Knott David M Jr

CIK

1892770

Location

SYOSSET, NY

Portfolio Value

Small $127,435,751

Diversification

Diversified

Filing Date

Global Rank

#4,833 / 8,232 ▼ 468

Top Industry

Biotechnology 56.8%

3Y Alpha vs SPY

+3.1%

Period ended 2 months ago

Filed May 14, 2026 · 31d

18 quarters · since Dec 2021

Clone Performance

Jun 2023–Jun 2026 · vs SPY

Hypothetical growth of cloning every reported 13F position and rebalancing on each filing, indexed to the same start.

Cloned portfolio

+91.9%

SPY

+76.3%

Annualised alpha

+3.5%

Max drawdown

−43.0%

Estimate. 13F holdings are quarter-lagged and long-only, so the clone rebalances about 45 days after each period end — when the filing becomes public — and excludes options and short positions. Past performance does not predict future results.

Portfolio Concentration

76 positions · as of Mar 31, 2026 · Δ vs Dec 31, 2025

Top Position

19.7%

−5.0 pts

Top 5

42.7%

−13.4 pts

Top 10

61.3%

−10.6 pts

HHI

650

Diversified−428

Portfolio Trend

18 quarters · across all stocks

Sector Breakdown

As of Mar 31, 2026

Sector	% Portfolio	Value	Positions
Healthcare	70.6%	$90,016,627	47
Financial Services	25.7%	$32,717,921	5
Technology	1.7%	$2,207,395	7
Energy	0.7%	$861,759	2
Industrials	0.3%	$413,235	4
Consumer Defensive	0.3%	$404,448	2
Basic Materials	0.3%	$323,711	3
Real Estate	0.2%	$228,336	2
Consumer Cyclical	0.1%	$176,051	3
Communication Services	0.1%	$86,268	1

Last Quarter's Activity

Export CSV

Mar 31, 2026 vs Dec 31, 2025

Added To

Positions the filer increased

16 positions

Ticker	Company	Δ Shares	Shares	Value
CNTB	Connect Biopharma Holdings Ltd	+187,835	387,835	$1,016,127
XERS	Xeris Biopharma Holdings, Inc.	+90,000	1,060,000	$6,148,000
AGIO	Agios Pharmaceuticals, Inc.	+75,058	93,058	$3,148,152
HELP	Cybin Inc.	+64,818	350,000	$1,680,000
TGTX	Tg Therapeutics, Inc.	+45,001	90,001	$2,989,833
VRDN	Viridian Therapeutics, Inc.DE	+36,000	181,000	$3,540,360
CNTA	Centessa Pharmaceuticals plc	+35,000	39,000	$1,549,080
RZLT	Rezolute, Inc.	+30,000	370,000	$1,128,500
ALKS	Alkermes plc.	+25,000	120,000	$4,243,200
KURA	Kura Oncology, Inc.	+13,558	52,767	$428,995
RARE	Ultragenyx Pharmaceutical Inc.	+13,063	33,069	$692,795
SNDX	Syndax Pharmaceuticals Inc	+7,000	422,000	$9,857,920
BBIO	BridgeBio Pharma, Inc.	+5,000	90,000	$6,683,400
OBIO	Orchestra BioMed Holdings, Inc.	+3,651	253,651	$1,078,016
COGT	Cogent Biosciences, Inc.	+2,000	104,000	$4,002,960
PTHS	Pelthos Therapeutics Inc.	+1,792	21,073	$442,743
No positions match the current search.

Trimmed

Positions the filer reduced

13 positions

Ticker	Company	Δ Shares	Shares	Value
SLDB	Solid Biosciences Inc.	−115,297	47,143	$339,429
CPRX	Catalyst Pharmaceuticals, Inc.	−69,000	120,000	$2,971,200
WVE	Wave Life Sciences Ltd.	−50,000	40,000	$290,000
TVTX	Travere Therapeutics, Inc.	−45,367	140,633	$4,178,206
RCUS	Arcus Biosciences, Inc.	−40,000	81,241	$1,754,805
JSPR	Jasper Therapeutics, Inc.	−20,600	160,789	$140,851
LENZ	LENZ Therapeutics, Inc.	−20,000	33,732	$308,647
CYTK	Cytokinetics Inc	−10,356	23,644	$1,558,376
PTGX	Protagonist Therapeutics, Inc	−10,000	63,000	$6,640,200
BMY	Bristol Myers Squibb Co	−8,378	13,622	$826,174
ACLX	Arcellx, Inc.	−6,267	19,433	$2,231,297
BIIB	Biogen Inc.	−2,000	4,000	$733,320
JNJ	Johnson & Johnson	−2,000	4,922	$1,203,133
No positions match the current search.

New Positions

Positions the filer opened this quarter

7 positions

Ticker	Company	Shares	Value
IOVA	Iovance Biotherapeutics, Inc.	1,600,000	$5,616,000
RLMD	Relmada Therapeutics, Inc.	439,300	$3,057,528
ARDX	Ardelyx, Inc.	207,000	$1,239,930
VSTM	Verastem, Inc.	104,000	$551,200
CGEM	Cullinan Therapeutics, Inc.	24,200	$343,882
RAIN	Rain Enhancement Technologies Holdco, Inc.	101,686	$258,282
BRSL	Brightstar Lottery PLC	2,500	$31,850
No positions match the current search.

Sold Out

Positions the filer fully exited

10 positions

Ticker	Company	Shares	Value
CLMT	Calumet, Inc. /DE	2,214,969	$44,011,434
TECX	Tectonic Therapeutic, Inc.	74,000	$1,543,640
BHVN	Biohaven Ltd.	110,720	$1,250,028
NKTR	Nektar Therapeutics	15,500	$655,340
SRRK	Scholar Rock Holding Corp	13,913	$612,867
XENE	Xenon Pharmaceuticals Inc.	10,962	$491,316
FATE	Fate Therapeutics Inc	365,000	$357,700
DAWN	Day One Biopharmaceuticals, Inc.	25,884	$241,238
QURE	uniQure N.V.	4,000	$95,720
FSK	FS KKR Capital Corp	2,875	$42,578
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

76 positions · $127,435,751 total · as of Mar 31, 2026

All sectors Basic Materials Communication Services Consumer Cyclical Consumer Defensive Energy Financial Services Healthcare Industrials Real Estate Technology

Showing 1–50 of 76 positions by value · page 1 of 2

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
APO	Apollo Global Management, Inc. Financial Services	Held	225,000	0	$25,069,500	−23.0%	19.67%
SNDX	Syndax Pharmaceuticals Inc Healthcare	Added	422,000	+7,000	$9,857,920	+13.1%	7.74%
BBIO	BridgeBio Pharma, Inc. Healthcare	Added	90,000	+5,000	$6,683,400	+2.8%	5.24%
PTGX	Protagonist Therapeutics, Inc Healthcare	Reduced	63,000	-10,000	$6,640,200	+4.1%	5.21%
XERS	Xeris Biopharma Holdings, Inc. Healthcare	Added	1,060,000	+90,000	$6,148,000	−19.3%	4.82%
JPM	Jpmorgan Chase & Co Financial Services	Held	19,477	0	$5,729,354	−8.7%	4.50%
IOVA	Iovance Biotherapeutics, Inc. Healthcare	NEW	1,600,000	NEW	$5,616,000	NEW	4.41%
ALKS	Alkermes plc. Healthcare	Added	120,000	+25,000	$4,243,200	+59.6%	3.33%
TVTX	Travere Therapeutics, Inc. Healthcare	Reduced	140,633	-45,367	$4,178,206	−41.2%	3.28%
COGT	Cogent Biosciences, Inc. Healthcare	Added	104,000	+2,000	$4,002,960	+10.5%	3.14%
VRDN	Viridian Therapeutics, Inc.DE Healthcare	Added	181,000	+36,000	$3,540,360	−21.5%	2.78%
AGIO	Agios Pharmaceuticals, Inc. Healthcare	Added	93,058	+75,058	$3,148,152	+542.5%	2.47%
RLMD	Relmada Therapeutics, Inc. Healthcare	NEW	439,300	NEW	$3,057,528	NEW	2.40%
TGTX	Tg Therapeutics, Inc. Healthcare	Added	90,001	+45,001	$2,989,833	+122.9%	2.35%
CPRX	Catalyst Pharmaceuticals, Inc. Healthcare	Reduced	120,000	-69,000	$2,971,200	−32.6%	2.33%
ACLX	Arcellx, Inc. Healthcare	Reduced	19,433	-6,267	$2,231,297	+33.2%	1.75%
AB	Alliancebernstein Holding L.P. Financial Services	Held	48,000	0	$1,797,120	−2.7%	1.41%
RCUS	Arcus Biosciences, Inc. Healthcare	Reduced	81,241	-40,000	$1,754,805	−39.3%	1.38%
HELP	Cybin Inc. Healthcare	Added	350,000	+64,818	$1,680,000	−28.0%	1.32%
DCGO	DocGo Inc. Healthcare	Held	2,670,850	0	$1,679,964	−28.4%	1.32%
CYTK	Cytokinetics Inc Healthcare	Reduced	23,644	-10,356	$1,558,376	−27.9%	1.22%
CNTA	Centessa Pharmaceuticals plc Healthcare	Added	39,000	+35,000	$1,549,080	+1448.5%	1.22%
ATRC	AtriCure, Inc. Healthcare	Held	51,400	0	$1,466,442	−27.9%	1.15%
ARDX	Ardelyx, Inc. Healthcare	NEW	207,000	NEW	$1,239,930	NEW	0.97%
JNJ	Johnson & Johnson Healthcare	Reduced	4,922	-2,000	$1,203,133	−16.0%	0.94%
RZLT	Rezolute, Inc. Healthcare	Added	370,000	+30,000	$1,128,500	+40.6%	0.89%
OBIO	Orchestra BioMed Holdings, Inc. Healthcare	Added	253,651	+3,651	$1,078,016	+3.9%	0.85%
MDGL	Madrigal Pharmaceuticals, Inc. Healthcare	Held	2,000	0	$1,046,940	−10.1%	0.82%
VERA	Vera Therapeutics, Inc. Healthcare	Held	26,000	0	$1,045,980	−20.6%	0.82%
CNTB	Connect Biopharma Holdings Ltd Healthcare	Added	387,835	+187,835	$1,016,127	+80.2%	0.80%
PFE	Pfizer Inc Healthcare	Held	32,337	0	$908,022	+12.8%	0.71%
BMY	Bristol Myers Squibb Co Healthcare	Reduced	13,622	-8,378	$826,174	−30.4%	0.65%
CNQ	Canadian Natural Resources Ltd Energy	Held	16,800	0	$818,664	+44.0%	0.64%
BIIB	Biogen Inc. Healthcare	Reduced	4,000	-2,000	$733,320	−30.6%	0.58%
RARE	Ultragenyx Pharmaceutical Inc. Healthcare	Added	33,069	+13,063	$692,795	+50.6%	0.54%
AAPL	Apple Inc. Technology	Held	2,494	0	$632,952	−6.6%	0.50%
MSFT	Microsoft Corp Technology	Held	1,600	0	$592,272	−23.5%	0.46%
VSTM	Verastem, Inc. Healthcare	NEW	104,000	NEW	$551,200	NEW	0.43%
ADMA	Adma Biologics, Inc. Healthcare	Held	60,200	0	$542,402	−50.6%	0.43%
IBM	International Business Machines Corp Technology	Held	2,142	0	$519,199	−18.2%	0.41%
PTHS	Pelthos Therapeutics Inc. Healthcare	Added	21,073	+1,792	$442,743	−25.9%	0.35%
KURA	Kura Oncology, Inc. Healthcare	Added	52,767	+13,558	$428,995	+5.3%	0.34%
EOLS	Evolus, Inc. Healthcare	Held	99,338	0	$408,279	−38.2%	0.32%
CGEM	Cullinan Therapeutics, Inc. Healthcare	NEW	24,200	NEW	$343,882	NEW	0.27%
SLDB	Solid Biosciences Inc. Healthcare	Reduced	47,143	-115,297	$339,429	−63.0%	0.27%
LENZ	LENZ Therapeutics, Inc. Healthcare	Reduced	33,732	-20,000	$308,647	−64.1%	0.24%
WVE	Wave Life Sciences Ltd. Healthcare	Reduced	40,000	-50,000	$290,000	−81.0%	0.23%
RAIN	Rain Enhancement Technologies Holdco, Inc. Industrials	NEW	101,686	NEW	$258,282	NEW	0.20%
KMB	Kimberly Clark Corp Consumer Defensive	Held	2,400	0	$231,528	−4.4%	0.18%
NVDA	Nvidia Corp Technology	Held	1,280	0	$223,232	−6.5%	0.18%