TWO SIGMA INVESTMENTS, LP
Position in OBIO — Orchestra BioMed Holdings, Inc.
CIK 1179392
NEW YORK, NY
Position in OBIO
as of Mar 31, 2026
· filed May 15, 2026
Position Value
$255,454
-$103,736 QoQ
Shares Held
60,107
-30.6% QoQ
Ownership
0.100%
of shares outstanding
% of Portfolio
0.00%
of 13F equity value
Holder Rank
—
not a current holder
Holding Since
Dec 2025
2 quarters on record
Voting authority
Sole 99.39774069575923.ToString("F0")%
Shared 0.ToString("F0")%
None 0.6022593042407707.ToString("F0")%
Common Shares in OBIO Over Time
Shares Held
Position Value (USD)
Position in Biotechnology
Healthcare · as of Mar 31, 2026TWO SIGMA INVESTMENTS, LP holds $5,506,832,621 across 316 Biotechnology names. OBIO ranks #259 (0.0% of the industry book) .
| # | Ticker | Company | Shares | Value (USD) | Open |
|---|---|---|---|---|---|
| 1 | ALNY |
Alnylam Pharmaceuticals, Inc.
|
1,992,577 | $659,283,951 | |
| 2 | REGN |
Regeneron Pharmaceuticals, Inc.
|
812,236 | $627,566,023 | |
| 3 | MRNA |
Moderna, Inc.
|
9,086,404 | $461,589,323 | |
| 4 | IONS |
Ionis Pharmaceuticals Inc
|
5,857,629 | $439,849,361 | |
| 5 | BBIO |
BridgeBio Pharma, Inc.
|
3,120,631 | $231,738,058 | |
| 6 | VRTX |
Vertex Pharmaceuticals Inc / Ma
|
378,146 | $168,857,314 | |
| 7 | RVMD |
Revolution Medicines, Inc.
|
1,558,807 | $151,593,980 | |
| 8 | VKTX |
Viking Therapeutics, Inc.
|
4,432,142 | $144,221,900 |
All Filings in OBIO
Export CSV
2 filing rows on record
| Report Date | Value (USD) | Shares | Type | Discretion | Filed | |
|---|---|---|---|---|---|---|
| 2026-03-31 | $255,454 | 60,107 | Shares | Sole | 2026-05-15 | |
| 2025-12-31 | $359,190 | 86,552 | Shares | Sole | 2026-02-17 | |
| No filing history on record for this holder in this stock. | ||||||