SPRB · Spruce Biosciences, Inc. · Shareholders & Ownership

$44.18 -0.97 (-2.15%)

Russell 2000 member Rebalance outlook locked

Market Cap

$127.58M

2.87M

Volume · Oct 26 47.49K Avg daily vol (3M) 80.17K

Every disclosed holder of SPRB in one list: 13F institutions, Schedule 13D and 13G filers, insiders (Forms 3, 4 and 5) and registered funds, each from its own latest filing. Holders nest by CIK and SEC reporting links, never by name, and each is summed once.

How the holder list picks a filing →

Who Owns SPRB

13F quarter Sep 30, 2026, combined view: filers that have not filed yet carry their Jun 30, 2026 positions

Holder group	Holders	Shares	% Out	Summed
Institutional (13F)	67	2,006,059	69.80%	Yes
Insiders (Forms 3, 4, 5)	5	31,984	1.11%	Yes
13D/G-only blocks	12	824,114	28.67%	Yes
Remaining	—	11,856	0.41%	Rest
Registered funds (N-PORT, not summed)	69	302,907	10.54%	No

Shares outstanding: 2,874,013, the issuer's latest cover-page count restated onto today's split basis.

13D/G-only counts each filer's latest 13D or 13G that no 13F report of the listing contains, that names no 13F filer and that no counted insider files. Funds are never summed: their shares sit inside their advisers' 13F reports.

Holders of SPRB

One row per holder Every filing By ultimate parent

All 13F Funds Insiders 13D/G Non-US

#	Holder	Shares	% Out	Change	As of	Notes
1	AIGH Capital Management LLC 13F CIK 1835943 · Unknown · Jun 30, 2026 carried, not yet filed for the newest quarter	250,000	8.70%	+250,000	Jun 30, 2026	carried, not yet filed for the newest quarter
2	Orin Hirschman 13G CIK 1131362 · Investment adviser · Jun 30, 2026 Rule 13d-1(b), qualified institution	250,000	8.70%	—	Jun 30, 2026	Rule 13d-1(b), qualified institution
3	ORBIMED ADVISORS LLC 13F CIK 1055951 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	200,000	6.96%	+200,000	Jun 30, 2026	carried, not yet filed for the newest quarter
3.1	ORBIMED ADVISORS LLC 13G CIK 1055951 · Registered investment adviser · Jun 30, 2026 Rule 13d-1(b), qualified institution, not summed	132,200	4.60%	—	Jun 30, 2026	Rule 13d-1(b), qualified institution, not summed
4	BlackRock, Inc. 13F CIK 2012383 · Holding company · Jun 30, 2026 carried, not yet filed for the newest quarter	187,836	6.54%	+170,898	Jun 30, 2026	carried, not yet filed for the newest quarter
4.1	BlackRock, Inc. 13G CIK 2012383 · Holding company · Jun 30, 2026 Rule 13d-1(b), qualified institution, not summed	187,836	6.54%	—	Jun 30, 2026	Rule 13d-1(b), qualified institution, not summed
4.2	iShares Russell 2000 ETF Fund S000004344 · Registered fund · Jun 30, 2026 iShares Trust, not summed	65,222	2.27%	—	Jun 30, 2026	iShares Trust, not summed
4.3	iShares Russell 2000 Value ETF Fund S000004342 · Registered fund · Jun 30, 2026 iShares Trust, not summed	16,862	0.59%	—	Jun 30, 2026	iShares Trust, not summed
4.4	iShares Micro-Cap ETF Fund S000004439 · Registered fund · Jun 30, 2026 iShares Trust, not summed	8,665	0.30%	—	Jun 30, 2026	iShares Trust, not summed
4.5	iShares Russell 2000 Growth ETF Fund S000004343 · Registered fund · Jun 30, 2026 iShares Trust, not summed	6,207	0.22%	—	Jun 30, 2026	iShares Trust, not summed
5	MILLENNIUM MANAGEMENT LLC 13F CIK 1273087 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	160,981	5.60%	+49,093	Jun 30, 2026	carried, not yet filed for the newest quarter
6	Millennium Management LLC 13G CIK 1319244 · Unknown · Jun 30, 2026 Rule 13d-1(c), passive investor	160,981	5.60%	+57,955	Jun 30, 2026	Rule 13d-1(c), passive investor
7	AWM Investment Company, Inc. 13G CIK 1535264 · Registered investment adviser · Jun 30, 2026 Rule 13d-1(b), qualified institution	146,988	5.11%	—	Jun 30, 2026	Rule 13d-1(b), qualified institution
8	Ikarian Capital, LLC 13F CIK 1778253 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	121,356	4.22%	0	Jun 30, 2026	carried, not yet filed for the newest quarter
9	VANGUARD CAPITAL MANAGEMENT LLC 13F CIK 2100119 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	119,331	4.15%	+100,994	Jun 30, 2026	carried, not yet filed for the newest quarter
10	VANGUARD TOTAL STOCK MARKET INDEX FUND Fund S000002848 · Registered fund · Jun 30, 2026 VANGUARD INDEX FUNDS, not summed	84,935	2.96%	+78,896	Jun 30, 2026	VANGUARD INDEX FUNDS, not summed
11	Alyeska Investment Group, L.P. 13F CIK 1453072 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	81,671	2.84%	+30,000	Jun 30, 2026	carried, not yet filed for the newest quarter
12	GEODE CAPITAL MANAGEMENT, LLC 13F CIK 1214717 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	70,548	2.45%	+57,659	Jun 30, 2026	carried, not yet filed for the newest quarter
13	Boone Peter David Mr 13G CIK 2096947 · Unknown · Nov 21, 2025 Rule 13d-1(c), passive investor	68,184	2.37%	—	Nov 21, 2025	Rule 13d-1(c), passive investor
14	ADAR1 Capital Management, LLC 13F CIK 1940272 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	67,717	2.36%	+9,117	Jun 30, 2026	carried, not yet filed for the newest quarter
14.1	ADAR1 Capital Management, LLC 13G CIK 1940272 · Registered investment adviser · Jun 30, 2026 Rule 13d-1(b), qualified institution, not summed	67,717	2.36%	+9,717	Jun 30, 2026	Rule 13d-1(b), qualified institution, not summed
15	Cable Car Capital, LP 13F CIK 1699575 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	60,000	2.09%	+60,000	Jun 30, 2026	carried, not yet filed for the newest quarter
16	CITADEL ADVISORS LLC 13F CIK 1423053 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	51,905	1.81%	-18,094	Jun 30, 2026	carried, not yet filed for the newest quarter
16.1	CITADEL ADVISORS LLC 13G CIK 1423053 · Registered investment adviser · Jun 30, 2026 Rule 13d-1(c), passive investor, not summed	51,919	1.81%	-18,146	Jun 30, 2026	Rule 13d-1(c), passive investor, not summed
17	STATE STREET CORP 13F CIK 93751 · Bank · Jun 30, 2026 carried, not yet filed for the newest quarter	50,450	1.76%	+45,050	Jun 30, 2026	carried, not yet filed for the newest quarter
17.1	STATE STREET SMALL/MID CAP EQUITY INDEX PORTFOLIO Fund S000050332 · Registered fund · Jun 30, 2026 STATE STREET INSTITUTIONAL INVESTMENT TRUST, not summed	1,200	0.04%	—	Jun 30, 2026	STATE STREET INSTITUTIONAL INVESTMENT TRUST, not summed
17.2	State Street Total Return V.I.S. Fund Fund S000001637 · Registered fund · Jun 30, 2026 STATE STREET VARIABLE INSURANCE SERIES FUNDS INC, not summed	69	0.00%	—	Jun 30, 2026	STATE STREET VARIABLE INSURANCE SERIES FUNDS INC, not summed
18	WELLINGTON MANAGEMENT GROUP LLP 13G CIK 902219 · Holding company · Mar 31, 2026 Rule 13d-1(b), qualified institution	48,796	1.70%	-10,153	Mar 31, 2026	Rule 13d-1(b), qualified institution
19	BOOTHBAY FUND MANAGEMENT, LLC 13F CIK 1549230 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	42,080	1.46%	0	Jun 30, 2026	carried, not yet filed for the newest quarter
20	STEMPOINT CAPITAL LP 13F CIK 1952142 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	41,388	1.44%	+35,028	Jun 30, 2026	carried, not yet filed for the newest quarter
21	Eversept Partners, LP 13F CIK 1697013 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	40,000	1.39%	+40,000	Jun 30, 2026	carried, not yet filed for the newest quarter
22	Carlyle Group Inc. 13F CIK 1527166 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	38,620	1.34%	0	Jun 30, 2026	carried, not yet filed for the newest quarter
23	HealthCap VIII, L.P. 13D CIK 1783281 · Unknown · Oct 7, 2025 Item 4 purpose: not restated by this amendment, the earlier 13D's purpose stands	36,640	1.27%	-12,502	Oct 7, 2025
24	GOLDMAN SACHS GROUP INC 13F CIK 886982 · Holding company · Jun 30, 2026 carried, not yet filed for the newest quarter	32,348	1.13%	+26,842	Jun 30, 2026	carried, not yet filed for the newest quarter
24.1	Goldman Sachs Small Cap Equity Insights Fund Fund S000009329 · Registered fund · Jul 31, 2026 Goldman Sachs Trust, not summed	1,551	0.05%	—	Jul 31, 2026	Goldman Sachs Trust, not summed
24.2	Goldman Sachs Variable Insurance Trust Small Cap Equity Insights Fund Fund S000009355 · Registered fund · Jun 30, 2026 Goldman Sachs Variable Insurance Trust, not summed	479	0.02%	—	Jun 30, 2026	Goldman Sachs Variable Insurance Trust, not summed
24.3	Goldman Sachs Absolute Return Tracker Fund Fund S000020314 · Registered fund · Aug 31, 2026 GOLDMAN SACHS TRUST, not summed	1	0.00%	—	Aug 31, 2026	GOLDMAN SACHS TRUST, not summed
25	VANGUARD EXTENDED MARKET INDEX FUND Fund S000002841 · Registered fund · Jun 30, 2026 VANGUARD INDEX FUNDS, not summed	31,892	1.11%	+19,985	Jun 30, 2026	VANGUARD INDEX FUNDS, not summed
26	Affinity Asset Advisors, LLC 13F CIK 1773195 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	30,000	1.04%	+30,000	Jun 30, 2026	carried, not yet filed for the newest quarter
27	DIADEMA PARTNERS LP 13F CIK 2026172 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	30,000	1.04%	+20,000	Jun 30, 2026	carried, not yet filed for the newest quarter
28	ARMISTICE CAPITAL, LLC 13G CIK 1601086 · Registered investment adviser · Sep 30, 2024 Rule 13d-1(b), qualified institution	28,923	1.01%	-810	Sep 30, 2024	Rule 13d-1(b), qualified institution
29	Stonepine Capital Management, LLC 13F CIK 1440771 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	28,795	1.00%	+28,795	Jun 30, 2026	carried, not yet filed for the newest quarter
30	Point72 Asset Management, L.P. 13F CIK 1603466 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	28,278	0.98%	+28,278	Jun 30, 2026	carried, not yet filed for the newest quarter
31	Quinn Opportunity Partners LLC 13F CIK 1633275 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	26,810	0.93%	0	Jun 30, 2026	carried, not yet filed for the newest quarter
32	5AM Opportunities II, L.P. 13G CIK 1844401 · Unknown · Sep 30, 2024 Rule 13d-1(c), passive investor	23,640	0.82%	—	Sep 30, 2024	Rule 13d-1(c), passive investor
33	UBS Group AG 13F CIK 1610520 · Bank · Jun 30, 2026 carried, not yet filed for the newest quarter	23,381	0.81%	+19,462	Jun 30, 2026	carried, not yet filed for the newest quarter
34	NOVO HOLDINGS A/S 13D CIK 1388325 · Unknown · Mar 26, 2024	22,080	0.77%	-14,667	Mar 26, 2024
35	ExodusPoint Capital Management, LP 13F CIK 1736225 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	22,000	0.77%	0	Jun 30, 2026	carried, not yet filed for the newest quarter
36	NORTHERN TRUST CORP 13F CIK 73124 · Bank · Jun 30, 2026 carried, not yet filed for the newest quarter	21,083	0.73%	+21,083	Jun 30, 2026	carried, not yet filed for the newest quarter
36.1	Small Cap Index Fund Fund S000001245 · Registered fund · Jun 30, 2026 Northern Funds, not summed	1,419	0.05%	—	Jun 30, 2026	Northern Funds, not summed
37	Knott David M Jr 13F CIK 1892770 · Unknown · Jun 30, 2026 carried, not yet filed for the newest quarter	20,000	0.70%	+20,000	Jun 30, 2026	carried, not yet filed for the newest quarter
38	Rosalind Advisors, Inc. 13F CIK 1622627 · Unknown · Jun 30, 2026 carried, not yet filed for the newest quarter	20,000	0.70%	+20,000	Jun 30, 2026	carried, not yet filed for the newest quarter
39	Szwarcberg Javier B. Insider CIK 1903669 · Jun 30, 2026 Director, CHIEF EXECUTIVE OFFICER, issuer-wide	19,270	0.67%	+266	Jun 30, 2026	Director, CHIEF EXECUTIVE OFFICER, issuer-wide
40	AMERIPRISE FINANCIAL INC 13F CIK 820027 · Investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	18,834	0.66%	+18,834	Jun 30, 2026	carried, not yet filed for the newest quarter
41	VANGUARD PORTFOLIO MANAGEMENT LLC 13F CIK 2100121 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	18,496	0.64%	+18,496	Jun 30, 2026	carried, not yet filed for the newest quarter
42	VANGUARD FIDUCIARY TRUST CO 13F CIK 933478 · Unknown · Jun 30, 2026 carried, not yet filed for the newest quarter	18,361	0.64%	+12,847	Jun 30, 2026	carried, not yet filed for the newest quarter
43	Aisling Capital V, LP 13G CIK 1776233 · Unknown · Dec 31, 2023 Rule 13d-1(d), exempt investor	16,073	0.56%	—	Dec 31, 2023	Rule 13d-1(d), exempt investor
44	Squadron Capital Management LLC 13G CIK 2050709 · Registered investment adviser · Mar 31, 2026 Rule 13d-1(b), qualified institution	12,200	0.42%	-57,800	Mar 31, 2026	Rule 13d-1(b), qualified institution
45	Balyasny Asset Management L.P. 13F CIK 1218710 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	12,138	0.42%	-27,862	Jun 30, 2026	carried, not yet filed for the newest quarter
46	RiverVest Venture Fund III, L.P. 13D CIK 1601559 · Unknown · Jan 7, 2025	9,609	0.33%	—	Jan 7, 2025
47	DIMENSIONAL FUND ADVISORS LP 13F CIK 354204 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	8,813	0.31%	+8,813	Jun 30, 2026	carried, not yet filed for the newest quarter
47.1	Dimensional U.S. Small Cap ETF Fund S000070906 · Registered fund · Jul 31, 2026 Dimensional ETF Trust, not summed	3,751	0.13%	+2,468	Jul 31, 2026	Dimensional ETF Trust, not summed
47.2	U.S. MICRO CAP PORTFOLIO Fund S000000948 · Registered fund · Jul 31, 2026 DFA INVESTMENT DIMENSIONS GROUP INC, not summed	1,968	0.07%	+1,575	Jul 31, 2026	DFA INVESTMENT DIMENSIONS GROUP INC, not summed
47.3	Dimensional U.S. Core Equity 2 ETF Fund S000070903 · Registered fund · Jul 31, 2026 Dimensional ETF Trust, not summed	681	0.02%	0	Jul 31, 2026	Dimensional ETF Trust, not summed
47.4	Dimensional US Core Equity 1 ETF Fund S000081780 · Registered fund · Jul 31, 2026 Dimensional ETF Trust, not summed	371	0.01%	—	Jul 31, 2026	Dimensional ETF Trust, not summed
47.5	U.S. SMALL CAP PORTFOLIO Fund S000000971 · Registered fund · Jul 31, 2026 DFA INVESTMENT DIMENSIONS GROUP INC, not summed	303	0.01%	—	Jul 31, 2026	DFA INVESTMENT DIMENSIONS GROUP INC, not summed
48	Gharib Samir M. Insider CIK 1533302 · Dec 15, 2025 PRESIDENT AND CFO, issuer-wide	8,263	0.29%	+647	Dec 15, 2025	PRESIDENT AND CFO, issuer-wide
49	Persistent Asset Partners Ltd 13F CIK 2056052 · Exempt reporting adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	7,677	0.27%	+5,149	Jun 30, 2026	carried, not yet filed for the newest quarter
50	STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 13F CIK 938076 · Pension or benefit plan · Jun 30, 2026 carried, not yet filed for the newest quarter	7,182	0.25%	+7,182	Jun 30, 2026	carried, not yet filed for the newest quarter

3 more nested rows are not shown here; Every filing lists them all.

Shares are restated onto today's split basis. Change compares each row with the same holder's previous filing in the same source; a dash means there is none to compare. Nested 13D/G, insider and fund rows are not summed, since a 13F report already holds them.

Showing 1–50 of 124 holders

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Key facts CIK 1683553 CUSIP 85209E208 13F (30d) 5 filings 5 filers Visit website Investor relations