OBIO · Orchestra BioMed Holdings, Inc.

$5.04 -0.15 (-2.80%) At close · Aug 31

Russell 2000 member Rebalance outlook locked

Market Cap

$311.64M

60.11M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Quarter:

Holders: 77

Total Value: $119,672,940

Total Shares: 27,734,180

Institutional Ownership Trend

24 quarters

Holder Concentration

Across 77 13F filers · Δ vs Mar 31, 2026

Top Holder

34.5%

−1.5 pts

Top 5

72.6%

−2.9 pts

Top 10

85.1%

−1.1 pts

HHI

1,711

Moderately concentrated−214

Quarterly Activity

vs Mar 31, 2026

New

Increased

Decreased

Sold Out

Unchanged

Holder count: +12

Institutional value: +21.8%

Shares held: +20.0%

Top Buyers

vs Mar 31, 2026

Institution	Added	Now Holds
Mega BlackRock, Inc.	+1,874,673	2,510,387
Large RTW INVESTMENTS, LP	+1,250,000	9,556,063
Mega GEODE CAPITAL MANAGEMENT, LLC	+522,416	1,007,908
Mid RICE HALL JAMES & ASSOCIATES, LLC	+404,999	424,000
Mega STATE STREET CORP	+346,640	516,050

Top Sellers

vs Mar 31, 2026

Institution	Sold	Now Holds
Mid Affinity Asset Advisors, LLC	−369,150	33,400
Mega VANGUARD CAPITAL MANAGEMENT LLC	−181,403	2,022,916
Mega BARCLAYS PLC	−45,824	13,518
Mega JANE STREET GROUP, LLC	−44,220	26,760
Mega TWO SIGMA INVESTMENTS, LP	−37,544	22,563

Top New Positions

vs Mar 31, 2026

Institution	Acquired	Value (USD)
Mega UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	642,154	$2,770,894
Mega VANGUARD PORTFOLIO MANAGEMENT LLC	274,973	$1,186,508
Mid Flat Footed LLC	251,372	$1,084,670
Mega Bank of New York Mellon Corp	86,103	$371,533
Mega Nuveen, LLC	52,118	$224,889

Top Sold-Out Positions

vs Mar 31, 2026

Institution	Previously Held	Last Value (USD)
Mega MILLENNIUM MANAGEMENT LLC	702,543	$2,985,807
Large MARSHALL WACE, LLP	188,484	$801,056
Mid 683 Capital Management, LLC	185,000	$786,250
Mega Qube Research & Technologies Ltd	108,953	$463,050
Large Point72 Asset Management, L.P.	87,888	$373,524

Filter: New 25 Increased 23 Reduced 14 Sold out 13 Unchanged 15

Showing 80 of 80

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

RTW INVESTMENTS, LP

$41,234,411

34.46%

9,556,063

PERCEPTIVE ADVISORS LLC

$21,738,564

18.16%

5,037,906

BlackRock, Inc.

$10,832,316

9.05%

2,510,387

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	10,473	$45,190	0.4%	Sole
BlackRock Investment Management, LLC	127,827	$551,573	5.1%	Sole
BLACKROCK ADVISORS LLC	313,337	$1,352,049	12.5%	Sole
BlackRock Fund Advisors	1,342,322	$5,792,119	53.5%	Sole
BlackRock Institutional Trust Company, N.A.	677,155	$2,921,923	27.0%	Sole
BlackRock Asset Management Ireland Ltd	39,273	$169,462	1.6%	Sole

VANGUARD CAPITAL MANAGEMENT LLC

$8,728,882

7.29%

2,022,916

GEODE CAPITAL MANAGEMENT, LLC

$4,349,122

3.63%

1,007,908

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	151,448	$653,498	15.0%	Defined
Held directly	856,460	$3,695,624	85.0%	Defined

Alyeska Investment Group, L.P.

$4,315,000

3.61%

1,000,000

Propel Bio Management, LLC

$3,869,264

3.23%

896,701

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Simplify Asset Management Inc.	896,701	$3,869,264	100.0%	Defined

UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC

$2,770,894

2.32%

642,154

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Asset Management Switzerland AG	642,154	$2,770,894	100.0%	Sole

STATE STREET CORP

$2,226,755

1.86%

516,050

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SSGA FUNDS MANAGEMENT, INC. joint	516,050	$2,226,755	100.0%	Defined

RICE HALL JAMES & ASSOCIATES, LLC

$1,829,560

1.53%

424,000

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$1,508,282

1.26%

349,544

NORTHERN TRUST CORP

$1,482,805

1.24%

343,640

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	337,345	$1,455,643	98.2%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC joint	6,295	$27,162	1.8%	Other

UBS Group AG

$1,405,709

1.17%

325,773

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS AG	17,586	$75,883	5.4%	Defined
UBS Switzerland AG	308,187	$1,329,826	94.6%	Defined

VANGUARD FIDUCIARY TRUST CO

$1,261,071

1.05%

292,253

VANGUARD PORTFOLIO MANAGEMENT LLC

$1,186,508

0.99%

274,973

Knott David M Jr

$1,094,504

0.91%

253,651

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Dorset Partners LLC	253,651	$1,094,504	100.0%	Defined

Flat Footed LLC

$1,084,670

0.91%

251,372

Simplify Asset Management Inc.

$946,654

0.79%

219,387

GOLDMAN SACHS GROUP INC

$774,999

0.65%

179,606

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	75,058	$323,875	41.8%	Defined
GOLDMAN SACHS ASSET MANAGEMENT, L.P.	104,548	$451,124	58.2%	Defined

DAFNA Capital Management LLC

$547,318

0.46%

126,841

Daytona Street Capital LLC

$415,957

0.35%

96,398

RENAISSANCE TECHNOLOGIES LLC

$388,350

0.32%

90,000

IFP Advisors, Inc

$386,658

0.32%

89,608

Bank of New York Mellon Corp

$371,533

0.31%

86,103

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Investments Corporation	23,039	$99,413	26.8%	Defined
The Bank of New York Mellon	63,063	$272,116	73.2%	Defined
Held directly	1	$4	0.0%	Defined

BRIDGEWAY CAPITAL MANAGEMENT, LLC

$347,789

0.29%

80,600

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$283,944

0.24%

65,804

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	65,804	$283,944	100.0%	Other

CITADEL ADVISORS LLC

$242,464

0.20%

56,191

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	56,191	$242,464	100.0%	Defined

Nuveen, LLC

$224,889

0.19%

52,118

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
TEACHERS ADVISORS, LLC joint	52,118	$224,889	100.0%	Defined

Holos Integrated Wealth LLC

$222,632

0.19%

51,595

NewEdge Advisors, LLC

$190,218

0.16%

44,083

Y-Intercept (Hong Kong) Ltd

$187,642

0.16%

43,486

DEUTSCHE BANK AG\

$171,183

0.14%

39,672

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DWS INVESTMENT MANAGEMENT AMERICAS, INC	784	$3,382	2.0%	Defined
DWS Investments UK Ltd	38,888	$167,801	98.0%	Defined

XTX Topco Ltd

$167,482

0.14%

38,814

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
XTX EXECUTION SERVICES LLC joint	38,814	$167,482	100.0%	Defined

WELLS FARGO & COMPANY/MN

$156,876

0.13%

36,356

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO BANK N A	36,356	$156,876	100.0%	Defined

HighTower Advisors, LLC

$152,643

0.13%

35,375

Affinity Asset Advisors, LLC

$144,121

0.12%

33,400

PRICE T ROWE ASSOCIATES INC /MD/

$141,053

0.12%

32,689

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T. Rowe Price International Ltd	32,689	$141,053	100.0%	Defined

RHUMBLINE ADVISERS

$137,821

0.12%

31,940

Meramec Financial Planners, LLC

$129,450

0.11%

30,000

MORGAN STANLEY

$125,824

0.11%

29,160

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO. LLC	10,835	$46,753	37.2%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	8,405	$36,267	28.8%	Defined
MORGAN STANLEY SMITH BARNEY LLC	9,920	$42,804	34.0%	Defined

ALGERT GLOBAL LLC

$122,917

0.10%

28,486

AXQ CAPITAL, LP

$109,808

0.09%

25,448

Invesco Ltd.

$106,532

0.09%

24,689

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invesco Advisers, Inc. joint	5,762	$24,863	23.3%	Defined
Invesco Trust Co joint	15,893	$68,578	64.4%	Defined
Invesco Capital Management LLC	3,034	$13,091	12.3%	Defined

MetLife Investment Management, LLC

$103,534

0.09%

23,994

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
METLIFE INC	23,994	$103,534	100.0%	Defined

BANK OF AMERICA CORP /DE/

$102,791

0.09%

23,822

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	23,822	$102,791	100.0%	Defined

TWO SIGMA INVESTMENTS, LP

$97,359

0.08%

22,563

CANADA PENSION PLAN INVESTMENT BOARD

$91,046

0.08%

21,100

JPMORGAN CHASE & CO

$90,096

0.08%

20,880

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JPMorgan Chase Bank, N.A.	16,522	$71,292	79.1%	Defined
J.P. Morgan Securities plc	4,358	$18,804	20.9%	Defined

NEW YORK STATE COMMON RETIREMENT FUND

$88,026

0.07%

20,400

CITIGROUP INC

$87,011

0.07%

20,165

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citigroup Financial Products Inc. joint	20,165	$87,011	100.0%	Defined

MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.

$79,188

0.07%

18,352

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Global X Management CO LLC joint	18,352	$79,188	100.0%	Defined

CITADEL ADVISORS LLC

$75,944

0.06%

17,600

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	17,600	$75,944	100.0%	Defined

JANE STREET GROUP, LLC

$66,278

0.06%

15,360

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	15,360	$66,278	100.0%	Defined

Vanguard Global Advisers, LLC

$60,185

0.05%

13,948

BARCLAYS PLC

$58,329

0.05%

13,518

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BARCLAYS BANK PLC	11,614	$50,114	85.9%	Defined
BARCLAYS CAPITAL INC.	1,904	$8,215	14.1%	Defined

ABLE Financial Group, LLC

$57,829

0.05%

13,402

Sargent Investment Group, LLC

$56,612

0.05%

13,120

Frec Markets, Inc.

$56,302

0.05%

13,048

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Frec Advisers LLC	13,048	$56,302	100.0%	Defined

CITADEL ADVISORS LLC

$52,211

0.04%

12,100

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	12,100	$52,211	100.0%	Defined

Police & Firemen's Retirement System of New Jersey

$50,722

0.04%

11,755

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Capital	11,755	$50,722	100.0%	Defined

JANE STREET GROUP, LLC

$49,191

0.04%

11,400

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	11,400	$49,191	100.0%	Defined

Garden State Investment Advisory Services LLC

$45,575

0.04%

10,562

China Universal Asset Management Co., Ltd.

$41,121

0.03%

9,530

BNP PARIBAS ARBITRAGE, SA

$35,443

0.03%

8,214

Legal & General Group Plc

$16,932

0.01%

3,924

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Legal & General Investment Management America Inc	3,924	$16,932	100.0%	Defined

Ameritas Investment Partners, Inc.

$15,607

0.01%

3,617

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
EATON VANCE MANAGEMENT	3,617	$15,607	100.0%	Other

Tower Research Capital LLC (TRC)

$15,538

0.01%

3,601

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Latour Trading LLC (Latour)	3,601	$15,538	100.0%	Defined

Russell Investments Group, Ltd.

$13,751

0.01%

3,187

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Russell Investment Management, LLC	3,187	$13,751	100.0%	Defined

Mirae Asset Global Investments Co., Ltd.

$11,555

0.01%

2,678

SIMPLEX TRADING, LLC

$11,063

0.01%

2,564

ROYAL BANK OF CANADA

$8,042

0.01%

1,864

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RBC CMA LTD.	1,411	$6,088	75.7%	Defined
RBC Capital Markets, LLC	452	$1,950	24.2%	Defined
Held directly	1	$4	0.0%	Sole

AdvisorNet Financial, Inc

$7,318

0.01%

1,696

GF FUND MANAGEMENT CO. LTD.

$5,061

0.00%

1,173

JONES FINANCIAL COMPANIES LLLP

$3,831

0.00%

888

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Edward D. Jones & Co., L.P.	888	$3,831	100.0%	Sole

CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM

$2,368

0.00%

549

FMR LLC

$1,142

0.00%

265

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	158	$681	59.6%	Defined
STRATEGIC ADVISERS LLC	107	$461	40.4%	Defined

Sterling Capital Management LLC

$604

0.00%

140

Optiver Holding B.V.

$172

0.00%

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Optiver VOF	40	$172	100.0%	Defined

Caitong International Asset Management Co., Ltd

$64

0.00%

SBI Securities Co., Ltd.

$25

0.00%

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Marshall Wace North America L.P. joint	188,484	$801,056	100.0%	Other

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
683 Capital Partners, LP	185,000	$786,250	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Hudson Bay Capital UK LLP	71,134	$302,319	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Brevan Howard US Investment Management, LP	19,321	$82,114	52.5%	Defined
Brevan Howard (Hong Kong) Ltd	17,448	$74,154	47.5%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Thakore Nainoor	18,919	$80,405	100.0%	Defined

Key facts CIK 1814114 CUSIP 68572M106 13F (30d) 64 filings 64 filers Visit website Investor relations