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Equibles

KRYS

Krystal Biotech, Inc.

Company with tickers: KRYS

CIK
1711279
CUSIP
501147102
Shares Outstanding
29,479,756
13F Activity (30d)
217 filings 212 filers

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Holders: 369
Total Value: $7,437,684,560
Total Shares: 28,792,524
Showing 1–100 of 379 holdings by value · page 1 of 4

Institutional Ownership Trend

25 quarters

Holder Concentration

Across 369 13F filers · Δ vs Dec 31, 2025
Top Holder
15.2%
Jun 2023 → Mar 2026 · range 10.1% – 16.1%
+0.1 pts
Top 5
48.5%
Jun 2023 → Mar 2026 · range 42.9% – 53.7%
−4.7 pts
Top 10
64.0%
Jun 2023 → Mar 2026 · range 59.1% – 66.5%
−1.9 pts
HHI
646
Jun 2023 → Mar 2026 · range 474 – 712
Broadly held −47

Quarterly Activity

vs Dec 31, 2025
New
75
Increased
140
Decreased
104
Sold Out
44
Unchanged
50
Holder count: +31
Institutional value: +5.0%
Shares held: +0.2%

Top Buyers

vs Dec 31, 2025
Institution Added Now Holds Open
Mid Soleus Capital Management, L.P. +212,028 1,153,087
Mega Invesco Ltd. +191,365 251,373
Mega FIRST TRUST ADVISORS LP +105,245 350,521
Mega RAYMOND JAMES FINANCIAL INC +79,526 156,064
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP +78,075 164,842

Top Sellers

vs Dec 31, 2025
Institution Sold Now Holds Open
Mega CITADEL ADVISORS LLC −377,179 32,126
Large MARSHALL WACE, LLP −115,411 68,343
Mega GOLDMAN SACHS GROUP INC −78,576 214,949
Mega BARCLAYS PLC −55,093 4,969
Mid ORBIMED ADVISORS LLC −50,700 69,100

Top New Positions

vs Dec 31, 2025
Institution Acquired Value (USD) Open
Mega VANGUARD PORTFOLIO MANAGEMENT LLC 1,456,727 $376,301,718
Mega VANGUARD CAPITAL MANAGEMENT LLC 1,165,324 $301,026,495
Mega VANGUARD FIDUCIARY TRUST CO 179,161 $46,280,869
Large SEB Asset Management AB 46,343 $11,971,323
Mid GILDER GAGNON HOWE & CO LLC 40,128 $10,365,864

Top Sold-Out Positions

vs Dec 31, 2025
Institution Previously Held Last Value (USD) Open
Mega VANGUARD GROUP INC 2,778,845 $685,096,443
Mega NORGES BANK 284,573 $70,158,627
Mid Skandinaviska Enskilda Banken AB (publ) 46,732 $11,521,307
Mid PERCEPTIVE ADVISORS LLC 17,500 $4,314,450
Large Verition Fund Management LLC 16,969 $4,183,537
Filter: New 75 Increased 140 Reduced 104 Sold out 44 Unchanged 50
Showing 100 of 379
All Common Calls Puts
Export CSV
Holder Value (USD) % of 13F Shares Open
Mega FMR LLC $1,129,888,320 15.19% 4,373,987
Mega BlackRock, Inc. $1,017,898,585 13.69% 3,940,456
Large Avoro Capital Advisors LLC $746,257,548 10.03% 2,888,888
Mega VANGUARD PORTFOLIO MANAGEMENT LLC $376,301,718 5.06% 1,456,727
Mega STATE STREET CORP $339,544,590 4.57% 1,314,434
Mega VANGUARD CAPITAL MANAGEMENT LLC $301,026,495 4.05% 1,165,324
Mid Soleus Capital Management, L.P. $297,865,433 4.00% 1,153,087
Mega Capital World Investors $213,041,670 2.86% 824,720
Mid Redmile Group, LLC $173,979,811 2.34% 673,505
Mega GEODE CAPITAL MANAGEMENT, LLC $166,351,621 2.24% 643,975
Mid Hood River Capital Management LLC $160,051,455 2.15% 619,586
Mega PRICE T ROWE ASSOCIATES INC /MD/ $125,304,315 1.68% 485,074
Mid Bellevue Group AG $124,454,701 1.67% 481,785
Mid Frazier Life Sciences Management, L.P. $124,331,224 1.67% 481,307
Mega DIMENSIONAL FUND ADVISORS LP $121,149,495 1.63% 468,990
Large WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC $105,182,220 1.41% 407,178
Mega FIRST TRUST ADVISORS LP $90,546,584 1.22% 350,521
Mega JANUS HENDERSON GROUP PLC $68,883,352 0.93% 266,659
Mega BANK OF AMERICA CORP /DE/ Bank $67,330,331 0.91% 260,647
Mega NORTHERN TRUST CORP Bank $65,216,239 0.88% 252,463
Mega Invesco Ltd. $64,934,672 0.87% 251,373
Mega CHARLES SCHWAB INVESTMENT MANAGEMENT INC $62,509,823 0.84% 241,986
Mega GOLDMAN SACHS GROUP INC $55,525,624 0.75% 214,949
Mega MORGAN STANLEY $54,010,058 0.73% 209,082
Mid BRAIDWELL LP $47,124,026 0.63% 182,425
Mega FRANKLIN RESOURCES INC $46,307,732 0.62% 179,265
Mega VANGUARD FIDUCIARY TRUST CO Bank $46,280,869 0.62% 179,161
Large Caption Management, LLC $43,914,400 0.59% 170,000
Mega PRINCIPAL FINANCIAL GROUP INC $41,865,922 0.56% 162,070
Mega RAYMOND JAMES FINANCIAL INC $40,314,451 0.54% 156,064
Large Woodline Partners LP $38,907,125 0.52% 150,616
Mega Bank of New York Mellon Corp Bank $38,568,980 0.52% 149,307
Mega UBS Group AG $37,075,376 0.50% 143,525
Mega Nuveen, LLC $37,034,820 0.50% 143,368
Mid TimesSquare Capital Management, LLC $29,020,185 0.39% 112,342
Large Pictet Asset Management Holding SA $28,586,982 0.38% 110,665
Large VOYA INVESTMENT MANAGEMENT LLC $28,001,112 0.38% 108,397
Mega JPMORGAN CHASE & CO $25,600,800 0.34% 99,105
Mega BNP PARIBAS ARBITRAGE, SA $24,031,767 0.32% 93,031
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP $23,946,264 0.32% 92,700
Large Public Sector Pension Investment Board Pension $23,839,319 0.32% 92,286
Large Handelsbanken Fonder AB $23,610,448 0.32% 91,400
Small S SQUARED TECHNOLOGY, LLC $22,271,058 0.30% 86,215
Mid SEGALL BRYANT & HAMILL, LLC $20,535,665 0.28% 79,497
Small Biondo Investment Advisors, LLC $18,610,664 0.25% 72,045
Mid ORBIMED ADVISORS LLC $17,849,912 0.24% 69,100
Large MARSHALL WACE, LLP $17,654,363 0.24% 68,343
Mega RHUMBLINE ADVISERS $17,591,333 0.24% 68,099
Mid C WorldWide Group Holding A/S $17,516,420 0.24% 67,809
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP $16,299,992 0.22% 63,100
Small ACT CAPITAL MANAGEMENT, LLC $15,622,418 0.21% 60,477
Mega Legal & General Group Plc $15,253,794 0.21% 59,050
Mega AMERIPRISE FINANCIAL INC $12,873,893 0.17% 49,837
Large SEI INVESTMENTS CO $12,029,962 0.16% 46,570
Large Bridgewater Associates, LP $11,977,523 0.16% 46,367
Large SEB Asset Management AB $11,971,323 0.16% 46,343
Small Palisades Investment Partners, LLC $11,729,019 0.16% 45,405
Mega TD Asset Management Inc $11,189,905 0.15% 43,318
Mega Swiss National Bank Bank $11,107,760 0.15% 43,000
Large 1832 Asset Management L.P. $11,004,432 0.15% 42,600
Mega VICTORY CAPITAL MANAGEMENT INC $10,517,498 0.14% 40,715
Mid GILDER GAGNON HOWE & CO LLC $10,365,864 0.14% 40,128
Small Atle Fund Management AB $9,707,407 0.13% 37,579
Mega UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC $9,541,562 0.13% 36,937
Mega MANUFACTURERS LIFE INSURANCE COMPANY, THE Insurance $9,317,344 0.13% 36,069
Mid MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC $9,263,096 0.12% 35,859
Large FEDERATED HERMES, INC. $9,169,068 0.12% 35,495
Mega NEUBERGER BERMAN GROUP LLC $8,546,258 0.11% 33,084
Mega ALLIANCEBERNSTEIN L.P. $8,247,899 0.11% 31,929
Mid CASTLEARK MANAGEMENT LLC $8,170,661 0.11% 31,630
Large NEW YORK STATE COMMON RETIREMENT FUND Pension $8,096,265 0.11% 31,342
Mega CITIGROUP INC $8,052,350 0.11% 31,172
Large Aberdeen Group plc $7,789,639 0.10% 30,155
Large PRUDENTIAL FINANCIAL INC $7,656,088 0.10% 29,638
Mega Fisher Asset Management, LLC $7,177,162 0.10% 27,784
Large Russell Investments Group, Ltd. $6,770,565 0.09% 26,210
Large CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM Pension $6,764,367 0.09% 26,186
Mega DEUTSCHE BANK AG\ Bank $6,414,342 0.09% 24,831
Mid Granite Investment Partners, LLC $6,273,042 0.08% 24,284
Large Fiera Capital Corp $6,237,393 0.08% 24,146
Small Elmind Capital, LP $5,683,040 0.08% 22,000
Large CANADA LIFE ASSURANCE Co Insurance $5,531,406 0.07% 21,413
Large STATE OF WISCONSIN INVESTMENT BOARD $5,344,899 0.07% 20,691
Mega VANGUARD ASSET MANAGEMENT, Ltd $5,322,941 0.07% 20,606
Large BESSEMER GROUP INC $5,240,020 0.07% 20,285
Mid Pinnacle Financial Partners, Inc. $5,212,897 0.07% 20,180
Mid EFG International AG $5,179,057 0.07% 20,049
Mid ADAR1 Capital Management, LLC $5,170,016 0.07% 20,014
Large Caption Management, LLC $5,166,400 0.07% 20,000
Small Tetragon Partners GP Ltd $5,080,637 0.07% 19,668
Large GW&K Investment Management, LLC $4,971,368 0.07% 19,245
Mega CITADEL ADVISORS LLC $4,882,248 0.07% 18,900
Small Lisanti Capital Growth, LLC $4,782,794 0.06% 18,515
Mega JANE STREET GROUP, LLC $4,778,920 0.06% 18,500
Large ZACKS INVESTMENT MANAGEMENT $4,628,835 0.06% 17,919
Mid Campbell & CO Investment Adviser LLC $4,596,804 0.06% 17,795
Large Rafferty Asset Management, LLC $4,568,905 0.06% 17,687
Mid State of Alaska, Department of Revenue $4,516,465 0.06% 17,484
Large Thrivent Financial for Lutherans $4,449,820 0.06% 17,226
Small Rhenman & Partners Asset Management AB $4,307,486 0.06% 16,675

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