MANUFACTURERS LIFE INSURANCE COMPANY, THE
InsurancePosition in UPB — Upstream Bio, Inc.
CIK 928047
TORONTO, A6
Position in UPB
as of Jun 30, 2026
· filed Sep 9, 2026
Position Value
$108,886
-$29,156 QoQ
Shares Held
15,735
+2.6% QoQ
Ownership
0.029%
of shares outstanding
% of Portfolio
0.00%
of 13F equity value
Holder Rank
#97
of 148 holders
Holding Since
Jun 2025
5 quarters on record
Voting authority
Sole 100%
Shared 0%
None 0%
Common Shares in UPB Over Time
Shares Held
Position Value (USD)
Position in Biotechnology
Healthcare · as of Jun 30, 2026MANUFACTURERS LIFE INSURANCE COMPANY, THE holds $1,663,805,623 across 242 Biotechnology names. UPB ranks #206 (0.0% of the industry book) .
| # | Ticker | Company | Shares | Value (USD) | Open |
|---|---|---|---|---|---|
| 1 | VRTX |
Vertex Pharmaceuticals Inc / Ma
|
554,085 | $275,230,642 | |
| 2 | ALNY |
Alnylam Pharmaceuticals, Inc.
|
893,795 | $269,059,108 | |
| 3 | BBIO |
BridgeBio Pharma, Inc.
|
1,955,733 | $145,662,993 | |
| 4 | JAZZ |
Jazz Pharmaceuticals plc
|
539,037 | $129,891,745 | |
| 5 | ROIV |
Roivant Sciences Ltd.
|
2,988,121 | $105,749,602 | |
| 6 | REGN |
Regeneron Pharmaceuticals, Inc.
|
147,961 | $92,259,601 | |
| 7 | RPRX |
Royalty Pharma plc
|
678,768 | $38,058,521 | |
| 8 | PTCT |
Ptc Therapeutics, Inc.
|
441,957 | $36,050,432 |
All Filings in UPB
Export CSV
5 filing rows on record
| Report Date | Value (USD) | Shares | Type | Discretion | Filed | |
|---|---|---|---|---|---|---|
| 2026-06-30 | $108,886 | 15,735 | Shares | Defined | 2026-09-09 | |
| 2026-03-31 | $138,042 | 15,338 | Shares | Defined | 2026-05-15 | |
| 2025-12-31 | $275,491 | 10,147 | Shares | Defined | 2026-02-13 | |
| 2025-09-30 | $227,450 | 12,092 | Shares | Defined | 2025-11-14 | |
| 2025-06-30 | $144,826 | 13,190 | Shares | Defined | 2025-08-14 | |
| No filing history on record for this holder in this stock. | ||||||