SPRB · Spruce Biosciences, Inc. · Holdings

$55.62 -0.12 (-0.22%)

Russell 2000 member Rebalance outlook locked

Market Cap

$160.20M

2.87M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Use institutional holdings through the 13F API or MCP →

Quarter:

Holders: 63

Total Value: $108,159,246

Total Shares: 2,002,949

Institutional Ownership Trend

23 quarters

Holder Concentration

Across 63 13F filers · Δ vs Mar 31, 2026

Top Holder

12.5%

−3.9 pts

Top 5

45.9%

−10.0 pts

Top 10

65.9%

−16.6 pts

HHI

582

Broadly held−294

Quarterly Activity

vs Mar 31, 2026

New

Increased

Decreased

Sold Out

Unchanged

Holder count: +31

Institutional value: +123.7%

Shares held: +170.8%

Top Buyers

vs Mar 31, 2026

Institution	Added	Now Holds
Mega BlackRock, Inc.	+170,898	187,836
Mega VANGUARD CAPITAL MANAGEMENT LLC	+100,994	119,331
Mega GEODE CAPITAL MANAGEMENT, LLC	+57,659	70,548
Mega MILLENNIUM MANAGEMENT LLC	+49,093	160,981
Mega STATE STREET CORP	+45,050	50,450

Top Sellers

vs Mar 31, 2026

Institution	Sold	Now Holds
Large Balyasny Asset Management L.P.	−27,862	12,138
Mega CITADEL ADVISORS LLC	−18,094	51,905
Large JONES FINANCIAL COMPANIES LLLP	−163	30

Top New Positions

vs Mar 31, 2026

Institution	Acquired	Value (USD)
Mid AIGH Capital Management LLC	250,000	$13,500,000
Mid ORBIMED ADVISORS LLC	200,000	$10,800,000
Mid Cable Car Capital, LP	60,000	$3,240,000
Mid Eversept Partners, LP	40,000	$2,160,000
Mid Affinity Asset Advisors, LLC	30,000	$1,620,000

Top Sold-Out Positions

vs Mar 31, 2026

Institution	Previously Held	Last Value (USD)
Mega WELLINGTON MANAGEMENT GROUP LLP	48,796	$3,188,816
Small Squadron Capital Management LLC	12,200	$797,270
Small Resolute Capital Asset Partners LLC	4,000	$261,400
Mid Sound Income Strategies, LLC	200	$13,070

Filter: New 35 Increased 16 Reduced 3 Sold out 4 Unchanged 9

Showing 63 of 63

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

AIGH Capital Management LLC

$13,500,000

12.48%

250,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Worth Venture Partners, LLC	61,158	$3,302,532	24.5%	Other
Held directly	188,842	$10,197,468	75.5%	Sole

ORBIMED ADVISORS LLC

$10,800,000

9.99%

200,000

BlackRock, Inc.

$10,143,144

9.38%

187,836

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	340	$18,360	0.2%	Sole
BlackRock Investment Management, LLC	7,934	$428,436	4.2%	Sole
BLACKROCK ADVISORS LLC	6,057	$327,078	3.2%	Sole
BlackRock Fund Advisors	99,753	$5,386,662	53.1%	Sole
BlackRock Institutional Trust Company, N.A.	73,752	$3,982,608	39.3%	Sole

MILLENNIUM MANAGEMENT LLC

$8,692,974

8.04%

160,981

Ikarian Capital, LLC

$6,553,224

6.06%

121,356

VANGUARD CAPITAL MANAGEMENT LLC

$6,443,874

5.96%

119,331

Alyeska Investment Group, L.P.

$4,410,234

4.08%

81,671

GEODE CAPITAL MANAGEMENT, LLC

$3,809,592

3.52%

70,548

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	10,768	$581,472	15.3%	Defined
Held directly	59,780	$3,228,120	84.7%	Defined

ADAR1 Capital Management, LLC

$3,656,718

3.38%

67,717

Cable Car Capital, LP

$3,240,000

3.00%

60,000

CITADEL ADVISORS LLC

$2,802,870

2.59%

51,905

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	4,945	$267,030	9.5%	Defined
Held directly	46,960	$2,535,840	90.5%	Defined

STATE STREET CORP

$2,724,300

2.52%

50,450

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SSGA FUNDS MANAGEMENT, INC. joint	50,450	$2,724,300	100.0%	Defined

BOOTHBAY FUND MANAGEMENT, LLC

$2,272,320

2.10%

42,080

STEMPOINT CAPITAL LP

$2,234,952

2.07%

41,388

Eversept Partners, LP

$2,160,000

2.00%

40,000

Carlyle Group Inc.

$2,085,480

1.93%

38,620

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Abingworth LLP	38,620	$2,085,480	100.0%	Defined

GOLDMAN SACHS GROUP INC

$1,746,792

1.62%

32,348

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	27,409	$1,480,086	84.7%	Defined
GOLDMAN SACHS ASSET MANAGEMENT, L.P.	4,939	$266,706	15.3%	Defined

DIADEMA PARTNERS LP

$1,620,000

1.50%

30,000

Affinity Asset Advisors, LLC

$1,620,000

1.50%

30,000

Stonepine Capital Management, LLC

$1,554,930

1.44%

28,795

Point72 Asset Management, L.P.

$1,527,012

1.41%

28,278

Quinn Opportunity Partners LLC

$1,447,740

1.34%

26,810

UBS Group AG

$1,262,574

1.17%

23,381

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS AG	23,381	$1,262,574	100.0%	Defined

ExodusPoint Capital Management, LP

$1,188,000

1.10%

22,000

NORTHERN TRUST CORP

$1,138,482

1.05%

21,083

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	20,658	$1,115,532	98.0%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC joint	425	$22,950	2.0%	Other

Rosalind Advisors, Inc.

$1,080,000

1.00%

20,000

Knott David M Jr

$1,080,000

1.00%

20,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Dorset Partners LLC	20,000	$1,080,000	100.0%	Defined

AMERIPRISE FINANCIAL INC

$1,017,036

0.94%

18,834

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Columbia Management Investment Advisers, LLC	18,834	$1,017,036	100.0%	Defined

VANGUARD PORTFOLIO MANAGEMENT LLC

$998,784

0.92%

18,496

VANGUARD FIDUCIARY TRUST CO

$991,494

0.92%

18,361

Balyasny Asset Management L.P.

$655,452

0.61%

12,138

DIMENSIONAL FUND ADVISORS LP

$475,902

0.44%

8,813

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Dimensional Fund Advisors Ltd.	398	$21,492	4.5%	Defined
DFA Australia Ltd.	457	$24,678	5.2%	Defined
Held directly	7,958	$429,732	90.3%	Sole

Persistent Asset Partners Ltd

$414,558

0.38%

7,677

STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM

$387,828

0.36%

7,182

Bank of New York Mellon Corp

$366,066

0.34%

6,779

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Investments Corporation	2,237	$120,798	33.0%	Defined
The Bank of New York Mellon	4,541	$245,214	67.0%	Defined
Held directly	1	$54	0.0%	Defined

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$318,384

0.29%

5,896

RENAISSANCE TECHNOLOGIES LLC

$253,800

0.23%

4,700

MORGAN STANLEY

$238,194

0.22%

4,411

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	2	$108	0.0%	Defined
MORGAN STANLEY & CO. LLC	1,006	$54,324	22.8%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	136	$7,344	3.1%	Defined
MORGAN STANLEY SMITH BARNEY LLC	327	$17,658	7.4%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	2,940	$158,760	66.7%	Defined

Pale Fire Capital SE

$206,172

0.19%

3,818

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Barta Jan joint	3,818	$206,172	100.0%	Defined

RHUMBLINE ADVISERS

$190,026

0.18%

3,519

DEUTSCHE BANK AG\

$143,208

0.13%

2,652

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DWS Investments UK Ltd	2,652	$143,208	100.0%	Defined

WELLS FARGO & COMPANY/MN

$125,766

0.12%

2,329

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO BANK N A	2,329	$125,766	100.0%	Defined

NEW YORK STATE COMMON RETIREMENT FUND

$102,600

0.09%

1,900

CITIGROUP INC

$68,310

0.06%

1,265

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citigroup Financial Products Inc. joint	1,265	$68,310	100.0%	Defined

MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.

$67,608

0.06%

1,252

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Global X Management CO LLC joint	1,252	$67,608	100.0%	Defined

JPMORGAN CHASE & CO

$60,858

0.06%

1,127

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JPMorgan Chase Bank, N.A.	1,127	$60,858	100.0%	Defined

Lion Point Capital, LP

$54,000

0.05%

1,000

Police & Firemen's Retirement System of New Jersey

$46,656

0.04%

864

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Capital	864	$46,656	100.0%	Defined

BARCLAYS PLC

$36,396

0.03%

674

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BARCLAYS BANK PLC	381	$20,574	56.5%	Defined
BARCLAYS CAPITAL INC.	293	$15,822	43.5%	Defined

BNP PARIBAS ARBITRAGE, SA

$24,462

0.02%

453

Vanguard Global Advisers, LLC

$24,408

0.02%

452

FMR LLC

$18,522

0.02%

343

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	343	$18,522	100.0%	Defined

Legal & General Group Plc

$14,256

0.01%

264

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Legal & General Investment Management America Inc	264	$14,256	100.0%	Defined

Ameritas Investment Partners, Inc.

$13,338

0.01%

247

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
EATON VANCE MANAGEMENT	247	$13,338	100.0%	Other

Tower Research Capital LLC (TRC)

$13,284

0.01%

246

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Latour Trading LLC (Latour)	246	$13,284	100.0%	Defined

Russell Investments Group, Ltd.

$11,718

0.01%

217

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Russell Investment Management, LLC	217	$11,718	100.0%	Defined

SBI Securities Co., Ltd.

$10,854

0.01%

201

ROYAL BANK OF CANADA

$8,964

0.01%

166

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RBC CMA LTD.	120	$6,480	72.3%	Defined
RBC Capital Markets, LLC	46	$2,484	27.7%	Defined

Sterling Capital Management LLC

$2,322

0.00%

JONES FINANCIAL COMPANIES LLLP

$1,620

0.00%

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Edward D. Jones & Co., L.P.	30	$1,620	100.0%	Sole

CALDWELL SUTTER CAPITAL, INC.

$702

0.00%

Friedenthal Financial

$378

0.00%

Cassaday & Co Wealth Management LLC

$108

0.00%

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Wellington Management Company LLP	20,219	$1,321,311	41.4%	Defined
Wellington Management Singapore Pte. Ltd.	3,962	$258,916	8.1%	Defined
Wellington Management International Ltd	1,834	$119,851	3.8%	Defined
Wellington Trust Company, NA joint	22,781	$1,488,738	46.7%	Defined

Key facts CIK 1683553 CUSIP 85209E208 13F (30d) 46 filings 46 filers Visit website Investor relations