UPB · Upstream Bio, Inc. · Holdings

$2.79 +0.04 (+1.45%) At close · Oct 27

Russell 2000 member Rebalance outlook locked

Market Cap

$153.63M

54.77M

Volume · Oct 27 1.18M Avg daily vol (3M) 817.31K

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Use institutional holdings through the 13F API or MCP → See every holder of UPB: 13F, 13D and 13G, insiders and funds →

The Sep 30, 2026 filing window is still open — showing the latest known positions. Funds that have not filed yet carry their prior-quarter positions; a fund that filed without this stock counts as sold out. Each fund's Change is measured against its own previous reported quarter, shown in the Reported column. Pick a completed quarter in the Quarter selector below to put every fund on one quarter and see the stock-wide activity breakdown.

Quarter:

Holders: 151

Total Value: $348,708,302

Total Shares: 50,546,370

Showing 1–100 of 152 holdings by value · page 1 of 2

Institutional Ownership Trend

8 quarters

Holder Concentration

Across 150 13F filers

Top Holder

16.1%

of institutional value

Top 5

47.6%

of institutional value

Top 10

62.5%

of institutional value

HHI

614

Broadly held

Who Holds UPB

Last 8 quarters through Sep 30, 2026 (filing window open)

Each kind of 13F filer's share of the common shares 13F filers report. Holder type comes from regulatory records, never the filer's name; style, turnover and horizon are measured from each filer's own 13F book. The quarter selector does not change this card.

Jun 30, 2026, the newest closed quarter: 148 filers, like-for-like change +4.3%; actively managed books +6.0%; index-like books -2.3%.

Holder type	Share	Filers	Change	New	Exited
Registered adviser	36.0%	67	+15.2%	15	18
Exempt adviser	3.8%	5	-5.0%	1	1
Adviser	0.2%	3	-91.7%	1	2
Bank	5.7%	13	+57.1%	3	0
Benefit plan	0.1%	4	-20.6%	1	0
Non-US	9.0%	7	+148.3%	2	1
Holding company	25.9%	8	+3.2%	2	0
Broker-dealer	0.0%	0	—	0	0
Insurer	0.0%	0	—	0	0
Unknown	19.2%	41	-12.0%	10	6

Style	Share	Filers	Change	New	Exited
Index-like	25.3%	23	-2.3%	0	0
Systematic-like	12.3%	19	+17.6%	5	3
Concentrated	13.4%	16	-11.5%	3	5
Diversified active	49.0%	90	+9.2%	27	20
Not measured	0.0%	0	—	0	0
Unknown	0.0%	0	—	0	0

Turnover	Share	Filers	Change	New	Exited
Low turnover	46.7%	69	+2.7%	12	11
Medium turnover	22.9%	33	-2.7%	8	8
High turnover	15.4%	34	+24.8%	12	7
Unknown	15.0%	12	+1.6%	3	2
Not measured	0.0%	0	—	0	0

Holding horizon	Share	Filers	Change	New	Exited
Short horizon	10.1%	22	-3.3%	4	4
Medium horizon	21.4%	26	-1.6%	5	5
Long horizon	45.7%	82	+12.2%	18	15
Unknown	22.9%	18	+1.4%	8	4
Not measured	0.0%	0	—	0	0

13F book size	Share	Filers	Change	New	Exited
Under $1B	13.9%	21	-1.1%	6	5
$1B to $10B	17.5%	30	-10.8%	8	12
$10B to $100B	12.0%	45	+22.4%	12	6
$100B or more	56.6%	52	+8.5%	9	5
Not measured	0.0%	0	—	0	0

Client base	Share	Filers	Change	New	Exited
Individuals and high net worth	0.3%	17	+13.3%	6	11
Pooled investment vehicles	24.0%	27	+8.5%	6	5
Registered funds and BDCs	8.6%	9	+7.1%	0	1
Pension and profit sharing plans	0.0%	1	-78.1%	0	0
Insurance companies	0.0%	2	+6.7%	0	0
Governments and sovereign funds	1.2%	3	+188.0%	1	0
Other investment advisers	0.0%	1	+62.8%	0	0
Diversified	1.7%	6	+566.2%	2	1
Other	0.0%	0	—	0	0
Unknown	64.0%	82	-1.7%	20	10

Private funds	Share	Filers	Change	New	Exited
Hedge funds	17.8%	33	+32.9%	8	6
Private equity funds	0.2%	4	-4.6%	1	3
Venture capital funds	1.4%	3	-34.7%	0	0
Real estate funds	0.0%	2	+334.7%	0	1
Securitized asset funds	0.0%	1	0.0%	0	0
Other private funds	12.4%	6	+7.2%	1	0
Mixed private funds	0.1%	1	-9.7%	0	1
Private funds, type not stated	0.2%	3	+7.5%	1	0
No private funds	7.8%	19	+0.5%	5	8
Unknown	60.1%	76	-1.4%	19	9

Location	Share	Filers	Change	New	Exited
United States	84.0%	115	+8.0%	29	24
Outside the US	16.0%	33	-22.0%	6	4

The Sep 30, 2026 filing window is still open, so its bar carries the Jun 30, 2026 positions of filers that have not filed yet.

How the mix is measured

Shares are 13F common shares restated to today's split basis; options and principal amounts are left out. The change compares only filers with a 13F in both quarters and keeps each filer in its bucket of the later quarter on both sides; a filer that continues under a new CIK is compared through its successor. Holder type comes from each filer's current regulatory profile; client base and private funds come from the Form ADV roster current at each quarter end (rosters from December 2019, so an earlier quarter reads Unknown). Style, turnover, horizon and book size are measured from each filer's 13F book in the newest measured quarter, and Not measured means none was. Actively managed books are those measured systematic-like, concentrated or diversified active.

Excluded 2 holders with no observed 2026-03-31 13F and 1 holder with no observed 2026-06-30 13F.

Conviction and Crowding

148 13F filers, quarter ended Jun 30, 2026

Measured across every 13F filer's common-share book once the quarter's filing window closed. Crowding counts filers with high turnover or that advise private funds on Form ADV.

Conviction holders

1.35% of filers hold it in their top 10

Mar 31, 2026: 2

Holders above 5%

median weight 0.000%

Mar 31, 2026: 1

Crowding

33.1%

of shares outstanding, 86th percentile

Mar 31, 2026: 28.2%

Private-fund advisers

29.8%

of shares outstanding

Institutional ownership

92.9%

119.9% of the estimated free float above 100%: filers can report lent or client shares more than once

Top 10 holders

62.5%

of 13F shares, Herfindahl 0.062

Active holders

+6.0%

like-for-like share change of active filers

5% stakes on record

1 13D, 4 13G (3 institutional, 0 passive, 1 exempt)

How long holders have held it value-weighted 5.7 quarters

Under 1 year 24.3% 1 to 3 years 75.7% 3 years or more 0.000% Since coverage start 0.000%

Managers in the top fifth by current three-year FundScore alpha were net sellers of $21,081 (0 buying, 1 selling).

Estimated Holder Cost Basis

Quarter ended Jun 30, 2026, on that quarter's share basis

Estimated, never filed: each 13F buy is costed at its quarter's average traded price and each sale keeps the average cost, so this is what holders paid on average if they traded evenly through each quarter.

Estimated avg cost

$17.94

estimated per share

Mar 31, 2026: $20.04

Quarter-end price

$6.92

implied by 13F values

Estimated gain or loss

-61.4%

price against the estimated cost

Estimated at a loss

100.0%

of costed 13F value

Estimated cost covers 79.5% of the 13F shares; positions already held when a filer's 13F history starts, or bought in a quarter without a trusted average price, have no estimate.

Shared Holders

Companies UPB's active holders also own, quarter ended Jun 30, 2026

#	Company	Shared holders	Similarity
1	HELP Helus Pharma Inc.	5	0.296
2	XLO Xilio Therapeutics, Inc.	3	0.294
3	PALI Palisade Bio, Inc.	5	0.267
4	CRVS Corvus Pharmaceuticals, Inc.	5	0.262
5	OVID Ovid Therapeutics Inc.	4	0.255
6	PHAT Phathom Pharmaceuticals, Inc.	4	0.248
7	CABA Cabaletta Bio, Inc.	3	0.231
8	KYTX Kyverna Therapeutics, Inc.	3	0.231
9	FBRX Forte Biosciences, Inc.	3	0.222
10	SPRB Spruce Biosciences, Inc.	3	0.222

Shareholder Targets

13F filers that own its peers but not UPB, quarter ended Jun 30, 2026

Found through its holder-overlap peers: HELP, XLO, PALI, CRVS, OVID, PHAT, CABA, KYTX, FBRX, SPRB, EYPT, BIOA, IVA, STTK, CRBP, MLYS, URGN, ARTV, ZNTL, ABEO. 527 filers in all.

#	Filer	In peers	Of book	Largest peers
1	RA CAPITAL MANAGEMENT, L.P. Registered adviser, Concentrated	$472,552,219 6 held	4.16%	MLYS, ARTV, BIOA
2	ADAGE CAPITAL PARTNERS GP, L.L.C. Registered adviser, Diversified active	$243,341,176 12 held	0.340%	EYPT, STTK, CABA
3	Catalys Pacific, LLC Exempt adviser, Unknown	$229,453,864 2 held	100.0%	MLYS, PHAT
4	Jupiter Topco LLC Unknown, Diversified active	$215,922,692 9 held	0.090%	OVID, EYPT, BIOA
5	Cormorant Asset Management, LP Registered adviser, Diversified active	$196,239,555 4 held	9.96%	EYPT, BIOA, CRBP
6	FRANKLIN RESOURCES INC Adviser, Diversified active	$191,678,575 10 held	0.040%	EYPT, MLYS, PHAT
7	RTW INVESTMENTS, LP Registered adviser, Diversified active	$167,215,336 1 held	1.43%	URGN
8	Frazier Life Sciences Management, L.P. Registered adviser, Concentrated	$165,334,002 3 held	3.60%	PHAT, STTK, XLO
9	T. Rowe Price Investment Management, Inc. Adviser, Diversified active	$151,907,237 2 held	0.100%	STTK, CABA
10	FEDERATED HERMES, INC. Adviser, Diversified active	$149,605,332 9 held	0.220%	EYPT, FBRX, OVID

Fund Ownership of UPB by Fund Type

Registered funds' Form N-PORT reports for the quarter ended Jun 30, 2026

Index funds and index ETFs hold 9.38% of shares outstanding.

Fund type	Of shares outstanding	Change	Shares	Funds
Index funds	2.13%	+0.14 pp	1,164,222	51
Index ETFs	7.26%	+0.26 pp	3,975,782	26
Active ETFs	0.66%	-0.29 pp	363,584	10
Active funds	16.57%	+7.13 pp	9,073,716	57
Unclassified	0.14%	+0.14 pp	77,747	5
All registered funds	26.76%	+7.38 pp	14,655,051	149

How fund types are measured

Each fund series counts once, with its latest Form N-PORT report dated inside the quarter; only long share positions count, restated to today's split basis. The fund type is the series' latest Form N-CEN answer on or before the quarter end (the index-fund box and the exchange-traded flag), never its name. Unclassified funds have no usable N-CEN; unit investment trusts are among them, so index ownership is a floor. Funds sit inside their advisers' 13F reports, so these shares overlap the 13F figures and are never added to them.

Holder type: Registered adviser 70 Exempt adviser 5 Adviser 3 Bank 13 Benefit plan 4 Non-US 7 Holding company 8 Unknown 41

Showing 100 of 152

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

FMR LLC

$56,487,246

16.20%

8,162,897

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	7,271,423	$50,318,247	89.1%	Defined
Fidelity Institutional Asset Management Trust Co	727,357	$5,033,310	8.9%	Defined
FIAM LLC	164,117	$1,135,689	2.0%	Defined

ORBIMED ADVISORS LLC

$39,399,635

11.30%

5,693,589

NORGES BANK

$26,078,843

7.48%

3,768,619

BlackRock, Inc.

$25,973,232

7.45%

3,753,358

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	152,431	$1,054,822	4.1%	Sole
BlackRock Asset Management Canada Ltd	321	$2,221	0.0%	Sole
BlackRock Investment Management, LLC	109,776	$759,649	2.9%	Sole
BLACKROCK ADVISORS LLC	495,363	$3,427,911	13.2%	Sole
BlackRock Fund Advisors	1,604,714	$11,104,620	42.8%	Sole
BlackRock Institutional Trust Company, N.A.	1,040,400	$7,199,568	27.7%	Sole
BlackRock Japan Co. Ltd	2,249	$15,563	0.1%	Sole
BlackRock Fund Managers Ltd.	9,279	$64,210	0.2%	Sole
BlackRock Investment Management (UK) Ltd.	22,412	$155,091	0.6%	Sole
BlackRock Asset Management Ireland Ltd	44,459	$307,656	1.2%	Sole
BlackRock (Luxembourg) S.A.	234,134	$1,620,207	6.2%	Sole
Aperio Group, LLC	37,820	$261,714	1.0%	Sole

Decheng Capital LLC

$18,856,086

5.41%

2,724,868

ENAVATE SCIENCES GP, LLC

$17,021,144

4.88%

2,459,703

VANGUARD CAPITAL MANAGEMENT LLC

$12,986,999

3.72%

1,876,734

MILLENNIUM MANAGEMENT LLC

$7,914,923

2.27%

1,143,775

D. E. Shaw & Co., Inc.

$7,169,423

2.06%

1,036,044

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
D. E. SHAW & CO, L.P.	837,568	$5,795,970	80.8%	Defined
D. E. Shaw Investment Management, L.L.C. joint	198,476	$1,373,453	19.2%	Defined

JPMORGAN CHASE & CO

$7,003,343

2.01%

1,012,044

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JPMorgan Chase Bank, N.A.	18,166	$125,708	1.8%	Defined
J.P. Morgan Investment Management Inc.	72,885	$504,364	7.2%	Defined
J.P. Morgan Securities LLC	916,682	$6,343,439	90.6%	Defined
J.P. Morgan Securities plc	4,311	$29,832	0.4%	Defined

Qube Research & Technologies Ltd

$6,771,220

1.94%

978,500

Parkman Healthcare Partners LLC

$6,471,909

1.86%

935,247

GEODE CAPITAL MANAGEMENT, LLC

$6,444,325

1.85%

931,261

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	130,972	$906,326	14.1%	Defined
Held directly	800,289	$5,537,999	85.9%	Defined

SEB Asset Management AB

$6,079,033

1.74%

878,473

Woodline Partners LP

$5,753,848

1.65%

831,481

STATE STREET CORP

$5,302,955

1.52%

766,323

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STATE STREET GLOBAL ADVISORS EUROPE LIMITED joint	766,323	$5,302,955	100.0%	Defined

VANGUARD PORTFOLIO MANAGEMENT LLC

$4,931,655

1.41%

712,667

Bain Capital Life Sciences Investors, LLC

$4,158,567

1.19%

600,949

AQR CAPITAL MANAGEMENT LLC

$3,770,491

1.08%

544,869

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RF&L WEALTH MANAGEMENT, LLC	23	$159	0.0%	Other
Compound Planning, Inc.	8	$55	0.0%	Other
Arax Advisory Partners	1,709	$11,826	0.3%	Other
HALBERT HARGROVE GLOBAL ADVISORS, LLC	1,070	$7,404	0.2%	Other
Stokes Family Office, LLC	854	$5,909	0.2%	Other
Held directly	541,205	$3,745,138	99.3%	Defined

MORGAN STANLEY

$3,630,451

1.04%

524,632

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	5,258	$36,385	1.0%	Defined
MORGAN STANLEY & CO. LLC	9,972	$69,006	1.9%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	462,064	$3,197,482	88.1%	Defined
MORGAN STANLEY SMITH BARNEY LLC	2,110	$14,601	0.4%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	45,228	$312,977	8.6%	Defined

BNP PARIBAS ARBITRAGE, SA

$3,539,898

1.02%

511,546

Walleye Capital LLC

$3,449,550

0.99%

498,490

Y-Intercept (Hong Kong) Ltd

$3,386,364

0.97%

642,574

Trexquant Investment LP

$3,227,695

0.93%

466,430

Point72 Asset Management, L.P.

$3,134,836

0.90%

453,011

BANK OF AMERICA CORP /DE/

$2,710,993

0.78%

391,762

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	391,762	$2,710,993	100.0%	Defined

DIMENSIONAL FUND ADVISORS LP

$2,640,761

0.76%

381,613

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Dimensional Fund Advisors Ltd.	4,862	$33,645	1.3%	Defined
DFA Australia Ltd.	7,036	$48,689	1.8%	Defined
Dimensional Ireland Ltd	28,174	$194,964	7.4%	Defined
Held directly	341,541	$2,363,463	89.5%	Sole

Altshuler Shaham Ltd

$2,630,022

0.75%

380,061

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Altshuler Shaham Provident & Pension Funds Ltd.	380,061	$2,630,022	100.0%	Defined

ARROWSTREET CAPITAL, LIMITED PARTNERSHIP

$2,475,671

0.71%

357,756

SAMSARA BIOCAPITAL, LLC

$2,447,721

0.70%

353,717

Propel Bio Management, LLC

$2,424,691

0.70%

350,389

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Simplify Asset Management Inc.	350,389	$2,424,691	100.0%	Defined

WELLINGTON MANAGEMENT GROUP LLP

$2,369,082

0.68%

342,353

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Wellington Management Company LLP	342,353	$2,369,082	100.0%	Defined

NORTHERN TRUST CORP

$2,057,632

0.59%

297,346

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	277,528	$1,920,493	93.3%	Defined
NORTHERN TRUST GLOBAL INVESTMENTS LTD	14,304	$98,983	4.8%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC joint	5,514	$38,156	1.9%	Other

Squarepoint Ops LLC

$2,013,055

0.58%

290,904

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Squarepoint Capital LLP	290,904	$2,013,055	100.0%	Defined

Voleon Capital Management LP

$1,973,819

0.57%

285,234

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$1,816,195

0.52%

262,456

JACOBS LEVY EQUITY MANAGEMENT, INC

$1,751,396

0.50%

253,092

GOLDMAN SACHS GROUP INC

$1,708,665

0.49%

246,917

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	246,917	$1,708,665	100.0%	Defined

XTX Topco Ltd

$1,677,034

0.48%

242,346

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
XTX EXECUTION SERVICES LLC joint	242,346	$1,677,034	100.0%	Defined

DEUTSCHE BANK AG\

$1,670,812

0.48%

241,447

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DWS Investment GmbH	208,418	$1,442,252	86.3%	Defined
DWS Investments UK Ltd	33,029	$228,560	13.7%	Defined

VANGUARD FIDUCIARY TRUST CO

$1,658,142

0.48%

239,616

UBS Group AG

$1,624,220

0.47%

234,714

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS AG	234,711	$1,624,200	100.0%	Defined
UBS Securities LLC	3	$20	0.0%	Defined

Schonfeld Strategic Advisors LLC

$1,562,259

0.45%

225,760

Jump Financial, LLC

$1,544,702

0.44%

223,223

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jump Trading Holdings, LLC	259	$1,792	0.1%	Defined
Leap GP LLC joint	222,964	$1,542,910	99.9%	Defined

SPHERA FUNDS MANAGEMENT LTD.

$1,520,324

0.44%

219,700

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Sphera Global Healthcare Management LP joint	219,700	$1,520,324	100.0%	Defined

ACADIAN ASSET MANAGEMENT LLC

$1,211,761

0.35%

175,110

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Acadian Inc	175,110	$1,211,761	100.0%	Defined

HRT FINANCIAL LP

$1,180,482

0.34%

170,590

Boxer Capital Management, LLC

$1,038,000

0.30%

150,000

RENAISSANCE TECHNOLOGIES LLC

$908,596

0.26%

131,300

EntryPoint Capital, LLC

$895,766

0.26%

129,446

ALGERT GLOBAL LLC

$820,919

0.24%

118,630

Bank of New York Mellon Corp

$593,368

0.17%

85,747

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Investments Corporation	28,571	$197,711	33.3%	Defined
The Bank of New York Mellon	56,356	$389,983	65.7%	Defined
BNY Mellon, NA joint	820	$5,674	1.0%	Defined

Nuveen, LLC

$586,608

0.17%

84,770

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Nuveen Asset Management, LLC joint	8,087	$55,962	9.5%	Defined
TEACHERS ADVISORS, LLC joint	76,683	$530,646	90.5%	Defined

AMERICAN CENTURY COMPANIES INC

$541,102

0.16%

78,194

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
AMERICAN CENTURY INVESTMENT MANAGEMENT INC	78,194	$541,102	100.0%	Defined

Man Group plc

$510,855

0.15%

73,823

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Numeric Investors LLC	73,823	$510,855	100.0%	Defined

GSA CAPITAL PARTNERS LLP

$479,888

0.14%

69,348

Simplify Asset Management Inc.

$429,821

0.12%

62,113

ALPS ADVISORS INC

$382,177

0.11%

55,228

Quantinno Capital Management LP

$379,478

0.11%

54,838

Virtus Investment Advisers, LLC

$371,174

0.11%

53,638

Invesco Ltd.

$369,505

0.11%

53,397

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invesco Advisers, Inc. joint	4,573	$31,644	8.6%	Defined
Invesco Trust Co joint	12,227	$84,610	22.9%	Defined
Invesco Capital Management LLC	36,597	$253,251	68.5%	Defined

ALLIANCEBERNSTEIN L.P.

$357,625

0.10%

51,680

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Equitable Holdings, Inc.	51,680	$357,625	100.0%	Defined

Brevan Howard Capital Management LP

$348,553

0.10%

50,369

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Brevan Howard US Investment Management, LP	50,369	$348,553	100.0%	Defined

Swiss National Bank

$332,852

0.10%

48,100

Russell Investments Group, Ltd.

$328,996

0.09%

47,543

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Russell Investment Management, LLC joint	28,112	$194,534	59.1%	Defined
Russell Investments Capital, LLC joint	11,507	$79,628	24.2%	Other
Russell Investments Trust Company joint	7,924	$54,834	16.7%	Other

Allspring Global Investments Holdings, LLC

$298,819

0.09%

43,182

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Allspring Global Investments, LLC reporting on behalf of UBS ASSET MANAGEMENT AMERICAS INC	43,182	$298,819	100.0%	Defined

RHUMBLINE ADVISERS

$293,297

0.08%

42,384

TWO SIGMA INVESTMENTS, LP

$292,889

0.08%

42,325

ExodusPoint Capital Management, LP

$284,031

0.08%

41,045

CITIGROUP INC

$279,145

0.08%

40,339

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citigroup Financial Products Inc. joint	40,339	$279,145	100.0%	Defined

CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM

$267,347

0.08%

38,634

Stonepine Capital Management, LLC

$231,349

0.07%

33,432

Mariner, LLC

$229,335

0.07%

33,141

WELLS FARGO & COMPANY/MN

$204,119

0.06%

29,497

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO BANK N A	29,497	$204,119	100.0%	Defined

BARCLAYS PLC

$202,118

0.06%

29,208

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BARCLAYS BANK PLC	27,978	$193,607	95.8%	Defined
BARCLAYS CAPITAL INC.	1,230	$8,511	4.2%	Defined

Creative Planning

$197,101

0.06%

28,483

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
CREATIVE PLANNING TRUST Co LLC	3,814	$26,392	13.4%	Defined
Held directly	24,669	$170,709	86.6%	Sole

Quantbot Technologies LP

$194,991

0.06%

28,178

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Manager 1	28,178	$194,991	100.0%	Sole

PRICE T ROWE ASSOCIATES INC /MD/

$194,161

0.06%

28,058

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T. Rowe Price International Ltd	28,058	$194,161	100.0%	Defined

AXQ CAPITAL, LP

$187,310

0.05%

27,068

nVerses Capital, LLC

$166,280

0.05%

24,029

DNB Asset Management AS

$163,312

0.05%

23,600

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DNB FUND	23,600	$163,312	100.0%	Other

VANGUARD ASSET MANAGEMENT, Ltd

$157,250

0.05%

22,724

Graham Capital Management, L.P.

$155,755

0.04%

22,508

LOS ANGELES CAPITAL MANAGEMENT LLC

$154,904

0.04%

22,385

Verdad Advisers, LP

$150,925

0.04%

21,810

MetLife Investment Management, LLC

$144,295

0.04%

20,852

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
METLIFE INC	20,852	$144,295	100.0%	Defined

SG Americas Securities, LLC

$140,738

0.04%

20,338

SEI INVESTMENTS CO

$138,579

0.04%

20,026

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SEI TRUST CO	20,026	$138,579	100.0%	Sole

WINTON GROUP Ltd

$137,016

0.04%

19,800

IEQ CAPITAL, LLC

$135,182

0.04%

19,535

DIADEMA PARTNERS LP

$132,123

0.04%

19,093

Shay Capital LLC

$124,560

0.04%

18,000

Quadrature Capital Ltd

$124,476

0.04%

17,988

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Quadrature US Inc.	17,988	$124,476	100.0%	Other

Entropy Technologies, LP

$121,390

0.03%

17,542

STATE OF WISCONSIN INVESTMENT BOARD

$118,089

0.03%

17,065

MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.

$112,221

0.03%

16,217

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Global X Management CO LLC joint	16,217	$112,221	100.0%	Defined

MANUFACTURERS LIFE INSURANCE COMPANY, THE

$108,886

0.03%

15,735

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MANULIFE FINANCIAL CORP joint	15,735	$108,886	100.0%	Defined

JANE STREET GROUP, LLC

$107,910

0.03%

15,594

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	11,174	$77,324	71.7%	Defined
Jane Street Global Trading, LLC	4,420	$30,586	28.3%	Defined

CITADEL ADVISORS LLC

$103,800

0.03%

15,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	15,000	$103,800	100.0%	Defined

MERCER GLOBAL ADVISORS INC /ADV

$92,395

0.03%

13,352

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Key facts CIK 2022626 CUSIP 91678A107 13F (30d) 12 filings 12 filers Visit website Investor relations