MILLENNIUM MANAGEMENT LLC

Position in SPRB — Spruce Biosciences, Inc.

CIK 1273087 NEW YORK, NY

Position in SPRB

as of Jun 30, 2026 · filed Aug 14, 2026 Compact

Position Value

$8,692,974

+$1,381,094 QoQ

Shares Held

160,981

+43.9% QoQ

Ownership

5.60%

of shares outstanding

% of Portfolio

0.01%

of 13F equity value

Holder Rank

of 63 holders

Holding Since

Dec 2020

14 quarters on record

Voting authority Sole 100% Shared 0% None 0%

Healthcare · as of Jun 30, 2026

MILLENNIUM MANAGEMENT LLC holds $4,631,421,099 across 322 Biotechnology names. SPRB ranks #124 (0.2% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	VRTX	Vertex Pharmaceuticals Inc / Ma	468,410	$232,673,299
2	INSM	INSMED Inc	2,048,005	$218,358,293
3	APGE	Apogee Therapeutics, Inc.	1,491,404	$197,954,052
4	JAZZ	Jazz Pharmaceuticals plc	763,880	$184,072,163
5	ONC	BeOne Medicines Ltd.	543,323	$154,830,755
6	AXSM	Axsome Therapeutics, Inc.	556,088	$136,113,659
7	BMRN	Biomarin Pharmaceutical Inc	2,071,816	$118,549,311
8	REGN	Regeneron Pharmaceuticals, Inc.	165,120	$102,958,924

14 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-06-30	$8,692,974	160,981	+43.9%	Shares	Sole	2026-08-14
2026-03-31	$7,311,880	111,888	+9.5%	Shares	Sole	2026-05-15
2024-03-31	$80,347	102,223	-80.0%	Shares	Sole	2024-05-15
2023-12-31	$1,495,592	510,441	-12.5%	Shares	Sole	2024-02-14
2023-09-30	$1,318,646	583,472	+1.0%	Shares	Sole	2023-11-14
2023-06-30	$1,241,964	577,658	-5.1%	Shares	Sole	2023-08-14
2023-03-31	$1,345,547	608,845	+312.8%	Shares	Sole	2023-05-15
2022-12-31	$161,803	147,496	+1.7%	Shares	Sole	2023-02-14
2022-09-30	$198,670	145,015	-23.7%	Shares	Sole	2022-11-14
2022-06-30	$330,855	190,147	+392.3%	Shares	Sole	2022-08-15
2021-09-30	$232,118	38,622	+124.3%	Shares	Sole	2021-11-15
2021-06-30	$192,991	17,216	-76.4%	Shares	Sole	2021-08-16
2021-03-31	$1,213,144	73,081	-41.4%	Shares	Sole	2021-05-17
2020-12-31	$3,031,651	124,708	—	Shares	Sole	2021-02-16
No filing history on record for this holder in this stock.