Mid
EcoR1 Capital, LLC
$63,871,322
9.31%
3,174,519
8.885%
—
Shares
2026-08-14
Mid
TCG Crossover Management, LLC
$58,253,516
8.49%
2,895,304
8.103%
—
Shares
2026-08-14
Mega
FMR LLC
4
$41,329,033
6.03%
2,054,127
5.749%
—
Shares
2026-08-13
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Fidelity Management & Research Co LLC
1,249,047
$25,130,825
60.8%
Defined
STRATEGIC ADVISERS LLC
79
$1,589
0.0%
Defined
Fidelity Institutional Asset Management Trust Co
679,340
$13,668,320
33.1%
Defined
FIAM LLC
125,661
$2,528,299
6.1%
Defined
Mid
Affinity Asset Advisors, LLC
$40,884,081
5.96%
2,032,012
5.687%
—
Shares
2026-08-13
Mega
BlackRock, Inc.
10
$39,506,439
5.76%
1,963,541
5.495%
—
Shares
2026-08-07
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE
22,576
$454,229
1.1%
Sole
BlackRock Asset Management Canada Ltd
166
$3,339
0.0%
Sole
BlackRock Investment Management, LLC
69,564
$1,399,627
3.5%
Sole
BLACKROCK ADVISORS LLC
53,596
$1,078,351
2.7%
Sole
BlackRock Fund Advisors
976,441
$19,645,992
49.7%
Sole
BlackRock Institutional Trust Company, N.A.
772,768
$15,548,092
39.4%
Sole
BlackRock Japan Co. Ltd
597
$12,011
0.0%
Sole
BlackRock Investment Management (UK) Ltd.
6,858
$137,982
0.3%
Sole
BlackRock Asset Management Ireland Ltd
45,617
$917,814
2.3%
Sole
Aperio Group, LLC
15,358
$309,002
0.8%
Sole
Small
Trails Edge Capital Partners, LP
$30,461,680
4.44%
1,514,000
4.237%
—
Shares
2026-08-14
Mega
STATE STREET CORP
1
$30,439,467
4.44%
1,512,896
4.234%
—
Shares
2026-09-22
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
STATE STREET GLOBAL ADVISORS EUROPE LIMITED
joint
1,512,896
$30,439,467
100.0%
Defined
Mega
VANGUARD CAPITAL MANAGEMENT LLC
$29,212,409
4.26%
1,451,909
4.063%
—
Shares
2026-08-13
Mega
Jupiter Topco LLC
2
$21,960,255
3.20%
1,091,464
3.055%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
JANUS HENDERSON INVESTORS UK Ltd
7,464
$150,175
0.7%
Defined
JANUS HENDERSON INVESTORS US LLC
1,084,000
$21,810,080
99.3%
Defined
Mid
Vestal Point Capital, LP
$20,381,560
2.97%
1,013,000
2.835%
—
Shares
2026-08-14
Large
Woodline Partners LP
$18,453,581
2.69%
917,176
2.567%
—
Shares
2026-08-14
Small
Sanofi
$16,536,970
2.41%
821,917
2.300%
—
Shares
2026-07-28
Mega
MORGAN STANLEY
5
$15,724,461
2.29%
781,534
2.187%
—
Shares
2026-08-13
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC
366
$7,363
0.0%
Defined
MORGAN STANLEY & CO. LLC
6,398
$128,727
0.8%
Defined
MORGAN STANLEY CAPITAL SERVICES, LLC
757,901
$15,248,968
97.0%
Defined
MORGAN STANLEY SMITH BARNEY LLC
7,700
$154,924
1.0%
Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC
9,169
$184,479
1.2%
Defined
Mid
683 Capital Management, LLC
1
$15,090,000
2.20%
750,000
2.099%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
683 Capital Partners, LP
750,000
$15,090,000
100.0%
Defined
Large
ADAGE CAPITAL PARTNERS GP, L.L.C.
$14,667,480
2.14%
729,000
2.040%
—
Shares
2026-08-14
Large
Balyasny Asset Management L.P.
$14,384,753
2.10%
714,948
2.001%
—
Shares
2026-08-14
Mega
GEODE CAPITAL MANAGEMENT, LLC
2
$14,125,989
2.06%
702,087
1.965%
—
Shares
2026-08-12
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC
95,316
$1,917,757
13.6%
Defined
Held directly
606,771
$12,208,232
86.4%
Defined
Mega
BANK OF AMERICA CORP /DE/
Bank
2
$13,036,994
1.90%
647,962
1.813%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
BANK OF AMERICA NA
69,974
$1,407,876
10.8%
Defined
BOFA SECURITIES, INC.
577,988
$11,629,118
89.2%
Defined
Small
STEMPOINT CAPITAL LP
$12,529,186
1.83%
622,723
1.743%
—
Shares
2026-08-14
Small
Palo Alto Investors LP
$12,142,198
1.77%
603,489
1.689%
—
Shares
2026-08-19
Mid
Sofinnova Investments, Inc.
$11,371,803
1.66%
565,199
1.582%
—
Shares
2026-08-14
Mega
VANGUARD PORTFOLIO MANAGEMENT LLC
$11,005,479
1.60%
546,992
1.531%
—
Shares
2026-08-13
Mega
GOLDMAN SACHS GROUP INC
2
$9,802,725
1.43%
487,213
1.364%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Large
Point72 Asset Management, L.P.
$8,215,599
1.20%
408,330
1.143%
—
Shares
2026-08-14
Mega
UBS Group AG
3
$6,255,025
0.91%
310,886
0.870%
—
Shares
2026-08-13
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
UBS Financial Services Inc
1,629
$32,775
0.5%
Defined
UBS AG
305,868
$6,154,064
98.4%
Defined
UBS Switzerland AG
3,389
$68,186
1.1%
Defined
Mega
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP
$6,025,940
0.88%
299,500
0.838%
—
Shares
2026-08-13
Large
FEDERATED HERMES, INC.
1
$5,834,800
0.85%
290,000
0.812%
—
Shares
2026-08-12
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
FEDERATED GLOBAL INVESTMENT MANAGEMENT CORP
290,000
$5,834,800
100.0%
Defined
Small
Ally Bridge Group (NY) LLC
$5,719,854
0.83%
284,287
0.796%
—
Shares
2026-08-14
Mega
CHARLES SCHWAB INVESTMENT MANAGEMENT INC
$5,168,284
0.75%
256,873
0.719%
—
Shares
2026-08-14
Mid
Nantahala Capital Management, LLC
$5,030,000
0.73%
250,000
0.700%
—
Shares
2026-08-19
Mid
Granahan Investment Management, LLC
$4,794,676
0.70%
238,304
0.667%
—
Shares
2026-08-14
Small
Apis Capital Advisors, LLC
$4,547,120
0.66%
226,000
0.633%
—
Shares
2026-08-14
Large
FRED ALGER MANAGEMENT, LLC
$4,394,208
0.64%
218,400
0.611%
—
Shares
2026-08-14
Mega
NORTHERN TRUST CORP
Bank
3
$4,046,050
0.59%
201,096
0.563%
—
Shares
2026-08-13
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
NORTHERN TRUST CO
joint
196,505
$3,953,680
97.7%
Defined
NORTHERN TRUST GLOBAL INVESTMENTS LTD
927
$18,651
0.5%
Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC
joint
3,664
$73,719
1.8%
Other
Mega
AMERIPRISE FINANCIAL INC
1
$3,886,841
0.57%
193,183
0.541%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Columbia Management Investment Advisers, LLC
193,183
$3,886,841
100.0%
Defined
Mega
VANGUARD FIDUCIARY TRUST CO
Bank
$3,847,346
0.56%
191,220
0.535%
—
Shares
2026-08-13
Mega
CITADEL ADVISORS LLC
$3,396,054
0.50%
168,790
0.472%
—
Shares
2026-09-02
Large
Connor, Clark & Lunn Investment Management Ltd.
2
$3,315,634
0.48%
164,793
0.461%
—
Shares
2026-08-13
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Manager 1
159,577
$3,210,689
96.8%
Sole
Held directly
5,216
$104,945
3.2%
Sole
Mega
MARSHALL WACE, LLP
1
$3,296,682
0.48%
163,851
0.459%
—
Shares
2026-08-13
This filing is a combination report: the position is filed across the managers below.
Mega
D. E. Shaw & Co., Inc.
2
$2,577,974
0.38%
128,130
0.359%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
D. E. SHAW & CO, L.P.
17,482
$351,737
13.6%
Defined
D. E. Shaw Investment Management, L.L.C.
joint
110,648
$2,226,237
86.4%
Defined
Large
Rockefeller Capital Management L.P.
2
$2,352,811
0.34%
116,939
0.327%
—
Shares
2026-08-13
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
ROCKEFELLER & CO. LLC
65
$1,307
0.1%
Defined
ROCKEFELLER FINANCIAL LLC
116,874
$2,351,504
99.9%
Defined
Large
Ensign Peak Advisors, Inc
$2,333,477
0.34%
115,978
0.325%
—
Shares
2026-08-14
Large
Jain Global LLC
$1,990,994
0.29%
98,956
0.277%
—
Shares
2026-08-14
Large
NOMURA ASSET MANAGEMENT INTERNATIONAL INC.
1
$1,885,887
0.27%
93,732
0.262%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
NOMURA HOLDINGS INC
joint
93,732
$1,885,887
100.0%
Defined
Small
Financial Enhancement Group LLC
$1,497,934
0.22%
74,450
0.208%
—
Shares
2026-07-07
Mid
ADAR1 Capital Management, LLC
$1,446,829
0.21%
71,910
0.201%
—
Shares
2026-08-14
Mega
Invesco Ltd.
3
$1,428,800
0.21%
71,014
0.199%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Invesco Advisers, Inc.
joint
3,661
$73,658
5.2%
Defined
Invesco Trust Co
joint
9,201
$185,124
13.0%
Defined
Invesco Capital Management LLC
58,152
$1,170,018
81.9%
Defined
Mega
Bank of New York Mellon Corp
Bank
4
$1,404,636
0.20%
69,813
0.195%
—
Shares
2026-08-06
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Mellon Investments Corporation
24,699
$496,943
35.4%
Defined
The Bank of New York Mellon
44,793
$901,235
64.2%
Defined
BNY Mellon, NA
joint
320
$6,438
0.5%
Defined
Held directly
1
$20
0.0%
Defined
Mega
NORGES BANK
Bank
$1,390,292
0.20%
69,100
0.193%
—
Shares
2026-08-12
Mid
Opaleye Management Inc.
$1,307,800
0.19%
65,000
0.182%
—
Shares
2026-08-14
Large
Quantinno Capital Management LP
$1,257,379
0.18%
62,494
0.175%
—
Shares
2026-08-13
Mega
DEUTSCHE BANK AG\
Bank
3
$1,249,793
0.18%
62,117
0.174%
—
Shares
2026-08-07
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
DWS Investment GmbH
38,760
$779,851
62.4%
Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC
367
$7,384
0.6%
Defined
DWS Investments UK Ltd
22,990
$462,558
37.0%
Defined
Large
PRUDENTIAL FINANCIAL INC
2
$1,226,112
0.18%
60,940
0.171%
—
Shares
2026-08-12
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
PGIM Quantitative Solutions LLC
48,140
$968,576
79.0%
Defined
Prudential Trust Co
12,800
$257,536
21.0%
Defined
Mid
SummitTX Capital, L.P.
$1,183,921
0.17%
58,843
0.165%
—
Shares
2026-08-14
Mega
WELLINGTON MANAGEMENT GROUP LLP
3
$1,156,416
0.17%
57,476
0.161%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Wellington Management Company LLP
19,134
$384,976
33.3%
Defined
Wellington Trust Company, NA
joint
35,816
$720,617
62.3%
Defined
Wellington Management Australia Pty Ltd
2,526
$50,823
4.4%
Defined
Mega
DIMENSIONAL FUND ADVISORS LP
3
$1,148,126
0.17%
57,064
0.160%
—
Shares
2026-08-11
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Dimensional Fund Advisors Ltd.
615
$12,373
1.1%
Defined
Dimensional Ireland Ltd
2,906
$58,468
5.1%
Defined
Held directly
53,543
$1,077,285
93.8%
Sole
Small
Moody Aldrich Partners LLC
$1,092,837
0.16%
54,316
0.152%
—
Shares
2026-07-15
Mega
Fisher Asset Management, LLC
$1,037,165
0.15%
51,549
0.144%
—
Shares
2026-08-04
Mega
Nuveen, LLC
2
$998,112
0.15%
49,608
0.139%
—
Shares
2026-08-11
This filing is a combination report: the position is filed across the managers below.
Mega
Swiss National Bank
Bank
$983,868
0.14%
48,900
0.137%
—
Shares
2026-08-11
Mid
J. Goldman & Co LP
$942,561
0.14%
46,847
0.131%
—
Shares
2026-08-14
Mega
PRICE T ROWE ASSOCIATES INC /MD/
1
$910,067
0.13%
45,232
0.127%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
T. Rowe Price International Ltd
45,232
$910,067
100.0%
Defined
Mid
XTX Topco Ltd
1
$865,160
0.13%
43,000
0.120%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
XTX EXECUTION SERVICES LLC
joint
43,000
$865,160
100.0%
Defined
Small
Ikarian Capital, LLC
$860,633
0.13%
42,775
0.120%
—
Shares
2026-08-14
Large
LOS ANGELES CAPITAL MANAGEMENT LLC
$741,100
0.11%
36,834
0.103%
—
Shares
2026-08-13
Mega
ALLIANCEBERNSTEIN L.P.
1
$740,617
0.11%
36,810
0.103%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Mega
WELLS FARGO & COMPANY/MN
4
$728,423
0.11%
36,204
0.101%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
WELLS FARGO BANK N A
19,731
$396,987
54.5%
Defined
WELLS FARGO ADVISORS FINANCIAL NETWORK, LLC
15,114
$304,093
41.7%
Defined
WELLS FARGO CLEARING SERVICES, LLC
325
$6,539
0.9%
Defined
Wells Fargo Securities, LLC
1,034
$20,804
2.9%
Defined
Mega
CITIGROUP INC
1
$728,323
0.11%
36,199
0.101%
—
Shares
2026-08-03
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Citigroup Financial Products Inc.
joint
36,199
$728,323
100.0%
Defined
Small
CRCM LP
$711,040
0.10%
35,340
0.099%
—
Shares
2026-08-18
Mega
RHUMBLINE ADVISERS
$632,009
0.09%
31,412
0.088%
—
Shares
2026-08-12
Mid
Tema ETFs LLC
Mutual Fund
$621,848
0.09%
30,907
0.086%
—
Shares
2026-07-10
Large
Tidal Investments LLC
$621,848
0.09%
30,907
0.086%
—
Shares
2026-08-13
Large
Corient Private Wealth LLC
$610,420
0.09%
30,339
0.085%
—
Shares
2026-08-27
Mega
AQR CAPITAL MANAGEMENT LLC
6
$579,695
0.08%
28,812
0.081%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Mega
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC
1
$565,955
0.08%
28,129
0.079%
—
Shares
2026-08-13
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
UBS Asset Management Switzerland AG
28,129
$565,955
100.0%
Defined
Mid
Y-Intercept (Hong Kong) Ltd
$565,050
0.08%
28,084
0.079%
—
Shares
2026-07-14
Small
SPHERA FUNDS MANAGEMENT LTD.
1
$560,865
0.08%
27,876
0.078%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Sphera Global Healthcare Management LP
joint
27,876
$560,865
100.0%
Defined
Mid
MARTINGALE ASSET MANAGEMENT L P
$548,068
0.08%
27,240
0.076%
—
Shares
2026-08-13
Mega
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM
Pension
$528,974
0.08%
26,291
0.074%
—
Shares
2026-08-24
Large
Rafferty Asset Management, LLC
$520,323
0.08%
25,861
0.072%
—
Shares
2026-08-14
Large
JACOBS LEVY EQUITY MANAGEMENT, INC
$505,816
0.07%
25,140
0.070%
—
Shares
2026-08-14
Mega
SUSQUEHANNA INTERNATIONAL GROUP, LLP
1
$425,115
0.06%
21,129
0.059%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Mega
VANGUARD ASSET MANAGEMENT, Ltd
$405,337
0.06%
20,146
0.056%
—
Shares
2026-08-13
Large
CREDIT AGRICOLE S A
1
$402,400
0.06%
20,000
0.056%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Credit Agricole Corporate & Investment Bank
joint
20,000
$402,400
100.0%
Defined
Small
Virtus Investment Advisers, LLC
$373,205
0.05%
18,549
0.052%
—
Shares
2026-08-11
Mega
Qube Research & Technologies Ltd
$367,069
0.05%
18,244
0.051%
—
Shares
2026-08-14
Mega
Legal & General Group Plc
2
$361,596
0.05%
17,972
0.050%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Legal & General Investment Management America Inc
2,267
$45,612
12.6%
Defined
Legal & General Investment Management Ltd
joint
15,705
$315,984
87.4%
Defined
Mega
AMERICAN CENTURY COMPANIES INC
1
$347,130
0.05%
17,253
0.048%
—
Shares
2026-08-12
This filing is a combination report: the position is filed across the managers below.
Mega
Russell Investments Group, Ltd.
3
$322,342
0.05%
16,021
0.045%
—
Shares
2026-08-06
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Russell Investment Management, LLC
joint
9,819
$197,558
61.3%
Defined
Russell Investments Capital, LLC
joint
2,177
$43,801
13.6%
Other
Russell Investments Trust Company
joint
4,025
$80,983
25.1%
Other
Mega
JPMORGAN CHASE & CO
4
$299,526
0.04%
14,887
0.042%
—
Shares
2026-08-12
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
JPMorgan Chase Bank, N.A.
9,676
$194,681
65.0%
Defined
J.P. Morgan Investment Management Inc.
2,450
$49,294
16.5%
Defined
J.P. Morgan Securities LLC
25
$503
0.2%
Defined
J.P. Morgan Securities plc
2,736
$55,048
18.4%
Defined
Large
MetLife Investment Management, LLC
1
$285,724
0.04%
14,201
0.040%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
METLIFE INC
14,201
$285,724
100.0%
Defined
Large
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.
Mutual Fund
2
$275,764
0.04%
13,706
0.038%
—
Shares
2026-08-14
This filing is a combination report: the position is filed across the managers below.
Manager
Shares
Value (USD)
% of position
Discretion
Global X Management CO LLC
joint
10,702
$215,324
78.1%
Defined
Global X Management (AUS) Ltd
joint
3,004
$60,440
21.9%
Defined
Large
Cresset Asset Management, LLC
$275,523
0.04%
13,694
0.038%
—
Shares
2026-08-14
Mid
BOOTHBAY FUND MANAGEMENT, LLC
$264,115
0.04%
13,127
0.037%
—
Shares
2026-08-14
Mid
PROFUND ADVISORS LLC
$262,847
0.04%
13,064
0.037%
—
Shares
2026-08-11
Mega
VICTORY CAPITAL MANAGEMENT INC
$257,133
0.04%
12,780
0.036%
—
Shares
2026-08-07
Large
GLENMEDE TRUST CO NA
Bank
$246,268
0.04%
12,240
0.034%
—
Shares
2026-08-10
Large
VIRGINIA RETIREMENT SYSTEMS ET Al
Pension
$232,386
0.03%
11,550
0.032%
—
Shares
2026-08-25
Mega
MANUFACTURERS LIFE INSURANCE COMPANY, THE
Insurance
1
$217,014
0.03%
10,786
0.030%
—
Shares
2026-09-09
This filing is a combination report: the position is filed across the managers below.
Mega
Vanguard Global Advisers, LLC
$212,809
0.03%
10,577
0.030%
—
Shares
2026-08-13
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