UPB · Upstream Bio, Inc. · Shareholders & Ownership
The latest filing states the doubt was alleviated.
“The Company has evaluated whether there are conditions and events, considered in the aggregate, that raise substantial doubt about the Company's ability to continue as a going concern within one year from the issuance of these condensed consolidated financial statements. The Company expects its cash, cash equivalents and short-term investments will be sufficient to fund its operating expenses and capital expenditure requirements for at least the next twelve months from the date of issuance of these condensed consolidated financial statements.”View the 10-Q filed May 13, 2026
Every disclosed holder of UPB in one list: 13F institutions, Schedule 13D and 13G filers, insiders (Forms 3, 4 and 5) and registered funds, each from its own latest filing. Holders nest by CIK and SEC reporting links, never by name, and each is summed once.
Who Owns UPB
13F quarter Sep 30, 2026, combined view: filers that have not filed yet carry their Jun 30, 2026 positionsNo chart: the summed disclosures exceed shares outstanding, so they are not parts of one whole.
| Holder group | Shares | % Out |
|---|---|---|
| Institutional (13F) | 50,509,381 | 92.22% |
| Insiders (Forms 3, 4, 5) | 167,425 | 0.31% |
| 13D/G-only blocks | 7,037,082 | 12.85% |
| Remaining | 2,942,847 | -5.37% |
| Registered funds (N-PORT, not summed) | 14,036,793 | 25.63% |
Shares outstanding: 54,771,041, the issuer's latest cover-page count restated onto today's split basis.
Remaining is negative: the summed disclosures exceed shares outstanding, as when filings are dated at different times or holders that do not disclose their links count the same shares. It is flagged, not clipped.
13D/G-only counts each filer's latest 13D or 13G that no 13F report of the listing contains, that names no 13F filer and that no counted insider files. Funds are never summed: their shares sit inside their advisers' 13F reports.
Holders of UPB
| # | Holder | Shares | As of | Notes |
|---|---|---|---|---|
| 1 |
FMR LLC
13F
CIK 315066 · Holding company · Jun 30, 2026
carried, not yet filed for the newest quarter
|
8,162,897 | ||
| 1.1 |
Fidelity Small Cap Growth Fund
Fund
S000007193 · Registered fund · Jul 31, 2026
Fidelity Securities Fund, not summed
|
1,371,372 | ||
| 1.2 |
Fidelity Stock Selector Small Cap Fund
Fund
S000005453 · Registered fund · Jul 31, 2026
Fidelity Capital Trust, not summed
|
1,321,800 | ||
| 1.3 |
Fidelity Series Small Cap Opportunities Fund
Fund
S000015587 · Registered fund · Jul 31, 2026
Fidelity Securities Fund, not summed
|
965,800 | ||
| 1.4 |
Select Health Care Portfolio
Fund
S000007466 · Registered fund · Aug 31, 2026
Fidelity Select Portfolios, not summed
|
800,000 | ||
| 1.5 |
Fidelity Small Cap Growth K6 Fund
Fund
S000057285 · Registered fund · Jul 31, 2026
Fidelity Securities Fund, not summed
|
693,618 | ||
| 2 |
ORBIMED ADVISORS LLC
13F
CIK 1055951 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
5,693,589 | ||
| 3 |
NORGES BANK
13F
CIK 1374170 · Non-US institution · Jun 30, 2026
carried, not yet filed for the newest quarter
|
3,768,619 | ||
| 3.1 |
NORGES BANK
13G
CIK 1374170 · Non-US institution · Jun 30, 2026
Rule 13d-1(b), qualified institution, not summed
|
4,206,586 | ||
| 4 |
BlackRock, Inc.
13F
CIK 2012383 · Holding company · Jun 30, 2026
carried, not yet filed for the newest quarter
|
3,753,358 | ||
| 4.1 |
BlackRock, Inc.
13G
CIK 2012383 · Holding company · Jun 30, 2026
Rule 13d-1(b), qualified institution, not summed
|
2,814,714 | ||
| 4.2 |
iShares Russell 2000 ETF
Fund
S000004344 · Registered fund · Jun 30, 2026
iShares Trust, not summed
|
921,063 | ||
| 4.3 |
iShares Russell 2000 Value ETF
Fund
S000004342 · Registered fund · Jun 30, 2026
iShares Trust, not summed
|
338,261 | ||
| 4.4 |
iShares Biotechnology ETF
Fund
S000004350 · Registered fund · Jun 30, 2026
iShares Trust, not summed
|
256,130 | ||
| 4.5 |
Master Small Cap Index Series
Fund
S000002716 · Registered fund · Jun 30, 2026
Quantitative Master Series LLC, not summed
|
55,900 | ||
| 5 |
Decheng Capital LLC
13F
CIK 2010850 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
|
2,724,868 | ||
| 6 |
|
2,724,868 | ||
| 7 |
ENAVATE SCIENCES GP, LLC
13F
CIK 1953107 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
|
2,459,703 | ||
| 8 |
HBM Healthcare Investments (Cayman) Ltd.
13G
CIK 1232258 · Unknown · Sep 30, 2025
Rule 13d-1(d), exempt investor
|
2,195,111 | ||
| 9 |
|
2,117,103 | ||
| 10 |
VANGUARD CAPITAL MANAGEMENT LLC
13F
CIK 2100119 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
1,876,734 | ||
| 11 |
VANGUARD TOTAL STOCK MARKET INDEX FUND
Fund
S000002848 · Registered fund · Jun 30, 2026
VANGUARD INDEX FUNDS, not summed
|
1,443,025 | ||
| 12 |
MILLENNIUM MANAGEMENT LLC
13F
CIK 1273087 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
1,143,775 | ||
| 13 |
D. E. Shaw & Co., Inc.
13F
CIK 1009207 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
|
1,036,044 | ||
| 14 |
JPMORGAN CHASE & CO
13F
CIK 19617 · Bank · Jun 30, 2026
carried, not yet filed for the newest quarter
|
1,012,044 | ||
| 15 |
Qube Research & Technologies Ltd
13F
CIK 1729829 · Exempt reporting adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
978,500 | ||
| 16 |
Parkman Healthcare Partners LLC
13F
CIK 1777015 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
935,247 | ||
| 17 |
GEODE CAPITAL MANAGEMENT, LLC
13F
CIK 1214717 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
931,261 | ||
| 18 |
SEB Asset Management AB
13F
CIK 2127509 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
|
878,473 | ||
| 19 |
Woodline Partners LP
13F
CIK 1784547 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
831,481 | ||
| 20 |
|
766,323 | ||
| 20.1 |
STATE STREET SMALL/MID CAP EQUITY INDEX PORTFOLIO
Fund
S000050332 · Registered fund · Jun 30, 2026
STATE STREET INSTITUTIONAL INVESTMENT TRUST, not summed
|
11,100 | ||
| 20.2 |
State Street(R) SPDR(R) Portfolio MSCI Global Stock Market ETF
Fund
S000036082 · Registered fund · Jun 30, 2026
SPDR INDEX SHARES FUNDS, not summed
|
2,240 | ||
| 20.3 |
State Street Total Return V.I.S. Fund
Fund
S000001637 · Registered fund · Jun 30, 2026
STATE STREET VARIABLE INSURANCE SERIES FUNDS INC, not summed
|
779 | ||
| 21 |
VANGUARD PORTFOLIO MANAGEMENT LLC
13F
CIK 2100121 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
712,667 | ||
| 22 |
Y-Intercept (Hong Kong) Ltd
13F
CIK 1772875 · Exempt reporting adviser · Sep 30, 2026
|
642,574 | ||
| 23 |
Bain Capital Life Sciences Investors, LLC
13F
CIK 1703031 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
|
600,949 | ||
| 24 |
AQR CAPITAL MANAGEMENT LLC
13F
CIK 1167557 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
544,869 | ||
| 25 |
MORGAN STANLEY
13F
CIK 895421 · Holding company · Jun 30, 2026
carried, not yet filed for the newest quarter
|
524,632 | ||
| 26 |
BNP PARIBAS ARBITRAGE, SA
13F
CIK 1166588 · Non-US institution · Jun 30, 2026
carried, not yet filed for the newest quarter
|
511,546 | ||
| 27 |
Walleye Capital LLC
13F
CIK 1758720 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
498,490 | ||
| 28 |
Trexquant Investment LP
13F
CIK 1633445 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
466,430 | ||
| 29 |
Point72 Asset Management, L.P.
13F
CIK 1603466 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
453,011 | ||
| 30 |
BANK OF AMERICA CORP /DE/
13F
CIK 70858 · Bank · Jun 30, 2026
carried, not yet filed for the newest quarter
|
391,762 | ||
| 31 |
VANGUARD EXTENDED MARKET INDEX FUND
Fund
S000002841 · Registered fund · Jun 30, 2026
VANGUARD INDEX FUNDS, not summed
|
386,877 | ||
| 32 |
DIMENSIONAL FUND ADVISORS LP
13F
CIK 354204 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
381,613 | ||
| 32.1 |
Dimensional U.S. Small Cap ETF
Fund
S000070906 · Registered fund · Jul 31, 2026
Dimensional ETF Trust, not summed
|
150,504 | ||
| 32.2 |
U.S. MICRO CAP PORTFOLIO
Fund
S000000948 · Registered fund · Jul 31, 2026
DFA INVESTMENT DIMENSIONS GROUP INC, not summed
|
73,550 | ||
| 32.3 |
U.S. SMALL CAP PORTFOLIO
Fund
S000000971 · Registered fund · Jul 31, 2026
DFA INVESTMENT DIMENSIONS GROUP INC, not summed
|
39,624 | ||
| 32.4 |
U.S. VECTOR EQUITY PORTFOLIO
Fund
S000000982 · Registered fund · Jul 31, 2026
DFA INVESTMENT DIMENSIONS GROUP INC, not summed
|
11,605 | ||
| 32.5 |
Dimensional US Core Equity Market ETF
Fund
S000069432 · Registered fund · Jul 31, 2026
Dimensional ETF Trust, not summed
|
10,145 | ||
| 33 |
Altshuler Shaham Ltd
13F
CIK 1324290 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
|
380,061 | ||
| 34 |
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP
13F
CIK 1164508 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
357,756 | ||
| 35 |
SAMSARA BIOCAPITAL, LLC
13F
CIK 1744967 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
353,717 | ||
| 36 |
Propel Bio Management, LLC
13F
CIK 1969764 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
350,389 | ||
| 37 |
WELLINGTON MANAGEMENT GROUP LLP
13F
CIK 902219 · Holding company · Jun 30, 2026
carried, not yet filed for the newest quarter
|
342,353 | ||
| 38 |
NORTHERN TRUST CORP
13F
CIK 73124 · Bank · Jun 30, 2026
carried, not yet filed for the newest quarter
|
297,346 | ||
| 38.1 |
Small Cap Index Fund
Fund
S000001245 · Registered fund · Jun 30, 2026
Northern Funds, not summed
|
18,296 | ||
| 39 |
Squarepoint Ops LLC
13F
CIK 1642575 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
290,904 | ||
| 40 |
Voleon Capital Management LP
13F
CIK 1479847 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
285,234 | ||
| 41 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC
13F
CIK 884546 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
262,456 | ||
| 41.1 |
Schwab U.S. Small-Cap ETF
Fund
S000026636 · Registered fund · Aug 31, 2026
SCHWAB STRATEGIC TRUST, not summed
|
160,187 | ||
| 41.2 |
Schwab Small-Cap Index Fund
Fund
S000005912 · Registered fund · Jul 31, 2026
SCHWAB CAPITAL TRUST, not summed
|
84,939 | ||
| 41.3 |
Schwab Total Stock Market Index Fund
Fund
S000005913 · Registered fund · Jul 31, 2026
SCHWAB CAPITAL TRUST, not summed
|
21,000 | ||
| 42 |
JACOBS LEVY EQUITY MANAGEMENT, INC
13F
CIK 884414 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
253,092 | ||
| 43 |
GOLDMAN SACHS GROUP INC
13F
CIK 886982 · Holding company · Jun 30, 2026
carried, not yet filed for the newest quarter
|
246,917 | ||
| 44 |
XTX Topco Ltd
13F
CIK 1828301 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
|
242,346 | ||
| 45 |
DEUTSCHE BANK AG\
13F
CIK 948046 · Non-US institution · Jun 30, 2026
carried, not yet filed for the newest quarter
|
241,447 | ||
| 45.1 |
DWS Small Cap Index VIP
Fund
S000006223 · Registered fund · Jun 30, 2026
DEUTSCHE DWS INVESTMENTS VIT FUNDS, not summed
|
5,514 | ||
| 46 |
VANGUARD FIDUCIARY TRUST CO
13F
CIK 933478 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
|
239,616 | ||
| 47 |
|
234,714 | ||
| 48 |
VANGUARD STRATEGIC SMALL-CAP EQUITY FUND
Fund
S000012432 · Registered fund · Jun 30, 2026
VANGUARD HORIZON FUNDS, not summed
|
234,635 | ||
| 49 |
Schonfeld Strategic Advisors LLC
13F
CIK 1665241 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
225,760 | ||
| 50 |
Jump Financial, LLC
13F
CIK 1831577 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
|
223,223 |
37 more nested rows are not shown here; Every filing lists them all.
Shares are restated onto today's split basis. Change compares each row with the same holder's previous filing in the same source; a dash means there is none to compare. Nested 13D/G, insider and fund rows are not summed, since a 13F report already holds them.
Showing 1–50 of 229 holders
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