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UPB · Upstream Bio, Inc. · Shareholders & Ownership

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$2.79 +0.04 (+1.45%) At close · Oct 27
Market Cap
$153.63M
Shares
54.77M
Volume · Oct 27 1.18M Avg daily vol (3M) 817.31K

Every disclosed holder of UPB in one list: 13F institutions, Schedule 13D and 13G filers, insiders (Forms 3, 4 and 5) and registered funds, each from its own latest filing. Holders nest by CIK and SEC reporting links, never by name, and each is summed once.

Who Owns UPB

13F quarter Sep 30, 2026, combined view: filers that have not filed yet carry their Jun 30, 2026 positions

No chart: the summed disclosures exceed shares outstanding, so they are not parts of one whole.

Holder group Shares % Out
Institutional (13F) 50,509,381 92.22%
Insiders (Forms 3, 4, 5) 167,425 0.31%
13D/G-only blocks 7,037,082 12.85%
Remaining 2,942,847 -5.37%
Registered funds (N-PORT, not summed) 14,036,793 25.63%

Shares outstanding: 54,771,041, the issuer's latest cover-page count restated onto today's split basis.

Remaining is negative: the summed disclosures exceed shares outstanding, as when filings are dated at different times or holders that do not disclose their links count the same shares. It is flagged, not clipped.

13D/G-only counts each filer's latest 13D or 13G that no 13F report of the listing contains, that names no 13F filer and that no counted insider files. Funds are never summed: their shares sit inside their advisers' 13F reports.

Holders of UPB

# Holder Shares
1
FMR LLC
13F CIK 315066 · Holding company · Jun 30, 2026
carried, not yet filed for the newest quarter
8,162,897
1.1
Fidelity Small Cap Growth Fund
Fund S000007193 · Registered fund · Jul 31, 2026
Fidelity Securities Fund, not summed
1,371,372
1.2
Fidelity Stock Selector Small Cap Fund
Fund S000005453 · Registered fund · Jul 31, 2026
Fidelity Capital Trust, not summed
1,321,800
1.3
Fidelity Series Small Cap Opportunities Fund
Fund S000015587 · Registered fund · Jul 31, 2026
Fidelity Securities Fund, not summed
965,800
1.4
Select Health Care Portfolio
Fund S000007466 · Registered fund · Aug 31, 2026
Fidelity Select Portfolios, not summed
800,000
1.5
Fidelity Small Cap Growth K6 Fund
Fund S000057285 · Registered fund · Jul 31, 2026
Fidelity Securities Fund, not summed
693,618
2
ORBIMED ADVISORS LLC
13F CIK 1055951 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
5,693,589
3
NORGES BANK
13F CIK 1374170 · Non-US institution · Jun 30, 2026
carried, not yet filed for the newest quarter
3,768,619
3.1
NORGES BANK
13G CIK 1374170 · Non-US institution · Jun 30, 2026
Rule 13d-1(b), qualified institution, not summed
4,206,586
4
BlackRock, Inc.
13F CIK 2012383 · Holding company · Jun 30, 2026
carried, not yet filed for the newest quarter
3,753,358
4.1
BlackRock, Inc.
13G CIK 2012383 · Holding company · Jun 30, 2026
Rule 13d-1(b), qualified institution, not summed
2,814,714
4.2
iShares Russell 2000 ETF
Fund S000004344 · Registered fund · Jun 30, 2026
iShares Trust, not summed
921,063
4.3
iShares Russell 2000 Value ETF
Fund S000004342 · Registered fund · Jun 30, 2026
iShares Trust, not summed
338,261
4.4
iShares Biotechnology ETF
Fund S000004350 · Registered fund · Jun 30, 2026
iShares Trust, not summed
256,130
4.5
Master Small Cap Index Series
Fund S000002716 · Registered fund · Jun 30, 2026
Quantitative Master Series LLC, not summed
55,900
5
Decheng Capital LLC
13F CIK 2010850 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
2,724,868
6
Xiangmin Cui
13G CIK 1834150 · Unknown · Mar 31, 2026
Rule 13d-1(d), exempt investor
2,724,868
7
ENAVATE SCIENCES GP, LLC
13F CIK 1953107 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
2,459,703
8
HBM Healthcare Investments (Cayman) Ltd.
13G CIK 1232258 · Unknown · Sep 30, 2025
Rule 13d-1(d), exempt investor
2,195,111
9
TCG Crossover GP I, LLC
13G CIK 1839947 · Unknown · Sep 30, 2025
Rule 13d-1(c), passive investor
2,117,103
10
VANGUARD CAPITAL MANAGEMENT LLC
13F CIK 2100119 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
1,876,734
11
VANGUARD TOTAL STOCK MARKET INDEX FUND
Fund S000002848 · Registered fund · Jun 30, 2026
VANGUARD INDEX FUNDS, not summed
1,443,025
12
MILLENNIUM MANAGEMENT LLC
13F CIK 1273087 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
1,143,775
13
D. E. Shaw & Co., Inc.
13F CIK 1009207 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
1,036,044
14
JPMORGAN CHASE & CO
13F CIK 19617 · Bank · Jun 30, 2026
carried, not yet filed for the newest quarter
1,012,044
15
Qube Research & Technologies Ltd
13F CIK 1729829 · Exempt reporting adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
978,500
16
Parkman Healthcare Partners LLC
13F CIK 1777015 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
935,247
17
GEODE CAPITAL MANAGEMENT, LLC
13F CIK 1214717 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
931,261
18
SEB Asset Management AB
13F CIK 2127509 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
878,473
19
Woodline Partners LP
13F CIK 1784547 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
831,481
20
STATE STREET CORP
13F CIK 93751 · Bank · Jun 30, 2026
carried, not yet filed for the newest quarter
766,323
20.1
STATE STREET SMALL/MID CAP EQUITY INDEX PORTFOLIO
Fund S000050332 · Registered fund · Jun 30, 2026
STATE STREET INSTITUTIONAL INVESTMENT TRUST, not summed
11,100
20.2
State Street(R) SPDR(R) Portfolio MSCI Global Stock Market ETF
Fund S000036082 · Registered fund · Jun 30, 2026
SPDR INDEX SHARES FUNDS, not summed
2,240
20.3
State Street Total Return V.I.S. Fund
Fund S000001637 · Registered fund · Jun 30, 2026
STATE STREET VARIABLE INSURANCE SERIES FUNDS INC, not summed
779
21
VANGUARD PORTFOLIO MANAGEMENT LLC
13F CIK 2100121 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
712,667
22
Y-Intercept (Hong Kong) Ltd
13F CIK 1772875 · Exempt reporting adviser · Sep 30, 2026
642,574
23
Bain Capital Life Sciences Investors, LLC
13F CIK 1703031 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
600,949
24
AQR CAPITAL MANAGEMENT LLC
13F CIK 1167557 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
544,869
25
MORGAN STANLEY
13F CIK 895421 · Holding company · Jun 30, 2026
carried, not yet filed for the newest quarter
524,632
26
BNP PARIBAS ARBITRAGE, SA
13F CIK 1166588 · Non-US institution · Jun 30, 2026
carried, not yet filed for the newest quarter
511,546
27
Walleye Capital LLC
13F CIK 1758720 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
498,490
28
Trexquant Investment LP
13F CIK 1633445 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
466,430
29
Point72 Asset Management, L.P.
13F CIK 1603466 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
453,011
30
BANK OF AMERICA CORP /DE/
13F CIK 70858 · Bank · Jun 30, 2026
carried, not yet filed for the newest quarter
391,762
31
VANGUARD EXTENDED MARKET INDEX FUND
Fund S000002841 · Registered fund · Jun 30, 2026
VANGUARD INDEX FUNDS, not summed
386,877
32
DIMENSIONAL FUND ADVISORS LP
13F CIK 354204 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
381,613
32.1
Dimensional U.S. Small Cap ETF
Fund S000070906 · Registered fund · Jul 31, 2026
Dimensional ETF Trust, not summed
150,504
32.2
U.S. MICRO CAP PORTFOLIO
Fund S000000948 · Registered fund · Jul 31, 2026
DFA INVESTMENT DIMENSIONS GROUP INC, not summed
73,550
32.3
U.S. SMALL CAP PORTFOLIO
Fund S000000971 · Registered fund · Jul 31, 2026
DFA INVESTMENT DIMENSIONS GROUP INC, not summed
39,624
32.4
U.S. VECTOR EQUITY PORTFOLIO
Fund S000000982 · Registered fund · Jul 31, 2026
DFA INVESTMENT DIMENSIONS GROUP INC, not summed
11,605
32.5
Dimensional US Core Equity Market ETF
Fund S000069432 · Registered fund · Jul 31, 2026
Dimensional ETF Trust, not summed
10,145
33
Altshuler Shaham Ltd
13F CIK 1324290 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
380,061
34
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP
13F CIK 1164508 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
357,756
35
SAMSARA BIOCAPITAL, LLC
13F CIK 1744967 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
353,717
36
Propel Bio Management, LLC
13F CIK 1969764 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
350,389
37
WELLINGTON MANAGEMENT GROUP LLP
13F CIK 902219 · Holding company · Jun 30, 2026
carried, not yet filed for the newest quarter
342,353
38
NORTHERN TRUST CORP
13F CIK 73124 · Bank · Jun 30, 2026
carried, not yet filed for the newest quarter
297,346
38.1
Small Cap Index Fund
Fund S000001245 · Registered fund · Jun 30, 2026
Northern Funds, not summed
18,296
39
Squarepoint Ops LLC
13F CIK 1642575 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
290,904
40
Voleon Capital Management LP
13F CIK 1479847 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
285,234
41
CHARLES SCHWAB INVESTMENT MANAGEMENT INC
13F CIK 884546 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
262,456
41.1
Schwab U.S. Small-Cap ETF
Fund S000026636 · Registered fund · Aug 31, 2026
SCHWAB STRATEGIC TRUST, not summed
160,187
41.2
Schwab Small-Cap Index Fund
Fund S000005912 · Registered fund · Jul 31, 2026
SCHWAB CAPITAL TRUST, not summed
84,939
41.3
Schwab Total Stock Market Index Fund
Fund S000005913 · Registered fund · Jul 31, 2026
SCHWAB CAPITAL TRUST, not summed
21,000
42
JACOBS LEVY EQUITY MANAGEMENT, INC
13F CIK 884414 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
253,092
43
GOLDMAN SACHS GROUP INC
13F CIK 886982 · Holding company · Jun 30, 2026
carried, not yet filed for the newest quarter
246,917
44
XTX Topco Ltd
13F CIK 1828301 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
242,346
45
DEUTSCHE BANK AG\
13F CIK 948046 · Non-US institution · Jun 30, 2026
carried, not yet filed for the newest quarter
241,447
45.1
DWS Small Cap Index VIP
Fund S000006223 · Registered fund · Jun 30, 2026
DEUTSCHE DWS INVESTMENTS VIT FUNDS, not summed
5,514
46
VANGUARD FIDUCIARY TRUST CO
13F CIK 933478 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
239,616
47
UBS Group AG
13F CIK 1610520 · Bank · Jun 30, 2026
carried, not yet filed for the newest quarter
234,714
48
VANGUARD STRATEGIC SMALL-CAP EQUITY FUND
Fund S000012432 · Registered fund · Jun 30, 2026
VANGUARD HORIZON FUNDS, not summed
234,635
49
Schonfeld Strategic Advisors LLC
13F CIK 1665241 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
225,760
50
Jump Financial, LLC
13F CIK 1831577 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
223,223

37 more nested rows are not shown here; Every filing lists them all.

Shares are restated onto today's split basis. Change compares each row with the same holder's previous filing in the same source; a dash means there is none to compare. Nested 13D/G, insider and fund rows are not summed, since a 13F report already holds them.

Showing 1–50 of 229 holders

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Key facts CIK 2022626 CUSIP 91678A107 13F (30d) 14 filings 14 filers Visit website Investor relations