ASND · Ascendis Pharma A/S · Holdings

$234.33 +4.38 (+1.90%)

Russell 1000 member Rebalance outlook locked

Market Cap

$15.39B

65.80M

Volume · Oct 20 392.92K Avg daily vol (3M) 688.59K

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Use institutional holdings through the 13F API or MCP → See every holder of ASND: 13F, 13D and 13G, insiders and funds →

Institutional holdings are being reconciled with SEC filings. Holder totals and changes may be incomplete until reconciliation finishes.

The Sep 30, 2026 filing window is still open — showing the latest known positions. Funds that have not filed yet carry their prior-quarter positions; a fund that filed without this stock counts as sold out. Each fund's Change is measured against its own previous reported quarter, shown in the Reported column. Pick a completed quarter in the Quarter selector below to put every fund on one quarter and see the stock-wide activity breakdown.

Quarter:

Holders: 322

Total Value: $18,047,332,050

Total Shares: 67,706,903

Showing 1–100 of 340 holdings by value · page 1 of 4

Institutional Ownership Trend

27 quarters

Holder Concentration

Across 315 13F filers

Top Holder

15.2%

of institutional value

Top 5

45.2%

of institutional value

Top 10

63.3%

of institutional value

HHI

572

Broadly held

Who Holds ASND

Last 8 quarters through Sep 30, 2026 (filing window open)

Each kind of 13F filer's share of the common shares 13F filers report. Holder type comes from regulatory records, never the filer's name; style, turnover and horizon are measured from each filer's own 13F book. The quarter selector does not change this card.

Jun 30, 2026, the newest closed quarter: 313 filers, like-for-like change +6.8%; actively managed books +3.1%; index-like books +85.2%.

Holder type	Share	Filers	Change	New	Exited
Registered adviser	51.4%	161	-1.9%	38	27
Exempt adviser	0.0%	3	-72.0%	2	4
Adviser	18.4%	8	-1.8%	1	2
Bank	3.2%	15	+33.4%	0	1
Insurer	1.3%	2	-2.5%	1	0
Broker-dealer	0.0%	3	+45.8%	2	0
Benefit plan	0.1%	4	+856.0%	3	0
Non-US	1.1%	6	-22.6%	1	3
Holding company	13.1%	10	+11.7%	2	0
Unknown	11.2%	101	+110.8%	38	13

Style	Share	Filers	Change	New	Exited
Index-like	7.8%	29	+85.2%	13	2
Systematic-like	1.8%	25	+47.3%	11	5
Concentrated	24.3%	30	+0.8%	7	4
Diversified active	66.1%	229	+3.1%	57	39
Not measured	0.0%	0	—	0	0
Unknown	0.0%	0	—	0	0

Turnover	Share	Filers	Change	New	Exited
Low turnover	54.0%	162	+4.7%	44	17
Medium turnover	36.3%	87	-4.8%	11	18
High turnover	3.8%	49	+34.6%	27	11
Unknown	5.8%	15	+465.8%	6	4
Not measured	0.0%	0	—	0	0

Holding horizon	Share	Filers	Change	New	Exited
Short horizon	6.1%	30	+317.2%	16	11
Medium horizon	17.4%	60	+24.7%	21	10
Long horizon	65.4%	194	-2.1%	41	23
Unknown	11.0%	29	-3.0%	10	6
Not measured	0.0%	0	—	0	0

13F book size	Share	Filers	Change	New	Exited
Under $1B	1.9%	61	-0.3%	17	16
$1B to $10B	6.3%	96	-8.6%	26	16
$10B to $100B	38.4%	88	-4.5%	33	13
$100B or more	53.3%	68	+19.6%	12	5
Not measured	0.0%	0	—	0	0

Client base	Share	Filers	Change	New	Exited
Individuals and high net worth	0.7%	60	+0.7%	16	12
Pooled investment vehicles	31.3%	49	-0.3%	14	7
Registered funds and BDCs	6.5%	21	-3.4%	3	3
Pension and profit sharing plans	0.0%	2	+7.9%	1	0
Insurance companies	0.1%	2	+25.0%	1	0
Governments and sovereign funds	0.4%	7	+24.0%	1	1
Corporations	0.0%	2	-20.3%	0	0
Other investment advisers	0.0%	3	+28.1%	0	1
Diversified	12.3%	14	-6.0%	2	3
Other	0.0%	0	—	0	0
Unknown	48.6%	153	+17.8%	50	23

Private funds	Share	Filers	Change	New	Exited
Hedge funds	18.9%	55	-6.2%	16	10
Private equity funds	0.7%	14	-27.8%	4	2
Venture capital funds	15.4%	2	-0.9%	0	0
Real estate funds	0.0%	2	+235.9%	0	1
Other private funds	2.5%	12	-24.7%	1	2
Mixed private funds	9.2%	5	+5.9%	0	1
Private funds, type not stated	2.8%	2	+0.7%	0	1
No private funds	1.9%	71	+80.4%	19	13
Securitized asset funds	0.0%	0	-100.0%	0	1
Unknown	48.6%	150	+18.2%	48	19

Location	Share	Filers	Change	New	Exited
United States	95.9%	257	+8.1%	70	36
Outside the US	4.1%	56	-16.8%	18	14

The Sep 30, 2026 filing window is still open, so its bar carries the Jun 30, 2026 positions of filers that have not filed yet.

How the mix is measured

Shares are 13F common shares restated to today's split basis; options and principal amounts are left out. The change compares only filers with a 13F in both quarters and keeps each filer in its bucket of the later quarter on both sides; a filer that continues under a new CIK is compared through its successor. Holder type comes from each filer's current regulatory profile; client base and private funds come from the Form ADV roster current at each quarter end (rosters from December 2019, so an earlier quarter reads Unknown). Style, turnover, horizon and book size are measured from each filer's 13F book in the newest measured quarter, and Not measured means none was. Actively managed books are those measured systematic-like, concentrated or diversified active.

Excluded 3 holders with no observed 2026-03-31 13F and 2 holders with no observed 2026-06-30 13F. Compared across CIK changes: JANUS HENDERSON GROUP PLC continues as Jupiter Topco LLC.

Conviction and Crowding

313 13F filers, quarter ended Jun 30, 2026

Measured across every 13F filer's common-share book once the quarter's filing window closed. Crowding counts filers with high turnover or that advise private funds on Form ADV.

Conviction holders

4.47% of filers hold it in their top 10

Mar 31, 2026: 18

Holders above 5%

median weight 0.019%

Mar 31, 2026: 8

Crowding

—

a foreign private issuer reports ordinary shares, a different unit from the listed shares

Private-fund advisers

—

of shares outstanding

Institutional ownership

—

a foreign private issuer reports ordinary shares, a different unit from the listed shares

Top 10 holders

64.0%

of 13F shares, Herfindahl 0.058

Active holders

+3.1%

like-for-like share change of active filers

5% stakes on record

0 13D, 7 13G (6 institutional, 1 passive, 0 exempt)

How long holders have held it value-weighted 18.7 quarters

Under 1 year 10.5% 1 to 3 years 14.1% 3 years or more 75.4% Since coverage start 0.000%

Managers in the top fifth by current three-year FundScore alpha were net sellers of $233,598 (0 buying, 1 selling).

Estimated Holder Cost Basis

Quarter ended Jun 30, 2026, on that quarter's share basis

Estimated, never filed: each 13F buy is costed at its quarter's average traded price and each sale keeps the average cost, so this is what holders paid on average if they traded evenly through each quarter.

Estimated avg cost

$179.48

estimated per share

Mar 31, 2026: $162.02

Quarter-end price

$266.72

implied by 13F values

Estimated gain or loss

+48.6%

price against the estimated cost

Estimated at a loss

0.000%

of costed 13F value

Estimated cost covers 35.1% of the 13F shares; positions already held when a filer's 13F history starts, or bought in a quarter without a trusted average price, have no estimate.

Shared Holders

Companies ASND's active holders also own, quarter ended Jun 30, 2026

#	Company	Shared holders	Similarity
1	RYTM Rhythm Pharmaceuticals, Inc.	17	0.295
2	DNTH Dianthus Therapeutics, Inc. /DE/	18	0.291
3	XENE Xenon Pharmaceuticals Inc.	18	0.283
4	ELVN Enliven Therapeutics, Inc.	17	0.283
5	TARS Tarsus Pharmaceuticals, Inc.	12	0.283
6	ORKA Oruka Therapeutics, Inc.	17	0.268
7	ROIV Roivant Sciences Ltd.	18	0.265
8	ABVX Abivax S.A.	22	0.258
9	RVMD Revolution Medicines, Inc.	27	0.257
10	INSM INSMED Inc	22	0.255

Shareholder Targets

13F filers that own its peers but not ASND, quarter ended Jun 30, 2026

Found through its holder-overlap peers: RYTM, DNTH, XENE, ELVN, TARS, ORKA, ROIV, ABVX, RVMD, INSM, ARGX, COGT, MLYS, PRAX, SYRE, CYTK, LXEO, PTGX, CRNX, PCVX. 1,115 filers in all.

#	Filer	In peers	Of book	Largest peers
1	BAKER BROS. ADVISORS LP Registered adviser, Concentrated	$4,714,443,604 10 held	23.7%	RVMD, INSM, RYTM
2	FARALLON CAPITAL MANAGEMENT LLC Registered adviser, Diversified active	$4,175,725,148 6 held	24.7%	RVMD, PTGX, ROIV
3	Darwin Global Management, Ltd. Exempt adviser, Concentrated	$3,397,842,760 4 held	87.8%	RVMD, INSM, ABVX
4	RTW INVESTMENTS, LP Registered adviser, Diversified active	$3,043,348,785 10 held	26.0%	ARGX, PTGX, INSM
5	Paradigm Biocapital Advisors LP Registered adviser, Concentrated	$2,195,630,834 7 held	47.6%	RVMD, SYRE, ORKA
6	NORGES BANK Non-US, Index-like	$1,431,067,092 9 held	0.140%	RVMD, INSM, ROIV
7	Nextech Invest, Ltd. Exempt adviser, Concentrated	$1,423,531,573 1 held	67.8%	RVMD
8	TCG Crossover Management, LLC Unknown, Diversified active	$1,384,485,171 5 held	33.3%	ABVX, COGT, SYRE
9	DEERFIELD MANAGEMENT COMPANY, L.P. Registered adviser, Diversified active	$1,278,236,026 6 held	21.7%	RVMD, PRAX, COGT
10	Orbis Allan Gray Ltd Unknown, Diversified active	$1,160,032,767 2 held	3.99%	INSM, PRAX

Fund Ownership of ASND by Fund Type

Registered funds' Form N-PORT reports for the quarter ended Jun 30, 2026

Index funds and index ETFs hold 0.40% of shares outstanding.

Fund type	Of shares outstanding	Change	Shares	Funds
Index funds	0.01%	0.00 pp	6,621	5
Index ETFs	0.39%	+0.38 pp	256,462	6
Active ETFs	0.64%	+0.61 pp	422,425	6
Active funds	3.76%	+0.49 pp	2,473,620	37
Unclassified	0.46%	+0.45 pp	301,434	3
All registered funds	5.26%	+1.94 pp	3,460,562	57

How fund types are measured

Each fund series counts once, with its latest Form N-PORT report dated inside the quarter; only long share positions count, restated to today's split basis. The fund type is the series' latest Form N-CEN answer on or before the quarter end (the index-fund box and the exchange-traded flag), never its name. Unclassified funds have no usable N-CEN; unit investment trusts are among them, so index ownership is a floor. Funds sit inside their advisers' 13F reports, so these shares overlap the 13F figures and are never added to them.

Holder type: Registered adviser 170 Exempt adviser 3 Adviser 8 Bank 15 Insurer 2 Broker-dealer 3 Benefit plan 4 Non-US 6 Holding company 10 Unknown 101

Showing 100 of 340

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

RA CAPITAL MANAGEMENT, L.P.

$2,742,280,613

15.19%

10,281,496

T. Rowe Price Investment Management, Inc.

$1,801,652,525

9.98%

6,754,846

Avoro Capital Advisors LLC

$1,363,235,525

7.55%

5,111,111

WESTFIELD CAPITAL MANAGEMENT CO LP

$1,279,793,774

7.09%

4,798,267

Jupiter Topco LLC

$973,200,466

5.39%

3,648,772

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JANUS HENDERSON INVESTORS UK Ltd	54,099	$14,429,285	1.5%	Defined
JANUS HENDERSON INVESTORS US LLC	3,556,954	$948,710,770	97.5%	Defined
Held directly	37,719	$10,060,411	1.0%	Defined

FMR LLC

$945,675,762

5.24%

3,545,575

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	3,066,330	$817,851,537	86.5%	Defined
FIDELITY MANAGEMENT TRUST CO	174,432	$46,524,503	4.9%	Defined
STRATEGIC ADVISERS LLC	157	$41,875	0.0%	Defined
Fidelity Institutional Asset Management Trust Co	130,770	$34,878,974	3.7%	Defined
FIAM LLC	173,886	$46,378,873	4.9%	Defined

Artisan Partners Limited Partnership

$702,546,881

3.89%

2,634,024

BlackRock, Inc.

$589,940,091

3.27%

2,211,833

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	32,510	$8,671,067	1.5%	Sole
BlackRock Investment Management (Australia) Ltd	66	$17,603	0.0%	Sole
BlackRock Asset Management Canada Ltd	2,444	$651,863	0.1%	Sole
BlackRock Investment Management, LLC	18,726	$4,994,598	0.8%	Sole
BLACKROCK ADVISORS LLC	37,252	$9,935,853	1.7%	Sole
BlackRock Fund Advisors	1,245,579	$332,220,830	56.3%	Sole
BlackRock Institutional Trust Company, N.A.	600,609	$160,194,432	27.2%	Sole
BlackRock Investment Management (UK) Ltd.	207,091	$55,235,311	9.4%	Sole
BlackRock International, Ltd.	84	$22,404	0.0%	Sole
BlackRock Asset Management Ireland Ltd	50,490	$13,466,692	2.3%	Sole
BlackRock Advisors (UK) Ltd	789	$210,442	0.0%	Sole
BlackRock (Luxembourg) S.A.	7,599	$2,026,805	0.3%	Sole
Aperio Group, LLC	8,591	$2,291,391	0.4%	Sole
SpiderRock Advisors, LLC	3	$800	0.0%	Sole

Capital International Investors

$530,403,126

2.94%

1,988,614

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
CAPITAL GROUP COMPANIES INC joint	1,988,614	$530,403,126	100.0%	Defined

MASSACHUSETTS FINANCIAL SERVICES CO /MA/

$500,180,281

2.77%

1,875,301

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MFS Institutional Advisors, Inc.	45,675	$12,182,436	2.4%	Defined
MFS Investment Management CO (LUX) S.A.R.L.	11,434	$3,049,676	0.6%	Defined
MFS Investment Management K.K.	10,935	$2,916,583	0.6%	Defined
MFS Heritage Trust CO	293,832	$78,370,871	15.7%	Defined
MFS INVESTMENT MANAGEMENT CANADA LTD	3,076	$820,430	0.2%	Defined
Held directly	1,510,349	$402,840,285	80.5%	Sole

FRANKLIN RESOURCES INC

$496,766,798

2.75%

1,862,503

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fiduciary Trust International of the South	30	$8,001	0.0%	Defined
FIDUCIARY TRUST INTERNATIONAL LLC	45	$12,002	0.0%	Defined
FRANKLIN ADVISERS INC	1,654,989	$441,418,666	88.9%	Defined
FRANKLIN ADVISORY SERVICES LLC	909	$242,448	0.0%	Defined
PUTNAM INVESTMENT MANAGEMENT LLC	151,263	$40,344,867	8.1%	Defined
PUTNAM ADVISORY CO LLC	55,267	$14,740,814	3.0%	Defined

WELLINGTON MANAGEMENT GROUP LLP

$413,052,191

2.29%

1,548,636

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Wellington Management Company LLP	1,469,450	$391,931,704	94.9%	Defined
Wellington Managment Canada LLC	3,748	$999,666	0.2%	Defined
Wellington Management Japan Pte Ltd	2,466	$657,731	0.2%	Defined
Wellington Management Singapore Pte. Ltd.	8,760	$2,336,467	0.6%	Defined
Wellington Management International Ltd	23,280	$6,209,241	1.5%	Defined
Wellington Trust Company, NA joint	35,336	$9,424,817	2.3%	Defined
Wellington Management Australia Pty Ltd	5,596	$1,492,565	0.4%	Defined

AMERICAN CENTURY COMPANIES INC

$373,561,364

2.07%

1,400,575

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
AMERICAN CENTURY INVESTMENT MANAGEMENT INC	1,400,575	$373,561,364	100.0%	Defined

PERCEPTIVE ADVISORS LLC

$310,387,665

1.72%

1,163,721

PRICE T ROWE ASSOCIATES INC /MD/

$299,400,934

1.66%

1,122,529

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T. Rowe Price International Ltd	24,751	$6,601,586	2.2%	Defined
Held directly	1,097,778	$292,799,348	97.8%	Sole

Capital World Investors

$241,669,924

1.34%

906,081

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
CAPITAL GROUP COMPANIES INC joint	906,081	$241,669,924	100.0%	Defined

PRINCIPAL FINANCIAL GROUP INC

$232,980,453

1.29%

873,502

Polar Capital Holdings Plc

$164,541,701

0.91%

616,908

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Polar Capital LLP	616,908	$164,541,701	100.0%	Defined

GOLDMAN SACHS GROUP INC

$149,238,906

0.83%

559,534

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	427,415	$114,000,128	76.4%	Defined
GOLDMAN SACHS ASSET MANAGEMENT, L.P.	130,740	$34,870,972	23.4%	Defined
Goldman Sachs Trust Company, N.A.	1,379	$367,806	0.2%	Defined

MORGAN STANLEY

$145,200,497

0.80%

544,393

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO. LLC	470	$125,358	0.1%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	358,643	$95,657,260	65.9%	Defined
MORGAN STANLEY AIP GP LP	28,543	$7,612,988	5.2%	Defined
MORGAN STANLEY INVESTMENT MANAGEMENT INC	973	$259,518	0.2%	Defined
MORGAN STANLEY SMITH BARNEY LLC	27,208	$7,256,917	5.0%	Defined
Morgan Stanley Bank, N.A.	2,814	$750,550	0.5%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	125,742	$33,537,906	23.1%	Defined

STATE STREET CORP

$137,085,811

0.76%

513,969

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STATE STREET GLOBAL ADVISORS EUROPE LIMITED joint	513,969	$137,085,811	100.0%	Defined

Invesco Ltd.

$110,474,354

0.61%

414,196

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invesco Advisers, Inc. joint	307,189	$81,933,448	74.2%	Defined
Invesco Trust Co joint	20,357	$5,429,619	4.9%	Defined
Invesco Asset Management Limited joint	31,258	$8,337,133	7.5%	Defined
Invesco Capital Management LLC	55,392	$14,774,154	13.4%	Defined

GEODE CAPITAL MANAGEMENT, LLC

$107,528,433

0.60%

403,151

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	16,647	$4,440,087	4.1%	Defined
Held directly	386,504	$103,088,346	95.9%	Defined

UBS Group AG

$107,189,699

0.59%

401,881

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Financial Services Inc	62,319	$16,621,723	15.5%	Defined
UBS AG	336,885	$89,853,967	83.8%	Defined
UBS Switzerland AG	742	$197,906	0.2%	Defined
UBS Securities LLC	1,935	$516,103	0.5%	Defined

ALLIANCEBERNSTEIN L.P.

$106,499,162

0.59%

399,292

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Equitable Holdings, Inc.	399,292	$106,499,162	100.0%	Defined

Vestal Point Capital, LP

$100,020,000

0.55%

375,000

JPMORGAN CHASE & CO

$98,094,543

0.54%

367,781

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
J.P. Morgan Trust Co of Delaware	408	$108,820	0.1%	Other
JPMorgan Chase Bank, N.A.	366	$97,619	0.1%	Defined
J.P. Morgan Investment Management Inc.	1,791	$477,695	0.5%	Defined
J.P. Morgan Securities LLC	276,479	$73,742,478	75.2%	Defined
JPMorgan Asset Management (UK) Ltd	88,729	$23,665,798	24.1%	Defined
55I, LLC	8	$2,133	0.0%	Other

FIL Ltd

$92,169,630

0.51%

345,567

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
FIL Investments International	345,567	$92,169,630	100.0%	Defined

AMERIPRISE FINANCIAL INC

$85,487,493

0.47%

320,514

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Columbia Management Investment Advisers, LLC	319,838	$85,307,191	99.8%	Defined
Ameriprise Financial Services, LLC	625	$166,700	0.2%	Defined
Ameriprise Bank, FSB	51	$13,602	0.0%	Defined

Bank of New York Mellon Corp

$85,193,563

0.47%

319,412

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Investments Corporation joint	57,926	$15,450,022	18.1%	Defined
BNY Mellon Securities Corporation	2,630	$701,473	0.8%	Defined
The Bank of New York Mellon	39,371	$10,501,033	12.3%	Defined
BNY Mellon, NA joint	1,933	$515,569	0.6%	Defined
BNY Mellon Advisors, Inc. joint	7,677	$2,047,609	2.4%	Defined
Newton Investment Management North America, LLC joint	209,874	$55,977,591	65.7%	Defined
Held directly	1	$266	0.0%	Defined

TWO SIGMA INVESTMENTS, LP

$81,563,776

0.45%

305,803

MILLENNIUM MANAGEMENT LLC

$71,136,357

0.39%

266,708

BANK OF AMERICA CORP /DE/

$69,517,365

0.39%

260,638

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	167,473	$44,668,398	64.3%	Defined
MERRILL LYNCH, PIERCE, FENNER & SMITH INC.	18,970	$5,059,678	7.3%	Defined
BOFA SECURITIES, INC.	3,640	$970,860	1.4%	Defined
MANAGED ACCOUNT ADVISORS LLC joint	70,555	$18,818,429	27.1%	Defined

Tri Locum Partners LP

$69,011,132

0.38%

258,740

ORBIMED ADVISORS LLC

$65,201,304

0.36%

244,456

SEI INVESTMENTS CO

$63,444,419

0.35%

237,869

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SEI INVESTMENTS MANAGEMENT CORP	2,445	$652,130	1.0%	Sole
SEI TRUST CO	235,424	$62,792,289	99.0%	Sole

Pictet Asset Management Holding SA

$62,422,882

0.35%

234,039

PFM Health Sciences, LP

$62,191,369

0.34%

233,171

Frazier Life Sciences Management, L.P.

$60,053,341

0.33%

225,155

Spyglass Capital Management LLC

$57,450,954

0.32%

215,398

ARS Investment Partners, LLC

$56,134,424

0.31%

210,462

SILVERARC CAPITAL MANAGEMENT, LLC

$55,006,732

0.30%

206,234

NEW YORK STATE COMMON RETIREMENT FUND

$51,154,495

0.28%

191,791

Empowered Funds, LLC

$49,948,919

0.28%

187,271

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
The Burney Company	365	$97,352	0.2%	Other
ARS Investment Partners, LLC	38,717	$10,326,598	20.7%	Other
Sapient Capital, LLC	148,159	$39,516,968	79.1%	Other
Held directly	30	$8,001	0.0%	Sole

JANE STREET GROUP, LLC

$49,914,247

0.28%

187,141

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	86,174	$22,984,329	46.0%	Defined
Jane Street Global Trading, LLC	100,967	$26,929,918	54.0%	Defined

Allspring Global Investments Holdings, LLC

$47,672,997

0.26%

178,738

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Allspring Funds Management, LLC reporting on behalf of Morgan Stanley Smith Barney, LLC	4,865	$1,297,591	2.7%	Other
Allspring Global Investments, LLC reporting on behalf of UBS ASSET MANAGEMENT AMERICAS INC	173,873	$46,375,406	97.3%	Defined

CITADEL ADVISORS LLC

$46,889,376

0.26%

175,800

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	175,800	$46,889,376	100.0%	Defined

BNP PARIBAS ARBITRAGE, SA

$46,262,317

0.26%

173,449

FRED ALGER MANAGEMENT, LLC

$45,728,343

0.25%

171,447

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Redwood Investments, LLC	26,667	$7,112,622	15.6%	Sole
Held directly	144,780	$38,615,721	84.4%	Sole

Rock Springs Capital Management LP

$45,009,000

0.25%

168,750

SG Americas Securities, LLC

$42,948,854

0.24%

161,026

RICE HALL JAMES & ASSOCIATES, LLC

$39,646,327

0.22%

148,644

LORD, ABBETT & CO. LLC

$38,532,504

0.21%

144,468

NEUBERGER BERMAN GROUP LLC

$38,062,276

0.21%

142,705

USS Investment Management Ltd

$37,610,187

0.21%

141,010

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
USS Investment Management Ltd	141,010	$37,610,187	100.0%	Sole

CITADEL ADVISORS LLC

$36,777,753

0.20%

137,889

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	12,478	$3,328,132	9.0%	Defined
Held directly	125,411	$33,449,621	91.0%	Defined

ODDO BHF ASSET MANAGEMENT SAS

$34,315,395

0.19%

128,657

Walleye Capital LLC

$33,608,053

0.19%

126,005

ARROWSTREET CAPITAL, LIMITED PARTNERSHIP

$33,545,907

0.19%

125,772

RENAISSANCE TECHNOLOGIES LLC

$31,926,117

0.18%

119,699

TD Asset Management Inc

$31,762,351

0.18%

119,085

Resolute Capital Asset Partners LLC

$31,640,193

0.18%

118,627

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$30,432,752

0.17%

114,100

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	114,100	$30,432,752	100.0%	Other

BRAUN STACEY ASSOCIATES INC

$30,352,423

0.17%

133,224

Eagle Health Investments LP

$28,314,461

0.16%

106,158

First Turn Management, LLC

$27,972,793

0.15%

104,877

NORTHERN TRUST CORP

$27,721,008

0.15%

103,933

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	103,103	$27,499,631	99.2%	Defined
NORTHERN TRUST GLOBAL INVESTMENTS LTD	830	$221,377	0.8%	Defined

VANGUARD PORTFOLIO MANAGEMENT LLC

$27,616,188

0.15%

103,540

Fiera Capital Corp

$27,555,643

0.15%

103,313

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fiera Capital Inc.	77,657	$20,712,675	75.2%	Other
Held directly	25,656	$6,842,968	24.8%	Sole

Woodline Partners LP

$27,330,531

0.15%

102,469

Q Global Advisors, LLC

$26,672,000

0.15%

100,000

Defilade Capital Management, L.P.

$25,296,524

0.14%

94,843

CITADEL ADVISORS LLC

$24,831,632

0.14%

93,100

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	93,100	$24,831,632	100.0%	Defined

Synergy Asset Management, LLC

$24,332,332

0.13%

91,228

Nuveen, LLC

$24,089,616

0.13%

90,318

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Nuveen Asset Management, LLC joint	14,416	$3,845,035	16.0%	Defined
TEACHERS ADVISORS, LLC joint	75,902	$20,244,581	84.0%	Defined

CANADA PENSION PLAN INVESTMENT BOARD

$22,798,692

0.13%

85,478

SAPIENT CAPITAL LLC

$21,808,115

0.12%

95,721

LOOMIS SAYLES & CO L P

$21,055,143

0.12%

78,941

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
LOOMIS SAYLES TRUST COMPANY, LLC	32,420	$8,647,062	41.1%	Defined
Held directly	46,521	$12,408,081	58.9%	Defined

BARCLAYS PLC

$20,414,748

0.11%

76,540

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BARCLAYS BANK PLC	72,128	$19,237,980	94.2%	Defined
BARCLAYS CAPITAL INC.	4,412	$1,176,768	5.8%	Defined

Driehaus Capital Management LLC

$18,686,669

0.10%

70,061

JANE STREET GROUP, LLC

$18,643,728

0.10%

69,900

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	69,900	$18,643,728	100.0%	Defined

ADAGE CAPITAL PARTNERS GP, L.L.C.

$17,736,880

0.10%

66,500

Caption Management, LLC

$16,616,656

0.09%

62,300

CASTLEARK MANAGEMENT LLC

$16,455,557

0.09%

61,696

Atika Capital Management LLC

$16,269,919

0.09%

61,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Atika Capital Partners LP	35,588	$9,492,031	58.3%	Defined
Optika Master Portfolio Ltd	15,412	$4,110,688	25.3%	Other
Held directly	10,000	$2,667,200	16.4%	Sole

MILLENNIUM MANAGEMENT LLC

$16,189,904

0.09%

60,700

VOYA INVESTMENT MANAGEMENT LLC

$14,491,430

0.08%

54,332

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Voya Investment Management Co. LLC joint	54,332	$14,491,430	100.0%	Defined

WELLS FARGO & COMPANY/MN

$13,430,150

0.07%

50,353

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO BANK N A	822	$219,243	1.6%	Defined
WELLS FARGO ADVISORS FINANCIAL NETWORK, LLC	11,872	$3,166,499	23.6%	Defined
WELLS FARGO CLEARING SERVICES, LLC	37,659	$10,044,408	74.8%	Defined

Cormorant Asset Management, LP

$13,336,000

0.07%

50,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Chen Bihua	50,000	$13,336,000	100.0%	Defined

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$13,202,640

0.07%

49,500

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	49,500	$13,202,640	100.0%	Other

RHUMBLINE ADVISERS

$12,965,792

0.07%

48,612

DAFNA Capital Management LLC

$12,927,651

0.07%

48,469

Russell Investments Group, Ltd.

$12,898,577

0.07%

48,360

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Russell Investment Management, LLC	31,556	$8,416,616	65.3%	Defined
Russell Investments Capital, LLC	8,193	$2,185,236	16.9%	Defined
Russell Investments France SAS	2,974	$793,225	6.1%	Defined
Russell Investments Trust Company	5,637	$1,503,500	11.7%	Defined

Trexquant Investment LP

$12,607,587

0.07%

47,269

ENVESTNET ASSET MANAGEMENT INC

$12,209,374

0.07%

45,776

Integral Health Asset Management, LLC

$12,002,400

0.07%

45,000

NOMURA ASSET MANAGEMENT CO LTD

$11,649,796

0.06%

43,678

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Nomura Asset Management Europe KVG mbH	43,678	$11,649,796	100.0%	Sole
Held directly	0	$0	0.0%	Sole

XTX Topco Ltd

$11,546,042

0.06%

43,289

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
XTX EXECUTION SERVICES LLC joint	43,289	$11,546,042	100.0%	Defined

Eversept Partners, LP

$11,101,153

0.06%

41,621

Quadrature Capital Ltd

$10,894,178

0.06%

40,845

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Quadrature US Inc.	40,845	$10,894,178	100.0%	Other

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Key facts CIK 1612042 CUSIP K08588103 13F (30d) 25 filings 25 filers Visit website Investor relations