SPRB
Spruce Biosciences, Inc.Company with tickers: SPRB
CIK
1683553
CUSIP
85209E208
Shares Outstanding
2,752,278
13F Activity (30d)
27 filings
26 filers
Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.
Holders: 32
Total Value: $48,343,628
Total Shares: 739,765
Institutional Ownership Trend
9 quarters
Holder Concentration
Across 32 13F filers · Δ vs Dec 31, 2025Top Holder
16.4%
−2.0 pts
Top 5
55.9%
−0.3 pts
Top 10
82.4%
−0.6 pts
HHI
875
Broadly held−19
Quarterly Activity
vs Dec 31, 2025
New
13
Increased
5
Decreased
5
Sold Out
9
Unchanged
9
Holder count:
+4
Institutional value:
-15.9%
Shares held:
+12.1%
Top Buyers
vs Dec 31, 2025| Institution | Added | Now Holds | Open |
|---|---|---|---|
| Mid Quinn Opportunity Partners LLC | +4,000 | 26,810 | |
| Mid ADAR1 Capital Management, LLC | +600 | 58,600 | |
| Mega GEODE CAPITAL MANAGEMENT, LLC | +157 | 12,889 | |
| Mid Tower Research Capital LLC (TRC) | +139 | 140 | |
| Large JONES FINANCIAL COMPANIES LLLP | +109 | 193 |
Top Sellers
vs Dec 31, 2025| Institution | Sold | Now Holds | Open |
|---|---|---|---|
| Small Squadron Capital Management LLC | −57,800 | 12,200 | |
| Mid BOOTHBAY FUND MANAGEMENT, LLC | −5,853 | 42,080 | |
| Large ExodusPoint Capital Management, LP | −3,271 | 22,000 | |
| Mega STATE STREET CORP | −1,000 | 5,400 | |
| Mega UBS Group AG | −983 | 3,919 |
Top New Positions
vs Dec 31, 2025| Institution | Acquired | Value (USD) | Open |
|---|---|---|---|
| Mega MILLENNIUM MANAGEMENT LLC | 111,888 | $7,311,880 | |
| Mega WELLINGTON MANAGEMENT GROUP LLP | 48,796 | $3,188,816 | |
| Mega VANGUARD CAPITAL MANAGEMENT LLC | 18,337 | $1,198,322 | |
| Mega BlackRock, Inc. | 16,938 | $1,106,898 | |
| Small DIADEMA PARTNERS LP | 10,000 | $653,500 |
Top Sold-Out Positions
vs Dec 31, 2025| Institution | Previously Held | Last Value (USD) | Open |
|---|---|---|---|
| Large Schonfeld Strategic Advisors LLC | 24,767 | $2,157,453 | |
| Mid Caligan Partners LP | 20,514 | $1,786,974 | |
| Small Stonepine Capital Management, LLC | 19,742 | $1,719,725 | |
| Small SUPERSTRING CAPITAL MANAGEMENT LP | 12,137 | $1,057,254 | |
| Small SkyView Investment Advisors, LLC | 3,000 | $261,330 |
| Holder | Value (USD) | % of 13F | Shares | Type | Discretion | Filed | Open | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Mid Ikarian Capital, LLC | $7,930,614 | 16.40% | 121,356 | Shares | Sole | 2026-05-15 | ||||
| Mega MILLENNIUM MANAGEMENT LLC | $7,311,880 | 15.12% | 111,888 | Shares | Sole | 2026-05-15 | ||||
| Mega CITADEL ADVISORS LLC | $4,574,434 | 9.46% | 69,999 | Shares | Defined | 2026-05-15 | ||||
| Mid ADAR1 Capital Management, LLC | $3,829,510 | 7.92% | 58,600 | Shares | Sole | 2026-05-18 | ||||
| Large Alyeska Investment Group, L.P. | $3,376,699 | 6.98% | 51,671 | Shares | Sole | 2026-05-15 | ||||
| Mega WELLINGTON MANAGEMENT GROUP LLP | $3,188,816 | 6.60% | 48,796 | Shares | Defined | 2026-05-15 | ||||
| Mid BOOTHBAY FUND MANAGEMENT, LLC | $2,749,928 | 5.69% | 42,080 | Shares | Other | 2026-05-15 | ||||
| Large Balyasny Asset Management L.P. | $2,614,000 | 5.41% | 40,000 | Shares | Sole | 2026-05-15 | ||||
| Large Carlyle Group Inc. | $2,523,817 | 5.22% | 38,620 | Shares | Defined | 2026-05-08 | ||||
| Mid Quinn Opportunity Partners LLC | $1,752,033 | 3.62% | 26,810 | Shares | Sole | 2026-05-15 | ||||
| Large ExodusPoint Capital Management, LP | $1,437,700 | 2.97% | 22,000 | Shares | Sole | 2026-05-14 | ||||
| Mega VANGUARD CAPITAL MANAGEMENT LLC | $1,198,322 | 2.48% | 18,337 | Shares | Defined | 2026-05-15 | ||||
| Mega BlackRock, Inc. | $1,106,898 | 2.29% | 16,938 | Shares | Sole | 2026-05-13 | ||||
| Mega GEODE CAPITAL MANAGEMENT, LLC | $842,295 | 1.74% | 12,889 | Shares | Defined | 2026-05-15 | ||||
| Small Squadron Capital Management LLC | $797,270 | 1.65% | 12,200 | Shares | Sole | 2026-05-15 | ||||
| Small DIADEMA PARTNERS LP | $653,500 | 1.35% | 10,000 | Shares | Sole | 2026-05-15 | ||||
| Small STEMPOINT CAPITAL LP | $415,626 | 0.86% | 6,360 | Shares | Sole | 2026-05-18 | ||||
| Mega VANGUARD FIDUCIARY TRUST CO Bank | $360,339 | 0.75% | 5,514 | Shares | Defined | 2026-05-15 | ||||
| Mega GOLDMAN SACHS GROUP INC | $359,817 | 0.74% | 5,506 | Shares | Defined | 2026-05-15 | ||||
| Mega STATE STREET CORP | $352,890 | 0.73% | 5,400 | Shares | Defined | 2026-05-15 | ||||
| Small Resolute Capital Asset Partners LLC | $261,400 | 0.54% | 4,000 | Shares | Sole | 2026-05-15 | ||||
| Mega UBS Group AG | $256,106 | 0.53% | 3,919 | Shares | Defined | 2026-05-05 | ||||
| Small Persistent Asset Partners Ltd | $165,204 | 0.34% | 2,528 | Shares | Sole | 2026-05-12 | ||||
| Mega MORGAN STANLEY | $92,469 | 0.19% | 1,415 | Shares | Defined | 2026-05-15 | ||||
| Micro Lion Point Capital, LP | $65,350 | 0.14% | 1,000 | Shares | Sole | 2026-05-15 | ||||
| Mega CITIGROUP INC | $61,363 | 0.13% | 939 | Shares | Defined | 2026-05-11 | ||||
| Mega Vanguard Global Advisers, LLC | $29,538 | 0.06% | 452 | Shares | Defined | 2026-05-15 | ||||
| Mid Sound Income Strategies, LLC | $13,070 | 0.03% | 200 | Shares | Sole | 2026-04-27 | ||||
| Large JONES FINANCIAL COMPANIES LLLP | $12,612 | 0.03% | 193 | Shares | Sole | 2026-05-15 | ||||
| Mid Tower Research Capital LLC (TRC) | $9,149 | 0.02% | 140 | Shares | Defined | 2026-05-15 | ||||
| Small CALDWELL SUTTER CAPITAL, INC. | $849 | 0.00% | 13 | Shares | Sole | 2026-05-06 | ||||
| Small Cassaday & Co Wealth Management LLC | $130 | 0.00% | 2 | Shares | Sole | 2026-05-07 | ||||
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