Affinity Asset Advisors, LLC
Filing Date
Global Rank
#1,364
/ 8,420
▲ 388
Top Industry
Biotechnology
89.7%
3Y Alpha vs SPY
+4.8%
Period ended 6 months ago
Filed Feb 13, 2026 · 4mo
21 quarters · since Dec 2020
Clone Performance
Jun 2023–Jun 2026 · vs SPYHypothetical growth of cloning every reported 13F position and rebalancing on each filing, indexed to the same start.
Cloned portfolio
+98.1%
SPY
+76.3%
Annualised alpha
+4.8%
Max drawdown
−46.0%
Estimate. 13F holdings are quarter-lagged and long-only, so the clone rebalances about 45 days after each period end — when the filing becomes public — and excludes options and short positions. Past performance does not predict future results.
Portfolio Concentration
79 positions · as of Dec 31, 2025 · Δ vs Sep 30, 2025Top Position
6.9%
−2.5 pts
Top 5
25.9%
−4.7 pts
Top 10
43.2%
−4.3 pts
HHI
281
Diversified−55
Portfolio Trend
21 quarters · across all stocks
Sector Breakdown
As of Dec 31, 2025| Sector | % Portfolio | Value |
|---|---|---|
| Healthcare | 100.0% | $1,353,070,822 |
| Financial Services | 0.0% | $651,500 |
Last Quarter's Activity
Export CSVAdded To
Positions the filer increased
25 positions
| Ticker | Company | Δ Shares | Shares | Value | Open |
|---|---|---|---|---|---|
| OVID | Ovid Therapeutics Inc. | +4,500,000 | 7,150,000 | $11,654,500 | |
| CGEM | Cullinan Therapeutics, Inc. | +1,668,289 | 1,932,106 | $19,997,297 | |
| SVRA | Savara Inc | +1,297,153 | 2,797,153 | $16,866,832 | |
| ROIV | Roivant Sciences Ltd. | +900,000 | 1,700,000 | $36,890,000 | |
| SGMT | Sagimet Biosciences Inc. | +798,245 | 1,148,245 | $6,797,610 | |
| KPTI | Karyopharm Therapeutics Inc. | +731,975 | 889,575 | $6,547,272 | |
| JBIO | Jade Biosciences, Inc. | +649,639 | 714,956 | $11,031,771 | |
| WVE | Wave Life Sciences Ltd. | +600,000 | 2,700,000 | $45,900,000 | |
| ENGN | enGene Therapeutics Inc. | +566,370 | 643,370 | $5,809,631 | |
| QURE | uniQure N.V. | +550,000 | 850,000 | $20,340,500 | |
| ZURA | Zura Bio Ltd | +539,320 | 1,813,671 | $9,503,636 | |
| CYTK | Cytokinetics Inc | +450,000 | 800,000 | $50,832,000 | |
| ABUS | Arbutus Biopharma Corp | +310,400 | 521,900 | $2,510,339 | |
| TSHA | Taysha Gene Therapies, Inc. | +300,000 | 3,300,000 | $18,150,000 | |
| BBIO | BridgeBio Pharma, Inc. | +255,000 | 320,000 | $24,476,800 | |
| RZLT | Rezolute, Inc. | +251,144 | 2,351,144 | $5,548,699 | |
| ABVX | Abivax S.A. | +145,000 | 505,000 | $68,101,775 | |
| MBX | MBX Biosciences, Inc. | +85,000 | 250,000 | $7,885,000 | |
| APGE | Apogee Therapeutics, Inc. | +61,500 | 1,234,926 | $93,212,214 | |
| NXTC | NextCure, Inc. | +55,412 | 247,294 | $3,509,101 | |
| CLDX | Celldex Therapeutics, Inc. | +50,000 | 350,000 | $9,506,000 | |
| AVTX | Avalo Therapeutics, Inc. | +44,837 | 1,051,054 | $19,087,140 | |
| AVR | Anteris Technologies Global Corp. | +36,684 | 486,684 | $2,428,553 | |
| ACLX | Arcellx, Inc. | +23,725 | 523,725 | $34,146,870 | |
| SYRE | Spyre Therapeutics, Inc. | +13,292 | 1,432,591 | $46,931,681 | |
| No positions match the current search. | |||||
Trimmed
Positions the filer reduced
20 positions
| Ticker | Company | Δ Shares | Shares | Value | Open |
|---|---|---|---|---|---|
| PRQR | ProQR Therapeutics N.V. | −1,145,722 | 2,454,278 | $4,957,641 | |
| LXEO | Lexeo Therapeutics, Inc. | −670,527 | 3,200,000 | $31,776,000 | |
| TRVI | Trevi Therapeutics, Inc. | −649,828 | 2,150,172 | $26,920,153 | |
| CNTA | Centessa Pharmaceuticals plc | −506,610 | 600,552 | $15,019,805 | |
| ERAS | Erasca, Inc. | −385,787 | 3,900,000 | $14,508,000 | |
| PCSC | Perceptive Capital Solutions Corp | −300,000 | 50,000 | $651,500 | |
| ALKS | Alkermes plc. | −250,000 | 1,000,000 | $27,980,000 | |
| INSM | INSMED Inc | −205,000 | 450,000 | $78,318,000 | |
| TVTX | Travere Therapeutics, Inc. | −200,000 | 300,000 | $11,463,000 | |
| ORKA | Oruka Therapeutics, Inc. | −156,838 | 802,342 | $24,318,986 | |
| OBIO | Orchestra BioMed Holdings, Inc. | −154,468 | 572,804 | $2,377,136 | |
| XENE | Xenon Pharmaceuticals Inc. | −150,000 | 1,250,000 | $56,025,000 | |
| DNTH | Dianthus Therapeutics, Inc. /DE/ | −147,100 | 115,000 | $4,739,150 | |
| ESTA | Establishment Labs Holdings Inc. | −110,000 | 200,000 | $14,576,000 | |
| IMVT | Immunovant, Inc. | −100,000 | 200,000 | $5,084,000 | |
| MDGL | Madrigal Pharmaceuticals, Inc. | −83,869 | 31,131 | $18,128,826 | |
| NUVL | Nuvalent, Inc. | −61,784 | 322,633 | $32,453,653 | |
| VERA | Vera Therapeutics, Inc. | −53,330 | 250,000 | $12,660,000 | |
| PTGX | Protagonist Therapeutics, Inc | −48,475 | 172,125 | $15,033,397 | |
| MLYS | Mineralys Therapeutics, Inc. | −20,000 | 730,000 | $26,491,700 | |
| No positions match the current search. | |||||
New Positions
Positions the filer opened this quarter
20 positions
| Ticker | Company | Shares | Value | Open |
|---|---|---|---|---|
| PRAX | Praxis Precision Medicines, Inc. | 185,000 | $54,526,900 | |
| AMGN | Amgen Inc | 145,000 | $47,459,950 | |
| FBRX | Forte Biosciences, Inc. | 1,011,890 | $27,594,240 | |
| TERN | Terns Pharmaceuticals, Inc. | 550,000 | $22,220,000 | |
| ANAB | Anaptysbio, Inc | 444,692 | $21,558,668 | |
| COGT | Cogent Biosciences, Inc. | 350,000 | $12,432,000 | |
| TNGX | Tango Therapeutics, Inc. | 1,000,000 | $8,860,000 | |
| STRO | Sutro Biopharma, Inc. | 748,382 | $8,658,779 | |
| RCUS | Arcus Biosciences, Inc. | 300,000 | $7,149,000 | |
| ASND | Ascendis Pharma A/S | 30,000 | $6,397,200 | |
| VRCA | Verrica Pharmaceuticals Inc. | 707,338 | $5,877,978 | |
| ARWR | Arrowhead Pharmaceuticals, Inc. | 70,000 | $4,647,300 | |
| IBIO | iBio, Inc. | 2,057,200 | $3,970,396 | |
| BLTE | Belite Bio, Inc | 20,000 | $3,199,200 | |
| AVBP | ArriVent BioPharma, Inc. | 150,000 | $3,018,000 | |
| RARE | Ultragenyx Pharmaceutical Inc. | 75,000 | $1,725,000 | |
| LENZ | LENZ Therapeutics, Inc. | 100,000 | $1,600,000 | |
| KZR | Kezar Life Sciences, Inc. | 229,076 | $1,440,888 | |
| MGNX | Macrogenics Inc | 484,308 | $779,735 | |
| XFOR | X4 Pharmaceuticals, Inc | 145,000 | $580,000 | |
| No positions match the current search. | ||||
Sold Out
Positions the filer fully exited
21 positions
| Ticker | Company | Shares | Value | Open |
|---|---|---|---|---|
| SPY | Spdr S&P 500 ETF Trust | 84,490 | $56,285,548 | |
| EXEL | Exelixis, Inc. | 500,000 | $20,650,000 | |
| SLNO | Soleno Therapeutics Inc | 200,000 | $13,520,000 | |
| ELVN | Enliven Therapeutics, Inc. | 400,000 | $8,188,000 | |
| TARS | Tarsus Pharmaceuticals, Inc. | 125,000 | $7,428,750 | |
| AKBA | Akebia Therapeutics, Inc. | 2,450,000 | $6,688,500 | |
| MNPR | Monopar Therapeutics | 79,483 | $6,491,376 | |
| NTLA | Intellia Therapeutics, Inc. | 300,000 | $5,181,000 | |
| OLMA | Olema Pharmaceuticals, Inc. | 500,000 | $4,895,000 | |
| OMER | Omeros Corp | 1,133,900 | $4,648,990 | |
| PCVX | Vaxcyte, Inc. | 125,000 | $4,502,500 | |
| INSP | Inspire Medical Systems, Inc. | 50,000 | $3,710,000 | |
| JAZZ | Jazz Pharmaceuticals plc | 25,000 | $3,295,000 | |
| AUTL | Autolus Therapeutics plc | 1,750,000 | $2,852,500 | |
| OCUL | Ocular Therapeutix, Inc | 239,000 | $2,793,910 | |
| UTHR | UNITED THERAPEUTICS Corp | 5,000 | $2,096,050 | |
| ATYR | aTYR PHARMA INC | 2,100,000 | $1,514,100 | |
| MIST | Milestone Pharmaceuticals Inc. | 666,666 | $1,333,332 | |
| CNTX | Context Therapeutics Inc. | 402,653 | $390,170 | |
| CBIO | Crescent Biopharma, Inc. | 17,998 | $213,996 | |
| SPRY | ARS Pharmaceuticals, Inc. | 2,500 | $25,125 | |
| No positions match the current search. | ||||
79 positions ·
$1,353,722,322 total
· as of Dec 31, 2025
Showing 1–50
of 79 positions by value
· page 1 of 2
| Ticker | Company | Type | Shares | Value (USD) | % of Portfolio | History |
|---|---|---|---|---|---|---|
| APGE |
Apogee Therapeutics, Inc.
Healthcare
|
Added | 1,234,926 | $93,212,214 | 6.89% | |
| INSM |
INSMED Inc
Healthcare
|
Reduced | 450,000 | $78,318,000 | 5.79% | |
| ABVX |
Abivax S.A.
Healthcare
|
Added | 505,000 | $68,101,775 | 5.03% | |
| XENE |
Xenon Pharmaceuticals Inc.
Healthcare
|
Reduced | 1,250,000 | $56,025,000 | 4.14% | |
| PRAX |
Praxis Precision Medicines, Inc.
Healthcare
|
NEW | 185,000 | $54,526,900 | 4.03% | |
| CYTK |
Cytokinetics Inc
Healthcare
|
Added | 800,000 | $50,832,000 | 3.75% | |
| AMGN |
Amgen Inc
Healthcare
|
NEW | 145,000 | $47,459,950 | 3.51% | |
| SYRE |
Spyre Therapeutics, Inc.
Healthcare
|
Added | 1,432,591 | $46,931,681 | 3.47% | |
| WVE |
Wave Life Sciences Ltd.
Healthcare
|
Added | 2,700,000 | $45,900,000 | 3.39% | |
| TEVA |
Teva Pharmaceutical Industries Ltd
Healthcare
|
Held | 1,400,000 | $43,694,000 | 3.23% | |
| ROIV |
Roivant Sciences Ltd.
Healthcare
|
Added | 1,700,000 | $36,890,000 | 2.73% | |
| ACLX |
Arcellx, Inc.
Healthcare
|
Added | 523,725 | $34,146,870 | 2.52% | |
| NUVL |
Nuvalent, Inc.
Healthcare
|
Reduced | 322,633 | $32,453,653 | 2.40% | |
| LXEO |
Lexeo Therapeutics, Inc.
Healthcare
|
Reduced | 3,200,000 | $31,776,000 | 2.35% | |
| ALKS |
Alkermes plc.
Healthcare
|
Reduced | 1,000,000 | $27,980,000 | 2.07% | |
| FBRX |
Forte Biosciences, Inc.
Healthcare
|
NEW | 1,011,890 | $27,594,240 | 2.04% | |
| TRVI |
Trevi Therapeutics, Inc.
Healthcare
|
Reduced | 2,150,172 | $26,920,153 | 1.99% | |
| MLYS |
Mineralys Therapeutics, Inc.
Healthcare
|
Reduced | 730,000 | $26,491,700 | 1.96% | |
| BBIO |
BridgeBio Pharma, Inc.
Healthcare
|
Added | 320,000 | $24,476,800 | 1.81% | |
| ORKA |
Oruka Therapeutics, Inc.
Healthcare
|
Reduced | 802,342 | $24,318,986 | 1.80% | |
| TERN |
Terns Pharmaceuticals, Inc.
Healthcare
|
NEW | 550,000 | $22,220,000 | 1.64% | |
| ANAB |
Anaptysbio, Inc
Healthcare
|
NEW | 444,692 | $21,558,668 | 1.59% | |
| QURE |
uniQure N.V.
Healthcare
|
Added | 850,000 | $20,340,500 | 1.50% | |
| CGEM |
Cullinan Therapeutics, Inc.
Healthcare
|
Added | 1,932,106 | $19,997,297 | 1.48% | |
| AVTX |
Avalo Therapeutics, Inc.
Healthcare
|
Added | 1,051,054 | $19,087,140 | 1.41% | |
| NRIX |
Nurix Therapeutics, Inc.
Healthcare
|
Held | 967,620 | $18,355,751 | 1.36% | |
| TSHA |
Taysha Gene Therapies, Inc.
Healthcare
|
Added | 3,300,000 | $18,150,000 | 1.34% | |
| MDGL |
Madrigal Pharmaceuticals, Inc.
Healthcare
|
Reduced | 31,131 | $18,128,826 | 1.34% | |
| SVRA |
Savara Inc
Healthcare
|
Added | 2,797,153 | $16,866,832 | 1.25% | |
| PTGX |
Protagonist Therapeutics, Inc
Healthcare
|
Reduced | 172,125 | $15,033,397 | 1.11% | |
| CNTA |
Centessa Pharmaceuticals plc
Healthcare
|
Reduced | 600,552 | $15,019,805 | 1.11% | |
| ESTA |
Establishment Labs Holdings Inc.
Healthcare
|
Reduced | 200,000 | $14,576,000 | 1.08% | |
| ERAS |
Erasca, Inc.
Healthcare
|
Reduced | 3,900,000 | $14,508,000 | 1.07% | |
| VERA |
Vera Therapeutics, Inc.
Healthcare
|
Reduced | 250,000 | $12,660,000 | 0.94% | |
| COGT |
Cogent Biosciences, Inc.
Healthcare
|
NEW | 350,000 | $12,432,000 | 0.92% | |
| OVID |
Ovid Therapeutics Inc.
Healthcare
|
Added | 7,150,000 | $11,654,500 | 0.86% | |
| TVTX |
Travere Therapeutics, Inc.
Healthcare
|
Reduced | 300,000 | $11,463,000 | 0.85% | |
| JBIO |
Jade Biosciences, Inc.
Healthcare
|
Added | 714,956 | $11,031,771 | 0.81% | |
| NAMS |
NewAmsterdam Pharma Co N.V.
Healthcare
|
Held | 275,000 | $9,647,000 | 0.71% | |
| CLDX |
Celldex Therapeutics, Inc.
Healthcare
|
Added | 350,000 | $9,506,000 | 0.70% | |
| ZURA |
Zura Bio Ltd
Healthcare
|
Added | 1,813,671 | $9,503,636 | 0.70% | |
| TNGX |
Tango Therapeutics, Inc.
Healthcare
|
NEW | 1,000,000 | $8,860,000 | 0.65% | |
| STRO |
Sutro Biopharma, Inc.
Healthcare
|
NEW | 748,382 | $8,658,779 | 0.64% | |
| RVMD |
Revolution Medicines, Inc.
Healthcare
|
Held | 100,000 | $7,965,000 | 0.59% | |
| MBX |
MBX Biosciences, Inc.
Healthcare
|
Added | 250,000 | $7,885,000 | 0.58% | |
| VRDN |
Viridian Therapeutics, Inc.DE
Healthcare
|
Held | 250,000 | $7,780,000 | 0.57% | |
| RCUS |
Arcus Biosciences, Inc.
Healthcare
|
NEW | 300,000 | $7,149,000 | 0.53% | |
| SGMT |
Sagimet Biosciences Inc.
Healthcare
|
Added | 1,148,245 | $6,797,610 | 0.50% | |
| KPTI |
Karyopharm Therapeutics Inc.
Healthcare
|
Added | 889,575 | $6,547,272 | 0.48% | |
| ASND |
Ascendis Pharma A/S
Healthcare
|
NEW | 30,000 | $6,397,200 | 0.47% |