SPRB · Spruce Biosciences, Inc. · Holdings

$44.18 -0.97 (-2.15%)

Russell 2000 member Rebalance outlook locked

Market Cap

$127.58M

2.87M

Volume · Oct 26 47.49K Avg daily vol (3M) 80.17K

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Use institutional holdings through the 13F API or MCP → See every holder of SPRB: 13F, 13D and 13G, insiders and funds →

The Sep 30, 2026 filing window is still open — showing the latest known positions. Funds that have not filed yet carry their prior-quarter positions; a fund that filed without this stock counts as sold out. Each fund's Change is measured against its own previous reported quarter, shown in the Reported column. Pick a completed quarter in the Quarter selector below to put every fund on one quarter and see the stock-wide activity breakdown.

Quarter:

Holders: 67

Total Value: $108,325,265

Total Shares: 2,006,059

Institutional Ownership Trend

24 quarters

Holder Concentration

Across 64 13F filers

Top Holder

12.5%

of institutional value

Top 5

45.9%

of institutional value

Top 10

65.8%

of institutional value

HHI

580

Broadly held

Who Holds SPRB

Last 8 quarters through Sep 30, 2026 (filing window open)

Each kind of 13F filer's share of the common shares 13F filers report. Holder type comes from regulatory records, never the filer's name; style, turnover and horizon are measured from each filer's own 13F book. The quarter selector does not change this card.

Jun 30, 2026, the newest closed quarter: 64 filers, like-for-like change +171.2%; actively managed books +119.8%; index-like books +695.3%.

Holder type	Share	Filers	Change	New	Exited
Registered adviser	65.6%	31	+103.1%	13	3
Exempt adviser	0.4%	1	+203.7%	0	0
Adviser	0.9%	1	new	1	0
Bank	5.3%	9	+945.6%	6	0
Benefit plan	0.4%	1	new	1	0
Non-US	0.2%	3	new	3	0
Holding company	11.4%	5	+214.9%	2	1
Broker-dealer	0.0%	0	—	0	0
Unknown	15.8%	13	+5306.9%	10	0

Style	Share	Filers	Change	New	Exited
Index-like	26.2%	14	+695.3%	7	0
Systematic-like	18.8%	6	+19.5%	1	0
Concentrated	21.1%	10	+592.4%	6	1
Diversified active	34.0%	34	+129.4%	22	3
Unknown	0.0%	0	—	0	0
Not measured	0.0%	0	—	0	0

Turnover	Share	Filers	Change	New	Exited
Low turnover	24.5%	30	+504.8%	21	1
Medium turnover	25.4%	16	+263.2%	11	1
High turnover	42.4%	14	+76.3%	3	1
Unknown	7.8%	4	+329.1%	1	1
Not measured	0.0%	0	—	0	0

Holding horizon	Share	Filers	Change	New	Exited
Short horizon	28.3%	10	+633.6%	3	1
Medium horizon	26.1%	15	+118.1%	10	1
Long horizon	24.1%	32	+84.8%	20	2
Unknown	21.5%	7	+168.4%	3	0
Not measured	0.0%	0	—	0	0

13F book size	Share	Filers	Change	New	Exited
Under $1B	13.6%	11	+73.5%	5	2
$1B to $10B	36.0%	14	+464.1%	9	1
$10B to $100B	9.9%	10	+30.4%	6	0
$100B or more	40.5%	29	+169.0%	16	1
Not measured	0.0%	0	—	0	0

Client base	Share	Filers	Change	New	Exited
Individuals and high net worth	0.0%	2	-93.0%	0	1
Pooled investment vehicles	52.9%	20	+75.4%	6	1
Registered funds and BDCs	11.1%	5	+614.4%	3	0
Insurance companies	0.0%	1	new	1	0
Governments and sovereign funds	0.2%	1	new	1	0
Other investment advisers	0.0%	0	—	0	0
Diversified	0.0%	1	new	1	0
Unknown	35.8%	34	+593.7%	24	2

Private funds	Share	Filers	Change	New	Exited
Hedge funds	42.8%	19	+48.9%	6	1
Private equity funds	1.9%	1	-9.4%	0	1
Other private funds	10.6%	3	new	3	0
Mixed private funds	0.0%	0	—	0	0
No private funds	10.7%	9	+574.2%	4	1
Unknown	34.0%	32	+667.8%	23	1

Location	Share	Filers	Change	New	Exited
United States	97.0%	54	+165.4%	28	4
Outside the US	3.0%	10	+832.0%	8	0

The Sep 30, 2026 filing window is still open, so its bar carries the Jun 30, 2026 positions of filers that have not filed yet.

How the mix is measured

Shares are 13F common shares restated to today's split basis; options and principal amounts are left out. The change compares only filers with a 13F in both quarters and keeps each filer in its bucket of the later quarter on both sides; a filer that continues under a new CIK is compared through its successor. Holder type comes from each filer's current regulatory profile; client base and private funds come from the Form ADV roster current at each quarter end (rosters from December 2019, so an earlier quarter reads Unknown). Style, turnover, horizon and book size are measured from each filer's 13F book in the newest measured quarter, and Not measured means none was. Actively managed books are those measured systematic-like, concentrated or diversified active.

Conviction and Crowding

64 13F filers, quarter ended Jun 30, 2026

Measured across every 13F filer's common-share book once the quarter's filing window closed. Crowding counts filers with high turnover or that advise private funds on Form ADV.

Conviction holders

1.56% of filers hold it in their top 10

Mar 31, 2026: 1

Holders above 5%

median weight 0.000%

Mar 31, 2026: 0

Crowding

49.4%

of shares outstanding, 97th percentile

Mar 31, 2026: 45.1%

Private-fund advisers

40.3%

of shares outstanding

Institutional ownership

72.9%

73.7% of the estimated free float

Top 10 holders

65.8%

of 13F shares, Herfindahl 0.058

Active holders

+119.8%

like-for-like share change of active filers

5% stakes on record

0 13D, 5 13G (3 institutional, 2 passive, 0 exempt)

How long holders have held it value-weighted 2.3 quarters

Under 1 year 90.6% 1 to 3 years 9.41% 3 years or more 0.001% Since coverage start 0.000%

Managers in the top fifth by current three-year FundScore alpha were net buyers of $1,118,130 (1 buying, 0 selling).

Estimated Holder Cost Basis

Quarter ended Jun 30, 2026, on that quarter's share basis

Estimated, never filed: each 13F buy is costed at its quarter's average traded price and each sale keeps the average cost, so this is what holders paid on average if they traded evenly through each quarter.

Estimated avg cost

$66.04

estimated per share

Mar 31, 2026: $97.03

Quarter-end price

$54.00

implied by 13F values

Estimated gain or loss

-18.2%

price against the estimated cost

Estimated at a loss

100.0%

of costed 13F value

Estimated cost covers 83.7% of the 13F shares; positions already held when a filer's 13F history starts, or bought in a quarter without a trusted average price, have no estimate.

Shared Holders

Companies SPRB's active holders also own, quarter ended Jun 30, 2026

#	Company	Shared holders	Similarity
1	PTHS Pelthos Therapeutics Inc.	5	0.505
2	EQ Equillium, Inc.	5	0.403
3	HELP Helus Pharma Inc.	7	0.399
4	CUE Cue Biopharma, Inc.	4	0.378
5	QTTB Q32 Bio Inc.	5	0.334
6	NXTC NextCure, Inc.	3	0.327
7	CNTB Connect Biopharma Holdings Ltd	4	0.322
8	RLMD Relmada Therapeutics, Inc.	6	0.321
9	VSTM Verastem, Inc.	5	0.315
10	OVID Ovid Therapeutics Inc.	5	0.307

Shareholder Targets

13F filers that own its peers but not SPRB, quarter ended Jun 30, 2026

Found through its holder-overlap peers: PTHS, EQ, HELP, CUE, QTTB, NXTC, CNTB, RLMD, VSTM, OVID, PRQR, QNRX, FBRX, KLRS, ACET, CLRB, TLPH, MLYS, MNPR, ARDX. 510 filers in all.

#	Filer	In peers	Of book	Largest peers
1	RA CAPITAL MANAGEMENT, L.P. Registered adviser, Concentrated	$345,256,342 6 held	3.04%	MLYS, MNPR, QTTB
2	Jupiter Topco LLC Unknown, Diversified active	$333,081,392 8 held	0.140%	MNPR, RLMD, OVID
3	Catalys Pacific, LLC Exempt adviser, Unknown	$213,245,549 1 held	92.9%	MLYS
4	SAMSARA BIOCAPITAL, LLC Registered adviser, Concentrated	$210,826,447 2 held	17.3%	MLYS, KLRS
5	DEERFIELD MANAGEMENT COMPANY, L.P. Registered adviser, Diversified active	$136,762,389 2 held	2.32%	MLYS, MNPR
6	ADAGE CAPITAL PARTNERS GP, L.L.C. Registered adviser, Diversified active	$128,045,088 9 held	0.180%	RLMD, HELP, MNPR
7	Rubric Capital Management LP Registered adviser, Diversified active	$82,633,770 1 held	0.760%	ARDX
8	ARMISTICE CAPITAL, LLC Registered adviser, Diversified active	$73,668,960 2 held	2.04%	MLYS, VSTM
9	Venrock Adviser, LLC Registered adviser, Concentrated	$72,822,022 2 held	2.21%	RLMD, HELP
10	Laurion Capital Management LP Registered adviser, Concentrated	$67,615,980 1 held	5.11%	MLYS

Fund Ownership of SPRB by Fund Type

Registered funds' Form N-PORT reports for the quarter ended Jun 30, 2026

Index funds and index ETFs hold 8.48% of shares outstanding.

Fund type	Of shares outstanding	Change	Shares	Funds
Index funds	1.04%	+0.69 pp	30,027	30
Index ETFs	7.44%	+6.81 pp	213,783	6
Active ETFs	0.07%	+0.07 pp	2,017	3
Active funds	0.26%	+0.26 pp	7,512	14
Unclassified	0.00%	0.00 pp	0	0
All registered funds	8.81%	+7.84 pp	253,339	53

How fund types are measured

Each fund series counts once, with its latest Form N-PORT report dated inside the quarter; only long share positions count, restated to today's split basis. The fund type is the series' latest Form N-CEN answer on or before the quarter end (the index-fund box and the exchange-traded flag), never its name. Unclassified funds have no usable N-CEN; unit investment trusts are among them, so index ownership is a floor. Funds sit inside their advisers' 13F reports, so these shares overlap the 13F figures and are never added to them.

Holder type: Registered adviser 34 Exempt adviser 1 Adviser 1 Bank 9 Benefit plan 1 Non-US 3 Holding company 5 Unknown 13

Showing 67 of 67

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

AIGH Capital Management LLC

$13,500,000

12.46%

250,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Worth Venture Partners, LLC	61,158	$3,302,532	24.5%	Other
Held directly	188,842	$10,197,468	75.5%	Sole

ORBIMED ADVISORS LLC

$10,800,000

9.97%

200,000

BlackRock, Inc.

$10,143,144

9.36%

187,836

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	340	$18,360	0.2%	Sole
BlackRock Investment Management, LLC	7,934	$428,436	4.2%	Sole
BLACKROCK ADVISORS LLC	6,057	$327,078	3.2%	Sole
BlackRock Fund Advisors	99,753	$5,386,662	53.1%	Sole
BlackRock Institutional Trust Company, N.A.	73,752	$3,982,608	39.3%	Sole

MILLENNIUM MANAGEMENT LLC

$8,692,974

8.02%

160,981

Ikarian Capital, LLC

$6,553,224

6.05%

121,356

VANGUARD CAPITAL MANAGEMENT LLC

$6,443,874

5.95%

119,331

Alyeska Investment Group, L.P.

$4,410,234

4.07%

81,671

GEODE CAPITAL MANAGEMENT, LLC

$3,809,592

3.52%

70,548

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	10,768	$581,472	15.3%	Defined
Held directly	59,780	$3,228,120	84.7%	Defined

ADAR1 Capital Management, LLC

$3,656,718

3.38%

67,717

Cable Car Capital, LP

$3,240,000

2.99%

60,000

CITADEL ADVISORS LLC

$2,802,870

2.59%

51,905

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	4,945	$267,030	9.5%	Defined
Held directly	46,960	$2,535,840	90.5%	Defined

STATE STREET CORP

$2,724,300

2.51%

50,450

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SSGA FUNDS MANAGEMENT, INC. joint	50,450	$2,724,300	100.0%	Defined

BOOTHBAY FUND MANAGEMENT, LLC

$2,272,320

2.10%

42,080

STEMPOINT CAPITAL LP

$2,234,952

2.06%

41,388

Eversept Partners, LP

$2,160,000

1.99%

40,000

Carlyle Group Inc.

$2,085,480

1.93%

38,620

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Abingworth LLP	38,620	$2,085,480	100.0%	Defined

GOLDMAN SACHS GROUP INC

$1,746,792

1.61%

32,348

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	27,409	$1,480,086	84.7%	Defined
GOLDMAN SACHS ASSET MANAGEMENT, L.P.	4,939	$266,706	15.3%	Defined

DIADEMA PARTNERS LP

$1,620,000

1.50%

30,000

Affinity Asset Advisors, LLC

$1,620,000

1.50%

30,000

Stonepine Capital Management, LLC

$1,554,930

1.44%

28,795

Point72 Asset Management, L.P.

$1,527,012

1.41%

28,278

Quinn Opportunity Partners LLC

$1,447,740

1.34%

26,810

UBS Group AG

$1,262,574

1.17%

23,381

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS AG	23,381	$1,262,574	100.0%	Defined

ExodusPoint Capital Management, LP

$1,188,000

1.10%

22,000

NORTHERN TRUST CORP

$1,138,482

1.05%

21,083

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	20,658	$1,115,532	98.0%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC joint	425	$22,950	2.0%	Other

Rosalind Advisors, Inc.

$1,080,000

1.00%

20,000

Knott David M Jr

$1,080,000

1.00%

20,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Dorset Partners LLC	20,000	$1,080,000	100.0%	Defined

AMERIPRISE FINANCIAL INC

$1,017,036

0.94%

18,834

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Columbia Management Investment Advisers, LLC	18,834	$1,017,036	100.0%	Defined

VANGUARD PORTFOLIO MANAGEMENT LLC

$998,784

0.92%

18,496

VANGUARD FIDUCIARY TRUST CO

$991,494

0.92%

18,361

Balyasny Asset Management L.P.

$655,452

0.61%

12,138

DIMENSIONAL FUND ADVISORS LP

$475,902

0.44%

8,813

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Dimensional Fund Advisors Ltd.	398	$21,492	4.5%	Defined
DFA Australia Ltd.	457	$24,678	5.2%	Defined
Held directly	7,958	$429,732	90.3%	Sole

Persistent Asset Partners Ltd

$414,558

0.38%

7,677

STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM

$387,828

0.36%

7,182

Bank of New York Mellon Corp

$366,066

0.34%

6,779

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Investments Corporation	2,237	$120,798	33.0%	Defined
The Bank of New York Mellon	4,541	$245,214	67.0%	Defined
Held directly	1	$54	0.0%	Defined

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$318,384

0.29%

5,896

RENAISSANCE TECHNOLOGIES LLC

$253,800

0.23%

4,700

MORGAN STANLEY

$238,194

0.22%

4,411

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	2	$108	0.0%	Defined
MORGAN STANLEY & CO. LLC	1,006	$54,324	22.8%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	136	$7,344	3.1%	Defined
MORGAN STANLEY SMITH BARNEY LLC	327	$17,658	7.4%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	2,940	$158,760	66.7%	Defined

Pale Fire Capital SE

$206,172

0.19%

3,818

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Barta Jan joint	3,818	$206,172	100.0%	Defined

RHUMBLINE ADVISERS

$190,026

0.18%

3,519

SkyView Investment Advisors, LLC

$162,000

0.15%

3,000

DEUTSCHE BANK AG\

$143,208

0.13%

2,652

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DWS Investments UK Ltd	2,652	$143,208	100.0%	Defined

WELLS FARGO & COMPANY/MN

$125,766

0.12%

2,329

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO BANK N A	2,329	$125,766	100.0%	Defined

NEW YORK STATE COMMON RETIREMENT FUND

$102,600

0.09%

1,900

CITIGROUP INC

$68,310

0.06%

1,265

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citigroup Financial Products Inc. joint	1,265	$68,310	100.0%	Defined

MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.

$67,608

0.06%

1,252

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Global X Management CO LLC joint	1,252	$67,608	100.0%	Defined

JPMORGAN CHASE & CO

$60,858

0.06%

1,127

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JPMorgan Chase Bank, N.A.	1,127	$60,858	100.0%	Defined

Lion Point Capital, LP

$54,000

0.05%

1,000

Police & Firemen's Retirement System of New Jersey

$46,656

0.04%

864

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Capital	864	$46,656	100.0%	Defined

BARCLAYS PLC

$36,396

0.03%

674

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BARCLAYS BANK PLC	381	$20,574	56.5%	Defined
BARCLAYS CAPITAL INC.	293	$15,822	43.5%	Defined

BNP PARIBAS ARBITRAGE, SA

$24,462

0.02%

453

Vanguard Global Advisers, LLC

$24,408

0.02%

452

FMR LLC

$18,522

0.02%

343

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	343	$18,522	100.0%	Defined

Legal & General Group Plc

$14,256

0.01%

264

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Legal & General Investment Management America Inc	264	$14,256	100.0%	Defined

Ameritas Investment Partners, Inc.

$13,338

0.01%

247

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
EATON VANCE MANAGEMENT	247	$13,338	100.0%	Other

Tower Research Capital LLC (TRC)

$13,284

0.01%

246

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Latour Trading LLC (Latour)	246	$13,284	100.0%	Defined

Russell Investments Group, Ltd.

$11,718

0.01%

217

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Russell Investment Management, LLC	217	$11,718	100.0%	Defined

SBI Securities Co., Ltd.

$9,764

0.01%

201

ROYAL BANK OF CANADA

$8,964

0.01%

166

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RBC CMA LTD.	120	$6,480	72.3%	Defined
RBC Capital Markets, LLC	46	$2,484	27.7%	Defined

GAMMA Investing LLC

$4,129

0.00%

Sterling Capital Management LLC

$2,866

0.00%

JONES FINANCIAL COMPANIES LLLP

$1,620

0.00%

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Edward D. Jones & Co., L.P.	30	$1,620	100.0%	Sole

CALDWELL SUTTER CAPITAL, INC.

$702

0.00%

Root Financial Partners, LLC

$388

0.00%

Friedenthal Financial

$378

0.00%

Cassaday & Co Wealth Management LLC

$108

0.00%

Farther Finance Advisors, LLC

$48

0.00%

Key facts CIK 1683553 CUSIP 85209E208 13F (30d) 5 filings 5 filers Visit website Investor relations