw Investment Management, L.L.C. joint	224,912	$2,249,120	55.1%	Defined

Susquehanna Portfolio Strategies, LLC

$4,047,040

0.15%

404,704

DAFNA Capital Management LLC

$4,002,480

0.15%

400,248

Hudson Bay Capital Management LP

$4,000,000

0.15%

400,000

WEDGE CAPITAL MANAGEMENT L L P/NC

$3,808,010

0.14%

380,801

Aquatic Capital Management LLC

$3,628,950

0.14%

362,895

CITIGROUP INC

$3,601,890

0.14%

360,189

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citigroup Financial Products Inc. joint	360,189	$3,601,890	100.0%	Defined

Assenagon Asset Management S.A.

$3,530,440

0.13%

353,044

MACKENZIE FINANCIAL CORP

$3,472,990

0.13%

347,299

Phocas Financial Corp.

$3,405,410

0.13%

340,541

ALLIANCEBERNSTEIN L.P.

$3,279,090

0.12%

327,909

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Equitable Holdings, Inc.	327,909	$3,279,090	100.0%	Defined

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$3,238,000

0.12%

323,800

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	323,800	$3,238,000	100.0%	Other

UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC

$3,205,660

0.12%

320,566

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Group AG	14,697	$146,970	4.6%	Defined
UBS Asset Management Switzerland AG	215,477	$2,154,770	67.2%	Sole
UBS Asset Management (UK) Ltd.	62,078	$620,780	19.4%	Defined
Held directly	28,314	$283,140	8.8%	Defined

ALPS ADVISORS INC

$3,179,600

0.12%

317,960

PRICE T ROWE ASSOCIATES INC /MD/

$3,058,970

0.12%

305,897

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T. Rowe Price International Ltd	305,897	$3,058,970	100.0%	Defined

WELLINGTON MANAGEMENT GROUP LLP

$2,939,250

0.11%

293,925

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Wellington Management Company LLP	232,467	$2,324,670	79.1%	Defined
Wellington Managment Canada LLC	2,371	$23,710	0.8%	Defined
Wellington Management Hong Kong Ltd	3,209	$32,090	1.1%	Defined
Wellington Trust Company, NA joint	50,452	$504,520	17.2%	Defined
Wellington Management Europe GmbH	5,426	$54,260	1.8%	Defined

RHUMBLINE ADVISERS

$2,798,390

0.11%

279,839

NFJ INVESTMENT GROUP, LLC

$2,787,920

0.11%

278,792

Rafferty Asset Management, LLC

$2,656,180

0.10%

265,618

Point72 Asset Management, L.P.

$2,609,170

0.10%

260,917

WINTON GROUP Ltd

$2,556,000

0.10%

255,600

DOLIVER ADVISORS, LP

$2,535,052

0.10%

304,328

MARSHALL WACE, LLP

$2,527,640

0.10%

252,764

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Marshall Wace North America L.P. joint	252,764	$2,527,640	100.0%	Other

CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM

$2,512,300

0.10%

251,230

MARTINGALE ASSET MANAGEMENT L P

$2,425,080

0.09%

242,508

CITADEL ADVISORS LLC

$2,322,000

0.09%

232,200

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	232,200	$2,322,000	100.0%	Defined

IEQ CAPITAL, LLC

$2,274,210

0.09%

227,421

WELLS FARGO & COMPANY/MN

$2,228,940

0.08%

222,894

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO BANK N A	216,566	$2,165,660	97.2%	Defined
WELLS FARGO ADVISORS FINANCIAL NETWORK, LLC	1,875	$18,750	0.8%	Defined
WELLS FARGO CLEARING SERVICES, LLC	4,403	$44,030	2.0%	Defined
Wells Fargo Securities, LLC	50	$500	0.0%	Defined

HUSSMAN STRATEGIC ADVISORS, INC.

$2,100,000

0.08%

210,000

PFM Health Sciences, LP

$2,073,570

0.08%

207,357

VANGUARD ASSET MANAGEMENT, Ltd

$1,962,800

0.07%

196,280

TUDOR INVESTMENT CORP ET AL

$1,951,280

0.07%

195,128

Key facts CIK 882796 CUSIP 09058V103 13F (30d) 10 filings 9 filers Visit website Investor relations