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UPB · Upstream Bio, Inc.

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$6.31 -0.09 (-1.41%)
Market Cap
$348.29M
Shares
54.42M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

The Jun 30, 2026 filing window is still open — showing the latest known positions. Funds that have not filed yet carry their prior-quarter positions; a fund that filed without this stock counts as sold out.
Holders: 141
Total Value: $394,321,726
Total Shares: 43,995,922
Showing 1–100 of 145 holdings by value · page 1 of 2

Institutional Ownership Trend

7 quarters

Holder Concentration

Across 142 13F filers
Top Holder
18.3%
Dec 2024 → Mar 2026 · range 14.7% – 18.3%
of institutional value
Top 5
50.4%
Dec 2024 → Mar 2026 · range 44.1% – 50.9%
of institutional value
Top 10
63.4%
Dec 2024 → Mar 2026 · range 62.6% – 75.7%
of institutional value
HHI
704
Dec 2024 → Mar 2026 · range 577 – 779
Broadly held
Showing 100 of 145
All Common Calls Puts
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Holder Value (USD) % of 13F Shares Open
Mega FMR LLC $72,914,067 18.49% 8,101,563
Mid ORBIMED ADVISORS LLC $51,242,301 13.00% 5,693,589
Mega BlackRock, Inc. $30,336,201 7.69% 3,370,689
Small Decheng Capital LLC $24,523,812 6.22% 2,724,868
Small ENAVATE SCIENCES GP, LLC $22,137,327 5.61% 2,459,703
Mega VANGUARD CAPITAL MANAGEMENT LLC $16,862,166 4.28% 1,873,574
Large FEDERATED HERMES, INC. $8,817,822 2.24% 979,758
Mega GEODE CAPITAL MANAGEMENT, LLC $8,555,553 2.17% 950,617
Mega MILLENNIUM MANAGEMENT LLC $8,435,907 2.14% 937,323
Large SEB Asset Management AB $7,906,257 2.01% 878,473
Mid Bain Capital Life Sciences Investors, LLC $7,804,899 1.98% 867,211
Large Woodline Partners LP $7,483,329 1.90% 831,481
Mega D. E. Shaw & Co., Inc. $7,384,320 1.87% 820,480
Small Parkman Healthcare Partners LLC $7,081,047 1.80% 786,783
Mid SAMSARA BIOCAPITAL, LLC $6,624,423 1.68% 736,047
Large Pictet Asset Management Holding SA $6,600,879 1.67% 733,431
Mega STATE STREET CORP $6,348,150 1.61% 705,350
Mega HSBC HOLDINGS PLC $5,762,934 1.46% 640,326
Large Qube Research & Technologies Ltd $5,573,889 1.41% 619,321
Mega MORGAN STANLEY $4,973,481 1.26% 552,609
Mid Y-Intercept (Hong Kong) Ltd $4,799,400 1.22% 693,555
Mega JPMORGAN CHASE & CO $4,167,009 1.06% 463,001
Mid Nantahala Capital Management, LLC $3,600,000 0.91% 400,000
Mid Altshuler Shaham Ltd $3,420,549 0.87% 380,061
Small SPHERA FUNDS MANAGEMENT LTD. $3,222,000 0.82% 358,000
Mega WELLINGTON MANAGEMENT GROUP LLP $3,081,177 0.78% 342,353
Small Propel Bio Management, LLC $3,076,011 0.78% 341,779
Mid Jump Financial, LLC $2,874,600 0.73% 319,400
Mega GOLDMAN SACHS GROUP INC $2,849,283 0.72% 316,587
Large Alyeska Investment Group, L.P. $2,684,961 0.68% 298,329
Mega NORTHERN TRUST CORP Bank $2,348,928 0.60% 260,992
Mega CHARLES SCHWAB INVESTMENT MANAGEMENT INC $2,319,561 0.59% 257,729
Small Prosight Management, LP $2,170,107 0.55% 241,123
Mega UBS Group AG $2,081,286 0.53% 231,254
Mega VANGUARD FIDUCIARY TRUST CO Bank $2,017,413 0.51% 224,157
Mid XTX Topco Ltd $1,883,493 0.48% 209,277
Mega ARROWSTREET CAPITAL, LIMITED PARTNERSHIP $1,665,783 0.42% 185,087
Mid TCG Crossover Management, LLC $1,629,567 0.41% 181,063
Mega DEUTSCHE BANK AG\ Bank $1,628,001 0.41% 180,889
Large Point72 Asset Management, L.P. $1,603,512 0.41% 178,168
Large Trexquant Investment LP $1,589,913 0.40% 176,657
Large Schonfeld Strategic Advisors LLC $1,452,141 0.37% 161,349
Small Boxer Capital Management, LLC $1,350,000 0.34% 150,000
Mega BNP PARIBAS ARBITRAGE, SA $1,134,000 0.29% 126,000
Large ExodusPoint Capital Management, LP $822,879 0.21% 91,431
Mega AMERICAN CENTURY COMPANIES INC $788,616 0.20% 87,624
Mega Bank of New York Mellon Corp Bank $732,447 0.19% 81,383
Mega DIMENSIONAL FUND ADVISORS LP $720,018 0.18% 80,002
Mega Nuveen, LLC $679,824 0.17% 75,536
Small EntryPoint Capital, LLC $662,112 0.17% 73,568
Mega AQR CAPITAL MANAGEMENT LLC $649,539 0.16% 72,171
Large MARSHALL WACE, LLP $600,930 0.15% 66,770
Large RENAISSANCE TECHNOLOGIES LLC $558,900 0.14% 62,100
Mega CITADEL ADVISORS LLC $483,300 0.12% 53,700
Large Quantinno Capital Management LP $444,501 0.11% 49,389
Mega BANK OF AMERICA CORP /DE/ Bank $436,140 0.11% 48,460
Mega Swiss National Bank Bank $432,900 0.11% 48,100
Small Simplify Asset Management Inc. $429,821 0.11% 62,113
Large Squarepoint Ops LLC $401,634 0.10% 44,626
Large ALPS ADVISORS INC $395,928 0.10% 43,992
Large STATE OF WISCONSIN INVESTMENT BOARD $375,039 0.10% 41,671
Mega RHUMBLINE ADVISERS $370,827 0.09% 41,203
Mega Invesco Ltd. $364,590 0.09% 40,510
Large CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM Pension $356,949 0.09% 39,661
Mid GSA CAPITAL PARTNERS LLP $353,088 0.09% 39,232
Small Stonepine Capital Management, LLC $315,000 0.08% 35,000
Mid ADAR1 Capital Management, LLC $315,000 0.08% 35,000
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP $305,100 0.08% 33,900
Mid Aquatic Capital Management LLC $283,356 0.07% 31,484
Mega ALLIANCEBERNSTEIN L.P. $279,090 0.07% 31,010
Mid Bleakley Financial Group, LLC $259,776 0.07% 28,864
Small AXQ CAPITAL, LP $247,527 0.06% 27,503
Large Mariner, LLC $245,826 0.06% 27,314
Mega PRICE T ROWE ASSOCIATES INC /MD/ $237,906 0.06% 26,434
Large TUDOR INVESTMENT CORP ET AL $237,708 0.06% 26,412
Mid MARTINGALE ASSET MANAGEMENT L P $236,007 0.06% 26,223
Mega VICTORY CAPITAL MANAGEMENT INC $232,794 0.06% 25,866
Mega CITADEL ADVISORS LLC $223,200 0.06% 24,800
Mega BARCLAYS PLC $222,480 0.06% 24,720
Large DNB Asset Management AS $211,635 0.05% 23,515
Mid Entropy Technologies, LP $210,024 0.05% 23,336
Small DIADEMA PARTNERS LP $194,481 0.05% 21,609
Large Man Group plc $190,386 0.05% 21,154
Large NISA INVESTMENT ADVISORS, LLC $176,022 0.04% 19,558
Large MetLife Investment Management, LLC $174,420 0.04% 19,380
Mega WELLS FARGO & COMPANY/MN $165,618 0.04% 18,402
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP $143,649 0.04% 15,961
Large MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. Mutual Fund $140,472 0.04% 15,608
Mega MANUFACTURERS LIFE INSURANCE COMPANY, THE Insurance $138,042 0.04% 15,338
Mega JANE STREET GROUP, LLC $137,700 0.03% 15,300
Mega FRANKLIN RESOURCES INC $131,301 0.03% 14,589
Mega Vanguard Global Advisers, LLC $117,531 0.03% 13,059
Large Corient Private Wealth LLC $109,413 0.03% 12,157
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP $108,900 0.03% 12,100
Large Point72 Asset Management, L.P. $103,500 0.03% 11,500
Large Creative Planning $97,650 0.02% 10,850
Small Virtus Investment Advisers, LLC $90,414 0.02% 10,046
Mid Shay Capital LLC $90,000 0.02% 10,000
Large STRS OHIO $88,200 0.02% 9,800
Mega Legal & General Group Plc $86,481 0.02% 9,609
Key facts CIK 2022626 CUSIP 91678A107 13F (30d) 13 filings 13 filers Visit website Investor relations

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