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  • OBIO Orchestra BioMed Holdings, Inc.

OBIO

Orchestra BioMed Holdings, Inc.

Company with tickers: OBIO

CIK
1814114
CUSIP
68572M106
Shares Outstanding
59,880,715
13F Activity (30d)
55 filings 55 filers
Holders: 65
Total Value: $98,217,243
Total Shares: 23,109,946

Institutional Ownership Trend

14 quarters

Holder Concentration

Across 65 13F filers · Δ vs Dec 31, 2025
Top Holder
35.9%
Jun 2023 → Mar 2026 · range 35.9% – 52.1%
−2.2 pts
Top 5
75.5%
Jun 2023 → Mar 2026 · range 75.5% – 87.7%
−1.1 pts
Top 10
86.3%
Jun 2023 → Mar 2026 · range 85.5% – 95.9%
+0.8 pts
HHI
1,925
Jun 2023 → Mar 2026 · range 1,925 – 3,198
Moderately concentrated −197

Quarterly Activity

vs Dec 31, 2025
New
19
Increased
23
Decreased
14
Sold Out
17
Unchanged
9
Holder count: +2
Institutional value: +8.8%
Shares held: +6.2%

Top Buyers

vs Dec 31, 2025
Institution Added Now Holds Open
Mega MILLENNIUM MANAGEMENT LLC +459,070 702,543
Mid BRIDGEWAY CAPITAL MANAGEMENT, LLC +45,600 70,600
Mega UBS Group AG +38,921 50,310
Mega BANK OF AMERICA CORP /DE/ +35,214 52,761
Small Daytona Street Capital LLC +31,100 52,600

Top Sellers

vs Dec 31, 2025
Institution Sold Now Holds Open
Mid Affinity Asset Advisors, LLC −170,254 402,550
Mega JANE STREET GROUP, LLC −116,685 70,980
Mid PERCEPTIVE ADVISORS LLC −89,350 5,037,906
Large RENAISSANCE TECHNOLOGIES LLC −80,400 70,900
Large Point72 Asset Management, L.P. −74,058 87,888

Top New Positions

vs Dec 31, 2025
Institution Acquired Value (USD) Open
Mega VANGUARD CAPITAL MANAGEMENT LLC 2,204,319 $9,368,355
Small Propel Bio Management, LLC 896,701 $3,810,979
Mega VANGUARD FIDUCIARY TRUST CO 235,214 $999,659
Small Simplify Asset Management Inc. 219,387 $932,394
Mid Brevan Howard Capital Management LP 36,769 $156,268

Top Sold-Out Positions

vs Dec 31, 2025
Institution Previously Held Last Value (USD) Open
Mega VANGUARD GROUP INC 1,604,556 $6,658,907
Mega PRICE T ROWE ASSOCIATES INC /MD/ 364,645 $1,513,276
Large ExodusPoint Capital Management, LP 95,635 $396,885
Mid XTX Topco Ltd 50,358 $208,985
Mega TD Asset Management Inc 45,692 $189,621
Filter: New 19 Increased 23 Reduced 14 Sold out 17 Unchanged 9
66 of 66 shown
All Common Calls Puts
Export CSV
Holder Value (USD) % of 13F Shares Open
Large RTW INVESTMENTS, LP $35,300,767 35.94% 8,306,063
Mid PERCEPTIVE ADVISORS LLC $21,411,100 21.80% 5,037,906
Mega VANGUARD CAPITAL MANAGEMENT LLC $9,368,355 9.54% 2,204,319
Large Alyeska Investment Group, L.P. $4,250,000 4.33% 1,000,000
Small Propel Bio Management, LLC $3,810,979 3.88% 896,701
Mega MILLENNIUM MANAGEMENT LLC $2,985,807 3.04% 702,543
Mega BlackRock, Inc. $2,701,783 2.75% 635,714
Mega GEODE CAPITAL MANAGEMENT, LLC $2,063,340 2.10% 485,492
Mid Affinity Asset Advisors, LLC $1,710,837 1.74% 402,550
Mega CHARLES SCHWAB INVESTMENT MANAGEMENT INC $1,128,370 1.15% 265,499
Small Knott David M Jr $1,078,016 1.10% 253,651
Mega VANGUARD FIDUCIARY TRUST CO Bank $999,659 1.02% 235,214
Small Simplify Asset Management Inc. $932,394 0.95% 219,387
Large MARSHALL WACE, LLP $801,056 0.82% 188,484
Mid 683 Capital Management, LLC $786,250 0.80% 185,000
Mega STATE STREET CORP $719,992 0.73% 169,410
Mega GOLDMAN SACHS GROUP INC $659,777 0.67% 155,242
Small DAFNA Capital Management LLC $539,074 0.55% 126,841
Mega NORTHERN TRUST CORP Bank $502,664 0.51% 118,274
Large Qube Research & Technologies Ltd $463,050 0.47% 108,953
Mid IFP Advisors, Inc $420,269 0.43% 98,887
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP $414,464 0.42% 97,521
Large Point72 Asset Management, L.P. $373,524 0.38% 87,888
Mega CITADEL ADVISORS LLC $336,536 0.34% 79,185
Large Hudson Bay Capital Management LP $302,319 0.31% 71,134
Large RENAISSANCE TECHNOLOGIES LLC $301,325 0.31% 70,900
Mid BRIDGEWAY CAPITAL MANAGEMENT, LLC $300,050 0.31% 70,600
Mega TWO SIGMA INVESTMENTS, LP $255,454 0.26% 60,107
Mega BARCLAYS PLC $252,203 0.26% 59,342
Mega JANE STREET GROUP, LLC $236,639 0.24% 55,680
Mega BANK OF AMERICA CORP /DE/ Bank $224,234 0.23% 52,761
Small Daytona Street Capital LLC $223,550 0.23% 52,600
Micro Holos Integrated Wealth LLC $219,278 0.22% 51,595
Mega UBS Group AG $213,817 0.22% 50,310
Mid NewEdge Advisors, LLC $187,352 0.19% 44,083
Mid Brevan Howard Capital Management LP $156,268 0.16% 36,769
Mega MORGAN STANLEY $151,465 0.15% 35,639
Micro Meramec Financial Planners, LLC $127,500 0.13% 30,000
Small Catalyst Funds Management Pty Ltd $117,487 0.12% 27,644
Mega CITIGROUP INC $108,498 0.11% 25,529
Micro Cannon Global Investment Management, LLC $96,079 0.10% 22,607
Mid RICE HALL JAMES & ASSOCIATES, LLC $80,754 0.08% 19,001
Small Diametric Capital, LP $80,405 0.08% 18,919
Large HighTower Advisors, LLC $77,668 0.08% 18,275
Mega FMR LLC $76,823 0.08% 18,076
Large OMERS ADMINISTRATION Corp $68,850 0.07% 16,200
Mega JANE STREET GROUP, LLC $65,025 0.07% 15,300
Mid ALGERT GLOBAL LLC $62,288 0.06% 14,656
Mega Vanguard Global Advisers, LLC $59,279 0.06% 13,948
Small ABLE Financial Group, LLC $56,958 0.06% 13,402
Small Frec Markets, Inc. $55,454 0.06% 13,048
Mid PRELUDE CAPITAL MANAGEMENT, LLC $52,653 0.05% 12,389
Mega CANADA PENSION PLAN INVESTMENT BOARD Pension $48,025 0.05% 11,300
Large Schonfeld Strategic Advisors LLC $46,550 0.05% 10,953
Small Garden State Investment Advisory Services LLC $44,888 0.05% 10,562
Mid China Universal Asset Management Co., Ltd. $42,585 0.04% 10,020
Mega JPMORGAN CHASE & CO $18,096 0.02% 4,258
Large Mirae Asset Global Investments Co., Ltd. $12,516 0.01% 2,945
Mid SIMPLEX TRADING, LLC $10,119 0.01% 2,381
Small AdvisorNet Financial, Inc $7,208 0.01% 1,696
Mega BNP PARIBAS ARBITRAGE, SA $6,188 0.01% 1,456
Mid GF FUND MANAGEMENT CO. LTD. $5,355 0.01% 1,260
Mega ROYAL BANK OF CANADA Bank $3,977 0.00% 936
Mid Tower Research Capital LLC (TRC) $2,324 0.00% 547
Large JONES FINANCIAL COMPANIES LLLP $1,649 0.00% 388
Mid SBI Securities Co., Ltd. Broker-Dealer $25 0.00% 6

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