ORBIMED ADVISORS LLC

CIK

1055951

Location

New York, NY

Portfolio Value

Mid $5,097,795,616

Diversification

Diversified

Filing Date

Global Rank

#661 / 8,623 ▲ 83 · as of Mar 2026

Top Industry

Biotechnology 56.5%

3Y Alpha vs SPY

+3.2%

Period ended 4 months ago

Filed May 15, 2026 · 3mo

25 quarters · since Mar 2020

Clone Performance

Jul 2023–Jul 2026 · vs SPY

Hypothetical growth of buying every stock this filer reported holding, rebalancing on each filing and indexed to the same start. Option positions cannot be bought this way and are left out.

Cloned portfolio

+80.7%

SPY

+67.9%

Annualised alpha

+3.0%

Max drawdown

−37.5%

Estimate. 13F holdings are quarter-lagged, so the clone rebalances about 45 days after each period end — when the filing becomes public — and it excludes option and short positions. It tracks 99% of reported value on average across 13 quarters. Past performance does not predict future results.

Portfolio Concentration

107 tracked positions · as of Mar 31, 2026 · Δ vs Dec 31, 2025

Top Position

11.0%

+2.6 pts

Top 5

37.0%

+9.3 pts

Top 10

49.5%

+7.2 pts

HHI

386

Diversified+102

Portfolio Trend

25 quarters · across all stocks

Sector Breakdown

As of Mar 31, 2026

Sector	% Portfolio	Value	Positions
Healthcare	100.0%	$5,097,795,616	107

Last Quarter's Activity

Export CSV

Mar 31, 2026 vs Dec 31, 2025

Added To

Positions the filer increased

24 positions

Ticker	Company	Δ Shares	Shares	Value
ESPR	Esperion Therapeutics, Inc.	+4,604,802	10,570,300	$28,962,622
RLMD	Relmada Therapeutics, Inc.	+2,105,264	4,715,864	$32,822,413
LXEO	Lexeo Therapeutics, Inc.	+1,477,450	3,602,450	$20,678,063
QURE	uniQure N.V.	+1,398,749	2,136,149	$34,926,036
MLYS	Mineralys Therapeutics, Inc.	+1,072,500	2,052,900	$55,613,061
DYN	Dyne Therapeutics, Inc.	+715,700	2,917,884	$52,901,236
XENE	Xenon Pharmaceuticals Inc.	+612,771	1,059,971	$61,637,313
PALI	Palisade Bio, Inc.	+461,580	2,333,000	$4,082,750
BCAX	Bicara Therapeutics Inc.	+458,200	667,300	$13,272,597
GPCR	Structure Therapeutics Inc.	+313,600	1,475,403	$71,114,424
PFE	Pfizer Inc	+293,600	1,946,500	$54,657,720
BMY	Bristol Myers Squibb Co	+150,000	925,000	$56,101,250
CRBP	Corbus Pharmaceuticals Holdings, Inc.	+140,000	1,737,287	$16,313,124
ABVX	Abivax S.A.	+97,800	465,700	$51,855,695
PRAX	Praxis Precision Medicines, Inc.	+78,000	172,500	$55,577,775
RYTM	Rhythm Pharmaceuticals, Inc.	+74,300	314,100	$27,317,277
ANRO	Alto Neuroscience, Inc.	+42,500	167,500	$3,765,400
RVMD	Revolution Medicines, Inc.	+26,100	52,000	$5,057,000
PTCT	Ptc Therapeutics, Inc.	+25,900	49,100	$3,345,183
PTGX	Protagonist Therapeutics, Inc	+20,400	42,100	$4,437,340
VERA	Vera Therapeutics, Inc.	+16,096	369,596	$14,868,847
ELV	Elevance Health, Inc.	+15,600	114,700	$33,578,425
ASND	Ascendis Pharma A/S	+10,000	181,977	$41,623,599
BTSG	BrightSpring Health Services, Inc.	+9,300	497,800	$21,211,258
No positions match the current search.

Trimmed

Positions the filer reduced

25 positions

Ticker	Company	Δ Shares	Shares	Value
ADCT	ADC Therapeutics SA	−4,504,828	1,318,026	$4,942,597
EYPT	EyePoint, Inc.	−1,399,167	1,069,147	$13,781,304
JANX	Janux Therapeutics, Inc.	−970,826	983,600	$13,672,040
ORIC	Oric Pharmaceuticals, Inc.	−947,827	2,693,929	$34,132,080
EW	Edwards Lifesciences Corp	−762,300	1,230,600	$98,546,448
TRVI	Trevi Therapeutics, Inc.	−736,300	2,454,400	$29,280,992
AVTX	Avalo Therapeutics, Inc.	−712,135	475,165	$7,094,213
CGON	CG Oncology, Inc.	−568,283	948,267	$64,178,710
ALMS	Alumis Inc.	−554,567	548,163	$12,076,030
CCCC	C4 Therapeutics, Inc.	−548,549	856,353	$2,252,208
TECX	Tectonic Therapeutic, Inc.	−348,000	226,600	$7,004,206
JBIO	Jade Biosciences, Inc.	−346,152	185,011	$2,599,404
BCRX	Biocryst Pharmaceuticals Inc	−316,600	1,425,200	$13,567,904
NPCE	NeuroPace Inc	−309,808	2,096,527	$27,569,330
CAI	Caris Life Sciences, Inc.	−309,200	2,806,811	$50,185,780
MBX	MBX Biosciences, Inc.	−297,316	3,637,887	$108,590,926
KALV	KalVista Pharmaceuticals, Inc.	−288,000	94,400	$1,900,272
ALNY	Alnylam Pharmaceuticals, Inc.	−169,800	119,000	$39,373,530
SYK	Stryker Corp	−142,500	182,500	$59,967,675
NTRA	Natera, Inc.	−103,800	262,000	$52,397,380
BIOA	BioAge Labs, Inc.	−79,090	711,811	$12,449,574
LLY	ELI LILLY & Co	−64,400	236,800	$217,801,536
ISRG	Intuitive Surgical Inc	−54,700	208,700	$96,208,613
KRYS	Krystal Biotech, Inc.	−50,700	69,100	$17,849,912
COGT	Cogent Biosciences, Inc.	−48,900	322,100	$12,397,629
No positions match the current search.

New Positions

Positions the filer opened this quarter

25 positions

Ticker	Company	Shares	Value
MYGN	Myriad Genetics Inc	125,000,000	$562,500,000
RCEL	AVITA Medical, Inc.	82,010,995	$303,440,681
AZN	Astrazeneca PLC	670,200	$132,176,844
MRK	Merck & Co., Inc.	663,400	$79,800,386
GH	Guardant Health, Inc.	435,200	$40,199,424
PVLA	Palvella Therapeutics, Inc.	184,600	$23,010,390
SNDX	Syndax Pharmaceuticals Inc	962,300	$22,479,328
STRO	Sutro Biopharma, Inc.	801,144	$19,956,497
NKTR	Nektar Therapeutics	275,000	$19,786,250
DFTX	Definium Therapeutics, Inc.	804,000	$15,195,600
AMGN	Amgen Inc	39,900	$14,038,815
ALHC	Alignment Healthcare, Inc.	791,000	$13,937,420
REGN	Regeneron Pharmaceuticals, Inc.	14,700	$11,357,808
BIIB	Biogen Inc.	61,600	$11,293,128
QGEN	Qiagen N.V.	250,000	$10,010,000
GILD	Gilead Sciences, Inc.	59,600	$8,306,452
HRTX	Heron Therapeutics, Inc. /De/	9,816,940	$7,853,552
CMPS	COMPASS Pathways plc	1,150,646	$6,363,072
ALXO	Alx Oncology Holdings Inc	2,866,256	$5,746,843
AORT	Artivion, Inc.	151,000	$5,529,620
SVRA	Savara Inc	635,000	$3,467,100
SLNO	Soleno Therapeutics Inc	100,000	$3,348,000
LFST	LifeStance Health Group, Inc.	500,000	$3,185,000
DRUG	Bright Minds Biosciences Inc.	40,000	$2,918,800
ATAI	AtaiBeckley Inc.	347,000	$1,228,380
No positions match the current search.

Sold Out

Positions the filer fully exited

17 positions

Ticker	Company	Shares	Value
TERN	Terns Pharmaceuticals, Inc.	2,153,300	$86,993,320
APLS	Apellis Pharmaceuticals, Inc.	2,429,868	$61,038,284
CI	Cigna Group	205,000	$56,422,150
UTHR	UNITED THERAPEUTICS Corp	105,200	$51,258,700
ROIV	Roivant Sciences Ltd.	2,190,907	$47,542,681
NBIX	Neurocrine Biosciences Inc	314,240	$44,568,659
EXAS	EXACT SCIENCES CORP	351,716	$35,720,276
BRKR	Bruker Corp	555,789	$26,183,219
CTMX	CytomX Therapeutics, Inc.	3,525,650	$15,019,269
VIR	Vir Biotechnology, Inc.	2,380,715	$14,355,711
TARS	Tarsus Pharmaceuticals, Inc.	154,400	$12,642,272
FOLD	AMICUS THERAPEUTICS, INC.	729,900	$10,393,776
CELC	Celcuity Inc.	85,664	$8,544,127
PMVP	PMV Pharmaceuticals, Inc.	4,975,291	$6,219,113
INSM	INSMED Inc	25,400	$4,420,616
OCUL	Ocular Therapeutix, Inc	157,300	$1,909,622
MPLT	MapLight Therapeutics, Inc.	56,000	$983,640
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

107 tracked positions · $5,097,795,616 total · filing declares 114 positions · $5,045,363,608 · as of Mar 31, 2026

All sectors Healthcare

Showing 1–50 of 107 positions by value · page 1 of 3

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
MYGN	Myriad Genetics Inc Healthcare	NEW	125,000,000	NEW	$562,500,000	NEW	11.03%
EWTX	Edgewise Therapeutics, Inc. Healthcare	Held	15,518,492	0	$488,832,498	+26.9%	9.59%
ELVN	Enliven Therapeutics, Inc. Healthcare	Held	7,959,538	0	$312,013,889	+154.5%	6.12%
RCEL	AVITA Medical, Inc. CALL + SHARES Healthcare	NEW	82,010,995	NEW	$303,440,681	NEW	5.95%
LLY	ELI LILLY & Co Healthcare	Reduced	236,800	-64,400	$217,801,536	−32.7%	4.27%
BSX	Boston Scientific Corp Healthcare	Reduced	2,382,100	-37,200	$149,476,775	−35.2%	2.93%
SION	Sionna Therapeutics, Inc. Healthcare	Reduced	3,530,702	-30,953	$141,545,843	−3.4%	2.78%
AZN	Astrazeneca PLC Healthcare	NEW	670,200	NEW	$132,176,844	NEW	2.59%
MBX	MBX Biosciences, Inc. Healthcare	Reduced	3,637,887	-297,316	$108,590,926	−12.5%	2.13%
CRVS	Corvus Pharmaceuticals, Inc. Healthcare	Held	7,165,006	0	$104,824,037	+90.0%	2.06%
ARGX	Argenx SE Healthcare	Reduced	136,900	-9,100	$99,971,225	−18.6%	1.96%
EW	Edwards Lifesciences Corp Healthcare	Reduced	1,230,600	-762,300	$98,546,448	−42.0%	1.93%
ISRG	Intuitive Surgical Inc Healthcare	Reduced	208,700	-54,700	$96,208,613	−35.5%	1.89%
CMPX	Compass Therapeutics, Inc. Healthcare	Held	15,219,994	0	$80,513,768	−1.5%	1.58%
MRK	Merck & Co., Inc. Healthcare	NEW	663,400	NEW	$79,800,386	NEW	1.57%
GPCR	Structure Therapeutics Inc. Healthcare	Added	1,475,403	+313,600	$71,114,424	−12.0%	1.40%
AVBP	ArriVent BioPharma, Inc. Healthcare	Held	3,027,328	0	$69,840,456	+14.7%	1.37%
IRON	Disc Medicine, Inc. Healthcare	Held	1,067,550	0	$68,259,147	−19.5%	1.34%
SPRY	ARS Pharmaceuticals, Inc. Healthcare	Held	8,288,510	0	$66,556,735	−31.1%	1.31%
CGON	CG Oncology, Inc. Healthcare	Reduced	948,267	-568,283	$64,178,710	+1.9%	1.26%
XENE	Xenon Pharmaceuticals Inc. Healthcare	Added	1,059,971	+612,771	$61,637,313	+207.5%	1.21%
SYK	Stryker Corp Healthcare	Reduced	182,500	-142,500	$59,967,675	−47.5%	1.18%
BMY	Bristol Myers Squibb Co Healthcare	Added	925,000	+150,000	$56,101,250	+34.2%	1.10%
MLYS	Mineralys Therapeutics, Inc. Healthcare	Added	2,052,900	+1,072,500	$55,613,061	+56.3%	1.09%
PRAX	Praxis Precision Medicines, Inc. Healthcare	Added	172,500	+78,000	$55,577,775	+99.5%	1.09%
PFE	Pfizer Inc Healthcare	Added	1,946,500	+293,600	$54,657,720	+32.8%	1.07%
DYN	Dyne Therapeutics, Inc. Healthcare	Added	2,917,884	+715,700	$52,901,236	+22.8%	1.04%
NTRA	Natera, Inc. Healthcare	Reduced	262,000	-103,800	$52,397,380	−37.5%	1.03%
ABVX	Abivax S.A. Healthcare	Added	465,700	+97,800	$51,855,695	+4.5%	1.02%
UPB	Upstream Bio, Inc. Healthcare	Held	5,693,589	0	$51,242,301	−66.9%	1.01%
DHR	Danaher Corp /De/ Healthcare	Reduced	265,800	-34,000	$50,395,680	−26.6%	0.99%
CAI	Caris Life Sciences, Inc. Healthcare	Reduced	2,806,811	-309,200	$50,185,780	−40.3%	0.98%
ASND	Ascendis Pharma A/S Healthcare	Added	181,977	+10,000	$41,623,599	+13.5%	0.82%
STTK	Shattuck Labs, Inc. Healthcare	Held	6,306,127	0	$40,548,396	+76.2%	0.80%
GH	Guardant Health, Inc. Healthcare	NEW	435,200	NEW	$40,199,424	NEW	0.79%
ALNY	Alnylam Pharmaceuticals, Inc. Healthcare	Reduced	119,000	-169,800	$39,373,530	−65.7%	0.77%
PRLD	Prelude Therapeutics Inc Healthcare	Held	10,909,256	0	$37,309,655	+17.9%	0.73%
CRNX	Crinetics Pharmaceuticals, Inc. Healthcare	Held	999,000	0	$36,283,680	−22.0%	0.71%
AXSM	Axsome Therapeutics, Inc. Healthcare	Reduced	213,921	-39,200	$36,156,927	−21.8%	0.71%
QURE	uniQure N.V. Healthcare	Added	2,136,149	+1,398,749	$34,926,036	+97.9%	0.69%
ORIC	Oric Pharmaceuticals, Inc. Healthcare	Reduced	2,693,929	-947,827	$34,132,080	+14.6%	0.67%
ELV	Elevance Health, Inc. Healthcare	Added	114,700	+15,600	$33,578,425	−3.3%	0.66%
RLMD	Relmada Therapeutics, Inc. Healthcare	Added	4,715,864	+2,105,264	$32,822,413	+160.3%	0.64%
FBRX	Forte Biosciences, Inc. Healthcare	Held	1,196,955	0	$31,001,134	−5.0%	0.61%
TRVI	Trevi Therapeutics, Inc. Healthcare	Reduced	2,454,400	-736,300	$29,280,992	−26.7%	0.57%
ESPR	Esperion Therapeutics, Inc. Healthcare	Added	10,570,300	+4,604,802	$28,962,622	+31.2%	0.57%
NPCE	NeuroPace Inc Healthcare	Reduced	2,096,527	-309,808	$27,569,330	−25.8%	0.54%
RYTM	Rhythm Pharmaceuticals, Inc. Healthcare	Added	314,100	+74,300	$27,317,277	+6.4%	0.54%
PVLA	Palvella Therapeutics, Inc. CALL + SHARES Healthcare	NEW	184,600	NEW	$23,010,390	NEW	0.45%
TMO	Thermo Fisher Scientific Inc. Healthcare	Held	46,500	0	$22,856,145	−15.2%	0.45%

Covers the securities this platform tracks: U.S.-listed common stock and the put/call positions reported on it. A 13F can also report security types outside that coverage — preferred shares, bonds, warrants, untracked share classes — so the filing's own declared total can exceed the figures above. The source filing is linked at the top of this table.