UPB · Upstream Bio, Inc.
$6.98
+0.13 (+1.90%)
At close · Aug 21
Going-concern doubt
— flagged Aug 11, 2026
Substantial doubt about the company's ability to continue as a going concern.
“The Company has evaluated whether there are conditions and events, considered in the aggregate, that raise substantial doubt about the Company's ability to continue as a going concern within one year from the issuance of these condensed consolidated financial statements.”View the 10-Q filed Aug 11, 2026
Market Cap
$375.18M
Shares
54.77M
Weekly off-exchange (dark pool / OTC) trading volume reported to FINRA under its OTC/ATS Transparency data. ATS volume is executed on alternating trading systems (dark pools); non-ATS OTC is other over-the-counter dealer volume. The off-exchange share is total off-exchange volume as a percentage of consolidated weekly trading volume for the same Monday–Friday week.
Off-Exchange Volume History
| Week Start | ATS Volume | Non-ATS OTC Volume | Total Off-Exchange | % of FINRA Weekly Volume |
|---|---|---|---|---|
| 2026-07-13 | 410,862 | 162,442 | 573,304 | 30.5% |
| 2026-07-06 | 686,844 | 259,318 | 946,162 | 36.2% |
| 2026-06-29 | 537,360 | 310,566 | 847,926 | 39.5% |
| 2026-06-22 | 945,971 | 444,705 | 1,390,676 | 35.6% |
| 2026-06-15 | 656,648 | 282,335 | 938,983 | 32.7% |
| 2026-06-08 | 1,046,746 | 404,836 | 1,451,582 | 36.3% |
| 2026-06-01 | 913,096 | 398,741 | 1,311,837 | 40.3% |
| 2026-05-25 | 545,653 | 213,542 | 759,195 | 41.4% |
| 2026-05-18 | 804,751 | 676,826 | 1,481,577 | 48.8% |
| 2026-05-11 | 852,401 | 692,854 | 1,545,255 | 44.8% |
| 2026-05-04 | 430,332 | 183,125 | 613,457 | 36.1% |
| 2026-04-27 | 712,901 | 262,372 | 975,273 | 40.0% |
| 2026-04-20 | 693,503 | 185,896 | 879,399 | 34.8% |
| 2026-04-13 | 848,205 | 585,155 | 1,433,360 | 41.9% |
| 2026-04-06 | 803,182 | 249,388 | 1,052,570 | 37.1% |
| 2026-03-30 | 771,961 | 299,470 | 1,071,431 | 32.6% |
| 2026-03-23 | 1,019,965 | 591,723 | 1,611,688 | 40.3% |
| 2026-03-16 | 1,010,263 | 1,177,923 | 2,188,186 | 35.8% |
| 2026-03-09 | 1,355,230 | 536,072 | 1,891,302 | 35.0% |
| 2026-03-02 | 1,419,387 | 864,079 | 2,283,466 | 41.6% |
| 2026-02-23 | 2,272,600 | 851,721 | 3,124,321 | 44.1% |
| 2026-02-16 | 3,082,456 | 2,614,631 | 5,697,087 | 39.5% |
| 2026-02-09 | 4,595,237 | 4,925,924 | 9,521,161 | 46.4% |
| 2026-02-02 | 866,485 | 449,809 | 1,316,294 | 41.6% |
| 2026-01-26 | 1,315,338 | 472,003 | 1,787,341 | 52.6% |
| 2026-01-19 | 789,684 | 211,990 | 1,001,674 | 49.7% |
| 2026-01-12 | 1,032,946 | 546,873 | 1,579,819 | 48.3% |
| 2026-01-05 | 1,101,507 | 421,957 | 1,523,464 | 47.7% |
| 2025-12-29 | 523,772 | 192,894 | 716,666 | 33.0% |
| 2025-12-22 | 454,825 | 132,827 | 587,652 | 38.1% |
| 2025-12-15 | 1,851,172 | 434,600 | 2,285,772 | 47.6% |
| 2025-12-08 | 505,086 | 348,874 | 853,960 | 41.5% |
| 2025-12-01 | 814,004 | 322,558 | 1,136,562 | 41.7% |
| 2025-11-24 | 455,399 | 836,936 | 1,292,335 | 49.8% |
| 2025-11-17 | 892,604 | 345,539 | 1,238,143 | 53.3% |
| 2025-11-10 | 742,661 | 580,649 | 1,323,310 | 54.8% |
| 2025-11-03 | 361,569 | 228,049 | 589,618 | 40.5% |
| 2025-10-27 | 331,954 | 297,191 | 629,145 | 39.4% |
| 2025-10-20 | 692,735 | 245,033 | 937,768 | 43.8% |
| 2025-10-13 | 539,252 | 165,586 | 704,838 | 40.8% |
| 2025-10-06 | 521,314 | 162,886 | 684,200 | 38.8% |
| 2025-09-29 | 397,107 | 341,396 | 738,503 | 39.0% |
| 2025-09-22 | 251,441 | 102,279 | 353,720 | 28.7% |
| 2025-09-15 | 564,307 | 677,833 | 1,242,140 | 28.9% |
| 2025-09-08 | 616,239 | 195,491 | 811,730 | 38.9% |
| 2025-09-01 | 1,147,758 | 615,862 | 1,763,620 | 41.2% |
| 2025-08-25 | 602,193 | 124,610 | 726,803 | 46.1% |
Showing 1–47 of 47 weeks
Key facts
CIK
2022626
CUSIP
91678A107
13F (30d)
146 filings
144 filers
Visit website
Investor relations